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1. 发明申请

US20120121732A1 Composition for Use in the Prevention and Treatment of Cardiovascular Diseases 有权
标题翻译：用于预防和治疗心血管疾病的组合物
公开(公告)号：US20120121732A1
公开(公告)日：2012-05-17
申请号：US13321314
申请日：2010-05-18
申请人： Hjh Che Anishas Hj. Che Idris , Nagendran Balasundram , Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram P. Manickam , Mohd Basri Wahid
发明人： Hjh Che Anishas Hj. Che Idris , Nagendran Balasundram , Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram P. Manickam , Mohd Basri Wahid
IPC分类号： A61K36/889 , A61P9/10
CPC分类号： A61K36/889 , A61K31/192 , A61K31/353 , A61K31/355 , A61K2300/00
摘要： The invention provides a composition the prevention and treatment of cardiovascular disease, wherein said composition compounds obtained from palm oil mill effluents, in particular from vegetative liquor from the milling of palm oil fruit.
摘要翻译：本发明提供了预防和治疗心血管疾病的组合物，其中所述从棕榈油研磨废水获得的组合物化合物，特别是来自研磨棕榈油果实的营养液。

2. 发明授权

US07387802B2 Treatment of vegetation liquors derived from oil-bearing fruit 失效
标题翻译：处理含油果实的植物酒
公开(公告)号：US07387802B2
公开(公告)日：2008-06-17
申请号：US10269224
申请日：2002-10-11
申请人： Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram
发明人： Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram
IPC分类号： A61K36/889
CPC分类号： A61K36/889
摘要： The present invention relates to processes for the treatment of liquors derived from oil-bearing fruit, for example from oil palm fruit, and to products therefrom. Typically a process involves removal of undissolved solids, oleaginous parts, colloids and higher weight molecules from the vegetation liquor to give an aqueous fraction containing phytochemicals, for example, flavonoids, phenolic acids and hydroxy acids. Subsequently, pH adjustment and solvent extraction upon said aqueous fraction realise an extract rich in hydroxy acids or phenolic acids or flavonoids or any combination thereof Applications of the substances subject of this invention are to be found in drinks, edible products, tonics, health supplements, antioxidant additives, cosmetics, soaps, shampoos, detergents, drugs or medicinal products.
摘要翻译：本发明涉及用于处理来自含油果实例如油棕果实的液体的方法及其产物。通常，该方法包括从植物液中除去未溶解的固体，油质部分，胶体和较高重量的分子，得到含有植物化学物质的水性部分，例如类黄酮，酚酸和羟基酸。随后，所述含水部分的pH调节和溶剂萃取实现了富含羟基酸或酚酸或类黄酮或其组合的提取物。本发明物质的应用可以在饮料，食用产品，补品，保健品，抗氧化添加剂，化妆品，肥皂，洗发剂，洗涤剂，药物或药用产品。

3. 发明申请

US20130184355A1 Anti-Obesity and Anti-Dyslipidemic Effects of Oil Palm Phenolics in Preventing Atherosclerosis and Cardiovascular Disease 审中-公开
标题翻译：油棕榈酚抗预防动脉粥样硬化和心血管疾病的抗肥胖和抗血脂异常作用
公开(公告)号：US20130184355A1
公开(公告)日：2013-07-18
申请号：US13521055
申请日：2011-01-07
申请人： Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalvana Sundram Manickam , Mohd Basri Wahid
发明人： Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalvana Sundram Manickam , Mohd Basri Wahid
IPC分类号： A61K31/05
CPC分类号： A61K36/889 , A61K31/05
摘要： A composition comprising extracts containing oil palm phenolics in an amount effective for use in a method of reducing cholesterol biosynthesis and thus preventing obesity. The composition up regulates fatty acid beta oxidation and down regulates cholesterol biosynthesis in livers. The composition is useful for prevention of obesity associated diseases. The composition delays the onset of obesity and attenuates the inflammatory response of atherogenic diet, whereby the composition aids to suppress the inflammatory response thereby ameliorating artherosclerosis. The composition delays weight gain or obesity thereby preventing the effects of dyslipidemia.
摘要翻译：一种组合物，其包含含有油棕榈酚类的提取物，其含量有效用于降低胆固醇生物合成的方法，从而防止肥胖。该组合物调节脂肪酸β氧化并下调肝脏胆固醇生物合成。该组合物可用于预防肥胖相关疾病。该组合物延迟了肥胖症的发作并且减弱了致动脉粥样化饮食的炎症反应，从而该组合物有助于抑制炎症反应从而改善动脉粥样硬化。组合物延缓体重增加或肥胖，从而防止血脂异常的影响。

4. 发明授权

US08071143B2 Methods for the treatment or prevention of diabetes mellitus and other metabolic imbalances 有权
标题翻译：治疗或预防糖尿病和其他代谢失调的方法
公开(公告)号：US08071143B2
公开(公告)日：2011-12-06
申请号：US12080361
申请日：2008-04-02
申请人： Kenneth C. Hayes , Kalyana Sundram , Ravigadevi Sambanthamurthi , Yew Ai Tan
发明人： Kenneth C. Hayes , Kalyana Sundram , Ravigadevi Sambanthamurthi , Yew Ai Tan
IPC分类号： A61K36/00 , A61K47/00
CPC分类号： A61K31/192 , A61K2300/00
摘要： The invention relates to methods for treatment and prevention of a metabolic imbalance, including diabetes mellitus and other related diseases or disorders, using an extract from a fruit of genus Elaeis.
摘要翻译：本发明涉及使用来自水蛭属的果实的提取物治疗和预防代谢失调的方法，包括糖尿病和其它相关疾病或病症。

5. 发明申请

US20110052728A1 BOTANICAL EXTRACT FROM THE AQUEOUS STREAM OF THE PALM OIL MILLING PROCESS FOR THE PREVENTION AND INHIBITION OF OXIDATIVE STRESS AND HAEMOLYSIS IN HUMAN RED BLOOD CELLS 有权
标题翻译：用于预防和抑制人类红血球中氧化应激和分解的棕榈油研磨过程的水溶液的植物萃取物
公开(公告)号：US20110052728A1
公开(公告)日：2011-03-03
申请号：US12677764
申请日：2008-09-11
申请人： Nagendran Balasundram , Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram P. Manickam , Mohid Basri Bin Wahid , Sammir Samman , Nihal S. Agar
发明人： Nagendran Balasundram , Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram P. Manickam , Mohid Basri Bin Wahid , Sammir Samman , Nihal S. Agar
IPC分类号： A61K36/889 , C12N5/078 , A61P7/00
CPC分类号： A61K36/889
摘要： The invention provides a composition for the prevention and inhibition of oxidative stress and haemolysis in human red blood cell wherein said composition compounds obtained from the aqueous stream of palm oil milling (palm oil vegetation liquor), in particular from vegetative liquor from the milling of palm oil fruit.
摘要翻译：本发明提供了一种用于预防和抑制人类红细胞中的氧化应激和溶血的组合物，其中所述由棕榈油研磨（棕榈油植物液）的水溶液获得的组合物化合物，特别是来自研磨棕榈的营养液油果。

6. 发明授权

US07538204B2 Recombinant enzyme and uses therefor 有权
标题翻译：重组酶及其用途
公开(公告)号：US07538204B2
公开(公告)日：2009-05-26
申请号：US11022382
申请日：2004-12-23
申请人： Umi Salamah Ramli , Mohd. Basri Wahid , Ravigadevi Sambanthamurthi , Cheah Suan Choo , Sharifah Shahrul Rabiah Syed Alwee , Siti Nor Akmar Abdullah , Ahmad Parveez Ghulam Kadir , Abrizah Othman , Mohd. Arif Abdul Manaf , Omar Abdul Rasid , Dzulfazly Aminudin , Abdul Masani Mat Yunus
发明人： Umi Salamah Ramli , Mohd. Basri Wahid , Ravigadevi Sambanthamurthi , Cheah Suan Choo , Sharifah Shahrul Rabiah Syed Alwee , Siti Nor Akmar Abdullah , Ahmad Parveez Ghulam Kadir , Abrizah Othman , Mohd. Arif Abdul Manaf , Omar Abdul Rasid , Dzulfazly Aminudin , Abdul Masani Mat Yunus
IPC分类号： C07H21/04 , C12N15/00 , C12N1/20
CPC分类号： C12N9/1029 , C12N15/8247
摘要： The present invention relates to an isolated nucleic acid molecule comprising a sequence of nucleotides encoding a β-ketoacyl ACP synthase II from a plant, or a variant, derivative, homolog or analog of said β-ketoacyl ACP synthase II. The invention also relates to an isolated β-ketoacyl ACP synthase II enzyme from a plant. The polynucleotide sequences of the present invention may be used inter alia for the generation of cells or plants comprising such cells which have a modified phenotype and/or which exhibit a desired characteristic.
摘要翻译：本发明涉及分离的核酸分子，其包含编码来自植物的β-酮酸酰基ACP合酶II的核苷酸序列，或所述β-酮酸酰基ACP合酶II的变体，衍生物，同系物或类似物。本发明还涉及来自植物的分离的β-酮酸酰基ACP合酶II酶。本发明的多核苷酸序列可以特别用于产生包含具有修饰表型和/或显示所需特征的这种细胞的细胞或植物。

7. 发明授权

US09326957B2 Methods for the treatment or prevention of diabetes mellitus and other metabolic imbalances 有权
标题翻译：治疗或预防糖尿病和其他代谢失调的方法
公开(公告)号：US09326957B2
公开(公告)日：2016-05-03
申请号：US13285731
申请日：2011-10-31
申请人： Kenneth C. Hayes , Kalyana Sundram , Ravigadevi Sambanthamurthi , Yew Ai Tan
发明人： Kenneth C. Hayes , Kalyana Sundram , Ravigadevi Sambanthamurthi , Yew Ai Tan
IPC分类号： A61K36/889 , A61K31/192
CPC分类号： A61K31/192 , A61K2300/00
摘要： The invention relates to methods for treatment and prevention of a metabolic imbalance, including diabetes mellitus and other related diseases or disorders, using an extract from a fruit of genus Elaeis.
摘要翻译：本发明涉及使用来自水蛭属的果实的提取物治疗和预防代谢失调的方法，包括糖尿病和其它相关疾病或病症。

8. 发明申请

US20150202245A1 NOVEL BIOACTIVE COMPOUND OBTAINED FROM OIL PALM BASE MATERIALS 有权
标题翻译：从油棕基材料获得的新型生物化合物
公开(公告)号：US20150202245A1
公开(公告)日：2015-07-23
申请号：US14417741
申请日：2013-07-28
申请人： Ravigadevi Sambanthamurthi , Tan Yew Ai , Syed Fairus Syed Abu Bakar , Che Anishas Che Idris , Leow Soon Sen , Mohd Jamil Elias , Wan Saridah Wan Omar , Mohd Sofian Mohamed Ideris
发明人： Ravigadevi Sambanthamurthi , Tan Yew Ai , Syed Fairus Syed Abu Bakar , Che Anishas Che Idris , Leow Soon Sen , Mohd Jamil Elias , Wan Saridah Wan Omar , Mohd Sofian Mohamed Ideris
IPC分类号： A61K36/889
CPC分类号： A61K36/889 , A61K31/05 , A61K2236/00
摘要： This disclosure is directed to a novel bioactive compound obtained from oil palm based materials and compositions containing said bioactive compound. The bioactive compound obtained in accordance with the present invention has a molecular mass of 482. The bioactive compound also has potent HIV reverse transcriptase activity and antioxidant activity.
摘要翻译：本公开涉及由油棕基材料和含有所述生物活性化合物的组合物获得的新型生物活性化合物。根据本发明获得的生物活性化合物的分子量为482.生物活性化合物还具有有效的HIV逆转录酶活性和抗氧化活性。

9. 发明申请

US20120238773A1 COMPOSITION COMPRISING CAFFEOYLSHIKIMIC ACIDS, PROTOCATECHUIC ACID, HYDROXYTYROSOL, HYDROXYBENZOIC ACID AND THEIR DERIVATIVES AND METHOD OF PREPARATION THEREOF 审中-公开
标题翻译：包含CAFFEOYLSHIICIC酸，丙酸酸，羟基苯甲酸，羟基苯甲酸及其衍生物的组合物及其制备方法
公开(公告)号：US20120238773A1
公开(公告)日：2012-09-20
申请号：US13322494
申请日：2010-05-26
申请人： T.G. Sambandan , ChoKyun Rha , Anthony J. Sinskey , Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram P. Manickam , Mohd Basri Wahid
发明人： T.G. Sambandan , ChoKyun Rha , Anthony J. Sinskey , Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram P. Manickam , Mohd Basri Wahid
IPC分类号： C07C69/732 , C07C67/48
CPC分类号： A61K36/889
摘要： A composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives extracted from any part of oil palm including but not confined to the vegetation liquor of palm oil milling and palm oil mill effluent, and a method for use in the preparation of a composition containing caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives. The method includes the steps of pre-concentrating an extract containing the caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives and isolating the caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives from said extract by liquid chromatography, wherein the elution activity of said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, with the caffeoylshikimic acids and their derivatives varying depending on the stationary phase and the composition of the mobile phase.
摘要翻译：一种组合物，其包含咖啡酰莽卡木酸，原儿茶酸，羟基酪醇，羟基苯甲酸，所述咖啡酰基莽草酸及其衍生物从油棕的任何部分提取，包括但不限于棕榈油研磨和棕榈油磨出料的植物液，以及使用方法在制备含有咖啡酰基莽草酸，原儿茶酸，羟基酪醇，羟基苯甲酸，所述咖啡酰莽卡米酸及其衍生物的组合物。该方法包括以下步骤：将含有咖啡酰基莽草酸，原儿茶酸，羟基酪醇，羟基苯甲酸，咖啡酰基莽草酸及其衍生物的提取物预浓缩，并分离出咖啡酰基莽草酸，原儿茶酸，羟基酪醇，羟基苯甲酸，所述咖啡酰莽卡米酸及其衍生物所述提取物通过液相色谱法，其中所述咖啡酰基莽草酸，原儿茶酸，羟基酪醇，羟基苯甲酸与咖啡酰基莽草酸及其衍生物的洗脱活性根据固定相和流动相的组成而变化。

10. 发明申请

US20090053333A1 TREATMENT OF VEGETATION LIQUORS DERIVED FROM OIL-BEARING FRUIT 有权
标题翻译：从油脂水果中提取的植物油液的处理
公开(公告)号：US20090053333A1
公开(公告)日：2009-02-26
申请号：US12126736
申请日：2008-05-23
申请人： Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram
发明人： Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram
IPC分类号： A61K36/00 , B01D61/14 , B01D61/16
CPC分类号： A61K36/889
摘要： The present invention relates to processes for the treatment of liquors derived from oil-bearing fruit, for example from oil palm fruit, and to products therefrom. Typically a process involves removal of undissolved solids, oleaginous parts, colloids and higher weight molecules from the vegetation liquor to give an aqueous fraction containing phytochemicals, for example, flavonoids, phenolic acids and hydroxy acids. Subsequently, pH adjustment and solvent extraction upon said aqueous fraction realise an extract rich in hydroxy acids or phenolic acids or flavonoids or any combination thereof. Applications of the substances subject of this invention are to be found in drinks, edible products, tonics, health supplements, antioxidant additives, cosmetics, soaps, shampoos, detergents, drugs or medicinal products.
摘要翻译：本发明涉及用于处理来自含油果实例如油棕果实的液体的方法及其产物。通常，该方法包括从植物液中除去未溶解的固体，油质部分，胶体和较高重量的分子，得到含有植物化学物质的水性部分，例如类黄酮，酚酸和羟基酸。随后，对所述含水部分进行pH调节和溶剂萃取，可以获得富含羟基酸或酚酸或类黄酮或其任何组合的提取物。本发明物质的应用可以在饮料，食用产品，补品，保健品，抗氧化添加剂，化妆品，肥皂，洗发剂，洗涤剂，药物或药用产品中找到。

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