专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08735551B2 Antibodies for epidermal growth factor receptor 3 (HER3) 有权
标题翻译：表皮生长因子受体3（HER3）抗体
公开(公告)号：US08735551B2
公开(公告)日：2014-05-27
申请号：US13214413
申请日：2011-08-22
申请人： Andrew Paul Garner , Elizabeth Anne Reisinger Sprague , Seth Alexander Ettenberg , Christian Kunz , Nicole Haubst , Winfried Elis
发明人： Andrew Paul Garner , Elizabeth Anne Reisinger Sprague , Seth Alexander Ettenberg , Christian Kunz , Nicole Haubst , Winfried Elis
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395
CPC分类号： C07K16/32 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3061 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to antibodies or fragments thereof that target a conformational epitope of a HER receptor. In particular, the invention relates to antibodies or fragments thereof that target a conformational epitope of HER3 receptor and compositions and methods of use thereof.
摘要翻译：本发明涉及靶向HER受体的构象表位的抗体或其片段。特别地，本发明涉及靶向HER3受体的构象表位的抗体或其片段，以及组合物及其使用方法。

2. 发明申请

US20090013869A1 PROCESS AND DEVICE FOR PRODUCING A PRESSURIZED GASEOUS PRODUCT BY LOW-TEMPERATURE SEPARATION OF AIR 审中-公开
标题翻译：通过空气低温分离生产加压气体产品的方法和装置
公开(公告)号：US20090013869A1
公开(公告)日：2009-01-15
申请号：US12168511
申请日：2008-07-07
申请人： Dietrich Rottmann , Christian Kunz
发明人： Dietrich Rottmann , Christian Kunz
IPC分类号： B01D53/18
CPC分类号： F25J3/04412 , F25J3/04084 , F25J3/0409 , F25J3/04296 , F25J3/04678 , F25J2200/20 , F25J2210/04 , F25J2230/40 , F25J2230/52 , F25J2245/02 , F25J2245/40 , F25J2250/20
摘要： The process and the device are used to produce a pressurized gaseous product by low-temperature separation of air in a distillation system, which has at least one high-pressure column (7) and one low-pressure column (8). A process air stream is compressed in a main air compressor. At least a part of the compressed process air stream (1) is introduced (6) into the high-pressure column (7). A first air stream (10, 13, 14, 17, 18), which is formed at least by a part of the process air stream (1), is compressed to a high air pressure (11, 15), which is at least 1 bar above the operating pressure of the high-pressure column (7). A liquid product stream (21, 47) is removed from the distillation system, brought (48, 51) to an elevated pressure in the liquid state, and evaporated or pseudo-evaporated with the first air stream (17) under this elevated pressure by indirect heat exchange (4), and finally drawn off as a gaseous product stream (50, 53). The first air stream (17) is condensed or pseudo-condensed in the indirect heat exchange (4). The first air stream (18) is evaporated downstream from the indirect heat exchange (4) with the product stream (49, 52), which is pressurized in the liquid state, in indirect heat exchange (20) with a gaseous stream (41) from the upper section of the high-pressure column (7). The evaporated first air stream (22) is recycled (23, 26) into the process air stream (1, 2). The evaporated first air stream (23) is compressed in a recompressor (24) upstream from where it is recycled into the process air stream.
摘要翻译：该方法和装置用于通过在具有至少一个高压塔（7）和一个低压塔（8）的蒸馏系统中低温分离空气来生产加压气态产物。工作空气流在主空气压缩机中被压缩。压缩过程空气流（1）的至少一部分被引入（6）到高压塔（7）中。至少由工艺空气流（1）的一部分形成的第一气流（10,13,14,17,18）被压缩至至少为高的空气压力（11,15） 1巴高于高压塔（7）的工作压力。将液体产物流（21,47）从蒸馏系统中取出，使（48,51）在液态下升高压力，并在该升高的压力下用第一气流（17）蒸发或假蒸发，间接热交换（4），最后作为气态产物流（50,53）排出。第一气流（17）在间接热交换（4）中被冷凝或者假冷凝。第一空气流（18）在间接热交换（4）的下游被蒸发，其中液态物质（49,52）以液态加压，与气流（41）进行间接热交换（20）从高压塔（7）的上部。蒸发的第一气流（22）被再循环（23,26）到工艺空气流（1,2）中。蒸发的第一气流（23）在再压缩机（24）中被压缩，从而将其再循环到工艺空气流中。

3. 发明授权

US06598424B2 Process and apparatus for separating a gas mixture with emergency operation 有权
公开(公告)号：US06598424B2
公开(公告)日：2003-07-29
申请号：US10094137
申请日：2002-03-11
申请人： Gerhard Zapp , Christian Kunz
发明人： Gerhard Zapp , Christian Kunz
IPC分类号： F25J300
CPC分类号： F25J3/04824 , F25J3/0409 , F25J3/04157 , F25J3/04218 , F25J3/04296 , F25J3/04375 , F25J3/04412 , F25J3/04545 , F25J3/04563 , F25J3/04575 , F25J3/04606 , F25J3/04878 , F25J2205/02 , F25J2205/04 , F25J2205/32 , F25J2210/04 , F25J2215/02 , F25J2215/40 , F25J2215/54 , F25J2240/44 , F25J2240/46 , F25J2245/42 , F25J2245/50 , Y10S62/913 , Y10S62/915
摘要： The process and the apparatus serve for separating a gas mixture in a separation plant. A feed gas (18) is introduced into a compressor system (6, 16) and then into the separation plant. In the event of loss or partial loss of the compressor system (6, 16) of the first feed gas compressor (6), a first auxiliary stream (91, 92) which has approximately the composition of the first product stream or approximately the composition of the feed gas is compressed (78, 89) to at least approximately the first pressure and is recirculated to the separation plant.

4. 发明授权

US06477860B2 Process for obtaining gaseous and liquid nitrogen with a variable proportion of liquid product 失效
标题翻译：用可变比例的液体产品获得气态和液氮的方法
公开(公告)号：US06477860B2
公开(公告)日：2002-11-12
申请号：US09810340
申请日：2001-03-19
申请人： Dietrich Rottmann , Christian Kunz
发明人： Dietrich Rottmann , Christian Kunz
IPC分类号： F25J304
CPC分类号： F25J3/0486 , F25J3/04018 , F25J3/0403 , F25J3/0409 , F25J3/04145 , F25J3/04206 , F25J3/04212 , F25J3/04321 , F25J3/04351 , F25J3/04357 , F25J3/04393 , F25J3/044 , F25J3/0443 , F25J3/04812 , F25J2200/32 , F25J2200/76 , F25J2215/44 , F25J2215/52 , F25J2215/56 , F25J2220/42 , F25J2220/50 , F25J2220/52 , F25J2230/42 , F25J2235/50 , F25J2240/46 , F25J2245/42 , F25J2250/42 , F25J2250/50
摘要： In a single column distillation system for obtaining gaseous and liquid nitrogen with a variable proportions of liquid product by low-temperature separation from air, a first portion (12, 13) of nitrogen-rich fraction (5, 7, 8) is fed downstream of circulation compressor (9) to the liquefaction chamber of a condenser-evaporator (14) associated with the single column and condensed under a pressure higher than the operating pressure of the single column (4). A liquid oxygen-enriched fraction (228, 231) from the distillation column system is at least partially evaporated in the evaporation chamber of condenser-evaporator (14). A portion (18) of nitrogen-rich liquid (15, 16) from condenser-evaporator (14) is drawn off at least at times as liquid product. A second oxygen-enriched gas (221, 521) is removed from one of columns (546) of the distillation system and/or from the evaporation chamber of condenser-evaporator (14), machine expanded(23), and heated in main heat exchanger (2).
摘要翻译：在用于通过与空气进行低温分离从而获得具有不同比例的液体产物的气态和液氮的单塔蒸馏系统中，将富氮馏分（5,7,8）的第一部分（12,13）进料到下游的循环压缩机（9）连接到与单塔相关联的冷凝器 - 蒸发器（14）的液化室，并在高于单塔（4）的操作压力的压力下冷凝。来自蒸馏塔系统的液体富氧馏分（228,231）在冷凝器 - 蒸发器（14）的蒸发室中至少部分蒸发。至少有时作为液体产物抽出来自冷凝器 - 蒸发器（14）的富氮液体（15,16）的一部分（18）。第二个富氧气体（221,521）从蒸馏系统的一个塔（546）和/或从冷凝器 - 蒸发器（14）的蒸发室，机器膨胀（23）中的一个中除去，并在主热中加热交换器（2）。

5. 发明授权

US06470707B2 Process for obtaining gaseous nitrogen 失效
标题翻译：获得气态氮的方法
公开(公告)号：US06470707B2
公开(公告)日：2002-10-29
申请号：US09810708
申请日：2001-03-19
申请人： Dietrich Rottmann , Christian Kunz
发明人： Dietrich Rottmann , Christian Kunz
IPC分类号： F25J304
CPC分类号： F25J3/044 , F25J3/04321 , F25J3/04351
摘要： For obtaining gaseous nitrogen by low-temperature separation from air, a distillation column system has a single column (4). Compressed air (1) is cooled in a main heat exchanger (2) and fed (3) to single column (4). A nitrogen-rich fraction (5, 7, 8) is drawn off from the distillation column system and compressed at least in part in a circulation compressor (9, 1063). A first part (12, 13) of nitrogen-rich fraction (5, 7, 8) is fed downstream from circulation compressor (9) to the liquefaction chamber of a condenser-evaporator (14) and is condensed under a pressure higher than the operating pressure of single column (4), so to form nitrogen-rich liquid (15, 16). A liquid oxygen-enriched fraction (231) from the distillation column system is at least partially evaporated in the evaporation chamber of condenser-evaporator (14). A first oxygen-enriched gas (234, 533) formed in the evaporation chamber of condenser-evaporator (14), is introduced into single column (4). A second portion (19, 20, 1064) of the nitrogen-rich fraction (5, 7, 8) is drawn off at least at times as gaseous nitrogen product. A second oxygen-enriched gas (221, 521) is removed from the evaporation chamber of condenser-evaporator (14), work expanded (23), and heated in main heat exchanger (2).
摘要翻译：为了通过与空气进行低温分离获得气态氮，蒸馏塔系统具有单柱（4）。压缩空气（1）在主热交换器（2）中冷却，并将（3）供给单塔（4）。将富氮馏分（5,7,8）从蒸馏塔系统中排出并至少部分压缩在循环压缩机（9,1063）中。将富氮馏分（5,7,8）的第一部分（12,13）从循环压缩机（9）的下游供给到冷凝器 - 蒸发器（14）的液化室，并在高于单塔（4）的操作压力，从而形成富氮液体（15,16）。来自蒸馏塔系统的液体富氧馏分（231）在冷凝器 - 蒸发器（14）的蒸发室中至少部分蒸发。形成在冷凝器 - 蒸发器（14）的蒸发室中的第一富氧气体（234,533）被引入单塔（4）中。至少有时作为气态氮产物排出富氮馏分（5,7,8）的第二部分（19,20,1046）。第二富氧气体（221,521）从冷凝器 - 蒸发器（14）的蒸发室中移出，工作膨胀（23），并在主热交换器（2）中加热。

6. 发明授权

US4939661A Apparatus for a video marine navigation plotter with electronic charting and methods for use therein 失效
标题翻译：用于具有电子图表的视频海洋导航绘图仪的装置及其中使用的方法
公开(公告)号：US4939661A
公开(公告)日：1990-07-03
申请号：US243317
申请日：1988-09-09
申请人： Christopher Barker , Christian Kunz , John A. Combs , John C. S. Park
发明人： Christopher Barker , Christian Kunz , John A. Combs , John C. S. Park
IPC分类号： G01C21/22
CPC分类号： G01C21/22
摘要： Apparatus for a video navigation plotter with electronic charting, specifically such a plotter designed for marine use, and various methods for processing navigational data therein and displaying resulting navigational data thereon are disclosed herein. Specifically, this plotter stores coastline data only for those cells which contain coastline data within a given geographic region of a pre-defined chart. The data for each of these cells is stored in a unique data structure that stores data for a plurality of line segments that, when drawn, collectively depicts the geographic data stored within that cell. Each segment is stored in terms of coordinate locations for a starting point followed by coordinate offset values for each successive point in that cell. Only those cells and their constituent segments are drawn for coastline data that exists within a specific region to be displayed. Once a coastline chart is displayed, the inventive plotter permits navigational data to be overlaid thereon and through this capability provides several useful features as set forth herein.
摘要翻译：本文公开了一种用于具有电子图表的视频导航绘图仪，专门用于海洋用途的这样的绘图仪，以及用于在其中处理导航数据并在其上显示所得到的导航数据的各种方法。具体来说，该绘图仪仅存储在预定义图表的给定地理区域内包含海岸线数据的单元格的海岸线数据。这些单元中的每一个的数据被存储在唯一的数据结构中，该数据结构存储多个线段的数据，当绘制时，它们共同描绘存储在该单元内的地理数据。每个段以起始点的坐标位置存储，然后存储该单元中每个连续点的坐标偏移值。仅对存在于要显示的特定区域内的海岸线数据绘制那些单元及其构成段。一旦显示了海岸线图表，本发明的绘图仪允许将导航数据覆盖在其上，并且通过该能力提供了如本文所阐述的若干有用的特征。

7. 发明申请

US20060005574A1 Method for extracting argon by low-temperature air separation 审中-公开
标题翻译：低温空气分离法提取氩气的方法
公开(公告)号：US20060005574A1
公开(公告)日：2006-01-12
申请号：US10510906
申请日：2003-04-01
申请人： Reinhard Glatthaar , Christian Kunz , Harald Ranke
发明人： Reinhard Glatthaar , Christian Kunz , Harald Ranke
IPC分类号： F25J3/00
CPC分类号： B01D3/141 , F25J3/04303 , F25J3/04412 , F25J3/04678 , F25J3/04703 , F25J3/04709 , F25J3/04939 , F25J2200/34 , F25J2290/10 , F25J2290/12
摘要： The invention relates to a process for recovering argon by low-temperature separation of air. Rectifying system (2, 4) exhibits at least one air separation column (4), which has a partition (5) that runs in lengthwise direction of the column, by which air separation column (4) is separated at the level of partition (5) into a first subsection and a second subsection (6, 7). A fluid (3) that contains oxygen and argon is introduced into first subsection (6). A stream (13) that contains oxygen and argon with an argon concentration of between 15% and 50% is removed in second subsection (7).
摘要翻译：本发明涉及通过低温分离空气来回收氩的方法。整流系统（2,4）具有至少一个空气分离柱（4），该空气分离塔具有在塔的长度方向上延伸的隔板（5），空气分离柱（4）在分隔层 5）转入第一个小节和第二个小节（6,7）。将含有氧气和氩气的流体（3）引入到第一部分（6）中。在第二子部分（7）中除去含有氩浓度为15％至50％的氧和氩的物流（13）。

8. 发明授权

US06776004B2 Air fractionation process and installation with mixing column and krypton-xenon recovery 失效
$Air fractionation process and installation with mixing column and krypton-xenon recovery$
公开(公告)号：US06776004B2
公开(公告)日：2004-08-17
申请号：US10601875
申请日：2003-06-24
申请人： Dietrich Rottmann , Christian Kunz
发明人： Dietrich Rottmann , Christian Kunz
IPC分类号： F25J302
CPC分类号： F25J3/04745 , C01B13/0248 , C01B2210/0046 , C01B2210/0084 , C01B2210/0085 , F25J3/04303 , F25J3/04466 , F25J3/04872 , F25J3/04969 , F25J2200/06 , F25J2200/34 , F25J2200/92 , F25J2200/94 , F25J2235/50 , F25J2245/50
摘要： A process and apparatus for low-temperature fractionation of air in a distillation column system for nitrogen-oxygen separation (5, 6) introduces into first feed air stream (4) into a distillation column system for nitrogen-oxygen separation. An oxygen-rich fraction (22) from the distillation column system for nitrogen-oxygen separation is pressurized (23) in liquid form and is added (25) to a mixing column (26). A heat transfer medium stream is introduced into the lower region of the mixing column (26) and is brought into countercurrent contact with the oxygen-rich fraction (22, 25). Gaseous top product (260) from the upper region of the mixing column (26) is introduced into an additional column (27). A liquid (38, 39, 40, 41) from the lower or middle region of the mixing column is introduced into the distillation column system. A krypton- and xenon-containing oxygen stream (44, 46, 47, 48) from the distillation column system is introduced into a krypton-xenon enriching column (36) from which a krypton- and xenon-enriched fraction (51) is obtained. A krypton- and xenon-depleted top fraction (28) is obtained from the upper region of the additional column (27).

9. 发明授权

US06276172B1 Process for producing ultrapure nitrogen 失效
标题翻译：超纯氮生产工艺
公开(公告)号：US06276172B1
公开(公告)日：2001-08-21
申请号：US09437263
申请日：1999-11-10
申请人： Dietrich Rottman , Christian Kunz
发明人： Dietrich Rottman , Christian Kunz
IPC分类号： F25J300
CPC分类号： F25J3/04218 , F25J3/04084 , F25J3/04212 , F25J3/04284 , F25J3/04351 , F25J3/04454 , F25J3/04963 , F25J3/08 , F25J2200/04 , F25J2200/10 , F25J2200/50 , F25J2200/72 , F25J2210/42 , F25J2215/44 , F25J2220/42 , F25J2220/44 , F25J2235/42 , F25J2245/42 , F25J2250/20 , F25J2250/42 , F25J2270/42 , F25J2290/62 , Y10S62/92
摘要： For producing ultrapure nitrogen by low-temperature fractionation of air in a rectification system having at least one rectification column, compressed and purified feed air is conducted into a high pressure column, an oxygen-free pressurized nitrogen fraction is produced from the high pressure column, conducted into a low-pressure column and in the low-pressure column carbon-monoxide-free low-pressure nitrogen is produced as overhead gas. The oxygen-free pressurized nitrogen fraction (1) is either taken off in the liquid state from an upper region of the high pressure column or is provided from a liquid tank (22) containing stored oxygen-free nitrogen and the oxygen-free pressurized nitrogen fraction (1) is expanded into the bottom-heated low-pressure column (2). Ascending vapour in the lowpressure column (2) by mass transfer with and an ultrapure nitrogen reflux applied at the top of the low-pressure column (2) and is freed from carbon monoxide using ultrapure nitrogen, withdrawn as carbon-monoxide-free overhead gas (5) at the top of the low-pressure column (2). After a pressure increase the overhead (5), is partially liquefied, and the liquefied part (17, 18) is expanded into a bottom-heated He—Ne—H2 column (4) from which the ultrapure nitrogen (19) is withdrawn in the liquid state.
摘要翻译：为了在具有至少一个精馏塔的精馏系统中通过空气的低温分馏制备超纯氮，将压缩和纯化的进料空气进入高压塔，由高压塔产生无氧加压氮馏分，进入低压塔，在低压塔中产生一氧化碳的低压氮作为塔顶气体。无氧加压氮馏分（1）从高压塔的上部区域以液态取出，或者由含有储存无氧氮的液体罐（22）和无氧加压氮馏分（1）膨胀到底部加热的低压塔（2）中。在低压塔（2）的顶部通过传质和超纯氮回流在低压塔（2）中升高蒸气，并使用超纯氮从一氧化碳中除去一氧化碳，作为一氧化碳的塔顶气体（5）在低压塔（2）的顶部。在压力增加之后，顶部（5）部分液化，液化部分（17,18）膨胀成底部加热的He-Ne-H2柱（4），超纯氮（19）从该塔中取出液态。

10. 发明授权

US06662595B2 Process and device for obtaining a compressed product by low temperature separation of air 失效
公开(公告)号：US06662595B2
公开(公告)日：2003-12-16
申请号：US10217329
申请日：2002-08-13
申请人： Horst Corduan , Dietrich Rottmann , Christian Kunz
发明人： Horst Corduan , Dietrich Rottmann , Christian Kunz
IPC分类号： F25J304
CPC分类号： F25J3/04218 , F25J3/04084 , F25J3/0409 , F25J3/042 , F25J3/04303 , F25J3/0446 , F25J3/04672 , F25J2200/06 , F25J2200/94 , F25J2215/50 , F25J2235/50
摘要： The process and device are used to obtain a compressed product by low temperature separation of air in a rectification system which has a pressure column and a low pressure column. A first flow of compressed and purified feedstock air is cooled in a main heat exchanger system and is fed into the pressure column. At least one fraction from the pressure column is expanded and fed into the low pressure column. An oxygen-rich fraction from the low pressure column is liquid-pressurized and delivered to a mixing column. A heat exchange medium is fed into the lower area of the mixing column and is brought into countercurrent contact with the oxygen-rich fraction. A gaseous top product is removed from the upper area of the mixing column. A product fraction is removed from the rectification system, liquid-pressurized, vaporized in indirect heat exchange with the gaseous top product of the mixing column and is withdrawn as the compressed product. Indirect heat exchange is carried out for vaporization of the liquid-pressurized product fraction in the main heat exchanger system.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式