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1. 发明授权

US5156007A Cryopump with improved second stage passageway 失效
标题翻译：具有改进的第二阶段通行证的CRYOPUMP
公开(公告)号：US5156007A
公开(公告)日：1992-10-20
申请号：US647848
申请日：1991-01-30
申请人： Allen J. Bartlett , Philip A. Lessard , Stephen J. Yamartino , John T. Harvell
发明人： Allen J. Bartlett , Philip A. Lessard , Stephen J. Yamartino , John T. Harvell
IPC分类号： F04B37/08 , F25D19/00
CPC分类号： F04B37/08 , F25D19/006 , Y10S417/901
摘要： Condensation on a cryopump second stage refrigerator cylinder is prevented by arranging a passageway between a colder second stage cylinder shield in thermal contact with the coldest section of the second stage and a warmer radiation shield in thermal contact with the warmer first stage. This arrangement produces a uniform and significant temperature differential in the passageway. The passageway is arranged so that the ratio of its length, L, to its width, W, is ideally greater than five. This ensures molecular collisions with the cold surface of the cylinder shield so that gas molecules are tightly bound to the cylinder shield. As a result, condensation on the refrigerator cylinder and resultant pressure variations are prevented.
摘要翻译：通过在与第二级的最冷部分热接触的较冷的第二级气缸罩与在较暖的第一级热接触的较暖的辐射屏蔽之间设置通道来防止在低温泵第二级冷藏箱上的冷凝。这种布置在通道中产生均匀且显着的温差。该通道被布置成使得其长度L与其宽度W之比理想地大于5。这确保了与气缸屏蔽件的冷表面的分子碰撞，使得气体分子紧密地结合到气缸罩。结果，可以防止冰箱圆筒上的冷凝和合成的压力变化。

2. 发明授权

US5862671A Purge and rough cryopump regeneration process, cryopump and controller 失效
标题翻译：吹扫和粗略的低温泵再生过程，低温泵和控制器
公开(公告)号：US5862671A
公开(公告)日：1999-01-26
申请号：US848973
申请日：1997-05-02
申请人： Philip A. Lessard , Paul E. Dresens , Maureen C. Buonpane , Timothy M. Pulling , Alan C. Brightman , Robert M. Patterson , Mark A. Stira , Allen J. Bartlett , Stephen J. Yamartino , Gary S. Ash , James A. O'Neil
发明人： Philip A. Lessard , Paul E. Dresens , Maureen C. Buonpane , Timothy M. Pulling , Alan C. Brightman , Robert M. Patterson , Mark A. Stira , Allen J. Bartlett , Stephen J. Yamartino , Gary S. Ash , James A. O'Neil
IPC分类号： F04B37/16 , F04B37/08 , B01D8/00
CPC分类号： F04B37/085 , Y10S417/901
摘要： A cryopump is regenerated by roughing the cryopump during purging. Purging and roughing is carried out in first a high temperature mode and then a lower ambient temperature mode. In the lower temperature mode, the cryogenic refrigerator is turned on. If the system fails a rough test after roughing at the lower temperature, it is repurged with the rough valve open.
摘要翻译：在清洗过程中，通过对低温泵进行粗加工来再生低温泵。首先在高温模式下进行吹扫和粗加工，然后在较低的环境温度模式下进行。在较低温度模式下，低温冰箱打开。如果系统在较低温度下进行粗加工后未能进行粗糙试验，则会在粗阀打开时重新进行。

3. 发明授权

US4860546A Vacuum system with molecular flow line 失效
标题翻译：具有分子流线的真空系统
公开(公告)号：US4860546A
公开(公告)日：1989-08-29
申请号：US230573
申请日：1988-08-10
申请人： John T. Harvell , Philip A. Lessard
发明人： John T. Harvell , Philip A. Lessard
IPC分类号： B01D8/00 , F04B37/08
CPC分类号： F04B37/08 , B01D8/00 , Y10S417/901
摘要： In a vacuum system having a load lock cooperating with a work chamber, a flow line is connected between the cryopump of the load lock and the work chamber. The flow line passes noncondensible gases which are not absorbed by the cryopump of the load lock to the work chamber 12 for absorption by the cryopump of the work chamber. Alternatively, the flow line is connected between the load lock cryopump and the cryopump of the work chamber for directly passing the noncondensible gases to the work chamber cryopump. The flow line prevents buildup of noncondensible gases within the cryopump of the load lock. The flow line may include baffles to damp pressure surges during cryopumping of the load lock. A control valve connected to the flow line allows operator control of the passing of noncondensible gases from the load lock cryopump to the work chamber or to the work chamber cryopump through the flow line. The dimensions of the flow line provide molecular flow of the noncondensible gases.
摘要翻译：在具有与工作室协作的负载锁定的真空系统中，流线连接在负载锁的低温泵和工作室之间。流动管线通过不被负载锁的低温泵吸收到工作室12中的非冷凝气体，以便被工作室的低温泵吸收。或者，流动管线连接在负载锁定低温泵和工作室的低温泵之间，用于将不可冷凝气体直接传递到工作室低温泵。流动管线可防止在负载锁的低温泵内产生不可冷凝气体。流动管线可以包括挡板，以在加载锁的低温泵送期间减轻压力冲击。连接到流动管线的控制阀允许操作者通过流动管线控制不可冷凝气体从负载锁定低温泵通到工作室或工作室低温泵。流线的尺寸提供了不凝性气体的分子流。

4. 发明授权

US4679401A Temperature control of cryogenic systems 失效
标题翻译：低温系统的温度控制
公开(公告)号：US4679401A
公开(公告)日：1987-07-14
申请号：US752354
申请日：1985-07-03
申请人： Philip A. Lessard , Allen J. Bartlett , John F. Peterson
发明人： Philip A. Lessard , Allen J. Bartlett , John F. Peterson
IPC分类号： B01D8/00 , F04B37/08
CPC分类号： B01D8/00 , F04B37/08 , Y10S417/901
摘要： To control the temperature of one or more heat sinks of a cryogenic refrigerator in a cryopump, refrigerant gas to the refrigerator is diverted through heat exchangers associated with the refrigerator heat sinks. The diverted refrigerant gas may be used to maintain the temperature of the first stage cryopumping surfaces above some level to avoid cross over hangup. The second stage cryopumping surfaces may be warmed by the diverted refrigerant to some temperature level for partial regeneration. Both heat sinks may be warmed for full regeneration of the cryopump. Bleed flow of refrigerant gas cooled by the first stage of the refrigerator can be directed past a thermal mass to cool that mass. By reversing the flow of refrigerant gas during cooldown of the system, the thermal mass can be used to more rapidly cool the refrigerator. The thermal mass is thermally isolated from the refrigerator heat sinks and is positioned within the vacuum vessel of the cryopump adjacent to the first stage of the refrigerator.
摘要翻译：为了控制低温泵中的低温冰箱的一个或多个散热器的温度，通向与冰箱散热器相关联的热交换器将制冷剂气体输送到冰箱。转向的制冷剂气体可用于将第一级低温泵的表面的温度保持在一定程度上，以避免交叉悬挂。可将第二级低温泵送表面由转向制冷剂加热到一定温度以进行部分再生。这两个散热片可能会被加热，以便低温泵完全再生。由冰箱的第一级冷却的制冷剂气体的流出可以被引导通过热质量以冷却该质量。通过在系统的冷却期间逆转制冷剂气体的流动，可以使用热质量来更快速地冷却冰箱。热物质与冰箱散热器热隔离，并且位于与冰箱的第一级相邻的低温泵的真空容器内。

5. 发明授权

US4438632A Means for periodic desorption of a cryopump 失效
标题翻译：用于定期解吸低温泵的方法
公开(公告)号：US4438632A
公开(公告)日：1984-03-27
申请号：US395120
申请日：1982-07-06
申请人： Philip A. Lessard , Allen J. Bartlett
发明人： Philip A. Lessard , Allen J. Bartlett
IPC分类号： F04B37/02 , F04B37/08 , B01D5/00
CPC分类号： F04B37/02 , F04B37/08 , Y10S417/901
摘要： The invention discloses a cryopump comprising a primary cryopanel 67 associated with a low temperature heat sink 60 having means for adsorbing a first low boiling point gas and a secondary cryopanel 80 associated with heat sink 60 and a higher temperature heat sink 48 having means for condensing a higher boiling point gas. There are means 90 for selectively conducting heat to the primary cryopanel to raise the temperature of the cryopanel above that which is necessary to cause said first gas to become desorbed from said cryopanel while having minimal effect on the capacity of the higher temperature heat sink.
摘要翻译：本发明公开了一种低温泵，其包括与低温散热器60相关的初级冷冻板67，低温散热器60具有用于吸附第一低沸点气体的装置和与散热器60相关联的次级冷冻板80以及具有冷凝装置高沸点气体。存在用于选择性地向初级冷冻板传导热量的装置90，以将冷冻板的温度升高到使得所述第一气体从所述冷冻板解吸附所必需的温度，同时对较高温度的散热器的容量具有最小的影响。

6. 再颁专利

USRE33878E Cryogenic recondenser with remote cold box 失效
公开(公告)号：USRE33878E
公开(公告)日：1992-04-14
申请号：US571870
申请日：1990-08-22
申请人： Allen J. Bartlett , Bruce R. Andeen , Philip A. Lessard
发明人： Allen J. Bartlett , Bruce R. Andeen , Philip A. Lessard
IPC分类号： F17C3/08 , F25B9/10 , F25J1/00 , H01F6/00
CPC分类号： F25J1/0276 , F17C3/085 , F25B9/10 , H01F6/00 , F17C2203/0629 , F17C2221/017 , F17C2223/0161 , F17C2223/033 , F17C2227/036 , F17C2265/034 , F17C2270/0509 , F17C2270/0536
摘要： A recondenser cycles a working volume of cryogen gas through a remote cold box and a coaxial recondensing, heat exchanger transfer line which is inserted into a cryostat. The working volume of gas is compressed to a high pressure and cooled through cooling means which include a mechanical refrigerator of the regenerator-displacer type. The cooled gas is expanded through a first JT valve to a medium pressure and further cooled. The further cooled medium pressure gas is transferred in a closed coaxial transfer line to a cryostat in which boil-off is recondensed. A second JT valve in the cryostat end of an inner tube coaxially positioned in an outer tube forming the transfer line expands the gas to a lower pressure and forms a liquid-gas mixture. The liquid-gas mixture is passed in heat exchange relation with the boil-off from an inner tube to an outer tube of a coaxial recondensing heat exchanger. The outer surface of the outer tube at the cryostat end of the transfer line has burrs which provide the necessary surface area on which to recondense the boil-off. The gas is transferred back to the cooling means through intermediate channels formed between the outer tube and the coaxially positioned inner tube.

7. 发明授权

US4766741A Cryogenic recondenser with remote cold box 失效
标题翻译：低温冷凝器与遥控冷藏箱
公开(公告)号：US4766741A
公开(公告)日：1988-08-30
申请号：US5082
申请日：1987-01-20
申请人： Allen J. Bartlett , Bruce R. Andeen , Philip A. Lessard
发明人： Allen J. Bartlett , Bruce R. Andeen , Philip A. Lessard
IPC分类号： F17C3/08 , F25B9/00 , F25B9/10 , F25J1/00 , F25J1/02 , F28F1/42 , H01F6/00 , H01F7/20 , F25B19/00
CPC分类号： H01F6/00 , F17C3/085 , F25B9/00 , F28F1/42 , F17C2205/0326 , F17C2205/0347 , F17C2205/0355 , F17C2221/017 , F17C2223/0161 , F17C2223/033 , F17C2227/0353 , F17C2227/036 , F17C2250/0626 , F17C2250/0636 , F17C2265/012 , F17C2270/0509 , F17C2270/0536
摘要： A recondenser cycles a working volume of cryogen gas through a remote cold box and a coaxial recondensing, heat exchanger transfer line which is inserted into a cryostat. The working volume of gas is compressed to a high pressure and cooled through cooling means which include a mechanical refrigerator of the regenerator-displacer type. The cooled gas is expanded through a first JT valve to a medium pressure and further cooled. The further cooled medium pressure gas is transferred in a closed coaxial transfer line to a cryostat in which boil-off is recondensed. A second JT valve in the cryostat end of an inner tube coaxially positioned in an outer tube forming the transfer line expands the gas to a lower pressure and forms a liquid-gas mixture. The liquid-gas mixture is passed in heat exchange relation with the boil-off from an inner tube to an outer tube of a coaxial recondensing heat exchanger. The outer surface of the outer tube at the cryostat end of the transfer line has burrs which provide the necessary surface area on which to recondense the boil-off. The gas is transferred back to the cooling means through intermediate channels formed between the outer tube and the coaxially positioned inner tube.
摘要翻译：再冷凝器通过远程冷箱和插入低温恒温器的同轴再冷凝换热器输送管线循环冷冻剂气体的工作体积。将气体的工作体积压缩至高压，并通过冷却装置冷却，冷却装置包括再生器置换器型机械式制冷机。冷却的气体通过第一JT阀膨胀至中压并进一步冷却。进一步冷却的中压气体在闭合的同轴输送管线中转移到冷凝器中，在该恒温器中再蒸发。同轴地位于形成输送管的外管的内管的低温恒温器端中的第二JT阀将气体膨胀到较低压力并形成液态气体混合物。液体 - 气体混合物与从内管到同轴再冷凝式热交换器的外管的蒸发热交换。在输送管线的低温恒温器端部的外管的外表面具有毛刺，其提供必要的表面积以重新冷凝该蒸发。通过形成在外管和同轴定位的内管之间的中间通道将气体转移回冷却装置。

8. 发明授权

US5261244A Cryogenic waterpump 失效
标题翻译：低温水泵
公开(公告)号：US5261244A
公开(公告)日：1993-11-16
申请号：US886721
申请日：1992-05-21
申请人： Philip A. Lessard , Douglas F. Aitken , Robert D. Bradford , Roland P. Graham , Steven A. Michaud , Karen J. Manning
发明人： Philip A. Lessard , Douglas F. Aitken , Robert D. Bradford , Roland P. Graham , Steven A. Michaud , Karen J. Manning
IPC分类号： B01D8/00 , F04B37/08
CPC分类号： F04B37/08 , B01D8/00 , Y10S417/901
摘要： A cold trap includes a set of baffles cooled by the cold finger of a closed cycle refrigerator. The baffles are vertically disposed in a vertical fluid conduit with frustoconical and conical surfaces for directing liquid to a circular trough during regeneration. After the liquid is collected, it is blown from the trough through a pressure relief valve by a nitrogen purge. The trough is formed in the upper surface of a connecting flange at the lower end of the fluid conduit.
摘要翻译：冷阱包括由闭合循环冰箱的冷手指冷却的一组挡板。挡板垂直设置在具有截头圆锥形和圆锥形表面的垂直流体导管中，用于在再生期间将液体引导到圆形槽。收集液体后，通过氮气吹扫从槽通过泄压阀吹出。槽形成在流体导管的下端处的连接凸缘的上表面中。

9. 发明授权

US06451564B1 Methods for producing L-isoleucine 有权
标题翻译：生产L-异亮氨酸的方法
公开(公告)号：US06451564B1
公开(公告)日：2002-09-17
申请号：US09608065
申请日：2000-06-30
申请人： Stephane Guillouet , Avital A. Rodal , Philip A. Lessard , Anthony J. Sinskey
发明人： Stephane Guillouet , Avital A. Rodal , Philip A. Lessard , Anthony J. Sinskey
IPC分类号： C12P1306
CPC分类号： C12P13/06 , C12N9/88 , C12Y403/01019
摘要： The present invention relates, in general, to the over-production of L-isoleucine by nonhuman organisms. More specifically, the present invention relates to methods for producing L-isoleucine comprising: (a) growing a transformed nonhuman organism under conditions that provide for synthesis of L-isoleucine, wherein the nonhuman organism comprises one or more copies of a transgene comprising at least one nucleotide sequence encoding catabolic threonine dehydratase; wherein the L-isoleucine is synthesized by the transformed nonhuman organism, the synthesis being greater than that of the corresponding non-transformed nonhuman organism; and (b) recovering the L-isoleucine from the culture medium in which the transformed nonhuman organism was cultured.
摘要翻译：本发明一般涉及非人类生物体过量生产L-异亮氨酸。更具体地说，本发明涉及生产L-异亮氨酸的方法，其包括：（a）在提供L-异亮氨酸合成的条件下生长转化的非人生物，其中所述非人生物体包含至少一个或多个转基因编码分解代谢苏氨酸脱水酶的一个核苷酸序列; 其中所述L-异亮氨酸由所述转化的非人生物合成，所述合成大于相应的未转化的非人生物的合成; 和（b）从其中培养转化的非人生物的培养基中回收L-异亮氨酸。

10. 发明授权

US06403351B1 Pyruvate carboxylase polypeptide from Corynebacterium glutamicum 有权
标题翻译：来自谷氨酸棒杆菌的丙酮酸羧化酶多肽
公开(公告)号：US06403351B1
公开(公告)日：2002-06-11
申请号：US09677575
申请日：2000-10-03
申请人： Anthony J. Sinskey , Philip A. Lessard , Laura B. Willis
发明人： Anthony J. Sinskey , Philip A. Lessard , Laura B. Willis
IPC分类号： C12N900
CPC分类号： C12N9/93
摘要： The present invention concerns an anaplerotic enzyme from Corynebacterium glutamicum which replenishes oxaloacetate consumed during lysine and glutamic acid production in industrial fermentations. In particular, isolated nucleic acid molecules are provided encoding the pyruvate carboxylase protein. Pyruvate carboxylase polypeptides are also provided.
摘要翻译：本发明涉及谷氨酸棒状杆菌的一种厌食酶，其补充在工业发酵过程中在赖氨酸和谷氨酸生产期间消耗的草酰乙酸酯。特别地，提供编码丙酮酸羧化酶蛋白质的分离的核酸分子。还提供了丙酮酸羧化酶多肽。

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