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    • 2. 发明授权
    • Methods and compositions for controlling biofouling using thiourea
compounds
    • 用硫脲化合物控制生物污染的方法和组合物
    • US6075022A
    • 2000-06-13
    • US536983
    • 1995-09-29
    • Mark L. ZollingerStephen D. Bryant
    • Mark L. ZollingerStephen D. Bryant
    • C02F1/00A01N43/40A01N43/46A01N43/84A01N47/28A01N47/36A01N47/38C02F1/50C09D5/14A01N43/00A01N43/36A61K31/535
    • A01N47/36C02F1/50
    • The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one thiourea to inhibit bacterial adhesion to the submergible surface. The present invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one thiourea to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the bactaria. The thiourea used in the method of the invention has the following formula a compound of the formula: The present invention also relates to compositions containing thiourea compounds and useable in the above methods. The compositions comprise at least one thiourea in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
    • 本发明涉及一种抑制细菌粘附在潜水表面上的方法。 该方法用有效量的至少一种硫脲与潜水表面接触,以抑制细菌粘附到潜水表面。 本发明还涉及一种用于控制水系统的生物污垢的方法。 该方法添加有效量的至少一种硫脲以抑制细菌粘附到水系统内的浸没表面。 这种方法有效地控制生物污染,而不会基本上杀死疫苗。 本发明方法中使用的硫脲具有下式的化合物:本发明还涉及含有硫脲化合物并可用于上述方法的组合物。 所述组合物包含至少一种硫脲,其量可有效地抑制细菌粘附到潜水或浸没的表面。
    • 4. 发明授权
    • Methods and compositions for controlling biofouling using
fluorosurfactants
    • 使用含氟表面活性剂控制生物污垢的方法和组合物
    • US5879623A
    • 1999-03-09
    • US579365
    • 1995-12-27
    • Daniel E. GloverJoe C. SteelhammerStephen D. Bryant
    • Daniel E. GloverJoe C. SteelhammerStephen D. Bryant
    • A61K8/00A61K8/21A61K8/46A61Q11/00C02F1/50C02F5/14C11D1/00C11D1/02C23F11/00B01D17/04B01J13/00
    • A61K8/21A61Q11/00C02F1/50C02F5/14C11D1/004Y10S516/917Y10S516/92
    • The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one fluorosurfactant to inhibit bacterial adhesion to the submergible surface. The present invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one fluorosurfactant to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the bacteria fouling organisms. The fluorosurfactant used in the method of the invention is an anionic or nonionic fluorosurfactant selected from: R.sub.f CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CO.sub.2 Li, (R.sub.f CH.sub.2 CH.sub.2 O)P(O) (ONH.sub.4).sub.2, (R.sub.f CH.sub.2 CH.sub.2 O).sub.2 P(O) (ONH.sub.4), (R.sub.f CH.sub.2 CH.sub.2 O)P(O) (OH).sub.2, (R.sub.f CH.sub.2 CH.sub.2 O).sub.2 P(O) (OH), R.sub.f CH.sub.2 CH.sub.2 O (CH.sub.2 CH.sub.2 O).sub.x H, R.sub.f CH.sub.2 CH.sub.2 O(CH.sub.2 CH.sub.2 O).sub.y H, R.sub.f CH.sub.2 CH.sub.2 SO.sub.3 H, or mixtures thereof. The group R.sub.f is F(CF.sub.2 CF.sub.2).sub.3-8, x varies from 2-20, and y varies from 2-20. The present invention also relates to a compositions containing a fluorosurfactant and useable in the above methods. The compositions comprise at least one fluorosurfactant in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
    • 本发明涉及一种抑制细菌粘附在潜水表面上的方法。 该方法与有效量的至少一种含氟表面活性剂接触该潜水表面以抑制细菌粘附到潜水表面。 本发明还涉及一种用于控制水系统的生物污垢的方法。 该方法添加有效量的至少一种含氟表面活性剂以抑制细菌粘附到水系统内的浸没表面。 该方法有效地控制生物污染,而不会基本上杀死细菌污染生物体。 用于本发明方法的含氟表面活性剂是选自以下的阴离子或非离子氟表面活性剂:RfCH 2 CH 2 SCH 2 CH 2 CO 2 Li,(R f CH 2 CH 2 O)P(O)(ONH 4)2,(R f CH 2 CH 2 O)2 P(O)(ONH 4),(R f CH 2 CH 2 O) (OH)2,(RfCH 2 CH 2 O)2 P(O)(OH),RfCH 2 CH 2 O(CH 2 CH 2 O)x H,RfCH 2 CH 2 O(CH 2 CH 2 O)y H,RfCH 2 CH 2 SO 3 H或其混合物。 基团Rf是F(CF 2 CF 2)3-8,x从2-20变化,y从2-20变化。 本发明还涉及包含含氟表面活性剂并可在上述方法中使用的组合物。 组合物包含至少一种含氟表面活性剂,其含量有效地抑制细菌粘附到潜水或浸没的表面。
    • 5. 发明授权
    • Methods and compositions for controlling biofouling using sulfonamides
    • 使用磺酰胺控制生物污损的方法和组合物
    • US06211172B1
    • 2001-04-03
    • US09298821
    • 1999-04-26
    • Mark L. ZollingerDaniel E. GloverMarilyn S. WhittemoreStephen D. Bryant
    • Mark L. ZollingerDaniel E. GloverMarilyn S. WhittemoreStephen D. Bryant
    • A01N4340
    • C09D5/14C02F1/50
    • The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one sulfonamide to inhibit bacterial adhesion to the submergible surface. The present invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one sulfonamide to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The sulfonamide used in the method of the invention has the following formula: The present invention also relates to a composition containing the sulfonamides and useable in the above methods. The compositions comprise at least one sulfonamide in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
    • 本发明涉及一种抑制细菌粘附在潜水表面上的方法。 该方法用有效量的至少一种磺酰胺接触潜表面以抑制细菌粘附到潜水表面。 本发明还涉及一种用于控制水系统的生物污垢的方法。 该方法添加有效量的至少一种磺酰胺以抑制细菌粘附到水系统内的浸没表面。 该方法有效地控制生物污染,而不会基本上杀死污染的生物体。 用于本发明方法的磺酰胺具有下式:本发明还涉及含有磺酰胺并可用于上述方法的组合物。 组合物包含至少一种有效抑制细菌粘附到潜水或浸没表面的量的磺酰胺。
    • 6. 发明授权
    • Methods for controlling biofouling using sulfamic acids
    • 使用氨基磺酸控制生物污染的方法
    • US6103131A
    • 2000-08-15
    • US901895
    • 1997-07-29
    • Thomas E. McNeelMarilyn S. WhittemoreStephen D. BryantGraciela H. Vunk
    • Thomas E. McNeelMarilyn S. WhittemoreStephen D. BryantGraciela H. Vunk
    • A61K8/40A01N41/02A61K8/46A61Q11/00C02F1/50
    • A01N41/02C02F1/50Y10S210/931
    • The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one sulfamic acid or salt thereof to inhibit bacterial adhesion to the submergible surface. The invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one sulfamic acid or salt thereof to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The sulfamic acid used in the method of the invention has the formula R.sup.1 R.sup.2 NS(O).sub.2 (OH). In this formula, R.sup.1 and R.sup.2 are independently a hydrogen, a C.sub.4 -C.sub.20 alkyl group or a cyclohexyl group. However, R.sup.1 and R.sup.2 are not both hydrogen. Alternatively, R.sup.1 and R.sup.2, together with the N, may also form a 5-8 membered heterocyclic ring having the formula: ##STR1## In the heterocyclic ring, X is O, NH, or CH.sub.2. The salt of sulfamic acid can be an acid salt or quaternized sulfamic acid salt. The present invention also relates to a composition containing sulfamic acids or salts thereof useable in the above methods. The compositions comprise at least one sulfamic acid or salt thereof in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
    • 本发明涉及一种抑制细菌粘附在潜水表面上的方法。 该方法用有效量的至少一种氨基磺酸或其盐接触潜水表面以抑制细菌粘附到潜水表面。 本发明还涉及一种用于控制水系统的生物污垢的方法。 该方法添加有效量的至少一种氨基磺酸或其盐以抑制细菌粘附到水性体系内的浸没表面。 该方法有效地控制生物污染,而不会基本上杀死污染的生物体。 在本发明方法中使用的氨基磺酸具有式R 1 R 2 NS(O)2(OH))。 在该式中,R 1和R 2独立地为氢,C 4 -C 20烷基或环己基。 然而,R1和R2不是氢。 或者,R 1和R 2与N一起也可以形成具有下式的5-8元杂环:在杂环中,X是O,NH或CH 2。 氨基磺酸的盐可以是酸盐或季铵化的氨基磺酸盐。 本发明还涉及含有上述方法中可用的氨基磺酸或其盐的组合物。 组合物包含至少一种氨基磺酸或其盐,其量可有效地抑制细菌粘附到潜水或浸没的表面。
    • 7. 发明授权
    • Methods for controlling biofouling using amino methyl phosphonic acids
    • 使用氨基甲基膦酸控制生物污染的方法
    • US5888405A
    • 1999-03-30
    • US901894
    • 1997-07-29
    • Thomas E. McNeelMarilyn S. WhittemoreStephen D. BryantGraciela H. Vunk
    • Thomas E. McNeelMarilyn S. WhittemoreStephen D. BryantGraciela H. Vunk
    • A01N57/18C02F1/50
    • C02F1/50Y10S210/931
    • The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one amino methyl phosphonic acid or salt thereof to inhibit bacterial adhesion to the submergible surface. The invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one amino methyl phosphonic acid or salt thereof to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The amino methyl phosphonic acid used in the methods of the invention has the formula R.sup.1 R.sup.2 NCH.sub.2 P(O)(OH).sub.2. In this formula, R.sup.1 and R.sup.2 are independently a C.sub.6 -C.sub.20 alkyl group or a CH.sub.2 P(O)(OH).sub.2 group. However, R.sup.1 and R.sup.2 are not both a CH.sub.2 P(O)(OH).sub.2 group. Alternatively, R.sup.1 and R.sup.2, together with the N, may also form a 5-8 membered heterocyclic ring having the formula: ##STR1## In the heterocyclic ring, X is O, NH, or CH.sub.2. The salt of an amino methyl phosphonic acid can be an acid salt or a quaternized amino methyl phosphonic acid salt. The invention also relates to a composition containing amino methyl phosphonic acids or salts thereof and useable in the above methods. The compositions comprise at least one amino methyl phosphonic acid or salt thereof in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
    • 本发明涉及一种抑制细菌粘附在潜水表面上的方法。 该方法用有效量的至少一种氨基甲基膦酸或其盐接触潜水表面以抑制细菌粘附到潜水表面。 本发明还涉及一种用于控制水系统的生物污垢的方法。 该方法添加有效量的至少一种氨基甲基膦酸或其盐以抑制细菌粘附到水性体系内的浸没表面。 该方法有效地控制生物污染,而不会基本上杀死污染的生物体。 用于本发明方法的氨基甲基膦酸具有式R 1 R 2 NCH 2 P(O)(OH)2。 在该式中,R 1和R 2独立地为C 6 -C 20烷基或CH 2 P(O)(OH)2基团。 然而,R1和R2不是CH2P(O)(OH)2基团。 或者,R 1和R 2与N一起也可以形成具有下式的5-8元杂环:在杂环中,X是O,NH或CH 2。 氨基甲基膦酸的盐可以是酸性盐或季铵化的氨基甲基膦酸盐。 本发明还涉及含有氨基甲基膦酸或其盐的组合物并且可以在上述方法中使用。 组合物包含至少一种氨基甲基膦酸或其盐,其量可有效地抑制细菌粘附到潜水或浸没的表面。
    • 10. 发明授权
    • Methods and compositions for controlling biofouling using N-alkyl
heterocyclic compounds
    • 使用N-烷基杂环化合物控制生物污损的方法和组合物
    • US5902808A
    • 1999-05-11
    • US536841
    • 1995-09-29
    • Marilyn S. WhittemoreDaniel E. GloverJoe C. SteelhammerStephen D. Bryant
    • Marilyn S. WhittemoreDaniel E. GloverJoe C. SteelhammerStephen D. Bryant
    • C02F1/00A01N43/40A01N43/84C02F1/50C09D5/14A61K31/535A01N43/00A01N43/36
    • C02F1/50C09D5/14
    • The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one N-alkyl heterocyclic compound to inhibit bacterial adhesion to the submergible surface. The present invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one N-alkyl heterocyclic compound to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The N-alkyl heterocyclic compound used in the method of the invention has the following formula: ##STR1## The substituent R.sup.1 is a C.sub.8 -C.sub.20 alkyl group. The heterocyclic ring is a 5-8 membered heterocyclic ring where X is O, NH, or CH.sub.2. R.sup.2 is methyl, hydroxymethyl, or hydroxyethyl. The integer n ranges from 0 to 3. The present invention also relates to a composition containing N-alkyl heterocyclic compounds and useable in the above methods. The compositions comprise at least one N-alkyl heterocyclic compound in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
    • 本发明涉及一种抑制细菌粘附在潜水表面上的方法。 该方法用有效量的至少一种N-烷基杂环化合物接触潜表面以抑制细菌粘附到潜水表面。 本发明还涉及一种用于控制水系统的生物污垢的方法。 该方法添加有效量的至少一种N-烷基杂环化合物以抑制细菌粘附到水系统内的浸没表面。 该方法有效地控制生物污染,而不会基本上杀死污染的生物体。 用于本发明方法的N-烷基杂环化合物具有下式:取代基R 1为C 8 -C 20烷基。 杂环是5-8元杂环,其中X是O,NH或CH2。 R2是甲基,羟甲基或羟乙基。 整数n的范围为0-3。本发明还涉及含有N-烷基杂环化合物并可用于上述方法的组合物。 组合物包含至少一种有效抑制细菌粘附到潜水或浸没表面的N-烷基杂环化合物。