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1. 发明授权

US07392077B2 Method for treating a patient at risk of loss of cardiac function by cardiac ischemia 有权
标题翻译：用心脏缺血治疗心脏功能丧失危险的患者的方法
公开(公告)号：US07392077B2
公开(公告)日：2008-06-24
申请号：US10822600
申请日：2004-04-12
申请人： Richard L. Mueller , U. Hiram Chee
发明人： Richard L. Mueller , U. Hiram Chee
IPC分类号： A61B5/00
CPC分类号： A61B17/32053 , A61B17/3417 , A61B17/3478 , A61B18/1492 , A61B18/22 , A61B2017/00247 , A61B2018/00392 , A61B2090/036
摘要： Various methods and devices for treating a patient who has lost, or is at risk of losing cardiac function by cardiac ischemia are disclosed. Treatment includes first imaging a patient's heart, or a portion thereof, to identify underperfused regions of cardiac muscle, and a source of oxygenated blood that is proximate to the underperfused region. Between the underperfused regions and the oxygenated blood source, a target area is selected where thermal or mechanical injury is introduced, and optionally reintroduced, to convert initial capillary blush, resulting from the injury.
摘要翻译：公开了用于治疗由于心脏缺血而失去或有丧失心脏功能风险的患者的各种方法和装置。治疗包括首先对患者的心脏或其一部分进行成像以识别心肌的不足灌注区域，以及接近欠灌注区域的充氧血液源。在欠灌注区域和氧合血液源之间，选择引入热或机械损伤的目标区域，并且可选地重新引入，以转化由损伤引起的初始毛细血管腮红。

2. 发明授权

US06748258B1 Method and devices for heart treatment 有权
标题翻译：心脏治疗方法和装置
公开(公告)号：US06748258B1
公开(公告)日：2004-06-08
申请号：US09706584
申请日：2000-11-03
申请人： Richard L. Mueller , U. Hiram Chee
发明人： Richard L. Mueller , U. Hiram Chee
IPC分类号： A61B505
CPC分类号： A61B17/32053 , A61B17/3417 , A61B17/3478 , A61B18/1492 , A61B18/22 , A61B2017/00247 , A61B2018/00392 , A61B2090/036
摘要： Various methods and devices for treating a patient who has lost, or is at risk of losing cardiac function by cardiac ischemia are disclosed. Treatment includes first imaging a patient's heart, or a portion thereof, to identify underperfused regions of cardiac muscle, and a source of oxygenated blood that is proximate to the underperfused region. Between the underperfused regions and the oxygenated blood source, a target area is selected where thermal or mechanical injury is introduced, and optionally reintroduced, to convert initial capillary blush, resulting from the injury.
摘要翻译：公开了用于治疗由于心脏缺血而失去或有丧失心脏功能风险的患者的各种方法和装置。治疗包括首先对患者的心脏或其一部分进行成像以识别心肌的不足灌注区域，以及接近欠灌注区域的充氧血液源。在欠灌注区域和氧合血液源之间，选择引入热或机械损伤的目标区域，并且可选地重新引入，以转化由损伤引起的初始毛细血管腮红。

3. 发明授权

US6123714A System for detaching an occlusive device within a body using a solderless, electrolytically severable joint 失效
公开(公告)号：US6123714A
公开(公告)日：2000-09-26
申请号：US743494
申请日：1996-11-04
申请人： Son Gia , Hong Doan , Pete Phong Pham , Ivan Sepetka , U. Hiram Chee , Michael Mariant , David Kupiecki
发明人： Son Gia , Hong Doan , Pete Phong Pham , Ivan Sepetka , U. Hiram Chee , Michael Mariant , David Kupiecki
IPC分类号： A61F2/82 , A61B17/00 , A61B17/12 , A61F2/06 , A61F2/84 , A61B17/08
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61F2/95 , A61B2017/00017 , A61B2017/00292 , A61B2017/12063 , A61B2018/1495
摘要： A solderless sacrificial link between a detachable member which is placed at and is intended to remain at a desired site within the mammalian body and the core wire used to introduce the detachable member. The detachable member device may be one used to create emboli in the vascular system or may be of any other type deliverable into the human body and detached into an ionic aqueous environment, either for later removal or permanent placement.

4. 发明授权

US5769796A Super-elastic composite guidewire 失效
标题翻译：超弹性复合导丝
公开(公告)号：US5769796A
公开(公告)日：1998-06-23
申请号：US789607
申请日：1997-01-22
申请人： Thomas J. Palermo , Gene Samson , Gregory E. Mirigian , U. Hiram Chee , Erik T. Engelson , Edward Snyder
发明人： Thomas J. Palermo , Gene Samson , Gregory E. Mirigian , U. Hiram Chee , Erik T. Engelson , Edward Snyder
IPC分类号： A61B5/00
CPC分类号： A61M25/09 , A61M2025/09091 , A61M2025/09175
摘要： This is a composite guidewire for use in a catheter and is used for accessing a targeted site in a lumen system of a patient's body. The guidewire core or guidewire section may be of a stainless steel or a high elasticity metal alloy, preferably a Ni--Ti alloy, also preferably having specified physical parameters. The composite guidewire assembly is especially useful for accessing peripheral or soft tissue targets. Variations include multi-section guidewire assemblies having (at least) super-elastic distal portions and super-elastic braided reinforcements along the mid or distal sections. A variation of the inventive guidewire includes the coating of the wire with a tie layer and then with a one or more lubricious polymers to enhance its suitability for use within catheters and with the interior of vascular lumen.
摘要翻译：这是用于导管的复合导丝，并用于进入患者体内的管腔系统中的目标部位。导丝芯或导丝部分可以是不锈钢或高弹性金属合金，优选Ni-Ti合金，也优选具有特定的物理参数。复合导丝组件对于接近外周或软组织靶是特别有用的。变型包括具有（至少）超弹性远端部分的多段导丝组件和沿着中部或远端部分的超弹性编织加强件。本发明的导丝的变体包括用连接层涂覆线材，然后使用一种或多种润滑聚合物来增强其在导管内和血管腔内部使用的适用性。

5. 发明授权

US5766160A Variable stiffness coils 失效
标题翻译：可变刚度线圈
公开(公告)号：US5766160A
公开(公告)日：1998-06-16
申请号：US480042
申请日：1995-06-06
申请人： Gene Samson , Ivan Sepetka , U. Hiram Chee , Christopher G. M. Ken , Nga T. Van
发明人： Gene Samson , Ivan Sepetka , U. Hiram Chee , Christopher G. M. Ken , Nga T. Van
IPC分类号： A61M31/00 , A61B17/12 , A61B17/00
CPC分类号： A61B17/1215 , A61B17/12022 , A61B17/12109 , A61B17/12145
摘要： This invention is an implantable vaso-occlusive device. It is a helically wound coil having a central section along its longitudinal axis which is somewhat stiffer than at least one of its end regions.
摘要翻译：本发明是可植入血管闭塞装置。它是螺旋缠绕的线圈，其沿其纵向轴线具有中心部分，该中心部分比其端部区域中的至少一个稍微更硬。

6. 发明授权

US5749837A Enhanced lubricity guidewire 失效
标题翻译：增强润滑性导丝
公开(公告)号：US5749837A
公开(公告)日：1998-05-12
申请号：US695185
申请日：1996-08-01
申请人： Thomas J. Palermo , Gene Samson , Gregory E. Mirigian , U. Hiram Chee
发明人： Thomas J. Palermo , Gene Samson , Gregory E. Mirigian , U. Hiram Chee
IPC分类号： A61M25/00 , A61B5/00
CPC分类号： A61M25/09 , A61M2025/0046 , A61M2025/09091 , A61M2025/09133 , A61M2025/09175
摘要： This invention is a surgical device. It is a guidewire for use in a catheter and is used for accessing a targeted site in a lumen system of a patient's body. The guidewire or guidewire section may be of a stainless steel or a high elasticity metal alloy, preferably a Ni--Ti alloy, having specified physical parameters. The guidewire is especially useful for accessing peripheral or soft tissue targets. A special variation of the inventive guidewire includes the coating of the wire with a tie layer and then with a one or more lubricious polymers to enhance its suitability for use within catheters and with the interior of vascular lumen.
摘要翻译：本发明是一种手术装置。它是用于导管的导丝，用于进入患者身体的管腔系统中的目标部位。导线或导丝部分可以是具有特定物理参数的不锈钢或高弹性金属合金，优选Ni-Ti合金。导丝对于访问外周或软组织靶是特别有用的。本发明的导丝的特殊变型包括用连接层涂覆线材，然后用一种或多种润滑聚合物涂覆，以增强其在导管内和血管腔内部使用的适用性。

7. 发明授权

US5226911A Vasoocclusion coil with attached fibrous element(s) 失效
标题翻译：带有连接纤维元件的血管闭塞线圈（S）
公开(公告)号：US5226911A
公开(公告)日：1993-07-13
申请号：US771013
申请日：1991-10-02
申请人： U. Hiram Chee , Mike Mariant
发明人： U. Hiram Chee , Mike Mariant
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00 , A61F2/00 , A61F2/01 , A61F5/00 , A61M29/00
CPC分类号： A61B17/1215 , A61B17/12022 , A61B17/12145 , A61F2/01 , A61B2017/00004 , A61B90/39 , A61F2002/016 , A61F2230/0091
摘要： A device for occluding a blood vessel comprising a helical metal coil having at least one fibrous element attached to its proximal end wherein the fibrous element(s) extends in a sinusoidal wave configuration, the loops of which extend about individual windings at spaced intervals along the axis of the coil.
摘要翻译：一种用于闭塞血管的装置，包括具有附接到其近端的至少一个纤维元件的螺旋金属线圈，其中所述纤维元件以正弦波形结构延伸，所述线圈沿着沿着线圈的轴线。

8. 发明授权

US08187251B2 Methods of treating cardiac arrhythmia 有权
标题翻译：治疗心律失常的方法
公开(公告)号：US08187251B2
公开(公告)日：2012-05-29
申请号：US11591126
申请日：2006-10-31
申请人： U. Hiram Chee , Richard L. Mueller , James R. Kermode , Curtis P. Tom , Douglas Murphy-Chutorian
发明人： U. Hiram Chee , Richard L. Mueller , James R. Kermode , Curtis P. Tom , Douglas Murphy-Chutorian
IPC分类号： A61M31/00
CPC分类号： A61B17/32037 , A61B17/282 , A61B17/3207 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/22077 , A61B2018/00392 , A61B2018/00839 , A61B2018/00875 , A61B2018/1425 , A61B2090/064 , A61B2090/067 , A61B2218/002 , A61M5/30 , A61M37/0092 , A61M2025/0089
摘要： Methods and apparatus of embodiments of the invention are adapted to treat tissue inside a patient's body. Aspects of the invention can be used in a wide variety of applications, but certain embodiments provide minimally invasive alternatives for treating atrial fibrillation by delivering a tissue-damaging agent to selected areas of the heart. One exemplary embodiment of the invention provides a method of treating cardiac arrhythmia. This method includes positioning a distal tissue-contacting portion of a body in surface contact with a tissue surface of cardiac tissue; detecting the surface contact between the tissue-contacting portion and the tissue surface; and thereafter, injecting a tissue-ablating agent into the cardiac tissue through the tissue-contacting portion of the body.
摘要翻译：本发明的实施例的方法和装置适于治疗患者体内的组织。本发明的各方面可以用于各种各样的应用中，但是某些实施方案提供了通过将组织损伤剂输送到心脏的选定区域来治疗心房颤动的微创替代方案。本发明的一个示例性实施方案提供了治疗心律失常的方法。该方法包括将身体的远端组织接触部分定位成与心脏组织的组织表面表面接触; 检测组织接触部分和组织表面之间的表面接触; 然后通过身体的组织接触部分将组织消融剂注入心脏组织。

9. 发明授权

US07588554B2 Method and apparatus for treating ischemic tissue 有权
公开(公告)号：US07588554B2
公开(公告)日：2009-09-15
申请号：US09891715
申请日：2001-06-26
申请人： Richard L. Mueller , U. Hiram Chee , James R. Kermode
发明人： Richard L. Mueller , U. Hiram Chee , James R. Kermode
IPC分类号： A61M31/00
CPC分类号： A61B17/3207 , A61B17/3203 , A61B17/320758 , A61B18/1477 , A61B18/24 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2018/00392 , A61B2018/1425 , A61B2090/395 , A61M5/3287 , A61M2025/0085
摘要： The invention described herein provides for methods and devices for treating tissues, and in particular, ischemic heart tissue. Preferred devices includes tools integrating both injury and treatment effectors in a single unit. An optional third effector provides an effector for marking locations on a tissue surface that have been visited by the device. Methods are provided in which a target tissue is identified, injury sites are created at known locations, and therapeutic-substance is infused at known locations different than the injury sites.

10. 发明授权

US07214223B2 Photoatherolytic catheter apparatus and method 失效
标题翻译：光疗溶剂导管装置及方法
公开(公告)号：US07214223B2
公开(公告)日：2007-05-08
申请号：US09816832
申请日：2001-03-22
申请人： Richard L. Mueller , U. Hiram Chee
发明人： Richard L. Mueller , U. Hiram Chee
IPC分类号： A61B18/22 , A61B18/24 , A61N5/067
CPC分类号： A61N5/062 , A61B18/245 , A61B2018/2261 , A61K41/0057 , A61K41/0071 , A61K47/6957 , A61N5/0601 , A61N2005/0602
摘要： A method and apparatus for treating an atherosclerotic target region of a coronary vessel in a patient are disclosed. The method includes delivering to the patient, a photoatherolytic compound, to cause accumulation of the compound in the target region, accessing the target region intraluminally with a guidewire, and advancing over the guidewire, a catheter having (i) a proximal main-body sleeve, (ii) a flexible, non-inflatable, translucent distal-end sleeve joined to the main-body sleeve at a catheter juncture, and (iii) an inner lumen extending through the two sleeves, said advancing being effective to position the catheter's distal-end sleeve within the target region. The guidewire is then removed and replaced by a fiber-optic bundle having a light-diffusing tip, until said tip is positioned adjacent the catheter juncture. After injecting a light-transmissive fluid through the catheter into the catheter's distal-end sleeve, the target vessel region is irradiated by passing a laser light beam through the fiber optic bundle.
摘要翻译：公开了一种用于治疗患者的冠状血管的动脉粥样硬化靶区域的方法和装置。该方法包括向患者输送光解剂，以引起化合物在目标区域中的积聚，用导丝线内光进入目标区域，并在导线上前进;导管，其具有（i）近端主体套筒，（ii）在导管接合处连接到主体套管的柔性，不可充气，半透明的远端套筒，以及（iii）延伸穿过两个套筒的内腔，所述前进可有效地定位导管的远端 - 在目标区域内的袖子。然后将导线移除并由具有光扩散尖端的光纤束代替，直到所述尖端邻近导管接合点定位。在通过导管将透光流体注入导管的远端套筒之后，通过使激光束穿过光纤束来照射靶血管区域。

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