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1. 发明申请

US20100249051A1 Bioactive Molecules from Co-Cultivation of Microbes 有权
标题翻译：微生物共培养的生物活性分子
公开(公告)号：US20100249051A1
公开(公告)日：2010-09-30
申请号：US12599730
申请日：2008-12-22
申请人： Anthony J. Sinskey , Philip A. Lessard , Kazuhiko Kurosawa
发明人： Anthony J. Sinskey , Philip A. Lessard , Kazuhiko Kurosawa
IPC分类号： A61K31/7036 , C07H15/238 , A61P31/04
CPC分类号： C07D498/10
摘要： Certain aspects of the invention relates to antibiotics, as well as pharmaceutically acceptable salts, pro-drugs and/or analogs thereof. Another aspect of the inventions relates to methods of use of said antibiotics.
摘要翻译：本发明的某些方面涉及抗生素，以及其药学上可接受的盐，前药和/或其类似物。本发明的另一方面涉及使用所述抗生素的方法。

2. 发明授权

US06451564B1 Methods for producing L-isoleucine 有权
标题翻译：生产L-异亮氨酸的方法
公开(公告)号：US06451564B1
公开(公告)日：2002-09-17
申请号：US09608065
申请日：2000-06-30
申请人： Stephane Guillouet , Avital A. Rodal , Philip A. Lessard , Anthony J. Sinskey
发明人： Stephane Guillouet , Avital A. Rodal , Philip A. Lessard , Anthony J. Sinskey
IPC分类号： C12P1306
CPC分类号： C12P13/06 , C12N9/88 , C12Y403/01019
摘要： The present invention relates, in general, to the over-production of L-isoleucine by nonhuman organisms. More specifically, the present invention relates to methods for producing L-isoleucine comprising: (a) growing a transformed nonhuman organism under conditions that provide for synthesis of L-isoleucine, wherein the nonhuman organism comprises one or more copies of a transgene comprising at least one nucleotide sequence encoding catabolic threonine dehydratase; wherein the L-isoleucine is synthesized by the transformed nonhuman organism, the synthesis being greater than that of the corresponding non-transformed nonhuman organism; and (b) recovering the L-isoleucine from the culture medium in which the transformed nonhuman organism was cultured.
摘要翻译：本发明一般涉及非人类生物体过量生产L-异亮氨酸。更具体地说，本发明涉及生产L-异亮氨酸的方法，其包括：（a）在提供L-异亮氨酸合成的条件下生长转化的非人生物，其中所述非人生物体包含至少一个或多个转基因编码分解代谢苏氨酸脱水酶的一个核苷酸序列; 其中所述L-异亮氨酸由所述转化的非人生物合成，所述合成大于相应的未转化的非人生物的合成; 和（b）从其中培养转化的非人生物的培养基中回收L-异亮氨酸。

3. 发明授权

US06403351B1 Pyruvate carboxylase polypeptide from Corynebacterium glutamicum 有权
标题翻译：来自谷氨酸棒杆菌的丙酮酸羧化酶多肽
公开(公告)号：US06403351B1
公开(公告)日：2002-06-11
申请号：US09677575
申请日：2000-10-03
申请人： Anthony J. Sinskey , Philip A. Lessard , Laura B. Willis
发明人： Anthony J. Sinskey , Philip A. Lessard , Laura B. Willis
IPC分类号： C12N900
CPC分类号： C12N9/93
摘要： The present invention concerns an anaplerotic enzyme from Corynebacterium glutamicum which replenishes oxaloacetate consumed during lysine and glutamic acid production in industrial fermentations. In particular, isolated nucleic acid molecules are provided encoding the pyruvate carboxylase protein. Pyruvate carboxylase polypeptides are also provided.
摘要翻译：本发明涉及谷氨酸棒状杆菌的一种厌食酶，其补充在工业发酵过程中在赖氨酸和谷氨酸生产期间消耗的草酰乙酸酯。特别地，提供编码丙酮酸羧化酶蛋白质的分离的核酸分子。还提供了丙酮酸羧化酶多肽。

4. 发明授权

US08314071B2 Bioactive molecules from co-cultivation of microbes 有权
标题翻译：生物活性分子共培养微生物
公开(公告)号：US08314071B2
公开(公告)日：2012-11-20
申请号：US12599730
申请日：2008-12-22
申请人： Anthony J. Sinskey , Philip A. Lessard , Kazuhiro Kurosawa
发明人： Anthony J. Sinskey , Philip A. Lessard , Kazuhiro Kurosawa
IPC分类号： A61K31/70 , C07H17/02
CPC分类号： C07D498/10
摘要： Certain aspects of the invention relate to antibiotics, as well as pharmaceutically acceptable salts, pro-drugs and/or analogs thereof. Another aspect of the invention relates to methods of use of said antibiotics.
摘要翻译：本发明的某些方面涉及抗生素，以及其药学上可接受的盐，前药和/或其类似物。本发明的另一方面涉及使用所述抗生素的方法。

5. 发明授权

US06884606B2 Pyruvate carboxylase from Corynebacterium glutamicum 有权
标题翻译：来自谷氨酸棒杆菌的丙酮酸羧化酶
公开(公告)号：US06884606B2
公开(公告)日：2005-04-26
申请号：US10045072
申请日：2002-01-15
申请人： Anthony J. Sinskey , Philip A. Lessard , Laura B. Willis
发明人： Anthony J. Sinskey , Philip A. Lessard , Laura B. Willis
IPC分类号： C12N1/21 , C12N9/00 , C12P13/08
CPC分类号： C12N9/93
摘要： The present invention concerns an anaplerotic enzyme from Corynebacterium glutamicum which replenishes oxaloacetate consumed during lysine and glutamic acid production in industrial fermentations. In particular, isolated nucleic acid molecules are provided encoding the pyruvate carboxylase protein. Pyruvate carboxylase polypeptides are also provided.
摘要翻译：本发明涉及谷氨酸棒状杆菌的一种厌食酶，其补充在工业发酵过程中在赖氨酸和谷氨酸生产期间消耗的草酰乙酸酯。特别地，提供编码丙酮酸羧化酶蛋白质的分离的核酸分子。还提供了丙酮酸羧化酶多肽。

6. 发明授权

US06171833B2 Pyruvate carboxylase from corynebacterium glutamicum 有权
标题翻译：来自谷氨酸棒杆菌的丙酮酸羧化酶
公开(公告)号：US06171833B2
公开(公告)日：2001-01-09
申请号：US09220081
申请日：1998-12-23
申请人： Anthony J. Sinskey , Philip A. Lessard , Laura B. Willis
发明人： Anthony J. Sinskey , Philip A. Lessard , Laura B. Willis
IPC分类号： C12N900
CPC分类号： C12N9/93
摘要： The present invention concerns an anaplerotic enzyme from Corynebacterium glutamicum which replenishes oxaloacetate consumed during lysine and glutamic acid production in industrial fermentations. In particular, isolated nucleic acid molecules are provided encoding the pyruvate carboxylase protein. Pyruvate carboxylase polypeptides are also provided.
摘要翻译：本发明涉及谷氨酸棒状杆菌的一种厌食酶，其补充在工业发酵过程中在赖氨酸和谷氨酸生产期间消耗的草酰乙酸酯。特别地，提供编码丙酮酸羧化酶蛋白质的分离的核酸分子。还提供了丙酮酸羧化酶多肽。

7. 发明授权

US06987017B2 Methods for producing L-isoleucine 有权
公开(公告)号：US06987017B2
公开(公告)日：2006-01-17
申请号：US10223644
申请日：2002-08-20
申请人： Stephane Guillouet , Anthony J. Sinskey , Avital A. Rodal , Philip A. Lessard
发明人： Stephane Guillouet , Anthony J. Sinskey , Avital A. Rodal , Philip A. Lessard
IPC分类号： C12N1/00
CPC分类号： C12P13/06 , C12N9/88 , C12Y403/01019
摘要： The present invention relates, in general, to the over-production of L-isoleucine by nonhuman organisms. More specifically, the present invention relates to methods for producing L-isoleucine comprising: (a) growing a transformed nonhuman organism under conditions that provide for synthesis of L-isoleucine, wherein the nonhuman organism comprises one or more copies of a transgene comprising at least one nucleotide sequence encoding catabolic threonine dehydratase; wherein the L-isoleucine is synthesized by the transformed nonhuman organism, the synthesis being greater than that of the corresponding non-transformed nonhuman organism; and (b) recovering the L-isoleucine from the culture medium in which the transformed nonhuman organism was cultured.

8. 发明授权

US5862671A Purge and rough cryopump regeneration process, cryopump and controller 失效
标题翻译：吹扫和粗略的低温泵再生过程，低温泵和控制器
公开(公告)号：US5862671A
公开(公告)日：1999-01-26
申请号：US848973
申请日：1997-05-02
申请人： Philip A. Lessard , Paul E. Dresens , Maureen C. Buonpane , Timothy M. Pulling , Alan C. Brightman , Robert M. Patterson , Mark A. Stira , Allen J. Bartlett , Stephen J. Yamartino , Gary S. Ash , James A. O'Neil
发明人： Philip A. Lessard , Paul E. Dresens , Maureen C. Buonpane , Timothy M. Pulling , Alan C. Brightman , Robert M. Patterson , Mark A. Stira , Allen J. Bartlett , Stephen J. Yamartino , Gary S. Ash , James A. O'Neil
IPC分类号： F04B37/16 , F04B37/08 , B01D8/00
CPC分类号： F04B37/085 , Y10S417/901
摘要： A cryopump is regenerated by roughing the cryopump during purging. Purging and roughing is carried out in first a high temperature mode and then a lower ambient temperature mode. In the lower temperature mode, the cryogenic refrigerator is turned on. If the system fails a rough test after roughing at the lower temperature, it is repurged with the rough valve open.
摘要翻译：在清洗过程中，通过对低温泵进行粗加工来再生低温泵。首先在高温模式下进行吹扫和粗加工，然后在较低的环境温度模式下进行。在较低温度模式下，低温冰箱打开。如果系统在较低温度下进行粗加工后未能进行粗糙试验，则会在粗阀打开时重新进行。

9. 发明授权

US5261244A Cryogenic waterpump 失效
标题翻译：低温水泵
公开(公告)号：US5261244A
公开(公告)日：1993-11-16
申请号：US886721
申请日：1992-05-21
申请人： Philip A. Lessard , Douglas F. Aitken , Robert D. Bradford , Roland P. Graham , Steven A. Michaud , Karen J. Manning
发明人： Philip A. Lessard , Douglas F. Aitken , Robert D. Bradford , Roland P. Graham , Steven A. Michaud , Karen J. Manning
IPC分类号： B01D8/00 , F04B37/08
CPC分类号： F04B37/08 , B01D8/00 , Y10S417/901
摘要： A cold trap includes a set of baffles cooled by the cold finger of a closed cycle refrigerator. The baffles are vertically disposed in a vertical fluid conduit with frustoconical and conical surfaces for directing liquid to a circular trough during regeneration. After the liquid is collected, it is blown from the trough through a pressure relief valve by a nitrogen purge. The trough is formed in the upper surface of a connecting flange at the lower end of the fluid conduit.
摘要翻译：冷阱包括由闭合循环冰箱的冷手指冷却的一组挡板。挡板垂直设置在具有截头圆锥形和圆锥形表面的垂直流体导管中，用于在再生期间将液体引导到圆形槽。收集液体后，通过氮气吹扫从槽通过泄压阀吹出。槽形成在流体导管的下端处的连接凸缘的上表面中。

10. 发明授权

US4679401A Temperature control of cryogenic systems 失效
标题翻译：低温系统的温度控制
公开(公告)号：US4679401A
公开(公告)日：1987-07-14
申请号：US752354
申请日：1985-07-03
申请人： Philip A. Lessard , Allen J. Bartlett , John F. Peterson
发明人： Philip A. Lessard , Allen J. Bartlett , John F. Peterson
IPC分类号： B01D8/00 , F04B37/08
CPC分类号： B01D8/00 , F04B37/08 , Y10S417/901
摘要： To control the temperature of one or more heat sinks of a cryogenic refrigerator in a cryopump, refrigerant gas to the refrigerator is diverted through heat exchangers associated with the refrigerator heat sinks. The diverted refrigerant gas may be used to maintain the temperature of the first stage cryopumping surfaces above some level to avoid cross over hangup. The second stage cryopumping surfaces may be warmed by the diverted refrigerant to some temperature level for partial regeneration. Both heat sinks may be warmed for full regeneration of the cryopump. Bleed flow of refrigerant gas cooled by the first stage of the refrigerator can be directed past a thermal mass to cool that mass. By reversing the flow of refrigerant gas during cooldown of the system, the thermal mass can be used to more rapidly cool the refrigerator. The thermal mass is thermally isolated from the refrigerator heat sinks and is positioned within the vacuum vessel of the cryopump adjacent to the first stage of the refrigerator.
摘要翻译：为了控制低温泵中的低温冰箱的一个或多个散热器的温度，通向与冰箱散热器相关联的热交换器将制冷剂气体输送到冰箱。转向的制冷剂气体可用于将第一级低温泵的表面的温度保持在一定程度上，以避免交叉悬挂。可将第二级低温泵送表面由转向制冷剂加热到一定温度以进行部分再生。这两个散热片可能会被加热，以便低温泵完全再生。由冰箱的第一级冷却的制冷剂气体的流出可以被引导通过热质量以冷却该质量。通过在系统的冷却期间逆转制冷剂气体的流动，可以使用热质量来更快速地冷却冰箱。热物质与冰箱散热器热隔离，并且位于与冰箱的第一级相邻的低温泵的真空容器内。

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