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    • 4. 发明授权
    • Membrane plasmapheresis module
    • 膜血浆置换模块
    • US4318813A
    • 1982-03-09
    • US164735
    • 1980-06-30
    • William EdelmanJames R. Hitchcock, Jr.William J. Schnell
    • William EdelmanJames R. Hitchcock, Jr.William J. Schnell
    • B01D63/08B01D63/14B01D31/00
    • B01D63/14B01D63/084Y10S128/03Y10S261/28
    • A membrane plasmapheresis module (10) comprises semipermeable membrane means (11) capable of permitting blood plasma to pass therethrough while preventing the passage of blood cells, and sealed housing means (18, 19) defining a blood inlet port (43) and blood outlet port (44) positioned adjacent opposite ends of a first flow path (60) extending along one side of the membrane (11). The housing (18, 19) also defines a plasma outlet port (38) adjacent one end of separate, second flow paths (62) extending along the other side of the membrane (11). The membrane (11) may be folded together about a fold line (12) to define a pair of membrane portions (14, 16) lying against each other. The first flow path (60) extends between the membrane portions (14, 16) and the second flow path (62) may optionally extend between each membrane portion (14, 16) and a wall of the sealed housing means (18, 19), or alternatively an adjacent fold (12) of the membrane portion. A plasma outlet port (38) is defined through the housing (18, 19) at a position spaced from the membrane (11). Channels (21) are defined in the interior surface of the housing (18, 19) and positioned to face the membrane (11) to serve as a manifold to collect blood plasma from the second flow path (62). The above-described channel (21) also extends across the fold line (12) into flow communication with the plasma outlet port (38). Also, blood inlet and outlet ports (43, 44) may extend in telescopic relation with aperture ports (40, 42) in the housing for securence of the inlet and outlet ports (43, 44).
    • 膜血浆置换模块(10)包括能够允许血浆穿过其中同时防止血细胞通过的半透膜装置(11),以及限定血液入口(43)和血液出口(43)的密封的壳体装置(18,19) 端口(44)位于沿着膜(11)的一侧延伸的第一流动路径(60)的相对端附近。 壳体(18,19)还限定了沿隔膜(11)的另一侧延伸的分开的第二流动路径(62)的一端附近的等离子体出口(38)。 膜(11)可围绕折线(12)折叠在一起,以限定彼此相对的一对膜部分(14,16)。 第一流动路径(60)在膜部分(14,16)之间延伸,并且第二流动路径(62)可任选地在每个膜部分(14,16)和密封的壳体装置(18,19)的壁之间延伸, ,或者替代地,膜部分的相邻折叠(12)。 等离子体出口(38)通过壳体(18,19)在与膜(11)间隔开的位置处被限定。 通道(21)限定在壳体(18,19)的内表面中并且定位成面对膜(11)以用作歧管以从第二流动路径(62)收集血浆。 上述通道(21)也跨越折叠线(12)延伸成与等离子体出口(38)流动连通。 此外,血液入口和出口端口(43,44)可以与壳体中的孔口(40,42)伸缩关系延伸,以确保入口和出口端口(43,44)。
    • 5. 发明授权
    • Control apparatus for the automatic treatment of diabetes
    • 用于自动治疗糖尿病的控制装置
    • US4073292A
    • 1978-02-14
    • US736996
    • 1976-10-29
    • William Edelman
    • William Edelman
    • A61B5/20A61M5/142A61M5/172A61M5/00
    • A61B5/201A61B5/14507A61M5/1723A61M5/14276Y10S128/13
    • The control apparatus of the invention comprises a feedback system to maintain the level of glucose in a diabetic within predetermined limits. Surgically implanted in the body are a means for sensing glucose levels and a means for dispensing insulin in an amount determined by the sensing mechanism. The sensing mechanism employs a chemical solution, which, like the insulin, is stored within a reservoir forming part of the surgical implant. Means are additionally provided to couple these reservoirs to the surface of the skin so as to permit their rechargings at regular time intervals. Integrated circuit technology is employed to translate an indication of an unacceptable glucose level into an automatic injection of insulin, with the electronics being of the type capable of being powered by batteries of the kind employed in pacemaker technology.
    • 本发明的控制装置包括将糖尿病患者的葡萄糖水平维持在预定限度内的反馈系统。 手术植入体内是用于检测葡萄糖水平的装置和用于由感测机构确定的量分配胰岛素的装置。 感测机构使用化学溶液,其像胰岛素一样储存在形成手术植入物的一部分的储液器中。 另外提供了将这些储存器联接到皮肤表面的装置,以便允许它们以规则的时间间隔进行充电。 采用集成电路技术将不可接受的葡萄糖水平的指示转化为胰岛素的自动注射,其中电子装置的类型能够由起搏器技术中采用的电池供电。
    • 8. 发明授权
    • Mesh pouches for implantable medical devices
    • 用于可植入医疗器械的网袋
    • US08591531B2
    • 2013-11-26
    • US11936054
    • 2007-11-06
    • Fatima BuevichArikha MosesFrank DoWilliam McJamesWilliam EdelmanMason DiamondSatish Pulapura
    • Fatima BuevichArikha MosesFrank DoWilliam McJamesWilliam EdelmanMason DiamondSatish Pulapura
    • A61B17/08B65D69/00
    • A61L31/10A61B2017/00889A61B2017/00893A61B2090/0815A61L31/146A61L31/148A61L31/16A61L2300/00A61N1/375
    • Biodegradable polymer-coated surgical meshes formed into pouches are described for use with cardiac rhythm management devices (CRMs) and other implantable medical devices. Such meshes are formed into a receptacle, e.g., a pouch or other covering, capable of encasing, surrounding and/or holding the cardiac rhythm management device or other implantable medical device for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other implantable medical device. Preferred embodiments include surgical mesh pouches coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The pouches of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use, and, optionally, include one or more drugs in the polymer matrix of the coating to provide prophylactic effects and/or alleviate side effects or complications associated with the surgery or implantation of the CRM or other implantable medical device.
    • 描述形成袋的可生物降解的聚合物涂覆的手术网与心律管理装置(CRM)和其他可植入医疗装置一起使用。 这样的网状物形成为能够包围,围绕和/或保持心律管理装置或其它可植入医疗装置的容器,例如袋或其它覆盖物,以确保其在适当位置,抑制或减少细菌生长, 在CRM或其他可植入医疗设备上或周围提供疼痛缓解和/或抑制瘢痕形成或纤维化。 优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网袋,其可以通过涂覆网的细丝或纤维来暂时固定那些丝或纤维的接触点和/或通过增加网的刚度而充当硬化剂 至少是其原始刚度的1.1倍。 本发明的小袋还可以缓解与其植入,插入或手术使用相关的各种术后并发症,并且任选地在包衣的聚合物基质中包括一种或多种药物以提供预防效果和/或缓解侧 与手术或植入CRM或其他可植入医疗器械相关的影响或并发症。
    • 9. 发明授权
    • Integral optical fiber coupler
    • 一体式光纤耦合器
    • US4729621A
    • 1988-03-08
    • US710196
    • 1985-03-11
    • William Edelman
    • William Edelman
    • A61B18/20A61N5/06G02B6/42G02B6/32
    • G02B6/4203
    • A device for transferring high energy electromagnetic radiation from a laser to an optical fiber, which comprises a cone-shaped coupler having a wide proximal end and a narrow distal end, wherein the proximal end is in the form of a convex surface which acts as a focussing lens adapted to receive radiation from a laser and to transmit said radiation into and through said optical fiber and the distal end is attached to the input end of the optical fiber to form an integral assembly therewith, said cone-shaped coupler having a taper angle .theta. defined by the equation ##EQU1## wherein N.A. is the numerical aperture of the fiber material and .mu. is the refractive index of the material of the coupler at the wavelength of the incident radiation. A process for removing an obstruction by laser surgery using said device is also disclosed.
    • 一种用于将高能电磁辐射从激光传输到光纤的装置,其包括具有宽近端和窄远端的锥形耦合器,其中所述近端呈凸形表面的形式,其作为 聚焦透镜,其适于接收来自激光器的辐射并且将所述辐射传输到所述光纤中并且穿过所述光纤并且所述远端附接到所述光纤的输入端以与其形成一体的组件,所述锥形耦合器具有锥角 θ,其中NA是纤维材料的数值孔径,μ是耦合器在入射辐射波长处的材料的折射率。 还公开了通过使用所述装置的激光手术去除梗阻的过程。