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1. 发明申请

US20120046710A1 METHODS, SYSTEMS, AND DEVICES FOR DEEP BRAIN STIMULATION USING HELICAL MOVEMENT OF THE CENTROID OF STIMULATION 审中-公开
标题翻译：使用刺激性心脏运动的深层脑刺激的方法，系统和装置
公开(公告)号：US20120046710A1
公开(公告)日：2012-02-23
申请号：US13198035
申请日：2011-08-04
申请人： Andrew DiGiore , David Karl Lee Peterson
发明人： Andrew DiGiore , David Karl Lee Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/0534 , A61N1/36185
摘要： A method of treating a target region in the brain includes a) contacting tissue to be stimulated with a lead of a stimulation device, the stimulation device comprising a pulse generator coupled to the lead, the lead having a plurality of segmented electrodes disposed at a distal end of the lead, the stimulation device being configured and arranged to stimulate a target region using a positionable centroid of stimulation; b) providing stimulation current to at least one of the segmented electrodes of the lead to generate a centroid of stimulation at a location and stimulate tissue around the location of the centroid of stimulation; c) repositioning the centroid of stimulation to a next location along a helical path by altering the provision of stimulation current to the plurality of electrodes and stimulating tissue around the location of the repositioned centroid of stimulation; and d) repeating c) for each location along the helical path. The method may optionally include collecting data associated with each of the locations of the centroid of stimulation; and displaying at least a portion of the collected data.
摘要翻译：治疗脑中靶区域的方法包括：a）使刺激装置的引导部分接触被刺激的组织，所述刺激装置包括连接到所述引线的脉冲发生器，所述引线具有设置在远端的多个分段电极所述刺激装置被配置和布置成使用可定位的刺激重心来刺激目标区域; b）向引线的至少一个分段电极提供刺激电流，以在位置处产生刺激的质心并刺激刺激质心位置周围的组织; c）通过改变对所述多个电极的刺激电流的提供并刺激所述重新定位的刺激质心的周围的组织来重新定位刺激的质心到沿着螺旋路径的下一个位置; 和d）重复c）沿着螺旋路径的每个位置。该方法可以可选地包括收集与刺激质心的每个位置相关联的数据; 并显示所收集的数据的至少一部分。

2. 发明授权

US08626297B2 Apparatus and methods for charging an implanted medical device power source 有权
标题翻译：用于对植入式医疗装置电源充电的装置和方法
公开(公告)号：US08626297B2
公开(公告)日：2014-01-07
申请号：US12233810
申请日：2008-09-19
申请人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
发明人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , H02J7/025 , H02J7/047 , H02J50/10
摘要： Apparatus and methods for charging an implanted medical device.
摘要翻译：用于对植入的医疗装置充电的装置和方法。

3. 发明授权

US08560085B2 Methods for making leads with segmented electrodes for electrical stimulation systems 有权
标题翻译：用于电刺激系统的分段电极的引线方法
公开(公告)号：US08560085B2
公开(公告)日：2013-10-15
申请号：US13369013
申请日：2012-02-08
申请人： Michael Adam Moffitt , Anne Margaret Pianca , Andrew DiGiore
发明人： Michael Adam Moffitt , Anne Margaret Pianca , Andrew DiGiore
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61B2090/3937 , A61B2090/3966 , A61N1/0534 , A61N1/086 , A61N1/36182
摘要： One embodiment is a stimulation lead including a lead body comprising a longitudinal surface, a distal end, and a proximal end; and multiple electrodes disposed along the longitudinal surface of the lead body near the distal end of the lead body. The multiple electrodes include multiple segmented electrodes. At least a first portion of the lead body, proximal to the electrodes, is transparent or translucent and at least a second portion of the lead body, separating two or more of the segmented electrodes, is opaque so that the segmented electrodes separated by the second portion of the lead body are visually distinct. Alternatively or additionally, the stimulation lead can include an indicator ring, a stripe, a groove, or a marking aligned with one or more of the segmented electrodes.
摘要翻译：一个实施例是包括包括纵向表面，远端和近端的引线主体的刺激引线; 以及沿引线本体的远端的纵向表面设置的多个电极。多个电极包括多个分段电极。引线本体的至少靠近电极的第一部分是透明或半透明的，并且分离两个或更多个分段电极的引线体的至少第二部分是不透明的，使得分段电极被第二部分分开铅体的部分在视觉上不同。或者或另外，刺激引线可以包括与一个或多个分段电极对准的指示环，条纹，凹槽或标记。

4. 发明授权

US08352035B2 Connector assemblies for implantable stimulators 有权
公开(公告)号：US08352035B2
公开(公告)日：2013-01-08
申请号：US12262789
申请日：2008-10-31
申请人： Brett Schleicher , Rafael Carbunaru , Todd K. Whitehurst , Kristen N. Jaax , Greg Baldwin , Andrew DiGiore
发明人： Brett Schleicher , Rafael Carbunaru , Todd K. Whitehurst , Kristen N. Jaax , Greg Baldwin , Andrew DiGiore
IPC分类号： A61N1/00
CPC分类号： A61N1/3754 , A61N1/37205 , A61N1/37235 , A61N1/375 , A61N1/3752 , A61N1/3787
摘要： Exemplary systems include a stimulator configured to be implanted within a patient, the stimulator having a body defined by at least one side surface disposed in between distal and proximal end surfaces, and a connector assembly configured to be coupled to the stimulator and extend parallel to the at least one side surface of the stimulator. The connector assembly is further configured to facilitate removable coupling of a lead having one or more electrodes disposed thereon to the stimulator.

5. 发明授权

US08315707B2 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 有权
标题翻译：用于避免，逆转和管理神经系统适应电刺激的系统和方法
公开(公告)号：US08315707B2
公开(公告)日：2012-11-20
申请号：US13423245
申请日：2012-03-18
申请人： Kristen Jaax , Andrew DiGiore
发明人： Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/00
CPC分类号： A61N1/37235 , A61N1/36132 , A61N1/36146 , A61N1/37264
摘要： A method of operating a neurostimulation device comprises varying a first stimulation parameter under user control while fixing a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first stimulation parameter and the fixed second stimulation parameter, outputting a pulsed electrical waveform from the neurostimulation device between electrodes in accordance with the stimulation parameter sets, such that a therapeutic effect is achieved while allowing neural tissue to undergo neurological accommodation, changing the second stimulation parameter, varying the first stimulation parameter under user control while fixing the second changed stimulation parameter, generating another plurality of stimulation parameter sets from the varied first stimulation parameter and the fixed changed second stimulation parameter, and outputting the pulsed electrical waveform from the neurostimulation device between the electrodes in accordance with the other stimulation parameter sets to maintain the therapeutic effect while the neural tissue is neurologically accommodated.
摘要翻译：操作神经刺激装置的方法包括在固定第二刺激参数的同时改变用户控制下的第一刺激参数，从变化的第一刺激参数和固定的第二刺激参数产生多个刺激参数集，输出来自神经刺激装置，根据刺激参数组，使得在允许神经组织经历神经学调节的同时实现治疗效果，改变第二刺激参数，在固定第二改变的刺激参数的同时改变用户控制下的第一刺激参数，从变化的第一刺激参数和固定改变的第二刺激参数产生另外多个刺激参数集合，并且根据另一个st从电极之间的神经刺激装置输出脉冲电波形模拟参数集，以在神经组织神经学适应的同时保持治疗效果。

6. 发明申请

US20110295330A1 ANCHORING UNITS FOR LEADS OF IMPLANTABLE ELECTRIC STIMULATION SYSTEMS AND METHODS OF MAKING AND USING 有权
标题翻译：可植入电刺激系统引导锚固单元及其制造和使用方法
公开(公告)号：US20110295330A1
公开(公告)日：2011-12-01
申请号：US13207876
申请日：2011-08-11
申请人： Brett Schleicher , Andrew DiGiore , Rafael Carbunaru , Courtney Lane , Kristen N. Jaax
发明人： Brett Schleicher , Andrew DiGiore , Rafael Carbunaru , Courtney Lane , Kristen N. Jaax
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/0558
摘要： A nerve stimulation lead has a distal end, a proximal end, and a longitudinal length. The nerve stimulation lead includes a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and a plurality of conductive wires electrically coupling the plurality of electrodes electrically to the plurality of terminals. The nerve stimulation lead also includes at least one anchoring unit disposed on the nerve stimulation lead. The at least one anchoring unit is configured and arranged for anchoring the nerve stimulation lead against a bony structure.
摘要翻译：神经刺激引线具有远端，近端和纵向长度。神经刺激引线包括设置在远端的多个电极，设置在近端的多个端子，以及将多个电极电连接到多个端子的多个导线。神经刺激引线还包括设置在神经刺激引线上的至少一个锚定单元。所述至少一个锚定单元被配置和布置成用于将神经刺激引线抵靠骨结构锚定。

7. 发明申请

US20110054567A1 METHODS TO AVOID FREQUENCY LOCKING IN A MULTI-CHANNEL NEUROSTIMULATION SYSTEM USING PULSE SHIFTING 有权
标题翻译：使用脉冲移位在多通道神经网络系统中避免频率锁定的方法
公开(公告)号：US20110054567A1
公开(公告)日：2011-03-03
申请号：US12550213
申请日：2009-08-28
申请人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K.L. Peterson , Andrew DiGiore , Michael Moffitt
发明人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K.L. Peterson , Andrew DiGiore , Michael Moffitt
IPC分类号： A61N1/08
CPC分类号： A61N1/36021 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B5/04004 , A61B5/0488 , A61B5/1118 , A61B5/112 , A61B5/4812 , A61B5/4836 , A61M5/1723 , A61N1/0529 , A61N1/08 , A61N1/306 , A61N1/36025 , A61N1/36031 , A61N1/36034 , A61N1/3605 , A61N1/3606 , A61N1/36062 , A61N1/36071 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36171 , A61N1/36178
摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the pulsed electrical waveforms that will potentially overlap temporally are predicted. Stimulation pulses in the respective pulsed electrical waveforms are temporally shifted in a manner that prevents overlap of the potentially overlapping pulse sets while preventing frequency locking between the timing channels.
摘要翻译：提供了一种用于治疗患者的方法和神经刺激系统。多个脉冲电波形分别在神经刺激系统的多个定时通道内递送，从而治疗患者。可以预测脉冲电波形内可能在时间上重叠的一组刺激脉冲。相应脉冲电波形中的刺激脉冲以防止可能重叠的脉冲组重叠的方式在时间上移位，同时防止定时通道之间的频率锁定。

8. 发明申请

US20110054518A1 BURR HOLE SEALING DEVICE FOR PREVENTING BRAIN SHIFT 有权
标题翻译：用于预防脑移位的双孔密封装置
公开(公告)号：US20110054518A1
公开(公告)日：2011-03-03
申请号：US12549174
申请日：2009-08-27
申请人： Rafael Carbunaru , Todd K. Whitehurst , Andrew DiGiore , Kristen Jaax
发明人： Rafael Carbunaru , Todd K. Whitehurst , Andrew DiGiore , Kristen Jaax
IPC分类号： A61B17/08 , A61M5/00
CPC分类号： A61N1/0539 , A61B17/3415 , A61B90/14 , A61B2017/3419 , A61B2090/103 , A61M2039/025 , A61M2039/0276 , A61M2039/0282
摘要： A burr hole sealing device for preventing brain shift during a stimulation lead implantation procedure is provided. The device includes a suction cup ring and a self-sealing membrane positioned within the aperture of the ring. The sealing device is attached adjacent to a burr hole and over a dura layer that is exposed in the bottom of the burr hole. The stimulation lead is disposed through the burr hole, through the membrane, through the dura layer and into brain tissue. The membrane is configured to allow the lead to pass therethrough while maintaining a tight seal around the diameter of the lead, thereby hindering leakage of cerebrospinal fluid out of the cranial cavity and maintaining a substantially fixed intracranial pressure. In one embodiment, the sealing device includes a syringe for adding fluid to, or removing fluid from, the cranial cavity in response to a detected change in intracranial pressure.
摘要翻译：提供了一种用于在刺激引线植入程序期间防止脑移位的钻孔密封装置。该装置包括吸盘环和位于环的孔内的自密封膜。密封装置邻近毛刺孔并暴露在钻孔底部的硬脑膜层上。刺激引线通过毛刺孔穿过膜，穿过硬脑膜层并进入脑组织。膜被配置为允许引线通过，同时保持围绕铅直径的紧密密封，从而阻止脑脊液从脑腔中泄漏并保持基本上固定的颅内压。在一个实施例中，密封装置包括用于响应于检测到的颅内压变化而将流体添加到颅腔或从头颅腔移除流体的注射器。

9. 发明申请

US20090248095A1 ANCHORING UNITS FOR LEADS OF IMPLANTABLE ELECTRIC STIMULATION SYSTEMS AND METHODS OF MAKING AND USING 有权
标题翻译：可植入电刺激系统引导锚固单元及其制造和使用方法
公开(公告)号：US20090248095A1
公开(公告)日：2009-10-01
申请号：US12413081
申请日：2009-03-27
申请人： Brett Schleicher , Andrew DiGiore , Rafael Carbunaru , Courtney Lane , Kristen N. Jaax
发明人： Brett Schleicher , Andrew DiGiore , Rafael Carbunaru , Courtney Lane , Kristen N. Jaax
IPC分类号： A61N1/00 , A61N1/04
CPC分类号： A61N1/0558
摘要： A nerve stimulation lead has a distal end, a proximal end, and a longitudinal length. The nerve stimulation lead includes a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and a plurality of conductive wires electrically coupling the plurality of electrodes electrically to the plurality of terminals. The nerve stimulation lead also includes at least one anchoring unit disposed on the nerve stimulation lead. The at least one anchoring unit is configured and arranged for anchoring the nerve stimulation lead against a bony structure.
摘要翻译：神经刺激引线具有远端，近端和纵向长度。神经刺激引线包括设置在远端的多个电极，设置在近端的多个端子，以及将多个电极电连接到多个端子的多个导线。神经刺激引线还包括设置在神经刺激引线上的至少一个锚定单元。所述至少一个锚定单元被配置和布置成用于将神经刺激引线抵靠骨结构锚定。

10. 发明申请

US20090192568A1 METHODS AND SYSTEMS FOR TREATING SEIZURES CAUSED BY BRAIN STIMULATION 失效
标题翻译：用于治疗由脑刺激引起的疾病的方法和系统
公开(公告)号：US20090192568A1
公开(公告)日：2009-07-30
申请号：US12339639
申请日：2008-12-19
申请人： Todd K. Whitehurst , Rafael Carbunaru , Kristen N. Jaax , Andrew DiGiore , Brett Schleicher , Greg Baldwin
发明人： Todd K. Whitehurst , Rafael Carbunaru , Kristen N. Jaax , Andrew DiGiore , Brett Schleicher , Greg Baldwin
IPC分类号： A61N1/36 , A61M37/00
CPC分类号： A61N1/36064 , A61N1/0529 , A61N1/0534 , A61N1/36082 , A61N1/37205 , A61N1/3756
摘要： Methods for treating seizures caused by brain stimulation include providing a stimulator, programming the stimulator with one or more stimulation parameters configured to treat a medical condition, applying at least one stimulus with the stimulator to a stimulation site within the brain of a patient in accordance with the one or more stimulation parameters, and monitoring the patient for a seizure caused by the at least one stimulus.
摘要翻译：用于治疗由脑刺激引起的癫痫发作的方法包括提供刺激器，用刺激器编程配置成治疗医疗状况的一个或多个刺激参数，使用刺激器施加至少一个刺激到患者脑内的刺激部位，一个或多个刺激参数，以及监测由至少一个刺激引起的癫痫发作的患者。

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