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1. 发明申请

US20160017085A1 METHOD FOR PRODUCING POLYTHIOL COMPOUND, POLYMERIZABLE COMPOSITION FOR OPTICAL MATERIAL, AND USES THEREOF 有权
标题翻译：用于生产聚合物的方法，用于光学材料的可聚合组合物及其用途
公开(公告)号：US20160017085A1
公开(公告)日：2016-01-21
申请号：US14871479
申请日：2015-09-30
申请人： MITSUI CHEMICALS, INC
发明人： Masaru KAWAGUCHI , Takeshi NISHIMURA
IPC分类号： C08G18/38 , G02B1/04 , C07C335/32 , C07C319/20 , C08G18/76 , C07C319/14
CPC分类号： C08G18/3876 , C07C319/08 , C07C319/14 , C07C319/20 , C07C335/32 , C07C381/00 , C08G18/7642 , G02B1/041 , C08L75/04 , C08L81/00 , C07C323/12 , C07C321/14
摘要： Provided is a method for producing a molded product comprising preparing a polymerizable composition for optical materials and curing the polymerizable composition for optical materials to produce the molded product. The preparation of the polymerizable composition comprises preparing a polythiol compound containing, as a main component, one kind or two or more kinds selected from a defined group of compounds, and preparing the polymerizable composition from the polythiol compound. The preparation of the polythiol compound comprises reacting 2-mercaptoethanol with a defined epihalohydrin compound to obtain a defined compound, reacting the defined compound with sodium sulfide to obtain a defined polyalcohol compound, reacting the polyalcohol compound with thiourea in the presence of hydrogen chloride to obtain an isothiuronium salt, adding aqueous ammonia to a reaction solution containing the isothiuronium salt thereby hydrolyzing the isothiuronium salt to obtain the polythiol compound and purifying the polythiol compound with hydrochloric acid.
摘要翻译：本发明提供一种成型品的制造方法，其包括制备光学材料用聚合性组合物，使光学材料用聚合性组合物固化，制造成型品。可聚合组合物的制备包括制备含有选自定义的一组化合物中的一种或两种以上的作为主要成分的多硫醇化合物，并由多硫醇化合物制备可聚合组合物。多硫醇化合物的制备包括使2-巯基乙醇与定义的表卤代醇化合物反应以获得规定的化合物，使定义的化合物与硫化钠反应，得到定义的多元醇化合物，使多元醇化合物与硫脲在氯化氢存在下反应，得到异硫脲鎓盐，向含有异硫脲鎓盐的反应溶液中加入氨水，从而水解异硫脲鎓盐，得到多硫醇化合物，并用盐酸纯化多硫醇化合物。

2. 发明申请

US20150133692A1 METHOD FOR PRODUCING POLYTHIOL COMPOUND, POLYMERIZABLE COMPOSITION FOR OPTICAL MATERIAL, AND USES THEREOF 有权
标题翻译：用于生产聚合物的方法，用于光学材料的可聚合组合物及其用途
公开(公告)号：US20150133692A1
公开(公告)日：2015-05-14
申请号：US14405222
申请日：2013-02-28
申请人： MITSUI CHEMICALS, INC.
发明人： Masaru Kawaguchi , Takeshi Nishimura
IPC分类号： C07C319/08 , C07C381/00
CPC分类号： C08G18/3876 , C07C319/08 , C07C319/14 , C07C319/20 , C07C335/32 , C07C381/00 , C08G18/7642 , G02B1/041 , C08L75/04 , C08L81/00 , C07C323/12 , C07C321/14
摘要： Provided is a method for producing a polythiol compound, comprising: a step for reacting 2-mercaptoethanol with a defined epihalohydrin compound at a temperature of 10° C. to 50° C. to obtain a defined polyalcohol compound; a step for reacting the polyalcohol compound thus obtained with thiourea in the presence of hydrogen chloride to obtain an isothiuronium salt; a step for adding, while maintaining a reaction solution containing the isothiuronium salt thus obtained at a temperature of 15° C. to 60° C., aqueous ammonia to the reaction solution within 80 minutes, thereby hydrolyzing the isothiuronium salt to obtain a defined polythiol compound; and a step for adding hydrochloric acid which is a concentration of 25% to 36% to the solution containing the polythiol compound thus obtained, washing the solution at a temperature of 10° C. to 50° C. to purify the polythiol compound.
摘要翻译：本发明提供一种多硫醇化合物的制造方法，其特征在于，包括：在10℃〜50℃的温度下使2-巯基乙醇与定义的表卤代醇化合物反应的步骤，得到规定的多元醇化合物; 将由此获得的多元醇化合物与硫脲在氯化氢存在下反应得到异硫脲鎓盐的步骤; 将在15℃至60℃的温度下将含有异硫脲鎓盐的反应溶液保持在反应溶液中的反应溶液在80分钟内加入到反应溶液中，从而水解异硫脲鎓盐以获得定义的多硫醇复合; 向含有所述多硫醇化合物的溶液中加入浓度为25％〜36％的盐酸的步骤，在10℃〜50℃的温度下洗涤，纯化多硫醇化合物。

3. 发明授权

US08785649B2 Ethynylphenylamidine compound or salt thereof, method for producing same, and fungicide for agricultural and horticultural use 有权
标题翻译：乙炔基苯脒化合物或其盐，其制备方法和用于农业和园艺用途的杀真菌剂
公开(公告)号：US08785649B2
公开(公告)日：2014-07-22
申请号：US13879488
申请日：2011-11-02
申请人： Satoru Masumoto , Hitoshi Mutsutani , Sachi Kimura
发明人： Satoru Masumoto , Hitoshi Mutsutani , Sachi Kimura
IPC分类号： C07C257/10 , C07D213/38
CPC分类号： C07F7/10 , A01N33/00 , A01N37/52 , A01N43/10 , A01N43/38 , A01N43/40 , A01N47/42 , A01N55/00 , C07C211/45 , C07C211/52 , C07C215/68 , C07C257/10 , C07C257/12 , C07C275/12 , C07C335/32 , C07C2601/14 , C07D209/48 , C07D213/58 , C07D333/20 , C07F7/081 , C07F7/1804
摘要： An object of the present invention is to provide a novel fungicide having an excellent fungicidal activity. The compound used as the fungicide of the present invention is an ethynylphenylamidine compound or a salt thereof, the compound being represented by Formula (1): wherein R1 and R2 are each hydrogen or C1-12 alkyl, or R1 and R2 may be bonded together to form C1-7 alkylene; R3 is hydrogen or C1-4 alkylthio; R4, R5, R6, and R7 are each hydrogen, halogen, etc.; and R8 is hydrogen, C1-20 alkyl, C3-8 cycloalkyl, C1-4 haloalkyl, phenyl, a heterocyclic group, or —(CH2)n-Si(R9)(R10)(R11) wherein R9, R10, and R11 are each C1-6 alkyl, and n is an integer of 0 or 1.
摘要翻译：本发明的目的是提供一种具有优异杀真菌活性的新型杀真菌剂。用作本发明的杀真菌剂的化合物是乙炔基苯脒化合物或其盐，该化合物由式（1）表示：其中R 1和R 2各自为氢或C 1-12烷基，或者R 1和R 2可以结合在一起以形成C 1-7亚烷基; R3是氢或C1-4烷硫基; R4，R5，R6和R7各自为氢，卤素等; 或R 8为氢，C 1-20烷基，C 3-8环烷基，C 1-4卤代烷基，苯基，杂环基或 - （CH 2）n -Si（R 9）（R 10）（R 11）其中R 9，R 10和R 11 各为C 1-6烷基，n为0或1的整数。

4. 发明申请

US20140066486A1 REL INHIBITORS AND METHODS OF USE THEREOF 审中-公开
标题翻译：相关抑制剂及其使用方法
公开(公告)号：US20140066486A1
公开(公告)日：2014-03-06
申请号：US14011341
申请日：2013-08-27
申请人： The Trustees of the University of Pennsylvania
发明人： Youhai H. CHEN , Ramachandran MURALI , Jing SUN
IPC分类号： C07D233/64 , C07C335/32
CPC分类号： C07D233/64 , A61K31/155 , A61K31/235 , A61K31/275 , A61K31/325 , A61K31/38 , A61K31/4174 , A61K31/426 , A61K31/519 , C07C335/32
摘要： This invention provides REL inhibitors which interfere with the DNA binding capacity of a REL protein. Additionally this invention provides methods of treating, abrogating, or preventing diseases which respond with a positive clinical score to a REL inhibitor. Methods of identifying REL inhibitor based on a REL protein three dimensional model are described.
摘要翻译：本发明提供了干扰REL蛋白的DNA结合能力的REL抑制剂。另外，本发明提供治疗，废除或预防对REL抑制剂具有阳性临床评分的疾病的方法。描述了基于REL蛋白三维模型识别REL抑制剂的方法。

5. 发明授权

US08642278B2 Inhibition of cell proliferation 有权
标题翻译：抑制细胞增殖
公开(公告)号：US08642278B2
公开(公告)日：2014-02-04
申请号：US11562903
申请日：2006-11-22
申请人： Said M. Sebti , Srikumar Chellappan , Nicholas James Lawrence
发明人： Said M. Sebti , Srikumar Chellappan , Nicholas James Lawrence
IPC分类号： A61K31/155 , A61K31/215 , A61K31/34 , A61K31/41 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/675 , C07D233/00 , C07D249/12
CPC分类号： C07C323/45 , C07C279/06 , C07C335/32 , C07D213/53 , C07D215/12 , C07D233/30 , C07D233/84 , C07D235/28 , C07D249/12 , C07D249/14 , C07D277/40 , C07D277/42 , C07D317/56 , C07D317/58
摘要： The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC50 values ranging from 80 nM to 500 nM. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non-small cell lung carcinoma, three different pancreatic cancer cell lines, two different glioblastoma cell lines, metastatic breast cancer, melanoma, and prostate cancer. Moreover, the disclosed compounds effectively disrupt angiogenesis and significantly inhibited tumors in nude mice derived from human epithelial lung carcinoma tumors. Accordingly, the disclosed compounds, pharmaceutical compositions comprising the compounds, methods of inhibiting cell proliferation, methods of treating subjects with cancer, and methods of preparing the disclosed compounds are provided.
摘要翻译：所公开的Rb：Raf-1相互作用的调节剂是Rb：Raf-1结合的有效的选择性破坏剂，IC 50值范围为80nM至500nM。此外，这些化合物令人惊奇地有效地抑制多种癌细胞，包括骨肉瘤，上皮性肺癌，非小细胞肺癌，三种不同的胰腺癌细胞系，两种不同的胶质母细胞瘤细胞系，转移性乳腺癌，黑素瘤和前列腺癌。此外，所公开的化合物有效地破坏了血管发生，并显着抑制了源自人上皮性肺癌肿瘤的裸鼠中的肿瘤。因此，提供了所公开的化合物，包含该化合物的药物组合物，抑制细胞增殖的方法，治疗患有癌症的受试者的方法以及制备所公开的化合物的方法。

6. 发明授权

US07598269B2 Methods and compositions for treating amyloid-related diseases 失效
标题翻译：用于治疗淀粉样蛋白相关疾病的方法和组合物
公开(公告)号：US07598269B2
公开(公告)日：2009-10-06
申请号：US11807759
申请日：2007-05-30
申请人： Xianqi Kong , Walter A. Szarek , Francine Gervais
发明人： Xianqi Kong , Walter A. Szarek , Francine Gervais
IPC分类号： A61K31/44 , A61K31/47 , C07D211/00
CPC分类号： C07D295/084 , C07C307/02 , C07C309/13 , C07C309/14 , C07C309/15 , C07C309/46 , C07C309/69 , C07C311/32 , C07C311/46 , C07C335/32 , C07C381/02 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D295/088 , C07F9/1651 , C07F9/2458
摘要： Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-+related disease.
摘要翻译：描述了治疗或预防淀粉样蛋白相关疾病的方法，化合物，药物组合物和试剂盒。

7. 发明申请

US20090176773A1 Non-Peptidic Inhibitors of AKAP/PKA Interaction 审中-公开
标题翻译： AKAP / PKA相互作用的非肽抑制剂
公开(公告)号：US20090176773A1
公开(公告)日：2009-07-09
申请号：US11914591
申请日：2006-05-18
申请人： Enno Klussmann , Walter Rosenthal , Jorg Rademann , Frank Christian , Sina Meyer
发明人： Enno Klussmann , Walter Rosenthal , Jorg Rademann , Frank Christian , Sina Meyer
IPC分类号： A61K31/536 , C07D207/44 , A61K31/40 , C07K16/44 , A01K67/027 , C12N5/00 , C07D265/30 , C07D241/04 , A61K31/5375 , A61K31/495 , C07D319/12 , A61K31/357 , C07D413/06 , A61K31/421 , C07D257/06 , A61K31/41 , C07D233/96 , A61K31/4166 , C07D211/82 , A61K31/44 , C07D413/10 , C07D407/12 , A61K31/5355 , A61P3/04 , A61P3/10 , A61P9/00 , A61P11/00 , A61P9/04 , A61P25/18 , A61P11/06 , A61P29/00 , A61P31/18
CPC分类号： C07C335/32 , C07C31/137 , C07C50/24 , C07C69/017 , C07C69/94 , C07C211/50 , C07C211/61 , C07C215/76 , C07C215/80 , C07C225/22 , C07C233/09 , C07C233/47 , C07C233/56 , C07C237/40 , C07C245/08 , C07C251/08 , C07C251/24 , C07C251/46 , C07C271/28 , C07C279/04 , C07C279/26 , C07C281/18 , C07C311/08 , C07C311/20 , C07C311/51 , C07C317/44 , C07C335/12 , C07C335/16 , C07C337/06 , C07C2601/14 , C07C2603/18 , C07C2603/24 , C07C2603/74 , C07D213/42 , C07D231/12 , C07D277/40 , C07D277/54 , C07D277/68 , C07D295/135 , C07D333/64
摘要： The invention relates to non-peptidic molecules which modulate, especially inhibit, the interaction of protein kinase A (PKA) and A kinase anchor proteins (AKAP) and to a host or target organism that comprises said non-peptidic compounds or recognition molecules directed to said compounds, such as e.g. antibodies or chelating agents. The invention also relates to a pharmaceutical agent, especially for use in the treatment of diseases that are associated with a disturbance of the cAMP signal path, especially insipid diabetes, hypertonia, pancreatic diabetes, duodenal ulcer, asthma, heart failure, obesity, AIDS, edema, hepatic cirrhosis, schizophrenia and others. The invention also relates to the use of the inventive molecules.
摘要翻译：本发明涉及调节，特别是抑制蛋白激酶A（PKA）和A激酶锚蛋白（AKAP）与包含所述非肽化合物或识别分子的宿主或靶生物的相互作用的非肽分子所述化合物，例如抗体或螯合剂。本发明还涉及药剂，特别是用于治疗与cAMP信号通路紊乱相关的疾病，特别是胰岛素性糖尿病，高渗，胰腺糖尿病，十二指肠溃疡，哮喘，心力衰竭，肥胖症，艾滋病，水肿，肝硬化，精神分裂症等。本发明还涉及本发明分子的用途。

8. 发明授权

US07429586B2 Non-imidazole aryloxyalkylamines 有权
标题翻译：非咪唑芳氧基烷基胺
公开(公告)号：US07429586B2
公开(公告)日：2008-09-30
申请号：US11453422
申请日：2006-06-15
申请人： Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Dale A. Rudolph , Chandravadan R. Shah , Wei Xiao
发明人： Richard Apodaca , Nicholas I. Carruthers , Curt A. Dvorak , Dale A. Rudolph , Chandravadan R. Shah , Wei Xiao
IPC分类号： A61K31/435 , C07D217/00
CPC分类号： C07D207/325 , A61K31/4402 , A61K31/4465 , A61K45/06 , C07C217/22 , C07C323/25 , C07C335/32 , C07D207/335 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/74 , C07D215/06 , C07D231/12 , C07D233/42 , C07D233/54 , C07D233/56 , C07D233/84 , C07D233/88 , C07D235/06 , C07D235/26 , C07D239/34 , C07D249/08 , C07D257/04 , C07D277/36 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D307/52 , C07D317/28 , C07D333/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D471/08 , A61K2300/00
摘要： Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译：式（I）的取代的芳氧基烷基胺，含有它们的组合物，以及制备和使用它们来治疗组胺介导的病症的方法。

9. 发明申请

US20080234384A1 BIARYL AND BIHETEROARYL COMPOUNDS USEFUL IN TREATING IRON DISORDERS 审中-公开
标题翻译： BIARYL和BIEETEROARYL化合物有用的治疗铁路疾病
公开(公告)号：US20080234384A1
公开(公告)日：2008-09-25
申请号：US12051741
申请日：2008-03-19
申请人： Mikhail Chafeev , Nagasree Chakka , Jean-Jacques Cadieux , Jianmin Fu , Rajender Kamboj , Vishnumurthy Kodumuru , Jonathan Langille , Shifeng Liu , Jianyu Sun , Serguei Sviridov , Zaihui Zhang
发明人： Mikhail Chafeev , Nagasree Chakka , Jean-Jacques Cadieux , Jianmin Fu , Rajender Kamboj , Vishnumurthy Kodumuru , Jonathan Langille , Shifeng Liu , Jianyu Sun , Serguei Sviridov , Zaihui Zhang
IPC分类号： A61K31/166 , C07C335/32 , A61K31/155 , C07C257/00 , C07C279/04 , C07C233/78
CPC分类号： C07D333/34 , C07C323/44 , C07C323/62 , C07C335/16 , C07C335/32 , C07D333/38
摘要： This invention is directed to compounds of formula (I): wherein m, n, R1, R2 and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment of iron disorders. This invention is also directed to pharmaceutical compositions comprising the compounds and methods of using the compounds to treat iron disorders.
摘要翻译：本发明涉及式（I）化合物：其中m，n，R 1，R 2和R 3如本文所定义，作为立体异构体，其对映体，互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药，用于治疗铁疾病。本发明还涉及包含该化合物的药物组合物和使用该化合物治疗铁疾病的方法。

10. 发明申请

US20070208177A1 Novel process for preparing 1-(mercaptomethyl)cyclopropaneacetic acid, a useful intermediate in the preparation of montelukast and salts thereof 失效
标题翻译：制备1-（巯基甲基）环丙烷乙酸的新方法，其是制备孟鲁司特及其盐的有用中间体
公开(公告)号：US20070208177A1
公开(公告)日：2007-09-06
申请号：US11700867
申请日：2007-02-01
申请人： Yanling Wang , Yuang Wang , Michael Brand , Joseph Kaspi
发明人： Yanling Wang , Yuang Wang , Michael Brand , Joseph Kaspi
IPC分类号： C07D215/16 , C07C335/14
CPC分类号： C07D215/18 , C07C253/30 , C07C319/02 , C07C335/32 , C07C2601/02 , C07C255/31 , C07C323/53
摘要： The present invention provides a novel montelukast intermediate and a simple and straightforward process for preparing it. According to the present invention, by using this intermediate and the process, essentially as described herein, montelukast acid and salts thereof are obtained.
摘要翻译：本发明提供了一种新颖的孟鲁司特中间体和一种简单直接的制备方法。根据本发明，通过使用基本上如本文所述的该中间体和方法，可以获得孟鲁司特酸及其盐。

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