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1. 发明授权

US08187251B2 Methods of treating cardiac arrhythmia 有权
标题翻译：治疗心律失常的方法
公开(公告)号：US08187251B2
公开(公告)日：2012-05-29
申请号：US11591126
申请日：2006-10-31
申请人： U. Hiram Chee , Richard L. Mueller , James R. Kermode , Curtis P. Tom , Douglas Murphy-Chutorian
发明人： U. Hiram Chee , Richard L. Mueller , James R. Kermode , Curtis P. Tom , Douglas Murphy-Chutorian
IPC分类号： A61M31/00
CPC分类号： A61B17/32037 , A61B17/282 , A61B17/3207 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/22077 , A61B2018/00392 , A61B2018/00839 , A61B2018/00875 , A61B2018/1425 , A61B2090/064 , A61B2090/067 , A61B2218/002 , A61M5/30 , A61M37/0092 , A61M2025/0089
摘要： Methods and apparatus of embodiments of the invention are adapted to treat tissue inside a patient's body. Aspects of the invention can be used in a wide variety of applications, but certain embodiments provide minimally invasive alternatives for treating atrial fibrillation by delivering a tissue-damaging agent to selected areas of the heart. One exemplary embodiment of the invention provides a method of treating cardiac arrhythmia. This method includes positioning a distal tissue-contacting portion of a body in surface contact with a tissue surface of cardiac tissue; detecting the surface contact between the tissue-contacting portion and the tissue surface; and thereafter, injecting a tissue-ablating agent into the cardiac tissue through the tissue-contacting portion of the body.
摘要翻译：本发明的实施例的方法和装置适于治疗患者体内的组织。本发明的各方面可以用于各种各样的应用中，但是某些实施方案提供了通过将组织损伤剂输送到心脏的选定区域来治疗心房颤动的微创替代方案。本发明的一个示例性实施方案提供了治疗心律失常的方法。该方法包括将身体的远端组织接触部分定位成与心脏组织的组织表面表面接触; 检测组织接触部分和组织表面之间的表面接触; 然后通过身体的组织接触部分将组织消融剂注入心脏组织。

2. 发明授权

US07588554B2 Method and apparatus for treating ischemic tissue 有权
公开(公告)号：US07588554B2
公开(公告)日：2009-09-15
申请号：US09891715
申请日：2001-06-26
申请人： Richard L. Mueller , U. Hiram Chee , James R. Kermode
发明人： Richard L. Mueller , U. Hiram Chee , James R. Kermode
IPC分类号： A61M31/00
CPC分类号： A61B17/3207 , A61B17/3203 , A61B17/320758 , A61B18/1477 , A61B18/24 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2018/00392 , A61B2018/1425 , A61B2090/395 , A61M5/3287 , A61M2025/0085
摘要： The invention described herein provides for methods and devices for treating tissues, and in particular, ischemic heart tissue. Preferred devices includes tools integrating both injury and treatment effectors in a single unit. An optional third effector provides an effector for marking locations on a tissue surface that have been visited by the device. Methods are provided in which a target tissue is identified, injury sites are created at known locations, and therapeutic-substance is infused at known locations different than the injury sites.

3. 发明申请

US20120238996A1 METHODS OF TREATING CARDIAC ARRHYTHMIA 审中-公开
标题翻译：治疗心脑血管病的方法
公开(公告)号：US20120238996A1
公开(公告)日：2012-09-20
申请号：US13481251
申请日：2012-05-25
申请人： U. Hiram Chee , Richard L. Mueller , James R. Kermode , Curtis P. Tom , Douglas Murphy-Chutorian
发明人： U. Hiram Chee , Richard L. Mueller , James R. Kermode , Curtis P. Tom , Douglas Murphy-Chutorian
IPC分类号： A61M37/00
CPC分类号： A61B17/32037 , A61B17/282 , A61B17/3207 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/22077 , A61B2018/00392 , A61B2018/00839 , A61B2018/00875 , A61B2018/1425 , A61B2090/064 , A61B2090/067 , A61B2218/002 , A61M5/30 , A61M37/0092 , A61M2025/0089
摘要： Methods and apparatus of embodiments of the invention are adapted to treat tissue inside a patient's body. Aspects of the invention can be used in a wide variety of applications, but certain embodiments provide minimally invasive alternatives for treating atrial fibrillation by delivering a tissue-damaging agent to selected areas of the heart. One exemplary embodiment of the invention provides a method of treating cardiac arrhythmia. This method includes positioning a distal tissue-contacting portion of a body in surface contact with a tissue surface of cardiac tissue; detecting the surface contact between the tissue-contacting portion and the tissue surface; and thereafter, injecting a tissue-ablating agent into the cardiac tissue through the tissue-contacting portion of the body.
摘要翻译：本发明的实施例的方法和装置适于治疗患者体内的组织。本发明的各方面可以用于各种各样的应用中，但是某些实施方案提供了通过将组织损伤剂输送到心脏的选定区域来治疗心房颤动的微创替代方案。本发明的一个示例性实施方案提供了治疗心律失常的方法。该方法包括将身体的远端组织接触部分定位成与心脏组织的组织表面表面接触; 检测组织接触部分和组织表面之间的表面接触; 然后通过身体的组织接触部分将组织消融剂注入心脏组织。

4. 发明授权

US07147633B2 Method and apparatus for treatment of atrial fibrillation 有权
公开(公告)号：US07147633B2
公开(公告)日：2006-12-12
申请号：US10099528
申请日：2002-03-14
申请人： U. Hiram Chee , Richard L. Mueller , James R. Kermode , Curtis P. Tom , Douglas Murphy-Chutorian
发明人： U. Hiram Chee , Richard L. Mueller , James R. Kermode , Curtis P. Tom , Douglas Murphy-Chutorian
IPC分类号： A61B18/18
CPC分类号： A61B17/32037 , A61B17/282 , A61B17/3207 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/22077 , A61B2018/00392 , A61B2018/00839 , A61B2018/00875 , A61B2018/1425 , A61B2090/064 , A61B2090/067 , A61B2218/002 , A61M5/30 , A61M37/0092 , A61M2025/0089
摘要： Methods and apparatus of embodiments of the invention are adapted to treat tissue inside a patient's body. Aspects of the invention can be used in a wide variety of applications, but certain embodiments provide minimally invasive alternatives for treating atrial fibrillation by delivering a tissue-damaging agent to selected areas of the heart. One exemplary embodiment of the invention provides a method of treating cardiac arrhythmia. This method includes positioning a distal tissue-contacting portion of a body in surface contact with a tissue surface of cardiac tissue; detecting the surface contact between the tissue-contacting portion and the tissue surface; and thereafter, injecting a tissue-ablating agent into the cardiac tissue through the tissue-contacting portion of the body.

5. 发明授权

US07392077B2 Method for treating a patient at risk of loss of cardiac function by cardiac ischemia 有权
标题翻译：用心脏缺血治疗心脏功能丧失危险的患者的方法
公开(公告)号：US07392077B2
公开(公告)日：2008-06-24
申请号：US10822600
申请日：2004-04-12
申请人： Richard L. Mueller , U. Hiram Chee
发明人： Richard L. Mueller , U. Hiram Chee
IPC分类号： A61B5/00
CPC分类号： A61B17/32053 , A61B17/3417 , A61B17/3478 , A61B18/1492 , A61B18/22 , A61B2017/00247 , A61B2018/00392 , A61B2090/036
摘要： Various methods and devices for treating a patient who has lost, or is at risk of losing cardiac function by cardiac ischemia are disclosed. Treatment includes first imaging a patient's heart, or a portion thereof, to identify underperfused regions of cardiac muscle, and a source of oxygenated blood that is proximate to the underperfused region. Between the underperfused regions and the oxygenated blood source, a target area is selected where thermal or mechanical injury is introduced, and optionally reintroduced, to convert initial capillary blush, resulting from the injury.
摘要翻译：公开了用于治疗由于心脏缺血而失去或有丧失心脏功能风险的患者的各种方法和装置。治疗包括首先对患者的心脏或其一部分进行成像以识别心肌的不足灌注区域，以及接近欠灌注区域的充氧血液源。在欠灌注区域和氧合血液源之间，选择引入热或机械损伤的目标区域，并且可选地重新引入，以转化由损伤引起的初始毛细血管腮红。

6. 发明授权

US06748258B1 Method and devices for heart treatment 有权
标题翻译：心脏治疗方法和装置
公开(公告)号：US06748258B1
公开(公告)日：2004-06-08
申请号：US09706584
申请日：2000-11-03
申请人： Richard L. Mueller , U. Hiram Chee
发明人： Richard L. Mueller , U. Hiram Chee
IPC分类号： A61B505
CPC分类号： A61B17/32053 , A61B17/3417 , A61B17/3478 , A61B18/1492 , A61B18/22 , A61B2017/00247 , A61B2018/00392 , A61B2090/036
摘要： Various methods and devices for treating a patient who has lost, or is at risk of losing cardiac function by cardiac ischemia are disclosed. Treatment includes first imaging a patient's heart, or a portion thereof, to identify underperfused regions of cardiac muscle, and a source of oxygenated blood that is proximate to the underperfused region. Between the underperfused regions and the oxygenated blood source, a target area is selected where thermal or mechanical injury is introduced, and optionally reintroduced, to convert initial capillary blush, resulting from the injury.
摘要翻译：公开了用于治疗由于心脏缺血而失去或有丧失心脏功能风险的患者的各种方法和装置。治疗包括首先对患者的心脏或其一部分进行成像以识别心肌的不足灌注区域，以及接近欠灌注区域的充氧血液源。在欠灌注区域和氧合血液源之间，选择引入热或机械损伤的目标区域，并且可选地重新引入，以转化由损伤引起的初始毛细血管腮红。

7. 发明授权

US07214223B2 Photoatherolytic catheter apparatus and method 失效
标题翻译：光疗溶剂导管装置及方法
公开(公告)号：US07214223B2
公开(公告)日：2007-05-08
申请号：US09816832
申请日：2001-03-22
申请人： Richard L. Mueller , U. Hiram Chee
发明人： Richard L. Mueller , U. Hiram Chee
IPC分类号： A61B18/22 , A61B18/24 , A61N5/067
CPC分类号： A61N5/062 , A61B18/245 , A61B2018/2261 , A61K41/0057 , A61K41/0071 , A61K47/6957 , A61N5/0601 , A61N2005/0602
摘要： A method and apparatus for treating an atherosclerotic target region of a coronary vessel in a patient are disclosed. The method includes delivering to the patient, a photoatherolytic compound, to cause accumulation of the compound in the target region, accessing the target region intraluminally with a guidewire, and advancing over the guidewire, a catheter having (i) a proximal main-body sleeve, (ii) a flexible, non-inflatable, translucent distal-end sleeve joined to the main-body sleeve at a catheter juncture, and (iii) an inner lumen extending through the two sleeves, said advancing being effective to position the catheter's distal-end sleeve within the target region. The guidewire is then removed and replaced by a fiber-optic bundle having a light-diffusing tip, until said tip is positioned adjacent the catheter juncture. After injecting a light-transmissive fluid through the catheter into the catheter's distal-end sleeve, the target vessel region is irradiated by passing a laser light beam through the fiber optic bundle.
摘要翻译：公开了一种用于治疗患者的冠状血管的动脉粥样硬化靶区域的方法和装置。该方法包括向患者输送光解剂，以引起化合物在目标区域中的积聚，用导丝线内光进入目标区域，并在导线上前进;导管，其具有（i）近端主体套筒，（ii）在导管接合处连接到主体套管的柔性，不可充气，半透明的远端套筒，以及（iii）延伸穿过两个套筒的内腔，所述前进可有效地定位导管的远端 - 在目标区域内的袖子。然后将导线移除并由具有光扩散尖端的光纤束代替，直到所述尖端邻近导管接合点定位。在通过导管将透光流体注入导管的远端套筒之后，通过使激光束穿过光纤束来照射靶血管区域。

8. 发明授权

US06676679B1 Method and apparatus for recurrent demand injury in stimulating angiogenesis 有权
标题翻译：刺激血管生成反复需求损伤的方法和装置
公开(公告)号：US06676679B1
公开(公告)日：2004-01-13
申请号：US09706343
申请日：2000-11-03
申请人： Richard L. Mueller , U. Hiram Chee
发明人： Richard L. Mueller , U. Hiram Chee
IPC分类号： A61B1734
CPC分类号： A61B17/3203 , A61B17/3207 , A61B17/320783 , A61B17/3478 , A61B90/37 , A61B2017/00247 , A61B2017/22077 , A61B2018/00392 , A61B2090/374
摘要： Various methods and devices for treating a patient who has lost, or is at risk of losing cardiac function by cardiac ischemia are disclosed. Treatment includes first imaging a patient's heart, or a portion thereof, to identify underperfused regions of cardiac muscle, and a source of oxygenated blood that is proximate to the underperfused region. Between the underperfused regions and the oxygenated blood source, a target area is selected where thermal or mechanical injury is introduced, and optionally reintroduced, to convert initial capillary blush, resulting from the injury.
摘要翻译：公开了用于治疗由于心脏缺血而失去或有丧失心脏功能风险的患者的各种方法和装置。治疗包括首先对患者的心脏或其一部分进行成像以识别心肌的不足灌注区域，以及接近欠灌注区域的充氧血液源。在欠灌注区域和氧合血液源之间，选择引入热或机械损伤的目标区域，并且可选地重新引入，以转化由损伤引起的初始毛细血管腮红。

9. 发明授权

US06554794B1 Non-deforming deflectable multi-lumen catheter 失效
标题翻译：不变形可挠性多腔导管
公开(公告)号：US06554794B1
公开(公告)日：2003-04-29
申请号：US09326118
申请日：1999-06-04
申请人： Richard L. Mueller , U. Hiram Chee , Steven A. Daniel , Amr Salahieh , Robert LaDuca , Lauren K. Lundquist , Richard D. Phipps , Daniel S. Brown
发明人： Richard L. Mueller , U. Hiram Chee , Steven A. Daniel , Amr Salahieh , Robert LaDuca , Lauren K. Lundquist , Richard D. Phipps , Daniel S. Brown
IPC分类号： A61M3700
CPC分类号： A61M25/0138 , A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2018/00392 , A61M5/31531 , A61M25/0026 , A61M25/0084 , A61M25/0136 , A61M25/0141 , A61M25/0144 , A61M25/0147 , A61M2025/0089
摘要： A non-deforming deflectable multi-lumen catheter with an outer jacket having a deflectable distal end portion, an eccentric pull wire lumen, coil and shim embedded therein. The deflectable distal portion optionally having one or more transaxial notches in the external surface of the outer jacket. A functional device is disposed within the lumen of an inner tube substantially coaxial with the outer jacket of the catheter. The distal tip of the functional device egressible from the distal tip of the catheter, and upon deflection, automatically aligns with the distal tip of the catheter and functional device.
摘要翻译：具有外护套的不变形可偏转多腔导管，其具有可偏转的远端部分，嵌入其中的偏心拉线管腔，线圈和垫片。可偏转的远端部分可选地在外护套的外表面中具有一个或多个轴向切口。功能装置设置在与导管的外护套基本同轴的内管的内腔内。功能装置的远端从导管的远端可流出并且在偏转时自动与导管和功能装置的远端对齐。

10. 发明授权

US06524324B1 Method and apparatus for demand injury in stimulating angiogenesis 有权
标题翻译：刺激血管生成需求损伤的方法和装置
公开(公告)号：US06524324B1
公开(公告)日：2003-02-25
申请号：US09706016
申请日：2000-11-03
申请人： Richard L. Mueller , U. Hiram Chee
发明人： Richard L. Mueller , U. Hiram Chee
IPC分类号： A61B1734
CPC分类号： A61B17/3203 , A61B17/3207 , A61B17/320783 , A61B17/3478 , A61B90/37 , A61B2017/00247 , A61B2017/22077 , A61B2018/00392 , A61B2090/374
摘要： Various methods and devices for treating a patient who has lost, or is at risk of losing cardiac function by cardiac ischemia are disclosed. Treatment includes first imaging a patient's heart, or a portion thereof, to identify underperfused regions of cardiac muscle, and a source of oxygenated blood that is proximate to the underperfused region. Between the underperfused regions and the oxygenated blood source, a target area is selected where thermal or mechanical injury is introduced, and optionally reintroduced, to convert initial capillary blush, resulting from the injury.
摘要翻译：公开了用于治疗由于心脏缺血而失去或有丧失心脏功能风险的患者的各种方法和装置。治疗包括首先对患者的心脏或其一部分进行成像以识别心肌的不足灌注区域，以及接近欠灌注区域的充氧血液源。在欠灌注区域和氧合血液源之间，选择引入热或机械损伤的目标区域，并且可选地重新引入，以转化由损伤引起的初始毛细血管腮红。

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