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    • 1. 发明授权
    • Process for producing benzo[f]quinoxaline compounds
    • 苯并[f]喹喔啉化合物的制备方法
    • US08772484B2
    • 2014-07-08
    • US13412682
    • 2012-03-06
    • Satoshi InouyeYuiko MiuraSuguru YoshidaTakamitsu Hosoya
    • Satoshi InouyeYuiko MiuraSuguru YoshidaTakamitsu Hosoya
    • C07D487/12C07D241/10
    • C07D241/38C07D241/20C07D241/44C07D241/54C07D487/04Y02P20/55
    • A simple process for producing v-coelenterazine compounds has been desired. Described is a process for producing a v-coelenterazine compound represented by general formula (II) comprising (1) the step of reacting a compound of general formula (VIII) with a methyltriphenylphosphonium salt in the presence of a base to give a compound represented by general formula (IX), (2) the step of performing a ring-closing metathesis reaction on any one selected from the group consisting of the compound represented by general formula (IX) and a compound of general formula (X) which is the compound of general formula (IX) wherein the amino is protected with R5, and then deprotecting R4 and, if any, R5 to give a v-coelenteramine compound represented by general formula (XIV), and (3) the step of reacting the compound of general formula (XIV) with a compound represented by general formula (XV) to give the compound of general formula (II).
    • 已经需要制备v-肠溶纤维素化合物的简单方法。 本发明描述了一种制备由通式(II)表示的β-环糊精化合物的方法,包括(1)在碱存在下使通式(Ⅷ)化合物与甲基三苯基鏻盐反应,得到由 通式(IX),(2)对选自由通式(IX)表示的化合物和作为化合物的通式(X)的化合物的任何一种进行闭环复分解反应的步骤 的通式(IX)的化合物,其中氨基被R 5保护,然后使R 4和(如果有的话)R 5脱保护,得到由通式(XIV)表示的v-内网络胺化合物,和(3) 通式(XIV)与通式(XV)表示的化合物反应,得到通式(II)的化合物。