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1. 再颁专利

USRE41328E1 Purification of Heparinase I, II and III from Flavobacterium heparinum 有权
标题翻译：从肝素肝素中纯化肝素酶I，II和III
公开(公告)号：USRE41328E1
公开(公告)日：2010-05-11
申请号：US12199215
申请日：2008-08-27
申请人： Ramnath Sasisekharan , Charles L. Cooney , Robert S. Langer , Daniel L. Lohse , Robert J. Linhardt
发明人： Ramnath Sasisekharan , Charles L. Cooney , Robert S. Langer , Daniel L. Lohse , Robert J. Linhardt
IPC分类号： C12N1/20 , C12N9/00 , C12N9/52
CPC分类号： C12N9/88 , Y10S435/822 , Y10S435/85
摘要： A purified heparinase I, II and III free of lyase activity and each having a molecular weight of 42,800 84,100, 70,800, respectively, are produced by culturing Flavobacterium heparinum. The kinetic properties of the heparinases have been determined as well as the conditions to optimize their activity and stability.
摘要翻译：不含裂解酶活性的纯化肝素酶I，II和III分别通过培养肝炎黄杆菌而产生，分子量分别为42,400,84,100,70,800。已经确定了肝素酶的动力学性质以及优化其活性和稳定性的条件。

2. 发明授权

US5854015A Method of making pure 3R-3'R stereoisomer of zeaxanthin for human ingestion 失效
标题翻译：制备玉米黄质的纯3R-3'R立体异构体进行人体摄取的方法
公开(公告)号：US5854015A
公开(公告)日：1998-12-29
申请号：US551166
申请日：1995-10-31
申请人： Kevin M. Garnett , Dennis L. Gierhart , Luis H. Guerra-Santos
发明人： Kevin M. Garnett , Dennis L. Gierhart , Luis H. Guerra-Santos
IPC分类号： A61K31/047 , C12P23/00
CPC分类号： A61K31/047 , Y10S435/85
摘要： A method is disclosed for making the 3R-3'R stereoisomer of zeaxanthin as a sole detectable or heavily dominant (more than about 90%) stereoisomer, for human ingestion. Zeaxanthin, a yellowish pigment which is naturally present in macular cells in the center of the human retina, absorbs blue and near-ultraviolet light radiation, thereby protecting the retinal cells against phototoxic damage. Zeaxanthin preparations which contain only the desired R--R isomer can be produced by a strain of Flavobacterium multivorum cells (ATCC accession number 55238). These cells (and other cells transformed with their zeaxanthin-producing genes) do not create any detectable quantities of the undesired S--S or S-R isomers of zeaxanthin, and they do not synthesize significant quantities of other carotenoids which might compete against zeaxanthin for alimentary uptake after oral ingestion. After synthesis using cell fermentation, the zeaxanthin can be concentrated to about 5-20% by simple and inexpensive steps such as solvent extraction, and can be purified to much higher levels by other methods if desired. The isomerically pure preparations can be taken orally, either as a therapeutic drug by patients suffering from macular degeneration, or as a nutritional supplement by anyone who wants to reduce his or her risk of suffering from age-related macular degeneration, which is widespread among people over the age of about 50 or 60.
摘要翻译：公开了一种用于使玉米黄质的3R-3'R立体异构体作为唯一可检测或重占优势（超过约90％）立体异构体的方法，用于人体摄取。天然存在于人类视网膜中心的黄斑细胞中的淡黄色素的玉米黄质吸收蓝色和近紫外光的辐射，从而保护视网膜细胞免受光毒性损伤。仅含有所需R-R异构体的玉米黄质制剂可以通过多变黄杆菌细菌菌株（ATCC登录号55238）产生。这些细胞（和其产生的玉米黄质的基因转化的其他细胞）不产生任何可检测量的玉米黄质的不希望的SS或SR异构体，并且它们不合成显着量的其它类胡萝卜素，其可以与口服玉米黄质竞争消化吸收摄入在使用细胞发酵合成后，可以通过简单且便宜的步骤如溶剂萃取将玉米黄质浓缩至约5-20％，并且如果需要可以通过其它方法纯化至更高的水平。异构纯的制剂可以口服给药，作为患有黄斑变性的患者的治疗药物，或作为营养补充剂，任何人谁希望降低患有年龄相关性黄斑变性的风险，这在人群中很普遍年龄约50或60岁。

3. 发明授权

US5342778A Microorganism belonging to the genus flavobacterium designated ferm BP-4010 失效
标题翻译：属于黄杆菌属的微生物，命名为BP-4010
公开(公告)号：US5342778A
公开(公告)日：1994-08-30
申请号：US950586
申请日：1992-09-25
申请人： Kazuhito Moriya , Koki Horikoshi
发明人： Kazuhito Moriya , Koki Horikoshi
IPC分类号： C02F1/40 , C02F3/00 , C02F3/34 , C12N1/20 , C12R1/20 , E02B15/10 , C12N1/26 , C12N1/00 , D06M16/00
CPC分类号： C12R1/20 , C02F3/34 , Y10S435/85
摘要： A microorganism belonging to the genus Flavobacterium possessing the capacity to decompose hydrocarbons, tolerance to sulfurous acids, tolerance to salinity, tolerance to organic solvents, and tolerance to pressure. The microorganism is a strain of the genus Flavobacterium DS-711 (FERM BP-4010).
摘要翻译：属于具有分解碳氢化合物的能力的微生物属的微生物，对亚硫酸的耐受性，对盐度的耐受性，对有机溶剂的耐受性和耐受性。微生物是属于黄杆菌属DS-711（FERM BP-4010）的菌株。

4. 发明授权

US5308759A Production of zeaxanthin and zeaxanthin-containing compositions 失效
标题翻译：玉米黄质和含玉米黄质的组合物的生产
公开(公告)号：US5308759A
公开(公告)日：1994-05-03
申请号：US841193
申请日：1992-02-21
申请人： Dennis L. Gierhart
发明人： Dennis L. Gierhart
IPC分类号： A23K1/00 , A23K1/16 , A23K1/18 , A23L1/275 , A61K8/00 , A61K8/23 , A61K8/24 , A61K8/30 , A61K8/60 , A61K8/64 , A61K8/66 , A61K8/67 , A61K8/73 , A61K8/97 , A61K8/99 , A61Q90/00 , C12N1/20 , C12P23/00 , C12R1/20
CPC分类号： C12R1/20 , A23K10/10 , A23K20/179 , A23K50/75 , A23K50/80 , A23L5/46 , C12N1/20 , C12P23/00 , Y10S435/85
摘要： Zeaxanthin is produced using Flavobacterium multivorum. The process and the nutrient medium used in the process provide greater zeaxanthin and cell yields per liter, at a lower cost, and more rapidly than known methods and microorganisms. Biomass compositions containing the microorganism of this invention are also disclosed.
摘要翻译：使用黄杆菌生产玉米黄质。在该方法中使用的方法和营养培养基以较低的成本提供更大的玉米黄质和每升的细胞产量，并且比已知的方法和微生物快得多。还公开了含有本发明微生物的生物质组合物。

5. 发明授权

US5000966A Quality improvement of alcoholic liquors by enzymatic decomposing of ethyl carbamate 失效
标题翻译：通过酶促分解氨基甲酸乙酯来改善醇酒的质量
公开(公告)号：US5000966A
公开(公告)日：1991-03-19
申请号：US282044
申请日：1988-12-09
申请人： Yasuhiro Sumino , Shigeya Kakimoto , Shun-ichi Akiyama
发明人： Yasuhiro Sumino , Shigeya Kakimoto , Shun-ichi Akiyama
IPC分类号： C12N9/78 , C12H1/00 , C12H1/14 , C12H1/15
CPC分类号： C12H1/003 , Y10S435/822 , Y10S435/824 , Y10S435/829 , Y10S435/83 , Y10S435/85 , Y10S435/852 , Y10S435/911 , Y10S435/921
摘要： Ethyl carbamate in an alcoholic liquor is decomposed by contacting the alcoholic liquor with a culture broth or processed matter thereof obtained from a microorganism which belongs to the genus Gluconobacter, Flavobacterium, Arthrobacter, Achromobacter, Alcaligenes, Pseudomonas, Klebsiella, Rhodotorula, Rhodosporidium, Trichosporon or Candida, and is capable of decomposing ethyl carbamate. The alcoholic liquor is improved in quality, and has a low ethyl carbamate content.

6. 发明授权

US4734494A Optically active 3-halo carbacephems 失效
标题翻译：光学活性3-卤代碳水化合物
公开(公告)号：US4734494A
公开(公告)日：1988-03-29
申请号：US926889
申请日：1986-11-06
申请人： Tadashi Hirata , Yukio Hashimoto , Ikuo Matsukuma , Shigeo Yoshiie , Seigo Takasawa
发明人： Tadashi Hirata , Yukio Hashimoto , Ikuo Matsukuma , Shigeo Yoshiie , Seigo Takasawa
IPC分类号： A61K31/435 , A61P31/04 , C07D463/00 , C12P17/18 , C12P41/00 , C07D487/04 , C07B19/02
CPC分类号： C12P17/184 , C07D463/06 , Y02P20/55 , Y10S435/822 , Y10S435/823 , Y10S435/824 , Y10S435/829 , Y10S435/83 , Y10S435/832 , Y10S435/842 , Y10S435/843 , Y10S435/848 , Y10S435/85 , Y10S435/859 , Y10S435/87 , Y10S435/873 , Y10S435/874 , Y10S435/882 , Y10S435/91 , Y10S435/911
摘要： Optically active cephalosporin analogs are produced by optically selective deacylation of an optically inactive acylated analog. The compounds are useful as intermediates in the preparation of optically active acylated antimicrobial agents.
摘要翻译：通过光学惰性酰化类似物的光学选择性脱酰化产生光学活性头孢菌素类似物。该化合物可用作制备光学活性酰化抗微生物剂的中间体。

7. 发明授权

US4335211A Process for producing optically active cephalosporin analogs 失效
标题翻译：光学活性头孢菌素类似物的制备方法
公开(公告)号：US4335211A
公开(公告)日：1982-06-15
申请号：US206556
申请日：1980-11-13
申请人： Yukio Hashimoto , Seigo Takasawa , Tadashi Hirata , Ikuo Matsukuma , Shigeo Yoshiie
发明人： Yukio Hashimoto , Seigo Takasawa , Tadashi Hirata , Ikuo Matsukuma , Shigeo Yoshiie
IPC分类号： C12P35/04 , C07D463/00 , C12P17/18 , C12R1/01 , C12R1/02 , C12R1/025 , C12R1/38 , C12R1/64
CPC分类号： C12P17/184 , C07D463/06 , C07D463/22 , Y10S435/823 , Y10S435/824 , Y10S435/829 , Y10S435/83 , Y10S435/832 , Y10S435/84 , Y10S435/842 , Y10S435/843 , Y10S435/848 , Y10S435/85 , Y10S435/859 , Y10S435/873 , Y10S435/874 , Y10S435/882 , Y10S435/91
摘要： Disclosed are optically active acylated cephalosporin analogs which are useful as antibacterial agents and methods for preparing such compounds.
摘要翻译：公开了可用作抗菌剂的光学活性酰化头孢菌素类似物和制备这些化合物的方法。

8. 发明授权

US4138291A Microbiological methods 失效
标题翻译：微生物方法
公开(公告)号：US4138291A
公开(公告)日：1979-02-06
申请号：US822756
申请日：1977-08-08
申请人： Robert M. Lafferty
发明人： Robert M. Lafferty
IPC分类号： C12N1/00 , C12N1/20 , C12N15/00 , C12N15/01 , C12P7/62 , C12D1/02
CPC分类号： C12P7/625 , Y10S435/85
摘要： The invention relates to a method of obtaining selected bacterial strains which can convert an assimilable carbon source selected from carbohydrates, methanol, ethanol, glycerin, carbon dioxide and spent lyes from caprolactam synthesis into poly-(D-3-hydroxybutyric acid), selected bacterial strains obtained thereby and their use in producing poly-(D-3-hydroxybutyric acid).
摘要翻译：本发明涉及一种获得选择的细菌菌株的方法，其可以将选自碳水化合物，甲醇，乙醇，甘油，二氧化碳和废碱的可同化碳源从己内酰胺合成转化成聚 - （D-3-羟基丁酸），选择的细菌由此获得的菌株及其在制备聚（D-3-羟基丁酸）中的用途。

9. 发明授权

US4001083A Process for producing isoamylase 失效
标题翻译：生产ISOMYLASE的方法
公开(公告)号：US4001083A
公开(公告)日：1977-01-04
申请号：US566585
申请日：1975-04-08
申请人： Robert Otto Horwath , Philip Rotheim
发明人： Robert Otto Horwath , Philip Rotheim
IPC分类号： C12N9/44 , C12D13/10
CPC分类号： C12Y302/01068 , C12N9/246 , Y10S435/83 , Y10S435/85 , Y10S435/859
摘要： Microorganisms which produce isoamylase are propagated under aerobic conditions in an aqueous nutrient medium having present maltitol. The presence of the maltitol induces the microorganisms to produce greater amounts of isoamylase as compared to the amounts of isoamylase produced by propagating the microorganisms without the presence of maltitol.

10. 发明授权

US3951743A Production of zeaxanthin 失效
标题翻译：玉米黄质的生产
公开(公告)号：US3951743A
公开(公告)日：1976-04-20
申请号：US489725
申请日：1974-07-18
申请人： David Shepherd , Jaroslav Dasek , Mariette Suzanne Catherine Carels
发明人： David Shepherd , Jaroslav Dasek , Mariette Suzanne Catherine Carels
IPC分类号： A23K1/00 , C12P23/00 , C12R1/20 , C12D13/02
CPC分类号： C12P23/00 , Y10S435/85
摘要： A process for the preparation of zeaxanthin which comprises culturing a microorganism of the genus Flavobacter producing this pigment in a nutrient medium containing at least one carbohydrate as assimilable carbon source, at least one source of assimilable amino nitrogen containing free amino acids, mineral salts, oligoelements and vitamins, the composition of the medium being modified by adding pyridoxine to it, and continuing culturing until a substantial quantity of intracellular zeaxanthin has been obtained.
摘要翻译：一种玉米黄质的制备方法，其包括在含有至少一种碳水化合物作为可同化碳源的至少一种含可游离氨基酸的可吸收的氨基酸源，无机盐，寡糖类的培养基中培养产生该颜料的黄杆菌属的微生物和维生素，通过向其中加入吡哆醇来修饰培养基的组成，并继续培养直到获得了大量的细胞内玉米黄质。

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