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1. 发明授权

US5126248A Process for preparation of riboflavin 失效
标题翻译：制备RIBOFLAVIN的方法
公开(公告)号：US5126248A
公开(公告)日：1992-06-30
申请号：US393868
申请日：1989-08-11
申请人： Akinobu Matsuyama , Kimitoshi Kawai , Sadao Kageyama , Shoichi Takao
发明人： Akinobu Matsuyama , Kimitoshi Kawai , Sadao Kageyama , Shoichi Takao
IPC分类号： C12P25/00
CPC分类号： C12P25/00 , Y10S435/942
摘要： Riboflavin is effectively obtained by culturing in a medium (1) a purine-requiring revertant derived from a riboflavin-producing yeast which belongs to the genus Saccharomyces and has a purine requirement or (2) a riboflavin-producing yeast which belongs to the genus Saccharomyces and is resistant to ammonium ion, and collecting the produced riboflavin.

2. 发明授权

US4794081A Process for the preparation of riboflavin 失效
标题翻译：制备核黄素的方法
公开(公告)号：US4794081A
公开(公告)日：1988-12-27
申请号：US643226
申请日：1984-08-21
申请人： Kimitoshi Kawai , Akinobu Matsuyama , Shoichi Takao
发明人： Kimitoshi Kawai , Akinobu Matsuyama , Shoichi Takao
IPC分类号： C12P25/00 , C12N1/16
CPC分类号： C12P25/00
摘要： Riboflavin is obtained directly from the culture in a high yield by cultivating a riboflavin-producing microorganism in a medium using a lower (C.sub.1 to C.sub.4) aliphatic compound, separating riboflavin contained in the culture in the form of heated aqueous solution from solid matters, and crystallizing riboflavin from the heated aqueous solution.Riboflavin is also prepared in a high yield by cultivating a riboflavin-producing yeast belonging to the genus Saccharomyces which has purine requirements and/or resistance to 3-amino-1,2,4-triazole in a medium and collecting riboflavin formed and accumulated in the medium.Moreover, riboflavin is prepared in a high yield even in the presence of iron ions by preliminarily cultivating in liquid a riboflavin-producing yeast belonging to the genus Saccharomyces and then cultivating it in a riboflavin-producing medium containing zinc ions.
摘要翻译：通过使用下（C1〜C4）脂肪族化合物在培养基中培养产生核黄素的微生物，从培养物中以固体物质加热的水溶液的形式分离核黄素，从高产量的培养物中获得核黄素，以及从加热的水溶液中结晶核黄素。核黄素还通过在培养基中培养属于酵母属的产生核黄素的酵母，其具有嘌呤要求和/或对3-氨基-1,2,4-三唑的抗性，并且收集形成并积累的核黄素介质。此外，即使在铁离子存在下，通过在液体中预先培养属于酵母属的产生核黄素的酵母菌素，然后在含有锌离子的产生核黄素的培养基中培养，也可以高产率制备核黄素。

3. 发明授权

US06900037B2 Method for producing amide compounds 失效
标题翻译：酰胺化合物的制备方法
公开(公告)号：US06900037B2
公开(公告)日：2005-05-31
申请号：US10172569
申请日：2002-06-13
申请人： Tohru Nagasawa , Akinobu Matsuyama
发明人： Tohru Nagasawa , Akinobu Matsuyama
IPC分类号： C12N1/21 , C12P13/02 , C12R1/01 , C12P7/40 , C12P41/00
CPC分类号： C12P13/02
摘要： The present invention provides a method for producing amide compounds using hydroxyl nitrile compounds and microorganisms and/or enzymatically active material having cyanide-resistant nitrile hydratase activity, e.g., Rhodococcus equi XL-l. Furthermore, the amide compounds can be produced while the enzymatic activity of this microorganism can be stably maintained during the reaction.
摘要翻译：本发明提供了使用羟基腈化合物和具有氰化物抗性腈水合酶活性的微生物和/或酶活性物质如红景天菌XL-1制备酰胺化合物的方法。此外，可以在反应期间稳定地保持该微生物的酶活性的同时产生酰胺化合物。

4. 发明授权

US5888804A Processes for production of optically active quinuclidinol 失效
标题翻译：光学活性奎宁环醇的制备方法
公开(公告)号：US5888804A
公开(公告)日：1999-03-30
申请号：US034284
申请日：1998-03-04
申请人： Akinobu Matsuyama , Takeshi Hamatani
发明人： Akinobu Matsuyama , Takeshi Hamatani
IPC分类号： C12P17/12 , C12P17/18 , C12R1/06 , C12R1/37 , C12R1/38 , C12R1/645 , C12R1/72 , C12R1/78 , C07C00/00
CPC分类号： C12P17/182 , Y10S435/83 , Y10S435/874
摘要： The present invention provide processes for producing an optically active quinuclidinol from a quinuclidinone using an asymmetric reduction by a microorganism and enzyme with commercial advantages in simple and easy manner. In the present invention, permit a microorganism or preparation thereof to act on a quinuclidinone (3-quinuclidinone), and recover or harvest an optically active quinuclidinol produced (3-quinuclidinol). The microorganisms capable of producing an (R)-3-quinuclidinol from a 3-quinuclidinone include the genus Nakazawaea, the genus Candida and the genus Proteus. The microorganisms capable of producing an (S)-3-quinuclidinol from a 3-quinuclidinone include the genus Arthrobacter, the genus Pseudomonas and the genus Rhodosporidium.
摘要翻译：本发明提供了使用微生物和酶的不对称还原，以简便易行的商业优点从奎宁环酮生产光学活性奎宁环醇的方法。在本发明中，允许微生物或其制备物作用于奎宁环酮（3-奎宁环酮），并回收或收获所产生的光学活性奎宁环醇（3-奎宁环醇）。能够从3-奎宁环酮生成（R）-3-奎宁环醇的微生物包括中爪哇属（Nakazawaea），假丝酵母属（Candida）和变形菌属（Proteus）。能够从3-奎宁环酮生成（S）-3-奎宁环醇的微生物包括节杆菌属，假单胞菌属和红球菌属。

5. 发明授权

US5401660A Process for producing optically active 1,3-butanediol by asymmetric assimilation 失效
标题翻译：通过不对称同化制备光学活性1,3-丁二醇的方法
公开(公告)号：US5401660A
公开(公告)日：1995-03-28
申请号：US964264
申请日：1992-10-21
申请人： Akinobu Matsuyama , Teruyuki Nikaido , Yoshinori Kobayashi
发明人： Akinobu Matsuyama , Teruyuki Nikaido , Yoshinori Kobayashi
IPC分类号： C12P7/18 , C12P41/00
CPC分类号： C12P41/001 , C12P7/18 , Y10S435/822 , Y10S435/911 , Y10S435/921 , Y10S435/938
摘要： An optically active 1,3-butanediol can be produced by either (1) treating a mixture of 1,3-butanediol enantiomers with a microorganism, which has been optionally treated, capable of asymmetrically assimilating said mixture, or (2) preparing a microorganism, which has been optionally treated, capable of asymmetrically reducing 4-hydroxy-2-butanone, and collecting optically active 1,3-butanediol.
摘要翻译：光学活性1,3-丁二醇可以通过（1）将1,3-丁二醇对映异构体与已经任意处理的能够不对称地同化所述混合物的微生物处理，或（2）制备微生物，其可任选地处理，能够不对称地还原4-羟基-2-丁酮，并收集光学活性的1,3-丁二醇。

6. 发明授权

US06902915B2 Heat-stable D-aminoacylase 失效
标题翻译：热稳定的D-氨基酸酰基酶
公开(公告)号：US06902915B2
公开(公告)日：2005-06-07
申请号：US10361509
申请日：2003-02-07
申请人： Shinji Tokuyama , Akinobu Matsuyama
发明人： Shinji Tokuyama , Akinobu Matsuyama
IPC分类号： C12N15/09 , C12N1/20 , C12N1/21 , C12N9/80 , C12N15/55 , C12P13/04 , C12P13/06 , C12P13/12 , C12P13/20 , C12P13/22 , C12R1/465 , C12N9/78 , C12P13/08
CPC分类号： C12R1/465 , C12N9/80 , C12P13/04
摘要： The present invention provides a novel D-aminoacylase, as well as method for producing a D-amino acid using the same. In order to achieve the above objective, the present inventors have succeeded in purifying heat-stable D-aminoacylase from microorganisms belonging to the genus Streptomyces by combining various purification methods. Furthermore, the present inventors found that the purified heat-stable D-aminoacylase is useful in industrial production of D-amino acids. By utilizing the heat-stable D-aminoacylase, it is possible to readily and efficiently produce the corresponding D-amino acids from N-acetyl-DL-amino acids (for example, N-acetyl-DL-methionine, N-acetyl-DL-valine, N-acetyl-DL-tryptophan, N-acetyl-DL-phenylalanine, N-acetyl-DL-alanine, N-acetyl-DL-leucine, and so on).
摘要翻译：本发明提供了一种新的D-氨基酸酰基酶，以及使用其制备D-氨基酸的方法。为了实现上述目的，本发明人通过组合各种纯化方法成功地从属于链霉菌属的微生物纯化热稳定的D-氨基酰化酶。此外，本发明人发现纯化的热稳定性D-氨基酸酰基酶可用于工业生产D-氨基酸。通过利用热稳定的D-氨基酸酰化酶，可以容易且有效地从N-乙酰基-DL-氨基酸（例如，N-乙酰基-DL-甲硫氨酸，N-乙酰基-DL- 缬氨酸，N-乙酰基-DL-色氨酸，N-乙酰基-DL-苯丙氨酸，N-乙酰基-DL-丙氨酸，N-乙酰基-DL-亮氨酸等）。

7. 发明授权

US06780619B2 D-aminoacylase and gene encoding the same 失效
标题翻译： D-氨基酸酰化酶和编码相同的基因
公开(公告)号：US06780619B2
公开(公告)日：2004-08-24
申请号：US09770517
申请日：2001-01-26
申请人： Kazuya Mitsuhashi , Hiroaki Yamamoto , Akinobu Matsuyama , Shinji Tokuyama
发明人： Kazuya Mitsuhashi , Hiroaki Yamamoto , Akinobu Matsuyama , Shinji Tokuyama
IPC分类号： C12P1304
CPC分类号： C12N9/80 , C12P13/04 , C12P13/227 , C12P41/007
摘要： The present invention provides the D-aminoacylase-encoding gene derived from Hypomyces mycophilus, a filamentous fungus, the polypeptide encoded by the gene, and the homologues thereof. The D-aminoacylase of the present invention is capable of producing D-tryptophan from N-acetyl-D-tryptophan. D-tryptophan is useful as a medicinal raw material or the like.
摘要翻译：本发明提供了源自嗜酸菌的D-氨基酸酰化酶编码基因，丝状真菌，由该基因编码的多肽及其同源物。本发明的D-氨基酰化酶能够从N-乙酰基-D-色氨酸产生D-色氨酸。 D-色氨酸可用作药用原料等。

8. 发明授权

US06514742B1 D-aminoacylases, method for producing the same, and method for producing D-amino acids using the same 失效
公开(公告)号：US06514742B1
公开(公告)日：2003-02-04
申请号：US09361901
申请日：1999-07-27
申请人： Kazuya Mitsuhashi , Hiroaki Yamamoto , Akinobu Matsuyama , Shinji Tokuyama
发明人： Kazuya Mitsuhashi , Hiroaki Yamamoto , Akinobu Matsuyama , Shinji Tokuyama
IPC分类号： C12N978
CPC分类号： C12P13/04 , C12N9/80 , C12P41/007
摘要： D-aminoacylase derived from fungi is provided. The fungi capable of producing D-aminoacylase include those belonging to the genus Hypomyces, Fusarium, Auricularia, Pythium, and Menisporopsis. The fungal D-aminoacylase is useful for efficiently producing D-amino acids from N-acetyl-D-amino acids.

9. 发明授权

US5672504A Process for enriching an �R,S!-1,2-epoxide in one enantiomer by using microbes to convert one enantiomer to the other or to preferentially open the epoxide ring 失效
标题翻译：通过使用微生物将一种对映异构体转化为另一对映异构体或优先开环环氧环来富集一种对映异构体中的[R，S]
公开(公告)号：US5672504A
公开(公告)日：1997-09-30
申请号：US547902
申请日：1995-10-25
申请人： Akinobu Matsuyama , Yoshinori Kobayashi
发明人： Akinobu Matsuyama , Yoshinori Kobayashi
IPC分类号： C07D303/08 , C12P17/02 , C12P41/00
CPC分类号： C07D303/08 , C12P17/02 , C12P41/00 , Y10S435/823 , Y10S435/832 , Y10S435/834 , Y10S435/839 , Y10S435/849 , Y10S435/875 , Y10S435/877 , Y10S435/881 , Y10S435/917 , Y10S435/918 , Y10S435/92
摘要： A microorganism or a preparation thereof is permitted to act on a mixture of enantiomers of an epoxide such as 3-chlorostyrene oxide and the product optically active epoxide is recovered. The microorganism able to produce an optically active (S)-epoxide from the mixture of enantiomers of the epoxide include, for example, a microorganism strain belonging to the genus Candida, the genus Rhodosporidium, the genus Rhodococcus and the genus Nosardioides. Examples of the microorganism capable of producing an optically active (R)-epoxide from said mixture include a microorganism strain belonging to the genus Trichosporon, the genus Geotrichum, the genus Corynebacterium, the genus Micrococcus and the genus Brevibacterium. The objective optically active epoxide can efficiently be obtained with ease and simplicity from the corresponding mixture of enantiomers of the epoxide.
摘要翻译：允许微生物或其制剂作用于环氧化物的对映异构体如3-氯苯乙烯氧化物的混合物，并回收产物光学活性环氧化物。能够从环氧化物的对映异构体的混合物中产生光学活性的（S） - 环氧化物的微生物包括例如属于假丝酵母属，红球菌属，红球菌属和仙人掌属的微生物菌株。能够从所述混合物生产光学活性（R） - 环氧化物的微生物的实例包括属于Trichosporon属，Geotrichum属，棒状杆菌属，Micrococcus属和短杆菌属的微生物菌株。目的光学活性环氧化物可以从环氧化物的相应对映异构体的混合物中容易且简单地获得。

10. 发明授权

US5288620A Process for the production of optically active 2-hydroxy-4-phenyl-3-butenoic acid 失效
标题翻译：光学活性2-羟基-4-苯基-3-丁烯酸的制备方法
公开(公告)号：US5288620A
公开(公告)日：1994-02-22
申请号：US885974
申请日：1992-05-20
申请人： Akinobu Matsuyama , Ichiro Takase , Yoichiro Ueda , Yoshinori Kobayashi
发明人： Akinobu Matsuyama , Ichiro Takase , Yoichiro Ueda , Yoshinori Kobayashi
IPC分类号： C12P7/42 , C12R1/01 , C12R1/22 , C12R1/645
CPC分类号： C12P7/42 , Y10S435/822 , Y10S435/824 , Y10S435/827 , Y10S435/83 , Y10S435/836 , Y10S435/84 , Y10S435/843 , Y10S435/85 , Y10S435/852 , Y10S435/853 , Y10S435/857 , Y10S435/873 , Y10S435/874 , Y10S435/885 , Y10S435/911 , Y10S435/921 , Y10S435/93
摘要： Optically active 2-hydroxy-4-phenyl-3-butenoic acid can be obtained by treating 2-oxo-4-phenyl-3-butenoic acid with an optionally treated microorganism capable of asymmetrically reducing the 2-oxo-4-phenyl-3-butenoic acid into (R)-2-hydroxy-4-phenyl-3-butenoic acid or (S)-2-hydroxy-4-phenyl-3-butenoic acid to thereby asymmetrically reduce the same into (R)-2-hydroxy-4-phenyl-3-butenoic acid or (S)-2-hydroxy-4-phenyl-3-butenoic acid.
摘要翻译：通过用任意处理的微生物处理2-氧代-4-苯基-3-丁烯酸可以获得光学活性的2-羟基-4-苯基-3-丁烯酸，其能够不对称地还原2-氧代-4-苯基-3-丁烯酸（R）-2-羟基-4-苯基-3-丁烯酸或（S）-2-羟基-4-苯基-3-丁烯酸，从而将其不对称地还原成（R）-2- 羟基-4-苯基-3-丁烯酸或（S）-2-羟基-4-苯基-3-丁烯酸。

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