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1. 发明申请

US20070198040A1 Temporarily Stiffened Mesh Prostheses 有权
标题翻译：临时加强网状假肢
公开(公告)号：US20070198040A1
公开(公告)日：2007-08-23
申请号：US11672929
申请日：2007-02-08
申请人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
发明人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
IPC分类号： A61F2/02 , B05D1/02
CPC分类号： A61F2/0063 , A61F2210/0004 , A61F2250/0067 , A61F2310/0097 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/402 , A61L2300/404 , A61L2300/406 , A61L2300/416 , A61L2300/45 , A61L2300/606 , A61L2430/02
摘要： The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general.
摘要翻译：本发明涉及医用假体及其制造方法。特别地，假体是具有特定涂层的临时硬化网，以提供初始刚度，从而允许更容易的手术处理以用于治疗或重建软组织缺陷。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网，所述可生物降解的聚合物可以通过涂覆网状物的细丝或纤维来临时固定那些丝或纤维的接触点和/或通过增加网状物的刚度至少是原始刚度的1.1倍。本发明的装置还可以提供与其植入，插入或手术使用相关的各种术后并发症的缓解。通过将生物活性剂和/或药物包括在涂层中，这些装置通常提供与手术或使用假体相关的副作用或并发症的预防和可以减轻。

2. 发明授权

US08636753B2 Temporarily stiffened mesh prostheses 有权
标题翻译：临时硬化网眼假体
公开(公告)号：US08636753B2
公开(公告)日：2014-01-28
申请号：US11672929
申请日：2007-02-08
申请人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
发明人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
IPC分类号： A61F2/02 , B05D1/02
CPC分类号： A61F2/0063 , A61F2210/0004 , A61F2250/0067 , A61F2310/0097 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/402 , A61L2300/404 , A61L2300/406 , A61L2300/416 , A61L2300/45 , A61L2300/606 , A61L2430/02
摘要： The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general.
摘要翻译：本发明涉及医用假体及其制造方法。特别地，假体是具有特定涂层的临时硬化网，以提供初始刚度，从而允许更容易的手术处理以用于治疗或重建软组织缺陷。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网，所述可生物降解的聚合物可以通过涂覆网状物的细丝或纤维来临时固定那些丝或纤维的接触点和/或通过增加网状物的刚度至少是原始刚度的1.1倍。本发明的装置还可以提供与其植入，插入或手术使用相关的各种术后并发症的缓解。通过将生物活性剂和/或药物包括在涂层中，这些装置通常提供与手术或使用假体相关的副作用或并发症的预防和可以减轻。

3. 发明申请

US20080132922A1 Mesh Pouches for Implantable Medical Devices 有权
标题翻译：用于植入式医疗器械的网袋
公开(公告)号：US20080132922A1
公开(公告)日：2008-06-05
申请号：US11936054
申请日：2007-11-06
申请人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
发明人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
IPC分类号： A61B17/08 , B65D69/00
CPC分类号： A61L31/10 , A61B2017/00889 , A61B2017/00893 , A61B2090/0815 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/00 , A61N1/375
摘要： Biodegradable polymer-coated surgical meshes formed into pouches are described for use with cardiac rhythm management devices (CRMs) and other implantable medical devices. Such meshes are formed into a receptacle, e.g., a pouch or other covering, capable of encasing, surrounding and/or holding the cardiac rhythm management device or other implantable medical device for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other implantable medical device. Preferred embodiments include surgical mesh pouches coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The pouches of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use, and, optionally, include one or more drugs in the polymer matrix of the coating to provide prophylactic effects and/or alleviate side effects or complications associated with the surgery or implantation of the CRM or other implantable medical device.
摘要翻译：描述形成袋的可生物降解的聚合物涂覆的手术网与心律管理装置（CRM）和其他可植入医疗装置一起使用。这样的网状物形成为能够包围，围绕和/或保持心律管理装置或其它可植入医疗装置的容器，例如袋或其它覆盖物，以确保其在适当位置，抑制或减少细菌生长，在CRM或其他可植入医疗设备上或周围提供疼痛缓解和/或抑制瘢痕形成或纤维化。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网袋，其可以通过涂覆网的细丝或纤维来暂时固定那些丝或纤维的接触点和/或通过增加网的刚度而充当硬化剂至少是其原始刚度的1.1倍。本发明的小袋还可以缓解与其植入，插入或手术使用相关的各种术后并发症，并且任选地在包衣的聚合物基质中包括一种或多种药物以提供预防效果和/或缓解侧与手术或植入CRM或其他可植入医疗器械相关的影响或并发症。

4. 发明申请

US20090018559A1 Temporarily Stiffened Mesh Prostheses 审中-公开
标题翻译：临时加强网状假肢
公开(公告)号：US20090018559A1
公开(公告)日：2009-01-15
申请号：US11936049
申请日：2007-11-06
申请人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
发明人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
IPC分类号： A61B17/08 , A61F2/02
CPC分类号： A61F2/0063 , A61F2210/0004 , A61F2250/0067 , A61F2310/0097 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/402 , A61L2300/404 , A61L2300/406 , A61L2300/416 , A61L2300/45 , A61L2300/606 , A61L2430/02
摘要： The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general.
摘要翻译：本发明涉及医用假体及其制造方法。特别地，假体是具有特定涂层的临时硬化网，以提供初始刚度，从而允许更容易的手术处理以用于治疗或重建软组织缺陷。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网，所述可生物降解的聚合物可以通过涂覆网状物的细丝或纤维来临时固定那些丝或纤维的接触点和/或通过增加网状物的刚度至少是原始刚度的1.1倍。本发明的装置还可以提供与其植入，插入或手术使用相关的各种术后并发症的缓解。通过将生物活性剂和/或药物包括在涂层中，这些装置通常提供与手术或使用假体相关的副作用或并发症的预防和可以减轻。

5. 发明授权

US08591531B2 Mesh pouches for implantable medical devices 有权
标题翻译：用于可植入医疗器械的网袋
公开(公告)号：US08591531B2
公开(公告)日：2013-11-26
申请号：US11936054
申请日：2007-11-06
申请人： Fatima Buevich , Arikha Moses , Frank Do , William McJames , William Edelman , Mason Diamond , Satish Pulapura
发明人： Fatima Buevich , Arikha Moses , Frank Do , William McJames , William Edelman , Mason Diamond , Satish Pulapura
IPC分类号： A61B17/08 , B65D69/00
CPC分类号： A61L31/10 , A61B2017/00889 , A61B2017/00893 , A61B2090/0815 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/00 , A61N1/375
摘要： Biodegradable polymer-coated surgical meshes formed into pouches are described for use with cardiac rhythm management devices (CRMs) and other implantable medical devices. Such meshes are formed into a receptacle, e.g., a pouch or other covering, capable of encasing, surrounding and/or holding the cardiac rhythm management device or other implantable medical device for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other implantable medical device. Preferred embodiments include surgical mesh pouches coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The pouches of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use, and, optionally, include one or more drugs in the polymer matrix of the coating to provide prophylactic effects and/or alleviate side effects or complications associated with the surgery or implantation of the CRM or other implantable medical device.
摘要翻译：描述形成袋的可生物降解的聚合物涂覆的手术网与心律管理装置（CRM）和其他可植入医疗装置一起使用。这样的网状物形成为能够包围，围绕和/或保持心律管理装置或其它可植入医疗装置的容器，例如袋或其它覆盖物，以确保其在适当位置，抑制或减少细菌生长，在CRM或其他可植入医疗设备上或周围提供疼痛缓解和/或抑制瘢痕形成或纤维化。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网袋，其可以通过涂覆网的细丝或纤维来暂时固定那些丝或纤维的接触点和/或通过增加网的刚度而充当硬化剂至少是其原始刚度的1.1倍。本发明的小袋还可以缓解与其植入，插入或手术使用相关的各种术后并发症，并且任选地在包衣的聚合物基质中包括一种或多种药物以提供预防效果和/或缓解侧与手术或植入CRM或其他可植入医疗器械相关的影响或并发症。

6. 发明申请

US20080128315A1 Resorbable Pouches for Implantable Medical Devices 有权
标题翻译：可植入医疗器械的可再吸收袋
公开(公告)号：US20080128315A1
公开(公告)日：2008-06-05
申请号：US11936051
申请日：2007-11-06
申请人： Fatima Buevich , Frank Do , William McJames , William Edelman , Arikha Moses , Mason Diamond
发明人： Fatima Buevich , Frank Do , William McJames , William Edelman , Arikha Moses , Mason Diamond
IPC分类号： A61B19/02 , B65D69/00 , A61K31/445 , A61K31/496 , A61K31/195 , A61P23/00 , A61P31/00
CPC分类号： A61B50/30 , A61B2017/00004 , A61B2017/00889 , A61B2017/00893 , A61B2050/314 , A61B2090/0815 , A61K31/195 , A61K31/445 , A61K31/496 , A61L31/04 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/45 , A61L2400/18 , A61N1/375
摘要： Biodegradable and resorbable polymer pouches are described for use with cardiac rhythm mamagent devices (CRMs) and other implantable medical devices (IMDs), i.e., a pouch, covering, or other receptacle capable of encasing, surrounding and/or holding the CRM or other IMD for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other IMD. Optionally, the biodegradable and resorbable pouches of the invention include one or more drugs in the polymer matrix to provide prophylactic effects and alleviate side effects or complications associated with the surgery or implantation of the CRM or other IMD.
摘要翻译：描述了可生物降解和可再吸收的聚合物袋用于心律疗法装置（CRMs）和其他可植入医疗装置（IMD），即可以封装，围绕和/或保持CRM或其他IMD的袋，覆盖物或其他插座以确保其在适当位置，抑制或减少细菌生长，在CRM或其他IMD上或周围提供止痛和/或抑制瘢痕形成或纤维化。任选地，本发明的可生物降解和可再吸收的袋包括聚合物基质中的一种或多种药物以提供预防效果并减轻与手术或植入CRM或其他IMD相关的副作用或并发症。

7. 发明授权

US09023114B2 Resorbable pouches for implantable medical devices 有权
标题翻译：可植入医疗器械的可吸收袋
公开(公告)号：US09023114B2
公开(公告)日：2015-05-05
申请号：US11936051
申请日：2007-11-06
申请人： Fatima Buevich , Frank Do , William McJames , William Edelman , Arikha Moses , Mason Diamond
发明人： Fatima Buevich , Frank Do , William McJames , William Edelman , Arikha Moses , Mason Diamond
IPC分类号： B65D83/10 , A61F2/02 , A61B19/02 , A61K31/195 , A61K31/445 , A61K31/496 , A61L31/14 , A61L31/16 , A61B17/00 , A61B19/00 , A61N1/375
CPC分类号： A61B50/30 , A61B2017/00004 , A61B2017/00889 , A61B2017/00893 , A61B2050/314 , A61B2090/0815 , A61K31/195 , A61K31/445 , A61K31/496 , A61L31/04 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/45 , A61L2400/18 , A61N1/375
摘要： Biodegradable and resorbable polymer pouches are described for use with cardiac rhythm mamagent devices (CRMs) and other implantable medical devices (IMDs), i.e., a pouch, covering, or other receptacle capable of encasing, surrounding and/or holding the CRM or other IMD for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other IMD. Optionally, the biodegradable and resorbable pouches of the invention include one or more drugs in the polymer matrix to provide prophylactic effects and alleviate side effects or complications associated with the surgery or implantation of the CRM or other IMD.
摘要翻译：描述了可生物降解和可再吸收的聚合物袋用于心律疗法装置（CRMs）和其他可植入医疗装置（IMD），即可以封装，围绕和/或保持CRM或其他IMD的袋，覆盖物或其他插座以确保其在适当位置，抑制或减少细菌生长，在CRM或其他IMD上或周围提供止痛和/或抑制瘢痕形成或纤维化。任选地，本发明的可生物降解和可再吸收的袋包括聚合物基质中的一种或多种药物以提供预防效果并减轻与手术或植入CRM或其他IMD相关的副作用或并发症。

8. 发明申请

US20100015237A1 NSAID Delivery from Polyarylates 有权
标题翻译：聚芳酯的NSAID递送
公开(公告)号：US20100015237A1
公开(公告)日：2010-01-21
申请号：US12499399
申请日：2009-07-08
申请人： Arikha Moses , Fatima Buevich , Satish Pulapura , Arvind Viswanathan
发明人： Arikha Moses , Fatima Buevich , Satish Pulapura , Arvind Viswanathan
IPC分类号： A61K9/14 , A61K31/192 , A61P29/00
CPC分类号： A61K31/195 , A61B17/06166 , A61B2017/00893
摘要： This invention provides biodegradable, sustained-release pharmaceutical compositions of non-steroidal, anti-inflammatory drugs (NSAIDs) formulated with biocompatible, biodegradable tyrosine-derived polyarylates. The compositionsare particularly suitable for localized delivery of NSAIDs for various disease states. For example, implantation of the compositions at the site of surgery leads to relatively high local concentrations of the NSAID to reduce or alleviate post-surgical pain. Long term zero order release of certain NSAIDs can also be provided by with certain polymer formulations.
摘要翻译：本发明提供用生物相容性，可生物降解的酪氨酸衍生的多芳基化合物配制的非甾体抗炎药（NSAID）的可生物降解的持续释放药物组合物。该组合物特别适用于各种疾病状态的NSAID的局部递送。例如，在手术部位植入组合物导致NSAID的局部浓度相对较高以减少或减轻手术后疼痛。某些NSAIDs的长期零级释放也可以通过某些聚合物配方提供。

9. 发明申请

US20110294760A1 Compositions and Methods for Preventing Sternal Wound Infections 有权
标题翻译：防止胸骨伤口感染的组合物和方法
公开(公告)号：US20110294760A1
公开(公告)日：2011-12-01
申请号：US12791586
申请日：2010-06-01
申请人： Raman Bahulekar , Arikha Moses , Satish Pulapura , William C. McJames, II , Fatima Buevich
发明人： Raman Bahulekar , Arikha Moses , Satish Pulapura , William C. McJames, II , Fatima Buevich
IPC分类号： A61K31/65 , A61K31/496 , A61P31/00 , A61K31/43
CPC分类号： A61K31/43 , A61K9/1647 , A61K31/496 , A61K31/65
摘要： The invention generally relates to compositions and methods for preventing sternal wound infections, such as mediastinitis. In certain embodiments, the invention provides an antimicrobial composition including at least one bioresorbable polymer, such as a tyrosine-derived polyesteramide, and at least one antimicrobial agent, in which the composition is adapted to be topically applied to an esophageal perforation in a subject or a median sternotomy incision site in the subject, and in which the at least one antimicrobial agent is present in an amount effective to inhibit development of mediastinitis in the subject.
摘要翻译：本发明一般涉及用于预防胸骨伤口感染如纵隔炎的组合物和方法。在某些实施方案中，本发明提供了包含至少一种生物可再吸收的聚合物，例如酪氨酸衍生的聚酯酰胺和至少一种抗微生物剂的抗微生物组合物，其中所述组合物适于局部施用于受试者的食道穿孔，或在受试者中的中位胸骨切开术切口部位，其中所述至少一种抗微生物剂以有效抑制受试者纵隔炎发展的量存在。

10. 发明授权

US09839628B2 Compositions and methods for preventing sternal wound infections 有权
公开(公告)号：US09839628B2
公开(公告)日：2017-12-12
申请号：US12791586
申请日：2010-06-01
申请人： Raman Bahulekar , Arikha Moses , Satish Pulapura , William C. McJames, II , Fatima Buevich
发明人： Raman Bahulekar , Arikha Moses , Satish Pulapura , William C. McJames, II , Fatima Buevich
IPC分类号： A61K31/445 , A61K31/43 , A61K9/16 , A61K31/496 , A61K31/65
CPC分类号： A61K31/43 , A61K9/1647 , A61K31/496 , A61K31/65
摘要： The invention generally relates to compositions and methods for preventing sternal wound infections, such as mediastinitis. In certain embodiments, the invention provides an antimicrobial composition including at least one bioresorbable polymer, such as a tyrosine-derived polyesteramide, and at least one antimicrobial agent, in which the composition is adapted to be topically applied to an esophageal perforation in a subject or a median sternotomy incision site in the subject, and in which the at least one antimicrobial agent is present in an amount effective to inhibit development of mediastinitis in the subject.

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