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1. 发明授权

US08314071B2 Bioactive molecules from co-cultivation of microbes 有权
标题翻译：生物活性分子共培养微生物
公开(公告)号：US08314071B2
公开(公告)日：2012-11-20
申请号：US12599730
申请日：2008-12-22
申请人： Anthony J. Sinskey , Philip A. Lessard , Kazuhiro Kurosawa
发明人： Anthony J. Sinskey , Philip A. Lessard , Kazuhiro Kurosawa
IPC分类号： A61K31/70 , C07H17/02
CPC分类号： C07D498/10
摘要： Certain aspects of the invention relate to antibiotics, as well as pharmaceutically acceptable salts, pro-drugs and/or analogs thereof. Another aspect of the invention relates to methods of use of said antibiotics.
摘要翻译：本发明的某些方面涉及抗生素，以及其药学上可接受的盐，前药和/或其类似物。本发明的另一方面涉及使用所述抗生素的方法。

2. 发明申请

US20100249051A1 Bioactive Molecules from Co-Cultivation of Microbes 有权
标题翻译：微生物共培养的生物活性分子
公开(公告)号：US20100249051A1
公开(公告)日：2010-09-30
申请号：US12599730
申请日：2008-12-22
申请人： Anthony J. Sinskey , Philip A. Lessard , Kazuhiko Kurosawa
发明人： Anthony J. Sinskey , Philip A. Lessard , Kazuhiko Kurosawa
IPC分类号： A61K31/7036 , C07H15/238 , A61P31/04
CPC分类号： C07D498/10
摘要： Certain aspects of the invention relates to antibiotics, as well as pharmaceutically acceptable salts, pro-drugs and/or analogs thereof. Another aspect of the inventions relates to methods of use of said antibiotics.
摘要翻译：本发明的某些方面涉及抗生素，以及其药学上可接受的盐，前药和/或其类似物。本发明的另一方面涉及使用所述抗生素的方法。

3. 发明授权

US06884606B2 Pyruvate carboxylase from Corynebacterium glutamicum 有权
标题翻译：来自谷氨酸棒杆菌的丙酮酸羧化酶
公开(公告)号：US06884606B2
公开(公告)日：2005-04-26
申请号：US10045072
申请日：2002-01-15
申请人： Anthony J. Sinskey , Philip A. Lessard , Laura B. Willis
发明人： Anthony J. Sinskey , Philip A. Lessard , Laura B. Willis
IPC分类号： C12N1/21 , C12N9/00 , C12P13/08
CPC分类号： C12N9/93
摘要： The present invention concerns an anaplerotic enzyme from Corynebacterium glutamicum which replenishes oxaloacetate consumed during lysine and glutamic acid production in industrial fermentations. In particular, isolated nucleic acid molecules are provided encoding the pyruvate carboxylase protein. Pyruvate carboxylase polypeptides are also provided.
摘要翻译：本发明涉及谷氨酸棒状杆菌的一种厌食酶，其补充在工业发酵过程中在赖氨酸和谷氨酸生产期间消耗的草酰乙酸酯。特别地，提供编码丙酮酸羧化酶蛋白质的分离的核酸分子。还提供了丙酮酸羧化酶多肽。

4. 发明授权

US06171833B2 Pyruvate carboxylase from corynebacterium glutamicum 有权
标题翻译：来自谷氨酸棒杆菌的丙酮酸羧化酶
公开(公告)号：US06171833B2
公开(公告)日：2001-01-09
申请号：US09220081
申请日：1998-12-23
申请人： Anthony J. Sinskey , Philip A. Lessard , Laura B. Willis
发明人： Anthony J. Sinskey , Philip A. Lessard , Laura B. Willis
IPC分类号： C12N900
CPC分类号： C12N9/93
摘要： The present invention concerns an anaplerotic enzyme from Corynebacterium glutamicum which replenishes oxaloacetate consumed during lysine and glutamic acid production in industrial fermentations. In particular, isolated nucleic acid molecules are provided encoding the pyruvate carboxylase protein. Pyruvate carboxylase polypeptides are also provided.
摘要翻译：本发明涉及谷氨酸棒状杆菌的一种厌食酶，其补充在工业发酵过程中在赖氨酸和谷氨酸生产期间消耗的草酰乙酸酯。特别地，提供编码丙酮酸羧化酶蛋白质的分离的核酸分子。还提供了丙酮酸羧化酶多肽。

5. 发明授权

US06987017B2 Methods for producing L-isoleucine 有权
公开(公告)号：US06987017B2
公开(公告)日：2006-01-17
申请号：US10223644
申请日：2002-08-20
申请人： Stephane Guillouet , Anthony J. Sinskey , Avital A. Rodal , Philip A. Lessard
发明人： Stephane Guillouet , Anthony J. Sinskey , Avital A. Rodal , Philip A. Lessard
IPC分类号： C12N1/00
CPC分类号： C12P13/06 , C12N9/88 , C12Y403/01019
摘要： The present invention relates, in general, to the over-production of L-isoleucine by nonhuman organisms. More specifically, the present invention relates to methods for producing L-isoleucine comprising: (a) growing a transformed nonhuman organism under conditions that provide for synthesis of L-isoleucine, wherein the nonhuman organism comprises one or more copies of a transgene comprising at least one nucleotide sequence encoding catabolic threonine dehydratase; wherein the L-isoleucine is synthesized by the transformed nonhuman organism, the synthesis being greater than that of the corresponding non-transformed nonhuman organism; and (b) recovering the L-isoleucine from the culture medium in which the transformed nonhuman organism was cultured.

6. 发明授权

US06451564B1 Methods for producing L-isoleucine 有权
标题翻译：生产L-异亮氨酸的方法
公开(公告)号：US06451564B1
公开(公告)日：2002-09-17
申请号：US09608065
申请日：2000-06-30
申请人： Stephane Guillouet , Avital A. Rodal , Philip A. Lessard , Anthony J. Sinskey
发明人： Stephane Guillouet , Avital A. Rodal , Philip A. Lessard , Anthony J. Sinskey
IPC分类号： C12P1306
CPC分类号： C12P13/06 , C12N9/88 , C12Y403/01019
摘要： The present invention relates, in general, to the over-production of L-isoleucine by nonhuman organisms. More specifically, the present invention relates to methods for producing L-isoleucine comprising: (a) growing a transformed nonhuman organism under conditions that provide for synthesis of L-isoleucine, wherein the nonhuman organism comprises one or more copies of a transgene comprising at least one nucleotide sequence encoding catabolic threonine dehydratase; wherein the L-isoleucine is synthesized by the transformed nonhuman organism, the synthesis being greater than that of the corresponding non-transformed nonhuman organism; and (b) recovering the L-isoleucine from the culture medium in which the transformed nonhuman organism was cultured.
摘要翻译：本发明一般涉及非人类生物体过量生产L-异亮氨酸。更具体地说，本发明涉及生产L-异亮氨酸的方法，其包括：（a）在提供L-异亮氨酸合成的条件下生长转化的非人生物，其中所述非人生物体包含至少一个或多个转基因编码分解代谢苏氨酸脱水酶的一个核苷酸序列; 其中所述L-异亮氨酸由所述转化的非人生物合成，所述合成大于相应的未转化的非人生物的合成; 和（b）从其中培养转化的非人生物的培养基中回收L-异亮氨酸。

7. 发明授权

US06403351B1 Pyruvate carboxylase polypeptide from Corynebacterium glutamicum 有权
标题翻译：来自谷氨酸棒杆菌的丙酮酸羧化酶多肽
公开(公告)号：US06403351B1
公开(公告)日：2002-06-11
申请号：US09677575
申请日：2000-10-03
申请人： Anthony J. Sinskey , Philip A. Lessard , Laura B. Willis
发明人： Anthony J. Sinskey , Philip A. Lessard , Laura B. Willis
IPC分类号： C12N900
CPC分类号： C12N9/93
摘要： The present invention concerns an anaplerotic enzyme from Corynebacterium glutamicum which replenishes oxaloacetate consumed during lysine and glutamic acid production in industrial fermentations. In particular, isolated nucleic acid molecules are provided encoding the pyruvate carboxylase protein. Pyruvate carboxylase polypeptides are also provided.
摘要翻译：本发明涉及谷氨酸棒状杆菌的一种厌食酶，其补充在工业发酵过程中在赖氨酸和谷氨酸生产期间消耗的草酰乙酸酯。特别地，提供编码丙酮酸羧化酶蛋白质的分离的核酸分子。还提供了丙酮酸羧化酶多肽。

8. 发明授权

US5534432A Polyhydroxybutyrate polymerase 失效
标题翻译：聚羟基丁酸聚合酶
公开(公告)号：US5534432A
公开(公告)日：1996-07-09
申请号：US418868
申请日：1995-04-07
申请人： Oliver P. Peoples , Anthony J. Sinskey
发明人： Oliver P. Peoples , Anthony J. Sinskey
IPC分类号： C12N1/21 , C12N9/00 , C12N9/04 , C12N9/10 , C12N15/52 , C12N15/60 , C12P7/62 , C12N5/04
CPC分类号： C12N9/0006 , C12N15/52 , C12N9/00 , C12N9/1029 , C12P7/625
摘要： A method for controlling and modifying biopolymer synthesis by manipulation of the genetics and enzymology of synthesis of polyhydroxybutyrate (PHB) and polyhydroxyalkanoate (PHA) polyesters at the molecular level in procaryotic and eukaryotic cells, especially plants. Examples demonstrate the isolation, characterization, and expression of the genes involved in the production of PHB and PHA polymers. Genes encoding the enzymes in the PHB and PHA synthetic pathway (beta-ketothiolase, acetoacetyl-CoA reductase and PHB polymerass or PHA polymerase) from Zoogloea ramigera strain I-16-M, Alcaligenes eutrophus, Nocardia salmonicolur, and P. olevorans were identified or isolated and expressed in a non-PHB producing organism, E. coli. Specific modifications to the polymers include variation in the chain length of the polymers and incorporation of different monomers into the polymers to produce co-polymers with different physical properties.
摘要翻译：通过在原核和真核细胞，特别是植物中的分子水平处理聚羟基丁酸酯（PHB）和聚羟基链烷酸酯（PHA）聚酯的遗传学和酶学方法来控制和改变生物聚合物合成的方法。实施例证明参与PHB和PHA聚合物生产的基因的分离，表征和表达。鉴定了来自Zoogloea苎麻菌株I-16-M，产碱假单胞菌，嗜N N sal ur ol ol ur ur ur ur ur and and in in the the the or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or or 分离并在非PHB产生生物体大肠杆菌中表达。对聚合物的具体修饰包括聚合物链长度的变化以及将不同单体引入到聚合物中以产生具有不同物理性质的共聚物。

9. 发明授权

US5091376A Non-capsule exopolysaccharide from Zoogloea ramigera 失效
标题翻译：来自Zoogloea ramigera的非胶囊外多糖
公开(公告)号：US5091376A
公开(公告)日：1992-02-25
申请号：US525197
申请日：1990-05-17
申请人： Donald D. Easson, Jr. , Oliver P. Peoples , Anthony J. Sinskey
发明人： Donald D. Easson, Jr. , Oliver P. Peoples , Anthony J. Sinskey
IPC分类号： C09K8/90 , C12N15/52 , C12P19/04
CPC分类号： C09K8/905 , C12N15/52 , C12P19/04
摘要： Two new bacterial strains designated Zoogloea ramigera 115SL and Zoogloea ramigera 115SLR, a rifampicin resistant derivative of 115SL, have been developed. These strains are derived from the wild type Zoogloea ramigera 115, ATCC 25935. The two new strains produce a novel exopolysaccharide (EPS) and have several desirable characteristics that are absent from the parent strain, including improved culture properties, since they do not produce an EPS capsule layer like that of the parent 115 strain. The 115SL EPS is instead excreted as a slime layer which is not confined to the immediate area surrounding the cells. Since cells are not trapped within a floc where they grow at a reduced rate or die because of nutrient starvation, the new strains have more consistent and reproducible growth cycles and increased growth rates. As a consequence, exopolysaccharide production is more consistent and titers are higher. The separation of the EPS from the cells is also much easier and more economical. The other very important characteristic of strains 115SL and 115SLR is that they are able to receive foreight DNA using conventional techniques due to the absence of the capsule layer. This facilitates the application of recombinant DNA technology to control and produce novel exopolysaccharides.
摘要翻译：已经开发了两种新的细菌菌株，称为Zoogloea ramigera 115SL和Zoogloea ramigera 115SLR，115SL的利福平抗性衍生物。这些菌株衍生自野生型Zoogloea ramigera 115，ATCC 25935.两种新菌株产生新颖的外多糖（EPS），并具有几种所需的特征，其不存在于亲本菌株中，包括改良的培养性质，因为它们不产生 EPS胶囊层像母体115株。相反，115SL EPS排泄成为不限于细胞周围的紧邻区域的粘液层。由于细胞不被捕获在絮状物中，它们以降低的速率生长或由于营养物质饥饿而死亡，所以新菌株具有更一致和可重现的生长周期和增加的生长速率。结果，外多糖生产更一致，滴度更高。 EPS与细胞的分离也更容易和更经济。菌株115SL和115SLR的另一个非常重要的特征是，由于不存在胶囊层，它们能够使用常规技术接收迫切的DNA。这有利于重组DNA技术的应用来控制和产生新的外多糖。

10. 发明申请

US20120238773A1 COMPOSITION COMPRISING CAFFEOYLSHIKIMIC ACIDS, PROTOCATECHUIC ACID, HYDROXYTYROSOL, HYDROXYBENZOIC ACID AND THEIR DERIVATIVES AND METHOD OF PREPARATION THEREOF 审中-公开
标题翻译：包含CAFFEOYLSHIICIC酸，丙酸酸，羟基苯甲酸，羟基苯甲酸及其衍生物的组合物及其制备方法
公开(公告)号：US20120238773A1
公开(公告)日：2012-09-20
申请号：US13322494
申请日：2010-05-26
申请人： T.G. Sambandan , ChoKyun Rha , Anthony J. Sinskey , Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram P. Manickam , Mohd Basri Wahid
发明人： T.G. Sambandan , ChoKyun Rha , Anthony J. Sinskey , Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram P. Manickam , Mohd Basri Wahid
IPC分类号： C07C69/732 , C07C67/48
CPC分类号： A61K36/889
摘要： A composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives extracted from any part of oil palm including but not confined to the vegetation liquor of palm oil milling and palm oil mill effluent, and a method for use in the preparation of a composition containing caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives. The method includes the steps of pre-concentrating an extract containing the caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives and isolating the caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives from said extract by liquid chromatography, wherein the elution activity of said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, with the caffeoylshikimic acids and their derivatives varying depending on the stationary phase and the composition of the mobile phase.
摘要翻译：一种组合物，其包含咖啡酰莽卡木酸，原儿茶酸，羟基酪醇，羟基苯甲酸，所述咖啡酰基莽草酸及其衍生物从油棕的任何部分提取，包括但不限于棕榈油研磨和棕榈油磨出料的植物液，以及使用方法在制备含有咖啡酰基莽草酸，原儿茶酸，羟基酪醇，羟基苯甲酸，所述咖啡酰莽卡米酸及其衍生物的组合物。该方法包括以下步骤：将含有咖啡酰基莽草酸，原儿茶酸，羟基酪醇，羟基苯甲酸，咖啡酰基莽草酸及其衍生物的提取物预浓缩，并分离出咖啡酰基莽草酸，原儿茶酸，羟基酪醇，羟基苯甲酸，所述咖啡酰莽卡米酸及其衍生物所述提取物通过液相色谱法，其中所述咖啡酰基莽草酸，原儿茶酸，羟基酪醇，羟基苯甲酸与咖啡酰基莽草酸及其衍生物的洗脱活性根据固定相和流动相的组成而变化。

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