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1. 发明申请

US20210382038A1 METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING 有权
公开(公告)号：US20210382038A1
公开(公告)日：2021-12-09
申请号：US17354521
申请日：2021-06-22
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： Freddy RADTKE , Rajwinder LEHAL , Viktoria REINMÜLLER , Jieping ZHU
IPC分类号： G01N33/50 , G01N33/574 , G01N33/53 , C12N15/63 , G01N33/68 , C12N15/09 , A61K31/351 , A61K31/407 , A61K31/44 , A61P35/00 , A61K31/09 , A61K45/06 , A61N5/10 , C07C205/38 , C07C217/90 , C07D213/64 , C07D213/73 , C12Q1/6897
摘要： The present invention relates to use of inhibitors of Notch signalling pathway selected from the group consisting of 6-(4-Tert-Butylphenoxy)Pyridin-3-Amine (I3), its derivatives, in treating and/or preventing cancers.

2. 发明授权

US11021413B2 Benzylpropargylether as nitrification inhibitors 有权
公开(公告)号：US11021413B2
公开(公告)日：2021-06-01
申请号：US15526581
申请日：2015-11-13
申请人： BASF SE
发明人： Barbara Navé , Joachim Dickhaut , Mihiret Tekeste Sisay , Alexander Wissemeier , Wolfram Zerulla , Gregor Pasda , Wolfgang Weigelt
IPC分类号： C07C43/176 , C05G3/90 , C05C3/00 , C07C43/215 , C07C43/285 , C07C43/29 , C07C65/28 , C07C205/34 , C07C205/38 , C07C235/42 , C07C255/54 , C07D249/08
摘要： The present invention relates to the use of compounds of formula (I) for reducing nitrification and to compositions comprising the compounds of formula (I) and to agricultural mixtures comprising at least one compound of formula (I) and at least one fertilizer. Furthermore, the present invention relates to a method for reducing nitrification comprising treating a plant growing on soil or soil substituents and/or the locus or soil or soil substituents where the plant is growing or is intended to grow with a compound of formula (I) or a composition comprising a compound of formula (I).

3. 发明申请

US20200068886A1 HALOGEN-SUBSTITUTED PHENOXYPHENYLAMIDINES AND THE USE THEREOF AS FUNGICIDES 审中-公开
公开(公告)号：US20200068886A1
公开(公告)日：2020-03-05
申请号：US16675336
申请日：2019-11-06
申请人： Bayer CropScience Aktiengesellschaft
发明人： Stefan HILLEBRAND , Mazen ES-SAYED , Ulrike WACHENDORFF-NEUMANN , Stephane BRUNET
IPC分类号： A01N37/52 , C07C257/18 , C07C205/38 , C07C217/90 , C07C257/12
摘要： The present invention relates to halogen-substituted phenoxyphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to an agrochemical formulation for this purpose, comprising the halogen-substituted phenoxyphenylamidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.

4. 发明申请

US20110313199A1 PROCESSES FOR PREPARING SUBSTANTIALLY PURE ARFORMOTEROL AND ITS INTERMEDIATES 审中-公开
标题翻译：制备实质性固醇及其中间体的方法
公开(公告)号：US20110313199A1
公开(公告)日：2011-12-22
申请号：US13141167
申请日：2009-12-28
申请人： Girish Dixit , Nandkumar Gaikwad , Nitin Sharadchandra Pradhan
发明人： Girish Dixit , Nandkumar Gaikwad , Nitin Sharadchandra Pradhan
IPC分类号： C07C233/88 , C07B57/00 , C07C213/02 , C07C209/28 , C07C205/37 , C07C205/38
CPC分类号： C07C213/08 , C07B2200/07 , C07C201/12 , C07C213/02 , C07C213/10 , C07C231/02 , C07D301/26 , C07C205/37 , C07C217/68 , C07C217/86 , C07C233/43
摘要： Provided herein are improved, convenient and industrially advantageous processes for the preparation of N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide (Arformoterol) or a pharmaceutically acceptable salt thereof, in high yield and purity. Provided further herein is an improved and industrially advantageous process for the preparation of a substantially enantiomerically pure arformoterol intermediate, (R)-4-methoxy-α-methyl-N-(phenylmethyl)benzeneethanamine.
摘要翻译：本文提供了制备N- [2-羟基-5 - [（1R）-1-羟基-2 - [[（1R）-2-（4-甲氧基苯基）-1- 甲基乙基]氨基]乙基]苯基]甲酰胺（Arformoterol）或其药学上可接受的盐。本文进一步提供了一种改进的和工业上有利的方法，用于制备基本上对映体纯的阿霉素中间体（R）-4-甲氧基-α-甲基-N-（苯基甲基）苯乙胺。

5. 发明授权

US6150558A Bis-o-amino(thio)phenols, and their preparation 有权
标题翻译：双 - 氨基（硫代）酚类及其制备方法
公开(公告)号：US6150558A
公开(公告)日：2000-11-21
申请号：US161144
申请日：1998-09-24
申请人： Recai Sezi , Michael Keitmann
发明人： Recai Sezi , Michael Keitmann
IPC分类号： C07D247/00 , C07C201/12 , C07C205/38 , C07C213/02 , C07C217/90 , C07D239/52 , C07D255/02 , C07D257/12 , C07D487/04 , G03F7/023
CPC分类号： C07C217/90 , C07D239/52 , G03F7/0233
摘要： The invention relates to novel bis-o-aminophenols, and bis-o-aminothiophenols of the following structure: ##STR1## where A.sup.1 to A.sup.6 are--independently of one another--H, F, CH.sub.3, CF.sub.3, OCH.sub.3, OCF.sub.3, CH.sub.2 CH.sub.3, CF.sub.2 CF.sub.3, OCH.sub.2 CH.sub.3 or OCF.sub.2 CF.sub.3, where at least one of the radicals A.sup.1 to A.sup.6 must be F or an F-containing group; T is O or S, and m is 0 or 1; and Z is a carbocyclic or heterocyclic aromatic radical.
摘要翻译：本发明涉及以下结构的新的双邻氨基苯酚和双-O-氨基噻吩：其中A1至A6彼此独立地为-H，F，CH3，CF3，OCH3，OCF3，CH2CH3，CF2CF3，OCH2CH3 或OCF 2 CF 3，其中基团A1至A6中的至少一个必须为F或含F的基团; T为O或S，m为0或1; Z是碳环或杂环芳族基团。

6. 发明授权

US5922919A Fungicidal methods, compounds and compositions containing benzophenones 失效
标题翻译：含有二苯甲酮的杀真菌方法，化合物和组合物
公开(公告)号：US5922919A
公开(公告)日：1999-07-13
申请号：US67096
申请日：1998-04-27
申请人： Jurgen Curtze , Christine Helene Gertrud Rudolph , Ludwig Schroder , Guido Albert
发明人： Jurgen Curtze , Christine Helene Gertrud Rudolph , Ludwig Schroder , Guido Albert
IPC分类号： A01N35/04 , C07C45/46 , C07C45/63 , C07C45/64 , C07C45/67 , C07C45/71 , C07C49/84 , C07C69/017 , C07C69/712 , C07C205/38 , C07C205/45 , C07C217/22 , C07C225/22 , C07C233/33 , C07C235/20 , C07C235/24 , C07C251/48 , C07C251/66 , C07C255/13 , C07C255/54 , C07C255/56 , C07C317/24 , C07C323/22 , C07C325/02 , C07D263/56 , C07D277/24 , C07D295/092 , C07D295/185 , C07D319/18 , C07D321/12 , C07F7/08 , C07F7/18 , C07C45/45
CPC分类号： C07D263/56 , A01N35/04 , C07C205/38 , C07C205/45 , C07C217/22 , C07C225/22 , C07C233/33 , C07C235/20 , C07C235/24 , C07C251/48 , C07C251/66 , C07C255/13 , C07C255/54 , C07C255/56 , C07C317/24 , C07C323/22 , C07C325/02 , C07C45/46 , C07C45/63 , C07C45/64 , C07C45/673 , C07C45/71 , C07C49/84 , C07C69/017 , C07C69/712 , C07D277/24 , C07D295/088 , C07D295/185 , C07D319/18 , C07D321/12 , C07F7/0818 , C07F7/1852
摘要： There is provided a method for the control of phytopathogenic fungi and disease caused thereby which comprises contacting said fungi with a fungicidally effective amount of a benzophenone compound of formula I ##STR1## There are further provided benzophenone compounds of formula Ia which are useful as fungicidal agents and compositions useful for the protection of plants from the damaging effects of phytopathogenic fungi and fungal disease.
摘要翻译：提供了一种用于控制由此引起的植物病原真菌和疾病的方法，其包括使所述真菌与杀真菌有效量的式I的二苯甲酮化合物接触。还提供了可用作杀真菌剂和有用组合物的式Ia的二苯甲酮化合物用于保护植物免受植物病原真菌和真菌病的破坏作用。

7. 发明授权

US5919970A Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity 失效
标题翻译：取代的二芳基或二杂芳基甲烷，具有类视黄醇激动剂，拮抗剂或反向激动剂型生物活性的醚和胺
公开(公告)号：US5919970A
公开(公告)日：1999-07-06
申请号：US840040
申请日：1997-04-24
申请人： Tae K. Song , Min Teng , Roshantha A. Chandraratna
发明人： Tae K. Song , Min Teng , Roshantha A. Chandraratna
IPC分类号： C07C65/28 , C07C69/94 , C07C205/38 , C07C235/56 , C07C247/16 , C07D213/80 , C07C235/84 , C07C69/76 , C07C233/81 , C07C261/00
CPC分类号： C07D213/80 , C07C205/38 , C07C235/56 , C07C247/16 , C07C65/28 , C07C69/94
摘要： Compounds of the formulaY.sub.3 (R.sub.4)--X--Y.sub.1 (R.sub.1 R.sub.2)--Z--Y.sub.2 (R.sub.2)--A--Bwhere the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist or retinoid inverse agonist type biological activity.
摘要翻译：符号具有本说明书中定义的含义的式Y3（R4）-X-Y1（R1R2）-Z-Y2（R2）-A-B的化合物具有类视黄醇，维生素A拮抗剂或维甲酸反向激动剂型生物活性。

8. 发明授权

US5917016A Photolabile compounds and methods for their use 失效
标题翻译： Photolabile化合物及其使用方法
公开(公告)号：US5917016A
公开(公告)日：1999-06-29
申请号：US6547
申请日：1998-01-13
申请人： Christopher P. Holmes
发明人： Christopher P. Holmes
IPC分类号： C07D521/00 , C07B61/00 , C07C205/38 , C07C217/18 , C07C233/18 , C07C271/22 , C07C323/12 , C07C323/16 , C07D277/14 , C07D277/34 , C07D279/06 , C07D317/28 , C07D403/04 , C07D417/04 , C07K1/00 , C07K1/04 , C07K1/06 , C07K1/08 , C07K17/02 , C40B40/10 , G06K19/06
CPC分类号： C07D403/04 , B82Y30/00 , C07C233/18 , C07D277/14 , C07D277/34 , C07D279/06 , C07D317/28 , C07D417/04 , C07K1/006 , C07K1/04 , C07K1/084 , G06K19/06 , B01J2219/0059 , B01J2219/00596 , B01J2219/00711 , B01J2219/00725 , C07B2200/11 , C40B40/10 , G06K2019/06234
摘要： Novel compounds are provided which are useful as photocleavable linking groups in solid phase synthesis. Compositions incorporating these linking groups and methods for their use are also described.
摘要翻译：提供了新的化合物，其可用作固相合成中的可光裂解连接基团。还描述了结合这些连接基团的组合物及其使用方法。

9. 发明授权

US5891358A Liquid crystal mixtures and devices 失效
标题翻译：液晶混合物和装置
公开(公告)号：US5891358A
公开(公告)日：1999-04-06
申请号：US676203
申请日：1996-07-10
申请人： Andrew John Slaney , Damien Gerard McDonnell , Amarjit Kaur Samra , Maurice Stanley , Victoria Minter , John William Goodby , Michael Hird , Simon John Cross , Chu Chuan Dong
发明人： Andrew John Slaney , Damien Gerard McDonnell , Amarjit Kaur Samra , Maurice Stanley , Victoria Minter , John William Goodby , Michael Hird , Simon John Cross , Chu Chuan Dong
IPC分类号： G02F1/13 , C07C25/18 , C07C43/20 , C07C69/75 , C07C69/753 , C07C69/76 , C07C69/773 , C07C69/86 , C07C69/92 , C07C205/37 , C07C205/38 , C07C205/43 , C07C205/59 , C09K19/02 , C09K19/12 , C09K19/18 , C09K19/20 , C09K19/30 , C09K19/06 , G02F1/133
CPC分类号： C07C205/37 , C07C205/43 , C09K19/0233 , C09K19/126 , C09K19/2007 , C09K19/3003 , C09K19/3068
摘要： The invention describes liquid crystal compounds of formula (I) which are suitable for use in liquid crystal devices including those devices which exploit the electroclinic effect, ##STR1## where X may be CN, NO.sub.2, CF.sub.3, CF.sub.2 H, CFH.sub.2, halogen, hydrogen, alkyl or alkoxy; X.sub.2 may be CN, NO.sub.2, CF.sub.3, CF.sub.2 H, CFH.sub.2, halogen, hydrogen, alkyl or alkoxy; X.sub.3 may be CN, NO.sub.2, CF.sub.3, CF.sub.2 H, CFH.sub.2, halogen, alkyl, alkoxy or hydrogen; X.sub.4 may be CN, NO.sub.2, CF.sub.3, CF.sub.2 H, CFH.sub.2, halogen, alkyl, alkoxy or hydrogen; provided that at lease one of X or X.sub.2 is CF.sub.3, CF.sub.2 H, CFH.sub.2, CN, NO.sub.2 or halogen; A and B are independently phenyl, mono-fluorinated phenyl, di-fluorinated phenyl or cyclohexyl; Y may be single bond, COO, OOC, C.dbd.C; q may be 0 or 1; R.sub.1 may be an end group of formula (II) wherein Z may be a single bond, O, CO.sub.2, (CH.sub.2).sub.n or (CH.sub.2).sub.n O where n may be 1 or 2; J and M may be independently H, C.sub.1-4 alkyl; W may be C.sub.1 -C.sub.12 straight or branched alkyl chain; R.sub.2 may contain 1-14 carbon atoms wherein one or more non-adjacent CH.sub.2 groups may be replaced by CO.sub.2 or O. X or X.sub.2 may give rise to steric hindrance with the nearest terminal group. The materials of the current invention may be mixed together and/or with other liquid crystal compounds. Suitable devices which the materials of the present invention may be incorporated in include beam steerers, piezoelectric actuators or sensors and pyroelectric sensors and displays in general. The materials of the present invention may also be useful as dopants in ferroelectrics and as second order non-linear optic materials for second harmonic conversion of light.
摘要翻译： PCT No.PCT / GB95 / 00018 Sec。 371日期：1996年7月10日 102（e）日期1996年7月10日PCT 1995年1月6日PCT PCT。 WO95 / 18848 PCT公开日期：1995年7月13日本发明描述了适用于液晶装置的液晶化合物，其中包括那些利用电击效应的装置，其中X可以是 CN，NO 2，CF 3，CF 2 H，CFH 2，卤素，氢，烷基或烷氧基; X 2可以是CN，NO 2，CF 3，CF 2 H，CFH 2，卤素，氢，烷基或烷氧基; X3可以是CN，NO2，CF3，CF2H，CFH2，卤素，烷基，烷氧基或氢; X 4可以是CN，NO 2，CF 3，CF 2 H，CFH 2，卤素，烷基，烷氧基或氢; 条件是X或X 2中至少一个为CF 3，CF 2 H，CFH 2，CN，NO 2或卤素; A和B独立地是苯基，单氟化苯基，二氟化苯基或环己基; Y可以是单键，COO，OOC，C = C; q可以是0或1; R 1可以是式（II）的端基，其中Z可以是单键O，CO 2，（CH 2）n或（CH 2）n O，其中n可以是1或2; J和M可以独立地是H，C 1-4烷基; W可以是C 1 -C 12直链或支链烷基链; R2可以含有1-14个碳原子，其中一个或多个不相邻的CH 2基团可以被CO 2或O取代。X或X 2可以引起与最近的末端基团的空间位阻。本发明的材料可以混合在一起和/或与其它液晶化合物混合。可并入本发明的材料的合适的装置包括光束转向器，压电致动器或传感器以及热电传感器和显示器。本发明的材料也可用作铁电体中的掺杂剂，并且可用作光二次谐波转换的二阶非线性光学材料。

10. 发明授权

US5712226A Optically active D-pyridyloxy phenoxy propionate herbicides 失效
标题翻译：光学活性D-吡啶氧基苯氧基丙酸酯除草剂
公开(公告)号：US5712226A
公开(公告)日：1998-01-27
申请号：US465889
申请日：1995-06-06
申请人： Hans Jurgen Nestler , Gerhard Horlein , Reinhard Handte , Hermann Bieringer , Friedhelm Schwerdtle , Peter Langeluddeke , Peter Frisch
发明人： Hans Jurgen Nestler , Gerhard Horlein , Reinhard Handte , Hermann Bieringer , Friedhelm Schwerdtle , Peter Langeluddeke , Peter Frisch
IPC分类号： C07C69/712 , A01N31/08 , A01N37/36 , A01N37/42 , A01N39/02 , A01N43/08 , A01N43/20 , A01N43/40 , A01N43/52 , A01N43/72 , A01N43/74 , A01N43/76 , A01N43/78 , A01N47/12 , A01N47/16 , A01N47/18 , A01N47/20 , A01N47/22 , A01N47/24 , A01P13/00 , A61K31/41 , C07C41/00 , C07C41/26 , C07C43/29 , C07C43/295 , C07C51/00 , C07C51/367 , C07C59/08 , C07C59/125 , C07C59/13 , C07C59/58 , C07C59/68 , C07C59/70 , C07C67/00 , C07C67/343 , C07C69/003 , C07C69/67 , C07C69/68 , C07C201/00 , C07C205/38 , C07C219/06 , C07C231/00 , C07C231/12 , C07C233/00 , C07C235/20 , C07C235/22 , C07C235/24 , C07C241/00 , C07C243/28 , C07C253/00 , C07C255/16 , C07C255/37 , C07C313/00 , C07C323/12 , C07C325/00 , C07C327/22 , C07C327/42 , C07D213/64 , C07D213/643 , C07D213/647 , C07D235/26 , C07D263/54 , C07D263/58 , C07D277/66 , C07D277/68 , C07D303/48 , C07D307/12 , C07D307/42 , C07D413/12
CPC分类号： A01N39/02 , A01N43/08 , A01N43/20 , A01N43/40 , A01N43/52 , A01N43/74 , A01N43/76 , A01N43/78 , A01N47/12 , A01N47/16 , A01N47/18 , A01N47/20 , C07C243/00 , C07C323/00 , C07C327/00 , C07C41/26 , C07C59/68 , C07C67/31 , C07C69/736 , C07D213/643 , C07D213/647 , C07D235/26 , C07D263/58 , C07D277/68 , C07D307/12 , C07B2200/07 , C07C2101/08 , C07C2101/14
摘要： Opticalls active enantiomers of the formula I ##STR1## where R is a group of the formulae ##STR2## R.sub.1 and R.sub.2, among others, are halogen or CF.sub.3 and Z is a carboxyl, carboxylate, carboxylic acid ester, thioester, carbonamide, carboxylic acid anilide, carbohydrazide or thioamide group, are interesting herbicides the effect of which is considerably superior to that of the optically inactive racemates.
摘要翻译：（I）其中R是下式的基团的光学活性对映异构体：其中R是下式的基团：其中R是下式的基团：（VI））R1和R2等是卤素或CF 3，Z是羧基，羧酸酯，羧酸酯，硫酯，碳酰胺，羧酸酰苯胺，碳酰肼或硫代酰胺基，是有意义的除草剂，其效果明显优于光学无活性的外消旋体。

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