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1. 发明申请

US20050162804A1 Position sensor with resistive element 有权
标题翻译：带电阻元件的位置传感器
公开(公告)号：US20050162804A1
公开(公告)日：2005-07-28
申请号：US11080795
申请日：2005-03-14
申请人： Allen Boronkay , Bruce Schena , Christopher Hasser
发明人： Allen Boronkay , Bruce Schena , Christopher Hasser
IPC分类号： G01D5/165 , H02H1/00
CPC分类号： G01D5/1655 , G01D5/165
摘要： A position sensor comprises a resistive element positionable on a first surface. A pair of leads are on the resistive element, the pair of leads adapted to supply a first voltage, such as by being grounded. An intermediate lead is positioned on the resistive element between the pair of leads, the intermediate lead being adapted to provide a second voltage. A contact element is positionable on a second surface, the contact element adapted to contact at least a portion of the resistive element to detect a voltage at a contact position, the detected voltage being related to the position or movement of the second surface relative to the first surface. In another version, a position sensor comprises a resistive element comprising first and second resistive strips. A plurality of leads are positioned on each resistive strip to provide a voltage to each resistive strip.
摘要翻译：位置传感器包括可定位在第一表面上的电阻元件。一对引线位于电阻元件上，该对引线适于提供第一电压，例如通过接地。中间引线位于一对引线之间的电阻元件上，中间引线适于提供第二电压。接触元件可定位在第二表面上，接触元件适于接触电阻元件的至少一部分以检测接触位置处的电压，检测到的电压与第二表面相对于第二表面的位置或移动有关第一表面。在另一个版本中，位置传感器包括包括第一和第二电阻条的电阻元件。多个引线位于每个电阻带上以向每个电阻带提供电压。

2. 发明申请

US20070026421A1 Method and apparatus for generating thermal melting curves in a microfluidic device 有权
标题翻译：用于在微流体装置中产生热解曲线的方法和装置
公开(公告)号：US20070026421A1
公开(公告)日：2007-02-01
申请号：US11352452
申请日：2006-02-09
申请人： Steven Sundberg , Michael Knapp , Ivor Knight , Deborah Boles , Aaron Rulison , Wesley Dong , Edward Donlon , Robert Moti , Andrew Fabans , Allen Boronkay , Michael Slater
发明人： Steven Sundberg , Michael Knapp , Ivor Knight , Deborah Boles , Aaron Rulison , Wesley Dong , Edward Donlon , Robert Moti , Andrew Fabans , Allen Boronkay , Michael Slater
IPC分类号： C12Q1/68
CPC分类号： G01N25/04 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L7/525 , B01L2200/10 , B01L2300/0627 , B01L2300/0816 , B01L2300/14 , B01L2300/18 , B01L2300/1833 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , C12Q1/68 , C12Q1/6844 , C12Q1/686 , C12Q1/6862 , G01N21/33 , G01N21/6428 , Y10T436/143333 , C12Q2565/629 , C12Q2565/101 , C12Q2527/107 , C12Q2527/101
摘要： The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products.
摘要翻译：本发明提供了采用微流体技术产生分子熔融曲线的新颖方法和装置。特别地，根据本发明的装置和方法可用于提供PCR扩增产物的分析。

3. 发明申请

US20110039303A1 MICROFLUIDIC AND NANOFLUIDIC DEVICES, SYSTEMS, AND APPLICATIONS 审中-公开
标题翻译：微流体和纳米流体装置，系统和应用
公开(公告)号：US20110039303A1
公开(公告)日：2011-02-17
申请号：US12526015
申请日：2008-02-05
申请人： Stevan Bogdan Jovanovich , Iuliu Ioan Blaga , Allen Boronkay , Joanne Horn , Michael Van Nguyen , William D. Nielsen , Mattias Vangbo
发明人： Stevan Bogdan Jovanovich , Iuliu Ioan Blaga , Allen Boronkay , Joanne Horn , Michael Van Nguyen , William D. Nielsen , Mattias Vangbo
IPC分类号： C12P19/34 , B01L3/00 , C07H21/04 , C07K14/00
CPC分类号： C12Q1/686 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/028 , B01L2200/0668 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/088 , B01L2300/0887 , B01L2300/0896 , B01L2300/1827 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , B82Y30/00 , F16K99/0001
摘要： The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.
摘要翻译：本发明公开了可编程微流体电路的集成，以实现处理生化和化学反应的实际应用并整合这些反应。在一些实施方案中，组合用于生化反应或化学工作流程的工作流程。公开了诸如具有Y阀和流过阀的可编程微流体电路的微型阀。在一些实施方案中，本发明的微型阀用于混合流体，其可以是整合过程的一部分。这些过程包括将样品和移动反应混合到用于模块化微流体的边缘或储存器，使用捕获区域以及将其注入到分离设备上的分析装置中。在一些实施例中，使用星形和嵌套星形设计，或者通过微通道中的通道的横截面积的改变来进行珠捕获。使用固定温度和通过微型泵将样品移动进一步公开了温度区之间样品的移动。

4. 发明授权

US07727477B2 Apparatus for priming microfluidics devices with feedback control 有权
标题翻译：用于启动具有反馈控制的微流体装置的装置
公开(公告)号：US07727477B2
公开(公告)日：2010-06-01
申请号：US11288838
申请日：2005-11-28
申请人： Allen Boronkay , Colin Kennedy , Matthew Latham
发明人： Allen Boronkay , Colin Kennedy , Matthew Latham
IPC分类号： G01N1/00 , G01N21/01
CPC分类号： B01L3/0293 , B01L3/5027 , B01L9/527 , B01L2200/146 , B01L2400/0487 , G01N27/44743 , G01N27/44756 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A priming unit for a microfluidics device contains a pressurization unit and pressure and temperature detectors as part of a feedback loop that controls the pressure applied by the pressurization unit and the time during which the pressure is applied. This control feature is particularly useful in controlling the exposure time of the microchannels to dyes in the priming liquids since certain dyes tend to adhere to the walls of the channels and produce non-uniform results.
摘要翻译：用于微流体装置的起动单元包含加压单元和作为反馈回路的一部分的压力和温度检测器，其控制由加压单元施加的压力和施加压力的时间。这种控制特征特别适用于控制微通道对底漆中染料的曝光时间，因为某些染料倾向于粘附到通道的壁上并产生不均匀的结果。

5. 发明申请

US20060163070A1 Apparatus for priming microfluidics devices with feedback control 有权
标题翻译：用于启动具有反馈控制的微流体装置的装置
公开(公告)号：US20060163070A1
公开(公告)日：2006-07-27
申请号：US11288838
申请日：2005-11-28
申请人： Allen Boronkay , Colin Kennedy , Matthew Latham
发明人： Allen Boronkay , Colin Kennedy , Matthew Latham
IPC分类号： G01N27/447
CPC分类号： B01L3/0293 , B01L3/5027 , B01L9/527 , B01L2200/146 , B01L2400/0487 , G01N27/44743 , G01N27/44756 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A priming unit for a microfluidics device contains a pressurization unit and pressure and temperature detectors as part of a feedback loop that controls the pressure applied by the pressurization unit and the time during which the pressure is applied. This control feature is particularly useful in controlling the exposure time of the microchannels to dyes in the priming liquids since certain dyes tend to adhere to the walls of the channels and produce non-uniform results.
摘要翻译：用于微流体装置的起动单元包含加压单元和作为反馈回路的一部分的压力和温度检测器，其控制由加压单元施加的压力和施加压力的时间。这种控制特征特别适用于控制微通道对底漆中染料的曝光时间，因为某些染料倾向于粘附到通道的壁上并产生不均匀的结果。

6. 发明申请

US20130344475A1 Microfluidic Devices 审中-公开
标题翻译：微流体装置
公开(公告)号：US20130344475A1
公开(公告)日：2013-12-26
申请号：US13896581
申请日：2013-05-17
申请人： Stevan Bogdan Jovanovich , Iuliu Ioan Blaga , Allen Boronkay
发明人： Stevan Bogdan Jovanovich , Iuliu Ioan Blaga , Allen Boronkay
IPC分类号： C12Q1/70 , C12Q1/24 , C12Q1/68
CPC分类号： C12Q1/6869 , B01F11/0071 , B01F13/0059 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0668 , B01L2200/10 , B01L2300/0627 , B01L2300/0636 , B01L2300/0654 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2400/0415 , B01L2400/0421 , B01L2400/0481 , B01L2400/0655 , C12N15/1003 , C12N15/1013 , C12Q1/24 , C12Q1/6806 , C12Q1/6844 , C12Q1/686 , C12Q1/70 , G01N2035/00514 , Y10T436/163333 , Y10T436/25875
摘要： Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
摘要翻译：公开了用于将微芯片连接到各种类型的模块的方法和装置。所公开的技术可用作各种应用的样品制备和分析系统，如DNA测序和基因分型，蛋白质组学，病原体检测，诊断和生物防治。

7. 发明申请

US20160053314A1 Microfluidic Devices 有权
公开(公告)号：US20160053314A1
公开(公告)日：2016-02-25
申请号：US14824333
申请日：2015-08-12
申请人： Stevan Bogdan Jovanovich , Iuliu Ioan Blaga , Allen Boronkay
发明人： Stevan Bogdan Jovanovich , Iuliu Ioan Blaga , Allen Boronkay
IPC分类号： C12Q1/68 , B01L3/00 , C12N15/10
CPC分类号： C12Q1/6869 , B01F11/0071 , B01F13/0059 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0668 , B01L2200/10 , B01L2300/0627 , B01L2300/0636 , B01L2300/0654 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2400/0415 , B01L2400/0421 , B01L2400/0481 , B01L2400/0655 , C12N15/1003 , C12N15/1013 , C12Q1/24 , C12Q1/6806 , C12Q1/6844 , C12Q1/686 , C12Q1/70 , G01N2035/00514 , Y10T436/163333 , Y10T436/25875
摘要： Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.

8. 发明申请

US20130029338A1 MICROFLUIDIC DEVICES 有权
标题翻译：微流体装置
公开(公告)号：US20130029338A1
公开(公告)日：2013-01-31
申请号：US13367326
申请日：2012-02-06
申请人： Stevan Bogdan Jovanovich , Iuliu Ioan Blaga , Allen Boronkay
发明人： Stevan Bogdan Jovanovich , Iuliu Ioan Blaga , Allen Boronkay
IPC分类号： C12M1/40 , G01N1/28 , C12Q1/68
CPC分类号： B01L3/50273 , B01F11/0071 , B01F13/0059 , B01J2219/005 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2300/0654 , B01L2300/0803 , B01L2300/0806 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1844 , B01L2400/0409 , B01L2400/0421 , B01L2400/043 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , B01L2400/086 , C12Q2565/629 , G01N1/34 , G01N27/44721 , G01N27/44743 , G01N27/44791 , G01N35/0098
摘要： Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
摘要翻译：公开了用于将微芯片连接到各种类型的模块的方法和装置。所公开的技术可用作各种应用的样品制备和分析系统，如DNA测序和基因分型，蛋白质组学，病原体检测，诊断和生物防治。

9. 发明申请

US20060188979A1 Method and apparatus for improved temperature control in microfluidic devices 有权
标题翻译：用于改善微流体装置温度控制的方法和装置
公开(公告)号：US20060188979A1
公开(公告)日：2006-08-24
申请号：US11323318
申请日：2005-12-30
申请人： Michael Spaid , Andrea Chow , Yevgeny Yurkovetsky , Seth Stern , Allen Boronkay , Morten Jensen , Carlton Brooks , Ken Swartz
发明人： Michael Spaid , Andrea Chow , Yevgeny Yurkovetsky , Seth Stern , Allen Boronkay , Morten Jensen , Carlton Brooks , Ken Swartz
IPC分类号： C12M1/34 , F25B29/00
CPC分类号： C12Q1/6818 , B01J2219/00364 , B01J2219/00495 , B01J2219/00704 , B01J2219/00722 , C07B2200/11 , C12Q1/6827 , C40B40/06 , C12Q2561/125 , C12Q2565/543 , C12Q2565/629 , C12Q2565/101
摘要： A microfluidic system and method for employing it to control fluid temperatures of fluids residing within microchannels of a microfluidic device. The microfluidic device is provided with a top layer and a bottom layer and microchannels configured therebetween. Temperature of the fluid within the microchannels is controlled in various ways including the use of electrical resistive heating elements and by providing zones located in contact with the top and bottom layers of the microfluidic device for circulating heat transfer of fluid therein.
摘要翻译：一种微流体系统和方法，用于控制微流体装置的微通道内流体的流体温度。微流体装置设置有顶层和底层以及在其间配置的微通道。微通道内的流体的温度以各种方式进行控制，包括使用电阻加热元件，并且通过提供与微流体装置的顶层和底层接触的区域，以循环其中的流体传热。

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