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1. 发明申请

US20070198040A1 Temporarily Stiffened Mesh Prostheses 有权
标题翻译：临时加强网状假肢
公开(公告)号：US20070198040A1
公开(公告)日：2007-08-23
申请号：US11672929
申请日：2007-02-08
申请人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
发明人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
IPC分类号： A61F2/02 , B05D1/02
CPC分类号： A61F2/0063 , A61F2210/0004 , A61F2250/0067 , A61F2310/0097 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/402 , A61L2300/404 , A61L2300/406 , A61L2300/416 , A61L2300/45 , A61L2300/606 , A61L2430/02
摘要： The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general.
摘要翻译：本发明涉及医用假体及其制造方法。特别地，假体是具有特定涂层的临时硬化网，以提供初始刚度，从而允许更容易的手术处理以用于治疗或重建软组织缺陷。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网，所述可生物降解的聚合物可以通过涂覆网状物的细丝或纤维来临时固定那些丝或纤维的接触点和/或通过增加网状物的刚度至少是原始刚度的1.1倍。本发明的装置还可以提供与其植入，插入或手术使用相关的各种术后并发症的缓解。通过将生物活性剂和/或药物包括在涂层中，这些装置通常提供与手术或使用假体相关的副作用或并发症的预防和可以减轻。

2. 发明授权

US08636753B2 Temporarily stiffened mesh prostheses 有权
标题翻译：临时硬化网眼假体
公开(公告)号：US08636753B2
公开(公告)日：2014-01-28
申请号：US11672929
申请日：2007-02-08
申请人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
发明人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
IPC分类号： A61F2/02 , B05D1/02
CPC分类号： A61F2/0063 , A61F2210/0004 , A61F2250/0067 , A61F2310/0097 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/402 , A61L2300/404 , A61L2300/406 , A61L2300/416 , A61L2300/45 , A61L2300/606 , A61L2430/02
摘要： The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general.
摘要翻译：本发明涉及医用假体及其制造方法。特别地，假体是具有特定涂层的临时硬化网，以提供初始刚度，从而允许更容易的手术处理以用于治疗或重建软组织缺陷。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网，所述可生物降解的聚合物可以通过涂覆网状物的细丝或纤维来临时固定那些丝或纤维的接触点和/或通过增加网状物的刚度至少是原始刚度的1.1倍。本发明的装置还可以提供与其植入，插入或手术使用相关的各种术后并发症的缓解。通过将生物活性剂和/或药物包括在涂层中，这些装置通常提供与手术或使用假体相关的副作用或并发症的预防和可以减轻。

3. 发明申请

US20080132922A1 Mesh Pouches for Implantable Medical Devices 有权
标题翻译：用于植入式医疗器械的网袋
公开(公告)号：US20080132922A1
公开(公告)日：2008-06-05
申请号：US11936054
申请日：2007-11-06
申请人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
发明人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
IPC分类号： A61B17/08 , B65D69/00
CPC分类号： A61L31/10 , A61B2017/00889 , A61B2017/00893 , A61B2090/0815 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/00 , A61N1/375
摘要： Biodegradable polymer-coated surgical meshes formed into pouches are described for use with cardiac rhythm management devices (CRMs) and other implantable medical devices. Such meshes are formed into a receptacle, e.g., a pouch or other covering, capable of encasing, surrounding and/or holding the cardiac rhythm management device or other implantable medical device for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other implantable medical device. Preferred embodiments include surgical mesh pouches coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The pouches of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use, and, optionally, include one or more drugs in the polymer matrix of the coating to provide prophylactic effects and/or alleviate side effects or complications associated with the surgery or implantation of the CRM or other implantable medical device.
摘要翻译：描述形成袋的可生物降解的聚合物涂覆的手术网与心律管理装置（CRM）和其他可植入医疗装置一起使用。这样的网状物形成为能够包围，围绕和/或保持心律管理装置或其它可植入医疗装置的容器，例如袋或其它覆盖物，以确保其在适当位置，抑制或减少细菌生长，在CRM或其他可植入医疗设备上或周围提供疼痛缓解和/或抑制瘢痕形成或纤维化。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网袋，其可以通过涂覆网的细丝或纤维来暂时固定那些丝或纤维的接触点和/或通过增加网的刚度而充当硬化剂至少是其原始刚度的1.1倍。本发明的小袋还可以缓解与其植入，插入或手术使用相关的各种术后并发症，并且任选地在包衣的聚合物基质中包括一种或多种药物以提供预防效果和/或缓解侧与手术或植入CRM或其他可植入医疗器械相关的影响或并发症。

4. 发明申请

US20090018559A1 Temporarily Stiffened Mesh Prostheses 审中-公开
标题翻译：临时加强网状假肢
公开(公告)号：US20090018559A1
公开(公告)日：2009-01-15
申请号：US11936049
申请日：2007-11-06
申请人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
发明人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
IPC分类号： A61B17/08 , A61F2/02
CPC分类号： A61F2/0063 , A61F2210/0004 , A61F2250/0067 , A61F2310/0097 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/402 , A61L2300/404 , A61L2300/406 , A61L2300/416 , A61L2300/45 , A61L2300/606 , A61L2430/02
摘要： The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general.
摘要翻译：本发明涉及医用假体及其制造方法。特别地，假体是具有特定涂层的临时硬化网，以提供初始刚度，从而允许更容易的手术处理以用于治疗或重建软组织缺陷。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网，所述可生物降解的聚合物可以通过涂覆网状物的细丝或纤维来临时固定那些丝或纤维的接触点和/或通过增加网状物的刚度至少是原始刚度的1.1倍。本发明的装置还可以提供与其植入，插入或手术使用相关的各种术后并发症的缓解。通过将生物活性剂和/或药物包括在涂层中，这些装置通常提供与手术或使用假体相关的副作用或并发症的预防和可以减轻。

5. 发明授权

US08591531B2 Mesh pouches for implantable medical devices 有权
标题翻译：用于可植入医疗器械的网袋
公开(公告)号：US08591531B2
公开(公告)日：2013-11-26
申请号：US11936054
申请日：2007-11-06
申请人： Fatima Buevich , Arikha Moses , Frank Do , William McJames , William Edelman , Mason Diamond , Satish Pulapura
发明人： Fatima Buevich , Arikha Moses , Frank Do , William McJames , William Edelman , Mason Diamond , Satish Pulapura
IPC分类号： A61B17/08 , B65D69/00
CPC分类号： A61L31/10 , A61B2017/00889 , A61B2017/00893 , A61B2090/0815 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/00 , A61N1/375
摘要： Biodegradable polymer-coated surgical meshes formed into pouches are described for use with cardiac rhythm management devices (CRMs) and other implantable medical devices. Such meshes are formed into a receptacle, e.g., a pouch or other covering, capable of encasing, surrounding and/or holding the cardiac rhythm management device or other implantable medical device for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other implantable medical device. Preferred embodiments include surgical mesh pouches coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The pouches of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use, and, optionally, include one or more drugs in the polymer matrix of the coating to provide prophylactic effects and/or alleviate side effects or complications associated with the surgery or implantation of the CRM or other implantable medical device.
摘要翻译：描述形成袋的可生物降解的聚合物涂覆的手术网与心律管理装置（CRM）和其他可植入医疗装置一起使用。这样的网状物形成为能够包围，围绕和/或保持心律管理装置或其它可植入医疗装置的容器，例如袋或其它覆盖物，以确保其在适当位置，抑制或减少细菌生长，在CRM或其他可植入医疗设备上或周围提供疼痛缓解和/或抑制瘢痕形成或纤维化。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网袋，其可以通过涂覆网的细丝或纤维来暂时固定那些丝或纤维的接触点和/或通过增加网的刚度而充当硬化剂至少是其原始刚度的1.1倍。本发明的小袋还可以缓解与其植入，插入或手术使用相关的各种术后并发症，并且任选地在包衣的聚合物基质中包括一种或多种药物以提供预防效果和/或缓解侧与手术或植入CRM或其他可植入医疗器械相关的影响或并发症。

6. 发明申请

US20080128315A1 Resorbable Pouches for Implantable Medical Devices 有权
标题翻译：可植入医疗器械的可再吸收袋
公开(公告)号：US20080128315A1
公开(公告)日：2008-06-05
申请号：US11936051
申请日：2007-11-06
申请人： Fatima Buevich , Frank Do , William McJames , William Edelman , Arikha Moses , Mason Diamond
发明人： Fatima Buevich , Frank Do , William McJames , William Edelman , Arikha Moses , Mason Diamond
IPC分类号： A61B19/02 , B65D69/00 , A61K31/445 , A61K31/496 , A61K31/195 , A61P23/00 , A61P31/00
CPC分类号： A61B50/30 , A61B2017/00004 , A61B2017/00889 , A61B2017/00893 , A61B2050/314 , A61B2090/0815 , A61K31/195 , A61K31/445 , A61K31/496 , A61L31/04 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/45 , A61L2400/18 , A61N1/375
摘要： Biodegradable and resorbable polymer pouches are described for use with cardiac rhythm mamagent devices (CRMs) and other implantable medical devices (IMDs), i.e., a pouch, covering, or other receptacle capable of encasing, surrounding and/or holding the CRM or other IMD for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other IMD. Optionally, the biodegradable and resorbable pouches of the invention include one or more drugs in the polymer matrix to provide prophylactic effects and alleviate side effects or complications associated with the surgery or implantation of the CRM or other IMD.
摘要翻译：描述了可生物降解和可再吸收的聚合物袋用于心律疗法装置（CRMs）和其他可植入医疗装置（IMD），即可以封装，围绕和/或保持CRM或其他IMD的袋，覆盖物或其他插座以确保其在适当位置，抑制或减少细菌生长，在CRM或其他IMD上或周围提供止痛和/或抑制瘢痕形成或纤维化。任选地，本发明的可生物降解和可再吸收的袋包括聚合物基质中的一种或多种药物以提供预防效果并减轻与手术或植入CRM或其他IMD相关的副作用或并发症。

7. 发明授权

US09023114B2 Resorbable pouches for implantable medical devices 有权
标题翻译：可植入医疗器械的可吸收袋
公开(公告)号：US09023114B2
公开(公告)日：2015-05-05
申请号：US11936051
申请日：2007-11-06
申请人： Fatima Buevich , Frank Do , William McJames , William Edelman , Arikha Moses , Mason Diamond
发明人： Fatima Buevich , Frank Do , William McJames , William Edelman , Arikha Moses , Mason Diamond
IPC分类号： B65D83/10 , A61F2/02 , A61B19/02 , A61K31/195 , A61K31/445 , A61K31/496 , A61L31/14 , A61L31/16 , A61B17/00 , A61B19/00 , A61N1/375
CPC分类号： A61B50/30 , A61B2017/00004 , A61B2017/00889 , A61B2017/00893 , A61B2050/314 , A61B2090/0815 , A61K31/195 , A61K31/445 , A61K31/496 , A61L31/04 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/45 , A61L2400/18 , A61N1/375
摘要： Biodegradable and resorbable polymer pouches are described for use with cardiac rhythm mamagent devices (CRMs) and other implantable medical devices (IMDs), i.e., a pouch, covering, or other receptacle capable of encasing, surrounding and/or holding the CRM or other IMD for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other IMD. Optionally, the biodegradable and resorbable pouches of the invention include one or more drugs in the polymer matrix to provide prophylactic effects and alleviate side effects or complications associated with the surgery or implantation of the CRM or other IMD.
摘要翻译：描述了可生物降解和可再吸收的聚合物袋用于心律疗法装置（CRMs）和其他可植入医疗装置（IMD），即可以封装，围绕和/或保持CRM或其他IMD的袋，覆盖物或其他插座以确保其在适当位置，抑制或减少细菌生长，在CRM或其他IMD上或周围提供止痛和/或抑制瘢痕形成或纤维化。任选地，本发明的可生物降解和可再吸收的袋包括聚合物基质中的一种或多种药物以提供预防效果并减轻与手术或植入CRM或其他IMD相关的副作用或并发症。

8. 发明授权

US10322206B2 Compositions and methods for wound healing 有权
公开(公告)号：US10322206B2
公开(公告)日：2019-06-18
申请号：US15472330
申请日：2017-03-29
申请人： George Pins , Glenn Gaudette , Adam Collette , William Edelman
发明人： George Pins , Glenn Gaudette , Adam Collette , William Edelman
IPC分类号： A61L17/08 , A61L17/10 , A61L17/12
摘要： The present invention relates, in part, to sutures which promote wound closure and/or healing. In particular, the present invention provides fibrin microthread sutures that mimic the mechanical behavior of a target tissue thereby reducing, for example, scarring, inflammation, and cell death at the ligature site, including monofilament sutures.

9. 发明授权

US5876397A Reduction of an arteriosclerotic lesion by selective absorption of electromagnetic energy in a component thereof 失效
标题翻译：通过在其组件中选择性吸收电磁能来减少动脉硬化病变
公开(公告)号：US5876397A
公开(公告)日：1999-03-02
申请号：US953329
申请日：1992-09-29
申请人： William Edelman , Robert F. Rosenbluth , Dennis Constantinou
发明人： William Edelman , Robert F. Rosenbluth , Dennis Constantinou
IPC分类号： A61B18/22 , A61B18/24 , A61B18/28 , A61B17/36
CPC分类号： A61B18/28 , A61B18/245 , A61B2018/2261
摘要： A novel method for reducing an arteriosclerotic lesion is disclosed in which the electromagnetic energy directed at the lesion is selectively absorbed by a lesion component, e.g. cholesterol. The resulting decomposition of said lesion component leads to reduction of the lesion with minimal risk of damage to blood constituents and adjacent healthy blood vessel tissue. Preferably, monochromatic electromagnetic energy is generated by a laser and is conducted to the vicinity of the lesion by at least one optical fiber.
摘要翻译：公开了一种用于减少动脉硬化病变的新方法，其中指向病变的电磁能量被病变部件选择性地吸收，例如，胆固醇。由此导致的所述损伤组分的分解导致损伤的减少，同时对血液成分和相邻的健康血管组织的损伤风险最小。优选地，单色电磁能量由激光产生，并通过至少一根光纤传导到病变附近。

10. 发明授权

US5865721A Intra-aortic balloon catheters 失效
标题翻译：主动脉内气囊导管
公开(公告)号：US5865721A
公开(公告)日：1999-02-02
申请号：US658386
申请日：1996-06-05
申请人： Robert R. Andrews , William Edelman , Joseph A. Levendusky , Robert L. O'Brien
发明人： Robert R. Andrews , William Edelman , Joseph A. Levendusky , Robert L. O'Brien
IPC分类号： A61F2/958 , A61M1/10 , A61M25/00 , B29C41/14 , B29C55/22 , A61N1/362
CPC分类号： B29C55/22 , A61M1/1072 , A61M25/1029 , A61M25/1034 , B29C41/14 , A61M25/0045 , A61M25/10 , B29L2031/7542
摘要： An intra-aortic balloon pump catheter includes an inner lumen formed by a thin walled superelastic metal alloy tube, namely of nitinol, with an inside diameter sufficient for a guidewire and a small outside diameter which allows reduction of the outer lumen and related components by at least one size French while providing gas shuttle capacity between the lumens for conventional intra-aortic balloon pump operation. The outer lumen is a tube formed of co-extruded plastics to enhance the size reduction and capacity goals, with an inner nylon portion for strength and a relatively thin polyurethane outer portion for biocompatability, flexibility and compatibility for bonding to a thin polyurethane balloon. The proximal end sleeve of the balloon is stretched and then stress-relieved by heating with an internal heater on a mounting mandrel to effect a desired small diameter sizing. A radiopaque metal marker ring of nitinol also is provided to improve imaging capabilities while being compatible with the lumen materials.
摘要翻译：主动脉内球囊泵导管包括由薄壁超弹性金属合金管（即镍钛诺）形成的内腔，其具有足以用于导丝的内径和小的外径，其允许通过以下方式减少外腔和相关部件至少一个尺寸的法国人，同时在传统的主动脉内球囊泵操作的腔之间提供气体穿梭能力。外腔是由共挤塑料形成的管，以增强尺寸减小和容量目标，其具有用于强度的内部尼龙部分和用于生物相容性的相对薄的聚氨酯外部部分，用于粘合到薄的聚氨酯气球的柔性和相容性。气囊的近端套筒被拉伸，然后通过用安装心轴上的内部加热器加热来减轻应力，以实现所需的小直径尺寸。还提供镍钛诺的不透射线的金属标记环以提高成像能力，同时与管腔材料相容。

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