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1. 发明授权

US06380182B1 Methods and compositions controlling biofouling using sulfamic acids 有权
标题翻译：使用氨基磺酸控制生物结垢的方法和组合物
公开(公告)号：US06380182B1
公开(公告)日：2002-04-30
申请号：US09575665
申请日：2000-06-12
申请人： Thomas E. McNeel , Marilyn S. Whittemore , Stephen D. Bryant , Graciela H. Vunk
发明人： Thomas E. McNeel , Marilyn S. Whittemore , Stephen D. Bryant , Graciela H. Vunk
IPC分类号： A61K3155
CPC分类号： A01N41/02 , C02F1/50 , Y10S210/931
摘要： The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one sulfamic acid or salt thereof to inhibit bacterial adhesion to the submergible surface. The invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one sulfamic acid or salt thereof to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The sulfamic acid used in the method of the invention has the formula R1R2NS(O)2(OH). In this formula, R1 and R2 are independently a hydrogen, a C4-C20 alkyl group or a cyclohexyl group. However, R1 and R 2 are not both hydrogen. Alternatively, R1 and R2, together with the N, may also form a 5-8 membered heterocyclic ring having the formula: In the heterocyclic ring, X is O, NH, or CH2. The salt of sulfamic acid can be an acid salt or quaternized sulfamic acid salt. The present invention also relates to a composition containing sulfamic acids or salts thereof useable in the above methods. The compositions comprise at least one sulfamic acid or salt thereof in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
摘要翻译：本发明涉及一种抑制细菌粘附在潜水表面上的方法。该方法用有效量的至少一种氨基磺酸或其盐接触潜水表面以抑制细菌粘附到潜水表面。本发明还涉及一种用于控制水系统的生物污垢的方法。该方法添加有效量的至少一种氨基磺酸或其盐以抑制细菌粘附到水性体系内的浸没表面。该方法有效地控制生物污染，而不会基本上杀死污染的生物体。在本发明方法中使用的氨基磺酸具有式R 1 R 2 NS（O）2（OH））。在该式中，R 1和R 2独立地为氢，C 4 -C 20烷基或环己基。然而，R1和R2不是氢。或者，R 1和R 2与N一起也可以形成具有下式的5-8元杂环：在杂环中，X是O，NH或CH 2。氨基磺酸的盐可以是酸盐或季铵化的氨基磺酸盐。本发明还涉及含有上述方法中可用的氨基磺酸或其盐的组合物。组合物包含至少一种氨基磺酸或其盐，其量可有效地抑制细菌粘附到潜水或浸没的表面。

2. 发明授权

US6103131A Methods for controlling biofouling using sulfamic acids 失效
标题翻译：使用氨基磺酸控制生物污染的方法
公开(公告)号：US6103131A
公开(公告)日：2000-08-15
申请号：US901895
申请日：1997-07-29
申请人： Thomas E. McNeel , Marilyn S. Whittemore , Stephen D. Bryant , Graciela H. Vunk
发明人： Thomas E. McNeel , Marilyn S. Whittemore , Stephen D. Bryant , Graciela H. Vunk
IPC分类号： A61K8/40 , A01N41/02 , A61K8/46 , A61Q11/00 , C02F1/50
CPC分类号： A01N41/02 , C02F1/50 , Y10S210/931
摘要： The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one sulfamic acid or salt thereof to inhibit bacterial adhesion to the submergible surface. The invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one sulfamic acid or salt thereof to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The sulfamic acid used in the method of the invention has the formula R.sup.1 R.sup.2 NS(O).sub.2 (OH). In this formula, R.sup.1 and R.sup.2 are independently a hydrogen, a C.sub.4 -C.sub.20 alkyl group or a cyclohexyl group. However, R.sup.1 and R.sup.2 are not both hydrogen. Alternatively, R.sup.1 and R.sup.2, together with the N, may also form a 5-8 membered heterocyclic ring having the formula: ##STR1## In the heterocyclic ring, X is O, NH, or CH.sub.2. The salt of sulfamic acid can be an acid salt or quaternized sulfamic acid salt. The present invention also relates to a composition containing sulfamic acids or salts thereof useable in the above methods. The compositions comprise at least one sulfamic acid or salt thereof in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
摘要翻译：本发明涉及一种抑制细菌粘附在潜水表面上的方法。该方法用有效量的至少一种氨基磺酸或其盐接触潜水表面以抑制细菌粘附到潜水表面。本发明还涉及一种用于控制水系统的生物污垢的方法。该方法添加有效量的至少一种氨基磺酸或其盐以抑制细菌粘附到水性体系内的浸没表面。该方法有效地控制生物污染，而不会基本上杀死污染的生物体。在本发明方法中使用的氨基磺酸具有式R 1 R 2 NS（O）2（OH））。在该式中，R 1和R 2独立地为氢，C 4 -C 20烷基或环己基。然而，R1和R2不是氢。或者，R 1和R 2与N一起也可以形成具有下式的5-8元杂环：在杂环中，X是O，NH或CH 2。氨基磺酸的盐可以是酸盐或季铵化的氨基磺酸盐。本发明还涉及含有上述方法中可用的氨基磺酸或其盐的组合物。组合物包含至少一种氨基磺酸或其盐，其量可有效地抑制细菌粘附到潜水或浸没的表面。

3. 发明授权

US5888405A Methods for controlling biofouling using amino methyl phosphonic acids 失效
标题翻译：使用氨基甲基膦酸控制生物污染的方法
公开(公告)号：US5888405A
公开(公告)日：1999-03-30
申请号：US901894
申请日：1997-07-29
申请人： Thomas E. McNeel , Marilyn S. Whittemore , Stephen D. Bryant , Graciela H. Vunk
发明人： Thomas E. McNeel , Marilyn S. Whittemore , Stephen D. Bryant , Graciela H. Vunk
IPC分类号： A01N57/18 , C02F1/50
CPC分类号： C02F1/50 , Y10S210/931
摘要： The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one amino methyl phosphonic acid or salt thereof to inhibit bacterial adhesion to the submergible surface. The invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one amino methyl phosphonic acid or salt thereof to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The amino methyl phosphonic acid used in the methods of the invention has the formula R.sup.1 R.sup.2 NCH.sub.2 P(O)(OH).sub.2. In this formula, R.sup.1 and R.sup.2 are independently a C.sub.6 -C.sub.20 alkyl group or a CH.sub.2 P(O)(OH).sub.2 group. However, R.sup.1 and R.sup.2 are not both a CH.sub.2 P(O)(OH).sub.2 group. Alternatively, R.sup.1 and R.sup.2, together with the N, may also form a 5-8 membered heterocyclic ring having the formula: ##STR1## In the heterocyclic ring, X is O, NH, or CH.sub.2. The salt of an amino methyl phosphonic acid can be an acid salt or a quaternized amino methyl phosphonic acid salt. The invention also relates to a composition containing amino methyl phosphonic acids or salts thereof and useable in the above methods. The compositions comprise at least one amino methyl phosphonic acid or salt thereof in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
摘要翻译：本发明涉及一种抑制细菌粘附在潜水表面上的方法。该方法用有效量的至少一种氨基甲基膦酸或其盐接触潜水表面以抑制细菌粘附到潜水表面。本发明还涉及一种用于控制水系统的生物污垢的方法。该方法添加有效量的至少一种氨基甲基膦酸或其盐以抑制细菌粘附到水性体系内的浸没表面。该方法有效地控制生物污染，而不会基本上杀死污染的生物体。用于本发明方法的氨基甲基膦酸具有式R 1 R 2 NCH 2 P（O）（OH）2。在该式中，R 1和R 2独立地为C 6 -C 20烷基或CH 2 P（O）（OH）2基团。然而，R1和R2不是CH2P（O）（OH）2基团。或者，R 1和R 2与N一起也可以形成具有下式的5-8元杂环：在杂环中，X是O，NH或CH 2。氨基甲基膦酸的盐可以是酸性盐或季铵化的氨基甲基膦酸盐。本发明还涉及含有氨基甲基膦酸或其盐的组合物并且可以在上述方法中使用。组合物包含至少一种氨基甲基膦酸或其盐，其量可有效地抑制细菌粘附到潜水或浸没的表面。

4. 发明授权

US07157017B2 Fungicidal compositions and methods using cyanodithiocarbimates 有权
标题翻译：使用氰基二硫代碳酸酯的杀真菌组合物和方法
公开(公告)号：US07157017B2
公开(公告)日：2007-01-02
申请号：US10721417
申请日：2003-11-26
申请人： Joseph G. E. Fenyes , Thomas E. McNeel , Stephen D. Bryant , Marilyn S. Whittemore , Zoltan G. Csuros , Mark L. Zollinger , Robert H. Miller , Naim B. Miguel
发明人： Joseph G. E. Fenyes , Thomas E. McNeel , Stephen D. Bryant , Marilyn S. Whittemore , Zoltan G. Csuros , Mark L. Zollinger , Robert H. Miller , Naim B. Miguel
IPC分类号： C14C9/00 , C14C3/26
CPC分类号： C14C9/00
摘要： The invention relates to control fungal growth on tanned hides, using cyanodithiocarbimates of formula (I): X is a halogen; R is a substituted or unsubstituted C1–C14 alkyl group, a substituted or unsubstituted C2–C14 alkenyl group, a substituted or unsubstituted C2–C14 alkynyl group, a substituted or unsubstituted group defined by Y—Ar—(CH2)m— or by Z—(CH2)n—; Ar is a substituted or unsubstituted aryl group selected from phenyl, or naphthyl; Y is H, halogen, NO2, R1, R1O, R1R2N; Z is NC, R1O, R1OC(O), R1OCH2CH2(OCH2CH2)p m ranges from 0 to 3; n ranges from 0 to 3; p ranges from 0 to 3; and R1 and R2 are independently H, substituted or unsubstituted C1–C5 alkyl.
摘要翻译：本发明涉及使用式（I）的氰基二硫代碳酸酯控制鞣制皮革上的真菌生长：X是卤素; R是取代或未取代的C 1 -C 14烷基，取代或未取代的C 2 -C 14亚烷基链烯基，取代或未取代的C 2 -C 14炔基，被Y-Ar-（CH 2 N 2）定义的取代或未取代的基团 >） - 或Z-（CH 2）n - ）。 Ar是取代或未取代的选自苯基或萘基的芳基; Y是H，卤素，NO 2，R 1，R 1，O，R 1， 2 N; Z是NC，R 1 O，R 1 OC（O），R 1 OCH 2 CH > 2（OCH 2）2 CH 2）m取代0〜3; n的范围从0到3; p范围从0到3; R 1和R 2独立地为H，取代或未取代的C 1 -C 15烷基。

5. 发明申请

US20130043194A1 Tagged Polymers, Water Treatment Compositions, And Methods Of Their Use In Aqueous Systems 有权
标题翻译：标签聚合物，水处理组合物及其在水系统中的使用方法
公开(公告)号：US20130043194A1
公开(公告)日：2013-02-21
申请号：US13561455
申请日：2012-07-30
申请人： Thomas E. McNeel , Marilyn S. Whittemore , Richard A. Clark , Jadwiga J. Grabowicz
发明人： Thomas E. McNeel , Marilyn S. Whittemore , Richard A. Clark , Jadwiga J. Grabowicz
IPC分类号： C08F26/06 , C02F1/00
CPC分类号： G01N33/1826 , C02F1/008 , C02F1/5209 , C02F2209/06 , C02F2303/20 , C09K11/06 , G01N33/18 , Y02A20/206 , Y10S210/917 , Y10T436/13
摘要： A method and composition is described for controlling the growth of fouling materials, such as scale, in aqueous systems using a tagged (fluorescent) polymer. The tagged polymer can be a fluorescent polymer which has at least one fluorescent monomeric unit derived from a fluorophore which has at least one terminal end comprising an olefinic group. The method of controlling the growth of at least one fouling material in an aqueous system can include the steps of adding the tagged polymer to the aqueous system to be treated, fluorometrically monitoring the concentration of the tagged polymer, and adjusting, as needed, the concentration of the tagged polymer and proportionally used water treatment compound or compounds effective to control the growth of at least one fouling material. The adjustment of pH before determination of the fluorescence signal can be employed to increase sensitivity of the fluorophore and minimize background interference.
摘要翻译：描述了一种方法和组合物，用于使用标记（荧光）聚合物在含水体系中控制污垢物质如水垢的生长。标记的聚合物可以是具有至少一种衍生自荧光团的荧光单体单元的荧光聚合物，该荧光团具有至少一个包含烯属基团的末端。控制水性体系中至少一种结垢材料的生长的方法可以包括以下步骤：将标记的聚合物加入待处理的水性体系中，荧光测量监测标记的聚合物的浓度，并根据需要调节浓度的标记聚合物和成比例地使用的水处理化合物或有效控制至少一种结垢材料生长的化合物。荧光信号测定前pH值的调节可用于提高荧光团的灵敏度，并使背景干扰最小化。

6. 发明授权

US09347928B2 Tagged polymers, water treatment compositions, and methods of their use in aqueous systems 有权
标题翻译：标签聚合物，水处理组合物及其在含水体系中的使用方法
公开(公告)号：US09347928B2
公开(公告)日：2016-05-24
申请号：US13561455
申请日：2012-07-30
申请人： Thomas E. McNeel , Marilyn S. Whittemore , Richard A. Clark , Jadwiga J. Grabowicz
发明人： Thomas E. McNeel , Marilyn S. Whittemore , Richard A. Clark , Jadwiga J. Grabowicz
IPC分类号： C02F1/52 , G01N33/18 , C09K11/06 , C02F1/00
CPC分类号： G01N33/1826 , C02F1/008 , C02F1/5209 , C02F2209/06 , C02F2303/20 , C09K11/06 , G01N33/18 , Y02A20/206 , Y10S210/917 , Y10T436/13
摘要： A method and composition is described for controlling the growth of fouling materials, such as scale, in aqueous systems using a tagged (fluorescent) polymer. The tagged polymer can be a fluorescent polymer which has at least one fluorescent monomeric unit derived from a fluorophore which has at least one terminal end comprising an olefinic group. The method of controlling the growth of at least one fouling material in an aqueous system can include the steps of adding the tagged polymer to the aqueous system to be treated, fluorometrically monitoring the concentration of the tagged polymer, and adjusting, as needed, the concentration of the tagged polymer and proportionally used water treatment compound or compounds effective to control the growth of at least one fouling material. The adjustment of pH before determination of the fluorescence signal can be employed to increase sensitivity of the fluorophore and minimize background interference.
摘要翻译：描述了一种方法和组合物，用于使用标记（荧光）聚合物在含水体系中控制污垢物质如水垢的生长。标记的聚合物可以是具有至少一种衍生自荧光团的荧光单体单元的荧光聚合物，其具有至少一个包含烯属基团的末端。控制水性体系中至少一种结垢材料的生长的方法可以包括以下步骤：将标记的聚合物加入待处理的水性体系中，荧光测量监测标记的聚合物的浓度，并根据需要调节浓度的标记聚合物和成比例地使用的水处理化合物或有效控制至少一种结垢材料生长的化合物。荧光信号测定前pH值的调节可用于提高荧光团的灵敏度，并使背景干扰最小化。

7. 发明授权

US06255324B1 Amino-and mercurio-substituted 4′,5'-dihydropsoralens and therapeutical uses thereof 有权
标题翻译：氨基和巯基取代的4'，5'-二氢补骨脂素及其治疗用途
公开(公告)号：US06255324B1
公开(公告)日：2001-07-03
申请号：US09199552
申请日：1998-11-25
申请人： Ned D. Heindel , Jeffrey D. Laskin , Diane E. Heck , Robert D. Rapp , Marilyn S. Whittemore , Thomas E. McNeel , Ivan Jabin
发明人： Ned D. Heindel , Jeffrey D. Laskin , Diane E. Heck , Robert D. Rapp , Marilyn S. Whittemore , Thomas E. McNeel , Ivan Jabin
IPC分类号： A61K314709
CPC分类号： C07D493/04 , C07D311/44 , C07D311/56 , C07F3/14
摘要： 5′-substituted, 4′,5′-dihydropsoralen compounds (5) bearing tertiary amines (and salts thereof), quaternary ammonium moieties or organomercurial moieties are described. Also described are 2-substituted mercurimethyl-2-3-dihydro-benzofurans of forumla (7): Also reported are versatile direct syntheses through a hitherto unknown compounds such as 3-R-4,8-dimethyl-4′,5′-dihydro-5′-bromomethylpsoralen or a 3-R-4,8-dimethyl-4′, 5′-dihydro-5′-iodomethylpsoralen to prepare a structurally diverse array of partially reduced psoralens and benzofurans. The presence of a permanent ammonium charge in these psoralens precludes membrane passage and the mono-unsaturation precludes the cross-linking of nuclear DNA, thereby minimizing the mutagenic/carcinogenic side effects long associated with psoralen-derived therapies. The presence of a mercury functionality provides a reactive cell-binding group on these psoralens with unique cytotoxicity without light activation and an enhancement of cytotoxicity activity upon light activation. The invention also relates to These partially reduced and quaternized psoralens, amino-substituted psoralens, and mercurio psoralens display impressive pharmacology against PAM 212 keratinocytes, a model cell line employed as a test system to indicate epidermal cytotoxicity and cancer. The compounds of the invention also have antimicrobicidal activity useful in pharmacologic agents for mammals (e.g. the treatment of tuberculosis) as well as in controlling the growth of microorganisms on substrates and in aqueous systems.
摘要翻译：描述了含有叔胺（及其盐），季铵部分或有机聚合物部分的5'取代的4'，5'-二氢补骨脂素化合物（5）。还描述了2-取代的缩水甘油二甲基-2,3-二氢 - 苯并呋喃论坛（7）：还报道了通过迄今为止未知的化合物如3-R-4,8-二甲基-4'，5'-二氢-5'-溴甲基口服或3-R-4,8- 二甲基-4'，5'-二氢-5'-碘甲基肌醇，以制备结构不同的部分还原的补骨脂素和苯并呋喃的阵列。在这些补骨脂素中存在永久铵电荷排除了膜通过，并且单不饱和度排除了核DNA的交联，从而使与补骨脂素衍生疗法长期相关的诱变/致癌副作用最小化。汞功能的存在在这些补骨脂素上提供了具有独特细胞毒性的反应性细胞结合基团，而没有光活化，并且在光活化时增强细胞毒性活性。本发明还涉及这些部分还原和季铵化的补骨脂素，氨基取代的补骨脂素和补骨脂素，对PAM 212角质形成细胞，用作指示表皮细胞毒性和癌症的测试系统的模型细胞系显示令人印象深刻的药理学。本发明的化合物还具有用于哺乳动物的药理学（例如治疗结核病）以及控制底物和水系统中的微生物生长的抗除菌活性。

8. 发明授权

US06177424B1 4′-Substituted-4′,5′-dihydropsoralens and therapeutical uses thereof 失效
标题翻译： 4'-取代-4'，5'-二氢补骨脂素及其治疗用途
公开(公告)号：US06177424B1
公开(公告)日：2001-01-23
申请号：US09450560
申请日：1999-11-30
申请人： Ned D. Heindel , Jeffrey D. Laskin , Marilyn S. Whittemore , Thomas E. McNeel , Christophe Guillon , Diane E. Heck , Robert D. Rapp
发明人： Ned D. Heindel , Jeffrey D. Laskin , Marilyn S. Whittemore , Thomas E. McNeel , Christophe Guillon , Diane E. Heck , Robert D. Rapp
IPC分类号： A61K3137
CPC分类号： C07D493/04
摘要： The invention relates to 4′-substituted-4′,5′-dihydropsoralen compounds of formula(V): In the formula R is hydrogen, a halogen, CN or an acyl group; T is a halogen, CN, a carboalkoxy group NR1R2, or (N+R1R2R3)X−, R1 and R2 are independently a C1-C6 alkyl, or R1 and R2 together with the nitrogen form a 5-8 member heterocyclic ring, or when T is (N+R1R2R3)X−, R1 and R2 together with the nitrogen form a 5-8 member heterocyclic ring or heterocyclic aromatic ring; R3 is hydrogen, a C1-C12 alkyl, or, when R1 and R2 together with the nitrogen form a heterocyclic aromatic ring, R3 is a double bond within the heterocyclic aromatic ring; X− is a halide. In another embodiment, the invention relates to processes for preparing 4′-substituted-4′,5′-dihydropsoralen compounds described above. The compounds of the invention have beneficial pharmaceutical properties and can be used alone or in pharmaceutical compositions used to treat a proliferative skin disorder and to treat microbial infections in a mammal by administering to the mammal an effective amount of a compound of the invention and then irradiating the mammal with ultraviolet light.
摘要翻译：本发明涉及式（Ⅴ）的4'-取代-4'，5'-二氢补骨脂素化合物：式中R是氢，卤素，CN或酰基; T是卤素，CN，烷氧羰基NR1R2或（N + R1R2R3）X-，R1和R2独立地是C1-C6烷基，或R1和R2与氮一起形成5-8元杂环，或当T是（N + R1R2R3）X - 时，R1和R2与氮一起形成5-8元杂环或杂环芳环; R3是氢，C1-C12烷基，或当R1和R2与氮一起形成杂环芳环时，R3是杂环芳环中的双键; X-是卤化物。在另一个实施方案中，本发明涉及制备上述4'-取代-4'，5'-二氢补骨脂素化合物的方法。本发明的化合物具有有益的药物性质，并且可以单独使用或用于治疗增殖性皮肤病症的药物组合物和通过向哺乳动物施用有效量的本发明化合物然后照射而治疗哺乳动物的微生物感染哺乳动物用紫外线照射。

9. 发明授权

US06211172B1 Methods and compositions for controlling biofouling using sulfonamides 失效
标题翻译：使用磺酰胺控制生物污损的方法和组合物
公开(公告)号：US06211172B1
公开(公告)日：2001-04-03
申请号：US09298821
申请日：1999-04-26
申请人： Mark L. Zollinger , Daniel E. Glover , Marilyn S. Whittemore , Stephen D. Bryant
发明人： Mark L. Zollinger , Daniel E. Glover , Marilyn S. Whittemore , Stephen D. Bryant
IPC分类号： A01N4340
CPC分类号： C09D5/14 , C02F1/50
摘要： The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one sulfonamide to inhibit bacterial adhesion to the submergible surface. The present invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one sulfonamide to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The sulfonamide used in the method of the invention has the following formula: The present invention also relates to a composition containing the sulfonamides and useable in the above methods. The compositions comprise at least one sulfonamide in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
摘要翻译：本发明涉及一种抑制细菌粘附在潜水表面上的方法。该方法用有效量的至少一种磺酰胺接触潜表面以抑制细菌粘附到潜水表面。本发明还涉及一种用于控制水系统的生物污垢的方法。该方法添加有效量的至少一种磺酰胺以抑制细菌粘附到水系统内的浸没表面。该方法有效地控制生物污染，而不会基本上杀死污染的生物体。用于本发明方法的磺酰胺具有下式：本发明还涉及含有磺酰胺并可用于上述方法的组合物。组合物包含至少一种有效抑制细菌粘附到潜水或浸没表面的量的磺酰胺。

10. 发明授权

US6030971A Methods and compositions for controlling biofouling using amides 有权
标题翻译：使用酰胺控制生物污损的方法和组合物
公开(公告)号：US6030971A
公开(公告)日：2000-02-29
申请号：US161756
申请日：1998-09-29
申请人： Marilyn S. Whittemore , Daniel E. Glover , Mark L. Zollinger , Stephen D. Bryant
发明人： Marilyn S. Whittemore , Daniel E. Glover , Mark L. Zollinger , Stephen D. Bryant
IPC分类号： C02F1/00 , A01N37/18 , A01N43/40 , A01N43/46 , A01N43/84 , C02F1/50 , C09D5/14 , A01N43/00 , A61K31/535
CPC分类号： A01N37/18 , C02F1/50
摘要： The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one amide to inhibit bacterial adhesion to the submergible surface. The present invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one amide to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the bacteria. The amide used in the method of the invention has the following formula: ##STR1## The present invention also relates to compositions containing amides and useable in the above methods. The compositions comprise at least one amide in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
摘要翻译：本发明涉及一种抑制细菌粘附在潜水表面上的方法。该方法与有效量的至少一种酰胺接触该潜水表面以抑制细菌粘附到潜水表面。本发明还涉及一种用于控制水系统的生物污垢的方法。该方法添加有效量的至少一种酰胺以抑制细菌粘附到水系统内的浸没表面。该方法有效地控制生物污损，而不会基本上杀死细菌。在本发明方法中使用的酰胺具有下式：本发明还涉及含有酰胺的组合物并且可用于上述方法。组合物包含至少一种有效抑制细菌粘附到潜水或浸没表面的酰胺。

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