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1. 发明申请

US20120197354A1 Techniques for Sensing and Adjusting a Compliance Voltage in an Implantable Stimulator Device 有权
标题翻译：用于感测和调整可植入刺激器装置中的合规电压的技术
公开(公告)号：US20120197354A1
公开(公告)日：2012-08-02
申请号：US13446784
申请日：2012-04-13
申请人： Jess Weigian Shi , Yuping He , Que T. Doan , David K.L. Peterson
发明人： Jess Weigian Shi , Yuping He , Que T. Doan , David K.L. Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/36125 , A61N1/36071 , A61N1/37
摘要： Disclosed herein are methods and circuitry for monitoring and adjusting a compliance voltage in an implantable stimulator devices to an optimal value that is sufficiently high to allow for proper circuit performance (i.e., sufficient current output), but low enough that power is not needlessly wasted via excessive voltage drops across the current output circuitry. The algorithm measures output voltages across the current source and sink circuitry during at least periods of actual stimulation when both the current sources and sinks are operable, and adjusts the compliance voltage so as to reduce these output voltages to within guard band values preferably indicative for operation in transistor saturation. The output voltages can additionally be monitored during periods between stimulation pulses to improve the accuracy of the measurement, and is further beneficial in that such additional measurements are not perceptible to the patient.
摘要翻译：本文公开了用于监测和调整可植入式刺激器装置中的顺应性电压的方法和电路，以达到足够高以允许适当的电路性能（即，足够的电流输出）的最佳值，但是足够低以使得功率不会被无用地浪费通过电流输出电路上的电压过大。当电流源和接收器都可操作时，该算法在至少实际刺激期间测量电流源和接收电路两端的输出电压，并且调整顺从电压，以便将这些输出电压降低到优选地指示操作的保护带值内晶体管饱和。在刺激脉冲之间的周期期间可以另外监视输出电压，以提高测量的准确度，并且进一步有益的是，这种附加测量对于患者是不可察觉的。

2. 发明申请

US20110172742A1 SMART CHARGER ALIGNMENT INDICATOR 有权
标题翻译： SMART CHARGER对准指示灯
公开(公告)号：US20110172742A1
公开(公告)日：2011-07-14
申请号：US13053998
申请日：2011-03-22
申请人： David K.L. Peterson
发明人： David K.L. Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/3787
摘要： Electrical energy is transmitted to charge the implanted medical device, and an electrical parameter (e.g., a steady-state voltage) indicating a rate at which the implanted medical device is charged by the electrical energy is detected. A threshold (e.g., by modifying a stored threshold value) at which the charge strength indicator generates a user-discernible signal is adjusted based on the detected electrical parameter.
摘要翻译：传输电能以对植入的医疗装置充电，并且检测指示通过电能对植入的医疗装置充电的速率的电参数（例如，稳态电压）。基于检测到的电参数来调整充电强度指示器产生用户可识别信号的阈值（例如，通过修改存储的阈值）。

3. 发明申请

US20100286749A1 Current Generation Architecture for an Implantable Stimulator Device Having Coarse and Fine Current Control 有权
标题翻译：具有粗细电流控制的植入式刺激器装置的当前一代架构
公开(公告)号：US20100286749A1
公开(公告)日：2010-11-11
申请号：US12838260
申请日：2010-07-16
申请人： Jordi Parramon , David K.L. Peterson , Paul J. Griffith
发明人： Jordi Parramon , David K.L. Peterson , Paul J. Griffith
IPC分类号： A61N1/36
CPC分类号： A61N1/36125 , A61N1/0531 , A61N1/0534 , A61N1/0541 , A61N1/0543 , A61N1/0551 , A61N1/36071
摘要： Disclosed herein is a current generation architecture for an implantable stimulator device such as an Implantable Pulse Generator (IPG). Current source and sink circuitry are both divided into coarse and fine portions, which respectively can provide a coarse and fine current resolution to a specified electrode on the IPG. The coarse portion is distributed across all of the electrodes and so can source or sink current to any of the electrodes. The coarse portion is divided into a plurality of stages, each of which is capable via an associated switch bank of sourcing or sinking a coarse amount of current to or from any one of the electrodes on the device. The fine portion of the current generation circuit preferably includes source and sink circuitry dedicated to each of the electrode on the device, which can comprise digital-to-analog current converters (DACs). The DACs also receives the above-noted reference current, which is amplified by the DACs in fine increments by appropriate selection of fine current control signals. When the coarse and fine current control circuitry are used in tandem, ample current with a fine current resolution can be achieved at any electrode and in a space- and power-efficient manner.
摘要翻译：本文公开了用于植入式脉冲发生器（IPG）的植入式刺激器装置的当前一代架构。电流源和接收电路都分为粗细部分，分别可以为IPG上的指定电极提供粗细和精细的电流分辨率。粗糙部分分布在所有电极上，因此可以将电流吸收或吸收到任何电极。粗略部分被分成多个级，每个级能够经由相关联的开关组，该器件对设备上的任何一个电极进行粗电流的吸收或吸收。电流产生电路的优良部分优选地包括专用于器件上每个电极的源极和漏极电路，其可以包括数模转换器（DAC）。 DAC还接收上述参考电流，其通过适当选择精细电流控制信号以细微增量由DAC放大。当粗调和精细电流控制电路串联使用时，可以在任何电极上以空间和功率有效的方式实现具有精细电流分辨率的充足电流。

4. 发明申请

US20100228325A1 SHORT DURATION PRE-PULSING TO REDUCE STIMULATION-EVOKED SIDE-EFFECTS 有权
标题翻译：短暂的预处理可以减少刺激反应的副作用
公开(公告)号：US20100228325A1
公开(公告)日：2010-09-09
申请号：US12782589
申请日：2010-05-18
申请人： Michael A. Moffitt , David K.L. Peterson
发明人： Michael A. Moffitt , David K.L. Peterson
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/36128 , A61N1/0553 , A61N1/36017 , A61N1/36071 , A61N1/36164 , A61N1/36167
摘要： A method and neurostimulation system of providing therapy to a patient is provided. At least one electrode is place in contact with tissue of a patient. A sub-threshold, hyperpolarizing, conditioning pre-pulse (e.g., an anodic pulse) is conveyed from the electrode(s) to render a first region of the tissue (e.g., dorsal root fibers) less excitable to stimulation, and a depolarizing stimulation pulse (e.g., a cathodic pulse) is conveyed from the electrode(s) to stimulate a second different region of the tissue (e.g., dorsal column fibers). The conditioning pre-pulse has a relatively short duration (e.g., less than 200 μs).
摘要翻译：提供了向患者提供治疗的方法和神经刺激系统。至少一个电极与患者的组织接触放置。从电极传送亚阈值超极化调理预脉冲（例如阳极脉冲），以使得组织的第一区域（例如，背根根纤维）对刺激不太兴奋，并且去极化刺激脉冲（例如，阴极脉冲）从电极传送以刺激组织的第二不同区域（例如，背部柱状纤维）。调节预脉冲具有相对短的持续时间（例如，小于200μs）。

5. 发明申请

US20100057177A1 MULTIPLE TUNABLE CENTRAL CATHODES ON A PADDLE FOR INCREASED MEDIAL-LATERAL AND ROSTRAL-CAUDAL FLEXIBILITY VIA CURRENT STEERING 有权
公开(公告)号：US20100057177A1
公开(公告)日：2010-03-04
申请号：US12204114
申请日：2008-09-04
申请人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K.L. Peterson
发明人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K.L. Peterson
IPC分类号： A61N1/05
CPC分类号： A61N1/36071 , A61N1/0553 , A61N1/36017 , A61N1/36185
摘要： A neurostimulation paddle lead, method of neurostimulation, and neurostimulation system are provided. The neurostimulation paddle lead carries a plurality of electrodes comprising at least four columns of electrodes having a spacing between two inner electrode columns less than a spacing between the inner electrode columns and adjacent outer electrode columns. The inner electrode columns may also be longitudinally offset from the outer electrode columns. The methods and neurostimulation systems steer current between the electrodes to modify a medial-lateral electrical field created adjacent spinal cord tissue.

6. 发明申请

US20100057165A1 MULTIPLE TUNABLE CENTRAL CATHODES ON A PADDLE FOR INCREASED MEDIAL-LATERAL AND ROSTRAL-CAUDAL FLEXIBILITY VIA CURRENT STEERING 有权
标题翻译：用于通过电流转向增加医疗 - 行走和护理 - 灵活性的平台上的多个可调中央阴茎
公开(公告)号：US20100057165A1
公开(公告)日：2010-03-04
申请号：US12204170
申请日：2008-09-04
申请人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K.L. Peterson
发明人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K.L. Peterson
IPC分类号： A61N1/34
CPC分类号： A61N1/0551 , A61N1/0553 , A61N1/36071
摘要： A neurostimulation paddle lead, method of neurostimulation, and neurostimulation system are provided. The neurostimulation paddle lead carries a plurality of electrodes comprising at least four columns of electrodes having a spacing between two inner electrode columns less than a spacing between the inner electrode columns and adjacent outer electrode columns. The inner electrode columns may also be longitudinally offset from the outer electrode columns. The methods and neurostimulation systems steer current between the electrodes to modify a medial-lateral electrical field created adjacent spinal cord tissue.
摘要翻译：提供神经刺激桨引导，神经刺激方法和神经刺激系统。神经刺激桨引线承载包括至少四列电极的多个电极，所述至少四列电极具有小于内电极柱和相邻外电极柱之间的间隔的两个内电极柱之间的间隔。内电极柱也可以与外电极柱纵向偏移。方法和神经刺激系统在电极之间引导电流以修改邻近脊髓组织产生的内侧 - 外侧电场。

7. 发明申请

US20080294226A1 SHORT DURATION PRE-PULSING TO REDUCE STIMULATION-EVOKED SIDE-EFFECTS 有权
标题翻译：短暂的预处理可以减少刺激反应的副作用
公开(公告)号：US20080294226A1
公开(公告)日：2008-11-27
申请号：US11752895
申请日：2007-05-23
申请人： Michael A. Moffitt , David K.L. Peterson
发明人： Michael A. Moffitt , David K.L. Peterson
IPC分类号： A61N1/32
CPC分类号： A61N1/36128 , A61N1/0553 , A61N1/36017 , A61N1/36071 , A61N1/36164 , A61N1/36167
摘要： A method and neurostimulation system of providing therapy to a patient is provided. At least one electrode is place in contact with tissue of a patient. A sub-threshold, hyperpolarizing, conditioning pre-pulse (e.g., an anodic pulse) is conveyed from the electrode(s) to render a first region of the tissue (e.g., dorsal root fibers) less excitable to stimulation, and a depolarizing stimulation pulse (e.g., a cathodic pulse) is conveyed from the electrode(s) to stimulate a second different region of the tissue (e.g., dorsal column fibers). The conditioning pre-pulse has a relatively short duration (e.g., less than 200 μs).
摘要翻译：提供了向患者提供治疗的方法和神经刺激系统。至少一个电极与患者的组织接触放置。从电极传送亚阈值超极化调节预脉冲（例如阳极脉冲），以使得组织的第一区域（例如，背根根纤维）对刺激不太兴奋，并且去极化刺激脉冲（例如，阴极脉冲）从电极传送以刺激组织的第二不同区域（例如，背部柱状纤维）。调理预脉冲具有相对较短的持续时间（例如，小于200μA）。

8. 发明申请

US20120290040A1 MANAGEMENT OF STIMULATION SAFETY LIMITS IN A NEUROSTIMULATION SYSTEM 有权
公开(公告)号：US20120290040A1
公开(公告)日：2012-11-15
申请号：US13470328
申请日：2012-05-13
申请人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
发明人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36185 , A61N1/37241
摘要： A neurostimulation system for management of stimulation safety limits. The system determines a tissue charge injection metric at each electrode, compares the metric to the hard stop charge limit, and prevents the neurostimulator from delivering stimulation energy to the tissue region in accordance based on the comparison. The hard stop limit may be user-programmable or may be automatically modified in response to detection of electrode characteristics. The system may quantitatively notify a user of a value of the injected charge injected into the tissue. The electrodes may be organized into different sets, in which case, the system may directly control tissue charge independently at each of the electrode sets. If current steering is provided, the system may displace the electrical stimulation energy along the tissue region in one direction, while preventing the charge injection value at each of the electrodes from meeting or exceeding the hard stop charge limit.

9. 发明申请

US20120101537A1 SYSTEM AND METHOD FOR INTRODUCING TISSUE STIMULATION LEAD INTO PATIENT USING REAL-TIME COUPLING EFFICIENCY MEASUREMENTS 有权
标题翻译：使用实时耦合效率测量将组织刺激引导引入患者的系统和方法
公开(公告)号：US20120101537A1
公开(公告)日：2012-04-26
申请号：US13244458
申请日：2011-09-24
申请人： David K.L. Peterson , Kerry Bradley
发明人： David K.L. Peterson , Kerry Bradley
IPC分类号： A61N1/372
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/3605 , A61N1/36185 , A61N1/372
摘要： A system and method for locating an implantable tissue stimulation lead within a patient. A measurement indicative of a coupling efficiency between the tissue stimulation lead and tissue at a location is taken. The location of the tissue stimulation lead relative to the tissue is tracked. Coupling efficiency information based on the measurement from the monitoring device is generated, tracking information based on the tissue stimulation lead location is generated, and the coupling efficiency information and tracking information is concurrently conveyed to the user.
摘要翻译：一种用于定位患者内的可植入组织刺激引线的系统和方法。采用指示组织刺激引线和组织在一处的耦合效率的测量。跟踪组织刺激引线相对于组织的位置。生成基于来自监视装置的测量的耦合效率信息，生成基于组织刺激引导位置的跟踪信息，并且耦合效率信息和跟踪信息被同时传送给用户。

10. 发明申请

US20100268298A1 DEEP BRAIN STIMULATION CURRENT STEERING WITH SPLIT ELECTRODES 有权
标题翻译：深层脑刺激电流转向与分离电极
公开(公告)号：US20100268298A1
公开(公告)日：2010-10-21
申请号：US12761622
申请日：2010-04-16
申请人： Michael A. Moffitt , Thomas A. Oleksyn , Kerry Bradley , David K.L. Peterson , Courtney Lane , Anne Margaret Pianca
发明人： Michael A. Moffitt , Thomas A. Oleksyn , Kerry Bradley , David K.L. Peterson , Courtney Lane , Anne Margaret Pianca
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0534 , A61N1/20 , A61N1/3606 , A61N1/36082 , A61N1/36182
摘要： A device for brain stimulation includes a lead having a longitudinal surface, a proximal end, a distal end and a lead body. The device also includes a plurality of electrodes disposed along the longitudinal surface of the lead near the distal end of the lead. The plurality of electrodes includes a first set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a first longitudinal position along the lead; and a second set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a second longitudinal position along the lead. The device further includes one or more conductors that electrically couple together all of the segmented electrodes of the first set of segmented electrodes.
摘要翻译：用于脑刺激的装置包括具有纵向表面，近端，远端和引线主体的引线。该装置还包括沿引线的远端附近的铅的纵向表面设置的多个电极。所述多个电极包括第一组分段电极，所述第一组分段电极包括沿着所述引线在第一纵向位置处围绕所述引线的圆周设置的至少两个分段电极; 以及第二组分段电极，其包括在沿着引线的第二纵向位置处围绕引线的圆周设置的至少两个分段电极。该装置还包括一个或多个导体，其将所有第一组分段电极组的所有分段电极电耦合在一起。

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