会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 5. 发明授权
    • Preparation of 5-vinylpyrrolidones
    • 5-乙烯基吡咯烷酮的制备
    • US5496958A
    • 1996-03-05
    • US266141
    • 1994-06-27
    • Rolf FischerWerner HoffmannErnst LangguthHardo Siegel
    • Rolf FischerWerner HoffmannErnst LangguthHardo Siegel
    • C07D207/26C07D207/267
    • C07D207/267
    • A process for the preparation of a 5-vinylpyrrolidone of the formula ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen or alkyl and R.sup.3 is preferably hydrogen but may further represent alkyl, cycloalkyl, aryl, alkylaryl, arylalkyl or a 5- to 6-membered aromatic or non-aromatic heterocyclic group containing 1 to 3 nitrogen atoms and/or an oxygen or sulfur atom, the process being carried out in two steps, first to react a 3-formylpropionic acid ester of the formula ##STR2## where each of R.sup.1 and R.sup.2 is hydrogen or C.sub.1 -C.sub.8 -alkyl, and R.sup.4 is hydrogen, alkyl, cycloalkyl, aryl, alkylaryl or arylalkyl, with a vinylymagnesium halide of the formulaCH.sub.2 .dbd.CH--Mg--X V,where X is chlorine, bromine or iodine, at a temperature of from -30.degree. to 100.degree. C., under a pressure from 0.001 to 10 bar and in a molar ratio of V:IV of from 0.3:1 to 3:1 to obtain as an intermediate product a gamma-vinylbutyrolactone of the formula ##STR3## where R.sup.1 and R.sup.2 have the abovementioned meaning; and then reacting said intermediate of the formula II with ammonia or a primary amine of the formulaR.sup.3 --NH.sub.2 III,where R.sup.3 has the abovementioned meaning, at a temperature of from 150.degree. to 350.degree. C. and under a pressure of from 0.1 to 200 bar.
    • 制备式I的5-乙烯基吡咯烷酮的方法,其中R1和R2各自为氢或烷基,R3优选为氢,但可进一步代表烷基,环烷基,芳基,烷基芳基,芳基烷基或5-至 含有1至3个氮原子和/或氧或硫原子的6元芳族或非芳族杂环基,该方法分两个步骤进行,首先使式(IV)的3-甲酰基丙酸酯与式 其中R1和R2各自为氢或C1-C8-烷基,R4为氢,烷基,环烷基,芳基,烷基芳基或芳基烷基,与式CH2 = CH-Mg-XV的卤化镁,其中X为氯 ,溴或碘,在-30℃至100℃的温度下,在0.001至10巴的压力下,V:IV的摩尔比为0.3:1至3:1,以获得中间体 产生式为“IMAGE”II的γ-乙烯基丁内酯,其中R1和R2具有上述含义; 然后使式II的中间体与式(III-NH2)III的氨或伯胺反应,其中R 3具有上述含义,在150℃至350℃的温度和0.1至 200吧。