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1. 发明授权

US08626297B2 Apparatus and methods for charging an implanted medical device power source 有权
标题翻译：用于对植入式医疗装置电源充电的装置和方法
公开(公告)号：US08626297B2
公开(公告)日：2014-01-07
申请号：US12233810
申请日：2008-09-19
申请人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
发明人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , H02J7/025 , H02J7/047 , H02J50/10
摘要： Apparatus and methods for charging an implanted medical device.
摘要翻译：用于对植入的医疗装置充电的装置和方法。

2. 发明授权

US08315707B2 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 有权
标题翻译：用于避免，逆转和管理神经系统适应电刺激的系统和方法
公开(公告)号：US08315707B2
公开(公告)日：2012-11-20
申请号：US13423245
申请日：2012-03-18
申请人： Kristen Jaax , Andrew DiGiore
发明人： Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/00
CPC分类号： A61N1/37235 , A61N1/36132 , A61N1/36146 , A61N1/37264
摘要： A method of operating a neurostimulation device comprises varying a first stimulation parameter under user control while fixing a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first stimulation parameter and the fixed second stimulation parameter, outputting a pulsed electrical waveform from the neurostimulation device between electrodes in accordance with the stimulation parameter sets, such that a therapeutic effect is achieved while allowing neural tissue to undergo neurological accommodation, changing the second stimulation parameter, varying the first stimulation parameter under user control while fixing the second changed stimulation parameter, generating another plurality of stimulation parameter sets from the varied first stimulation parameter and the fixed changed second stimulation parameter, and outputting the pulsed electrical waveform from the neurostimulation device between the electrodes in accordance with the other stimulation parameter sets to maintain the therapeutic effect while the neural tissue is neurologically accommodated.
摘要翻译：操作神经刺激装置的方法包括在固定第二刺激参数的同时改变用户控制下的第一刺激参数，从变化的第一刺激参数和固定的第二刺激参数产生多个刺激参数集，输出来自神经刺激装置，根据刺激参数组，使得在允许神经组织经历神经学调节的同时实现治疗效果，改变第二刺激参数，在固定第二改变的刺激参数的同时改变用户控制下的第一刺激参数，从变化的第一刺激参数和固定改变的第二刺激参数产生另外多个刺激参数集合，并且根据另一个st从电极之间的神经刺激装置输出脉冲电波形模拟参数集，以在神经组织神经学适应的同时保持治疗效果。

3. 发明申请

US20110054518A1 BURR HOLE SEALING DEVICE FOR PREVENTING BRAIN SHIFT 有权
标题翻译：用于预防脑移位的双孔密封装置
公开(公告)号：US20110054518A1
公开(公告)日：2011-03-03
申请号：US12549174
申请日：2009-08-27
申请人： Rafael Carbunaru , Todd K. Whitehurst , Andrew DiGiore , Kristen Jaax
发明人： Rafael Carbunaru , Todd K. Whitehurst , Andrew DiGiore , Kristen Jaax
IPC分类号： A61B17/08 , A61M5/00
CPC分类号： A61N1/0539 , A61B17/3415 , A61B90/14 , A61B2017/3419 , A61B2090/103 , A61M2039/025 , A61M2039/0276 , A61M2039/0282
摘要： A burr hole sealing device for preventing brain shift during a stimulation lead implantation procedure is provided. The device includes a suction cup ring and a self-sealing membrane positioned within the aperture of the ring. The sealing device is attached adjacent to a burr hole and over a dura layer that is exposed in the bottom of the burr hole. The stimulation lead is disposed through the burr hole, through the membrane, through the dura layer and into brain tissue. The membrane is configured to allow the lead to pass therethrough while maintaining a tight seal around the diameter of the lead, thereby hindering leakage of cerebrospinal fluid out of the cranial cavity and maintaining a substantially fixed intracranial pressure. In one embodiment, the sealing device includes a syringe for adding fluid to, or removing fluid from, the cranial cavity in response to a detected change in intracranial pressure.
摘要翻译：提供了一种用于在刺激引线植入程序期间防止脑移位的钻孔密封装置。该装置包括吸盘环和位于环的孔内的自密封膜。密封装置邻近毛刺孔并暴露在钻孔底部的硬脑膜层上。刺激引线通过毛刺孔穿过膜，穿过硬脑膜层并进入脑组织。膜被配置为允许引线通过，同时保持围绕铅直径的紧密密封，从而阻止脑脊液从脑腔中泄漏并保持基本上固定的颅内压。在一个实施例中，密封装置包括用于响应于检测到的颅内压变化而将流体添加到颅腔或从头颅腔移除流体的注射器。

4. 发明授权

US08670833B2 Methods and apparatus for using sensors with a deep brain stimulation system 有权
标题翻译：使用具有深脑刺激系统的传感器的方法和装置
公开(公告)号：US08670833B2
公开(公告)日：2014-03-11
申请号：US12959890
申请日：2010-12-03
申请人： James Makous , Brett Schleicher , Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
发明人： James Makous , Brett Schleicher , Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61N1/0534
摘要： A system and method for applying stimulation to a target stimulation site within a patient, while avoiding undesirable eye movement side effects of the stimulation, are provided. The method includes determining whether eye movement, sensed by internal or external electrodes, is a side effect of a conveyed electrical stimulus. If the eye movement is a side effect, the electrical current distribution of the stimulus is modified in order to steer a locus of the electrical stimulus from one tissue region of the patient to another different tissue region of the patient, thereby mitigating the eye movement side effects. For example, the locus of the electrical stimulus may be steered away from the oculomotor nerve. Eye movement side effects of DBS treatment may include apraxia of lid opening, downward movement and adduction of only one eyeball, and/or continuous deviation of both eyeballs.
摘要翻译：提供了一种用于将刺激应用于患者内的目标刺激部位同时避免刺激的不期望的眼睛运动副作用的系统和方法。该方法包括确定由内部或外部电极感测的眼睛运动是否是所传送的电刺激的副作用。如果眼睛运动是副作用，则刺激的电流分布被修改以便将电刺激的轨迹从患者的一个组织区域引导到患者的另一不同组织区域，从而减轻眼睛运动侧效果。例如，电刺激的轨迹可以被转向离开眼动神经。 DBS治疗的眼睛运动副作用可能包括盖开口的不适，仅有一只眼球的向下运动和内收，和/或两只眼球的连续偏差。

5. 发明授权

US08155750B2 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 有权
标题翻译：用于避免，逆转和管理神经系统适应电刺激的系统和方法
公开(公告)号：US08155750B2
公开(公告)日：2012-04-10
申请号：US12509340
申请日：2009-07-24
申请人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
发明人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
IPC分类号： A61N1/00
CPC分类号： A61N1/37235 , A61N1/36132 , A61N1/36146 , A61N1/37264
摘要： A method and programmer for programming a neurostimulation device are provided. The method comprises varying a first stimulation parameter under user control, automatically varying a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first and second stimulation parameters, outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes in accordance with the stimulation parameter sets, such that neural tissue is stimulated without undergoing neurological accommodation that would otherwise occur if the second stimulation parameter were not varied, and programming the neurostimulation device with a new set of stimulation parameters based on a result of the neural tissue stimulation The programmer comprises a user interface capable of receiving an input from a user, a processor configured for performing the previous steps, and output circuitry configured for transmitting the stimulation parameter sets and the new stimulation parameter set to the neurostimulation device.
摘要翻译：提供了一种用于编程神经刺激装置的方法和编程器。该方法包括在用户控制下改变第一刺激参数，自动改变第二刺激参数，从变化的第一和第二刺激参数产生多个刺激参数集合，从神经刺激装置在多个电极之间输出脉冲电波形根据刺激参数集，使得神经组织被刺激而不经历如果第二刺激参数没有变化否则会发生神经学调节，并且基于神经组织的结果用新的一组刺激参数来编程神经刺激装置刺激编程器包括能够接收来自用户的输入，被配置为执行前述步骤的处理器的用户界面以及被配置为将刺激参数集和新刺激参数集发送到神经刺激装置的输出电路。

6. 发明申请

US20110160797A1 METHODS TO CONCURRENTLY STIMULATE DIFFERENT BRAIN TARGETS 审中-公开
标题翻译：同时刺激不同脑部目标的方法
公开(公告)号：US20110160797A1
公开(公告)日：2011-06-30
申请号：US12976764
申请日：2010-12-22
申请人： James C. Makous , Courtney Lane , Kristen Jaax , Andrew DiGiore
发明人： James C. Makous , Courtney Lane , Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/36
CPC分类号： A61N1/36067 , A61N1/00 , A61N1/0534 , A61N1/36064 , A61N1/36171
摘要： A method for treating a patient having a dysfunction using a stimulation lead within the brain of a patient is provided. The stimulation lead carries a plurality of electrodes adjacent to a plurality of brain regions. Pulsed electrical waveforms having different sets of stimulation parameters are generated and then concurrently delivered to the plurality of electrodes, thereby concurrently stimulating the plurality of brain regions to treat the dysfunction.
摘要翻译：提供了一种使用患者脑内的刺激铅治疗具有功能障碍的患者的方法。刺激引线携带与多个脑区域相邻的多个电极。产生具有不同组刺激参数的脉冲电波形，然后同时传送到多个电极，从而同时刺激多个脑区域来治疗功能障碍。

7. 发明申请

US20110125223A1 NEUROSTIMULATION SYSTEM AND METHOD FOR COMPOUNDING CURRENT TO MINIMIZE CURRENT SOURCES 有权
标题翻译：用于组合电流以最小化电流源的神经网络系统和方法
公开(公告)号：US20110125223A1
公开(公告)日：2011-05-26
申请号：US12952738
申请日：2010-11-23
申请人： Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
发明人： Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N1/0551 , A61N1/36185 , A61N1/37223 , A61N1/37241 , A61N1/37288 , A61N2001/083
摘要： A neurostimulation system and method of providing therapy to a patient implanted with a plurality of electrodes using a plurality of electrical sources is provided. A source-electrode coupling configuration is determined from the electrical sources and electrodes. Electrical current is respectively conveyed between active ones of the plurality of electrical sources and active subsets of the plurality of electrodes in accordance with the determined source-electrode coupling configuration. The total number of the electrodes in the active electrode subsets is greater than the total number of the active electrical sources.
摘要翻译：提供了一种使用多个电源向注入多个电极的患者提供治疗的神经刺激系统和方法。源电极耦合配置由电源和电极确定。根据所确定的源电极耦合配置，电流分别在多个电源中的有效电源和多个电极的有效子集之间传送。有源电极子集中的电极总数大于有源电源的总数。

8. 发明申请

US20110009919A1 METHOD TO ENHANCE AFFERENT AND EFFERENT TRANSMISSION USING NOISE RESONANCE 有权
标题翻译：使用噪声共振方法来提高实际和有效的传输
公开(公告)号：US20110009919A1
公开(公告)日：2011-01-13
申请号：US12501170
申请日：2009-07-10
申请人： Rafael Carbunaru , Michael Moffitt , Kristen Jaax , Andrew DiGiore , Courtney Lane
发明人： Rafael Carbunaru , Michael Moffitt , Kristen Jaax , Andrew DiGiore , Courtney Lane
IPC分类号： A61N1/36
CPC分类号： A61N1/0551 , A61N1/0529 , A61N1/36057 , A61N1/36071 , A61N1/36114 , A61N1/36128 , A61N1/36164
摘要： Methods of providing therapy to a patient are provided. In one method, the patient has a neuron to which a sub-threshold biological electrical stimulus is applied. The method comprises applying electrical noise energy to the neuron, wherein resonance between the biological electrical stimulus and the electrical noise energy is created, such that an action potential is propagated along the axon of the neuron. In another method, the patient has a neuron to which a supra-threshold biological electrical stimulus is applied. This method comprises applying supra-threshold electrical noise energy to the neuron, thereby preventing an action potential from being propagated along the axon of the neuron. Still another method comprises applying an electrical stimulus to a neuron, and applying supra-threshold electrical noise energy to the neuron, thereby preventing or reversing any neurological accommodation of the neuron that may occur in response to the electrical stimulus.
摘要翻译：提供了向患者提供治疗的方法。在一种方法中，患者具有应用亚阈值生物电刺激的神经元。该方法包括向神经元施加电噪声能量，其中产生生物电刺激和电噪声能量之间的共振，使得动作电位沿神经元的轴突传播。在另一种方法中，患者具有应用超临界生物电刺激的神经元。该方法包括将超阈值电噪声能量应用于神经元，从而防止动作电位沿神经元的轴突传播。另一种方法包括对神经元施加电刺激，以及向神经元施加超阈值电噪声能量，从而防止或反转可能响应于电刺激而发生的神经元的任何神经学适应。

9. 发明申请

US20090082835A1 Apparatus and Methods For Charging An Implanted Medical Device Power Source 有权
标题翻译：一种植入式医疗器械电源充电装置及方法
公开(公告)号：US20090082835A1
公开(公告)日：2009-03-26
申请号：US12233810
申请日：2008-09-19
申请人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
发明人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
IPC分类号： A61N1/00
CPC分类号： A61N1/3787 , H02J7/025 , H02J7/047 , H02J50/10
摘要： Apparatus and methods for charging an implanted medical device.
摘要翻译：用于对植入的医疗装置充电的装置和方法。

10. 发明授权

US09345878B2 System and method for compensating for shifting of neurostimulation leads in a patient 有权
标题翻译：用于补偿患者神经刺激导线移位的系统和方法
公开(公告)号：US09345878B2
公开(公告)日：2016-05-24
申请号：US12495442
申请日：2009-06-30
申请人： Andrew DiGiore , Kristen Jaax , Courtney Lane
发明人： Andrew DiGiore , Kristen Jaax , Courtney Lane
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N2001/083
摘要： A method for determining a change in position of a neurostimulation lead relative to a stimulation target tissue of a patient is provided. The method comprises implanting a first proximity sensor on a surface of the patient, implanting a second proximity sensor on the surface of the patient, measuring a change in a distance between the first and second proximity sensors, and inferring the change in position of the lead relative to the stimulation target tissue from the measured change in distance. The method further comprises inferring an increase in a distance between the lead and the stimulation target tissue when the distance between the first and second proximity sensors increases. The method also comprises conveying electrical stimulation energy to therapeutically stimulate the stimulation target tissue, and modulating a stimulation parameter in response to the measured change in distance.
摘要翻译：提供了一种用于确定神经刺激引线相对于患者的刺激目标组织的位置变化的方法。该方法包括在患者的表面上植入第一接近传感器，在患者的表面上植入第二接近传感器，测量第一和第二接近传感器之间的距离的变化，并推断引线的位置变化相对于刺激目标组织的距离测量的变化。该方法还包括当第一和第二接近传感器之间的距离增加时，推断引线和刺激目标组织之间的距离的增加。该方法还包括传送电刺激能量以治疗刺激刺激目标组织，以及响应于所测量的距离变化来调制刺激参数。

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