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1. 发明授权

US5126248A Process for preparation of riboflavin 失效
标题翻译：制备RIBOFLAVIN的方法
公开(公告)号：US5126248A
公开(公告)日：1992-06-30
申请号：US393868
申请日：1989-08-11
申请人： Akinobu Matsuyama , Kimitoshi Kawai , Sadao Kageyama , Shoichi Takao
发明人： Akinobu Matsuyama , Kimitoshi Kawai , Sadao Kageyama , Shoichi Takao
IPC分类号： C12P25/00
CPC分类号： C12P25/00 , Y10S435/942
摘要： Riboflavin is effectively obtained by culturing in a medium (1) a purine-requiring revertant derived from a riboflavin-producing yeast which belongs to the genus Saccharomyces and has a purine requirement or (2) a riboflavin-producing yeast which belongs to the genus Saccharomyces and is resistant to ammonium ion, and collecting the produced riboflavin.

2. 发明授权

US4794081A Process for the preparation of riboflavin 失效
标题翻译：制备核黄素的方法
公开(公告)号：US4794081A
公开(公告)日：1988-12-27
申请号：US643226
申请日：1984-08-21
申请人： Kimitoshi Kawai , Akinobu Matsuyama , Shoichi Takao
发明人： Kimitoshi Kawai , Akinobu Matsuyama , Shoichi Takao
IPC分类号： C12P25/00 , C12N1/16
CPC分类号： C12P25/00
摘要： Riboflavin is obtained directly from the culture in a high yield by cultivating a riboflavin-producing microorganism in a medium using a lower (C.sub.1 to C.sub.4) aliphatic compound, separating riboflavin contained in the culture in the form of heated aqueous solution from solid matters, and crystallizing riboflavin from the heated aqueous solution.Riboflavin is also prepared in a high yield by cultivating a riboflavin-producing yeast belonging to the genus Saccharomyces which has purine requirements and/or resistance to 3-amino-1,2,4-triazole in a medium and collecting riboflavin formed and accumulated in the medium.Moreover, riboflavin is prepared in a high yield even in the presence of iron ions by preliminarily cultivating in liquid a riboflavin-producing yeast belonging to the genus Saccharomyces and then cultivating it in a riboflavin-producing medium containing zinc ions.
摘要翻译：通过使用下（C1〜C4）脂肪族化合物在培养基中培养产生核黄素的微生物，从培养物中以固体物质加热的水溶液的形式分离核黄素，从高产量的培养物中获得核黄素，以及从加热的水溶液中结晶核黄素。核黄素还通过在培养基中培养属于酵母属的产生核黄素的酵母，其具有嘌呤要求和/或对3-氨基-1,2,4-三唑的抗性，并且收集形成并积累的核黄素介质。此外，即使在铁离子存在下，通过在液体中预先培养属于酵母属的产生核黄素的酵母菌素，然后在含有锌离子的产生核黄素的培养基中培养，也可以高产率制备核黄素。

3. 发明授权

US5466588A Production of high optical purity D-lactic acid 失效
标题翻译：生产高光学纯度的D-乳酸
公开(公告)号：US5466588A
公开(公告)日：1995-11-14
申请号：US250094
申请日：1994-05-26
申请人： Michio Kosaki , Kimitoshi Kawai
发明人： Michio Kosaki , Kimitoshi Kawai
IPC分类号： C12P7/56
CPC分类号： C12P7/56
摘要： D-lactic acid is continuously produced by conducting fermentation in a D-lactic acid-producing medium by using as a seed culture a part of a broth obtained in a previous fermentation step of D-lactic acid and elevating a concentration of said growth-promoter to such an effect that a optical purity of the D-lactic acid may be prevented from decreasing. Instead, air may be used.
摘要翻译：通过使用在D-乳酸的先前发酵步骤中获得的一部分肉汤作为种子培养物，在D-乳酸生产培养基中进行发酵，并提高所述生长促进剂的浓度，连续生产D-乳酸达到可以防止D-乳酸的光学纯度降低的效果。相反，可以使用空气。

4. 发明授权

US4882277A Continuous process for preparing organic acids by fermentation 失效
标题翻译：通过发酵制备有机酸的连续工艺
公开(公告)号：US4882277A
公开(公告)日：1989-11-21
申请号：US943698
申请日：1986-12-19
申请人： Michael Czytko , Kiyoshi Ishii , Kimitoshi Kawai
发明人： Michael Czytko , Kiyoshi Ishii , Kimitoshi Kawai
IPC分类号： C12P7/40 , B01D61/44 , C12M1/12 , C12P7/56
CPC分类号： C12P7/56 , B01D61/44 , B01D61/445 , C12M29/18 , C12M47/10
摘要： Organic acids are prepared by fermentation and then separated from the fermentation broth by means of an electrodialysis.The present process does not require an addition of an alkali. The organic acids are recovered as free acids with high purity and at high yields.
摘要翻译：有机酸通过发酵制备，然后通过电渗析与发酵液分离。本方法不需要加入碱。有机酸以高纯度和高收率回收为游离酸。

5. 发明授权

US4457863A Antitumor substance 失效
标题翻译：抗肿瘤物质
公开(公告)号：US4457863A
公开(公告)日：1984-07-03
申请号：US377490
申请日：1982-05-12
申请人： Kimitoshi Kawai , Kunio Sugawara , Tsuyoshi Morinaga
发明人： Kimitoshi Kawai , Kunio Sugawara , Tsuyoshi Morinaga
IPC分类号： A61K38/00 , C07K14/415 , C07G7/00
CPC分类号： C07K14/415 , A61K38/00
摘要： A new substance having antitumor activity is obtained from an epidermal portion of rice. A substance called RBF-P is obtained by adding ethanol to an aqueous alkaline extract of rice bran, removing the insolubles and precipitating the substance by addition of an acid. This substance comprises an active substance called RBF-PM, which is insoluble in methanol, and an active substance called RBF-X, which is soluble in acetone. The substance RBF-PM is a protein containing extremely little cystine and said protein can suppress solid cancers of mice. The substance RBF-X is a mixture of hexane-solubles such as fatty acids and a hexane-insoluble called RBF-H. A synergistic suppressive action on ascites hepatoma of mice is exhibited by the combination of the RBF-H and the fatty acids.
摘要翻译：从水稻的表皮部分获得具有抗肿瘤活性的新物质。通过向米糠水性碱性提取物中加入乙醇，除去不溶物并通过加入酸沉淀物质，得到称为RBF-P的物质。该物质包含不溶于甲醇的称为RBF-PM的活性物质和可溶于丙酮的称为RBF-X的活性物质。物质RBF-PM是含有极少胱氨酸的蛋白质，所述蛋白质可以抑制小鼠的固体癌症。物质RBF-X是己烷可溶物如脂肪酸和不溶于己烷的称为RBF-H的混合物。通过RBF-H和脂肪酸的组合显示对小鼠腹水肝细胞瘤的协同抑制作用。

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