专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08718738B2 Method and apparatus for coupling a sample probe with a sample site 有权
标题翻译：用于将样品探针与样品位点偶联的方法和装置
公开(公告)号：US08718738B2
公开(公告)日：2014-05-06
申请号：US12393867
申请日：2009-02-26
申请人： Thomas B. Blank , Roxanne E. Abul-Haj
发明人： Thomas B. Blank , Roxanne E. Abul-Haj
IPC分类号： A61B5/00 , G02B6/24
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B2562/146 , G01N21/01 , G01N21/359 , G01N21/474
摘要： The invention comprises method and apparatus for fluid delivery between a sample probe and a sample. The fluid delivery system includes: a fluid reservoir, a delivery channel, a manifold or plenum, a channel or moat, a groove, and/or a dendritic pathway to deliver a thin and distributed layer of a fluid to a sample probe head and/or to a sample site. The fluid delivery system reduces sampling errors due to mechanical tissue distortion, specular reflectance, probe placement, and/or mechanically induced sample site stress/strain associated with optical sampling of the sample.
摘要翻译：本发明包括用于在样品探针和样品之间流体递送的方法和装置。流体输送系统包括：流体储存器，输送通道，歧管或增压室，通道或沟槽，沟槽和/或树枝状路径，以将薄的和分布的流体层递送到样品探针头和/ 或到一个样本站点。流体输送系统减少由于样品的光学取样所引起的机械组织变形，镜面反射率，探针放置和/或机械诱导的样本位点应力/应变引起的采样误差。

2. 发明授权

US07606608B2 Optical sampling interface system for in-vivo measurement of tissue 有权
标题翻译：用于体内测量组织的光学取样界面系统
公开(公告)号：US07606608B2
公开(公告)日：2009-10-20
申请号：US11008001
申请日：2004-12-08
申请人： Thomas B. Blank , George Acosta , Mutua Mattu , Marcy Makarewicz , Stephen L. Monfre , Alexander D. Lorenz , Timothy L. Ruchti , Kevin H. Hazen , Donovan D. Berry , Roxanne E. Abul-Haj
发明人： Thomas B. Blank , George Acosta , Mutua Mattu , Marcy Makarewicz , Stephen L. Monfre , Alexander D. Lorenz , Timothy L. Ruchti , Kevin H. Hazen , Donovan D. Berry , Roxanne E. Abul-Haj
IPC分类号： A61B5/1455
CPC分类号： G01N21/359 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/6833
摘要： An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.
摘要翻译：公开了一种光学采样接口系统，其最小化并补偿由采样变化和测量位置状态波动引起的误差。本发明的实施例使用至少一个引导组织弯液面的形成的引导件，使由于表面不规则性引起的干扰最小化，控制组织体积的变化，使用两部分引导系统，使用指导控制样品探针的旋转并允许探针的z轴移动，使用独立的基本模块和样品模块与导轨结合使用，并使用控制旋转的指南。可选组件包括闭塞元件和耦合流体。

3. 发明授权

US07640140B2 Method of processing noninvasive spectra 有权
标题翻译：无创光谱处理方法
公开(公告)号：US07640140B2
公开(公告)日：2009-12-29
申请号：US11095331
申请日：2005-03-30
申请人： Timothy L. Ruchti , Thomas B. Blank , Alexander D. Lorenz
发明人： Timothy L. Ruchti , Thomas B. Blank , Alexander D. Lorenz
IPC分类号： G06F19/00 , A61B5/00
CPC分类号： A61B5/14532
摘要： This invention provides a method and apparatus that corrects for tissue related interference calibration and/or measurement of biological parameters noninvasively. The invention concerns such terms as outlier identification, filtering, spectral correction, and baseline subtraction steps that, when used together, provides for noninvasive measurement of biological parameters, such as glucose concentration.
摘要翻译：本发明提供一种非侵入性校正组织相关干扰校准和/或生物参数测量的方法和装置。本发明涉及诸如异常值识别，过滤，光谱校正和基线减法步骤之类的术语，当它们一起使用时，提供诸如葡萄糖浓度的生物学参数的非侵入性测量。

4. 发明授权

US07183102B2 Apparatus using reference measurement for calibration 失效
标题翻译：使用参考测量仪进行校准
公开(公告)号：US07183102B2
公开(公告)日：2007-02-27
申请号：US11122669
申请日：2005-05-04
申请人： Stephen L. Monfre , Kevin H. Hazen , Timothy L. Ruchti , Thomas B. Blank , James R. Henderson
发明人： Stephen L. Monfre , Kevin H. Hazen , Timothy L. Ruchti , Thomas B. Blank , James R. Henderson
IPC分类号： C12M1/34
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/1495 , G01N21/274 , G01N21/359 , G01N21/49
摘要： A method and apparatus for calibrating noninvasive or implantable glucose analyzers that uses either alternative invasive glucose determinations or noninvasive glucose determinations to calibrate noninvasive or implantable glucose analyzers. Use of an alternative invasive or noninvasive glucose determination in the calibration allows minimization of errors due to sampling methodology, and spatial and temporal variations that are built into the calibration model. An additional embodiment uses statistical correlations between noninvasive and alternative invasive glucose determinations and traditional invasive glucose determinations to adjust noninvasive or alternative invasive glucose concentrations to traditional invasive glucose concentrations. The invention provides a means for calibrating on the basis of glucose determinations that reflect the matrix observed and the variable measured by the analyzer more closely. A glucose analyzer couples an invasive fingerstick meter to a noninvasive glucose analyzer for calibration, validation, adaptation, and safety check of the calibration model embodied in the noninvasive analyzer.
摘要翻译：一种用于校准无创或可植入的葡萄糖分析仪的方法和装置，其使用替代的侵入性葡萄糖测定或非侵入性葡萄糖测定来校准无创或可植入的葡萄糖分析仪。在校准中使用替代入侵或非侵入性葡萄糖测定可以最大限度地减少由采样方法引起的误差，以及内置于校准模型中的空间和时间变化。另外的实施方案使用非侵入性和替代性侵入性葡萄糖测定与传统的侵入性葡萄糖测定之间的统计学相关性来调整对于传统侵入性葡萄糖浓度的非侵入性或替代性侵入性葡萄糖浓度。本发明提供了一种用于基于反映观察到的基质的葡萄糖测定和由分析仪更仔细测量的变量进行校准的方法。葡萄糖分析仪将无创手指计与无创葡萄糖分析仪相结合，用于非侵入性分析仪中体现的校准模型的校准，验证，适应和安全性检查。

5. 发明授权

US06998247B2 Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers 失效
标题翻译：使用替代部位葡萄糖测定来校准和维护无创和可植入分析仪的方法和设备
公开(公告)号：US06998247B2
公开(公告)日：2006-02-14
申请号：US10377916
申请日：2003-02-28
申请人： Stephen L. Monfre , Kevin H. Hazen , Timothy L. Ruchti , Thomas B. Blank , James R. Henderson
发明人： Stephen L. Monfre , Kevin H. Hazen , Timothy L. Ruchti , Thomas B. Blank , James R. Henderson
IPC分类号： C12Q1/54
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/1495 , G01N21/274 , G01N21/359 , G01N21/49
摘要： Methods for calibrating noninvasive or implantable glucose analyzers utilize either alternative invasive glucose determinations or noninvasive glucose determinations for calibrating noninvasive or implantable glucose analyzers. Use of an alternative invasive or noninvasive glucose determination in the calibration allows minimization of errors due to sampling methodology, and spatial and temporal variation that are built into the calibration model. An additional method uses statistical correlations between noninvasive and alternative invasive glucose determinations and traditional invasive glucose determinations to adjust noninvasive or alternative invasive glucose concentrations to traditional invasive glucose concentrations. The methods provide a means for calibrating on the basis of glucose determinations that reflect the matrix observed and the variable measured by the analyzer more closely. A glucose analyzer couples an invasive fingerstick meter to a noninvasive glucose analyzer for calibration, validation, adaptation, and safety check of the calibration model embodied in the noninvasive analyzer.
摘要翻译：用于校准无创或可植入葡萄糖分析仪的方法利用替代侵入性葡萄糖测定或非侵入性葡萄糖测定来校准无创或可植入的葡萄糖分析仪。在校准中使用替代入侵或无创葡萄糖测定可以最小化由采样方法引起的误差，以及内置于校准模型中的空间和时间变化。一种额外的方法使用非侵入性和替代性侵入性葡萄糖测定与传统侵入性葡萄糖测定之间的统计学相关性来调整传统侵入性葡萄糖浓度的无创或替代侵入性葡萄糖浓度。这些方法提供了一种基于反映观察到的基质的葡萄糖测定和由分析仪更接近测量的变量进行校准的方法。葡萄糖分析仪将无创手指计与无创葡萄糖分析仪相结合，用于非侵入性分析仪中体现的校准模型的校准，验证，适应和安全性检查。

6. 发明授权

US06839584B2 Method and apparatus for minimizing spectral interference due to within and between sample variations during in-situ spectral sampling of tissue 失效
标题翻译：用于在组织的原位光谱采样期间最小化由于样品变化之内和之间的光谱干扰的方法和装置
公开(公告)号：US06839584B2
公开(公告)日：2005-01-04
申请号：US09954856
申请日：2001-09-17
申请人： Marcy Makarewicz , Mutua Mattu , Thomas B. Blank , George Acosta , Edward Handy , William Hay , Timothy Stippick , Benjamin Richie
发明人： Marcy Makarewicz , Mutua Mattu , Thomas B. Blank , George Acosta , Edward Handy , William Hay , Timothy Stippick , Benjamin Richie
IPC分类号： A61B20060101 , A61B5/00
CPC分类号： A61B5/14532 , A61B5/061 , A61B5/1459 , A61B5/6824 , A61B2562/146
摘要： An apparatus and method for reproducibly interfacing a living tissue sample to the measurement probe of a spectrometer instrument in-situ minimizes spectral interference related to sampling variations. A minimal contact subject interface includes supports replaceably mounted on a base. An optical coupling means, such as a fiber optic probe, contacts the measurement site through a probe aperture in the base. During use, a subject rests an extremity on the support elements, so that the extremity is reproducibly positioned and supported in relation to the optical coupling means. The supports have a small contact area, minimizing contact with the skin at the measurement site. The interface module is adjustable to fit any subject.By reproducibly positioning and supporting the body appendage using minimal contact supports, spectral interference due to variations in placement, applied pressure, and temperature transients secondary to contact with the interface module are greatly minimized.
摘要翻译：将生物组织样本可再现地将光谱仪器的测量探针接地的设备和方法原位最小化与采样变化相关的光谱干扰。最小接触主体界面包括可替换地安装在基座上的支撑件。诸如光纤探针的光学耦合装置通过基座中的探针孔接触测量部位。在使用期间，被摄体将支撑元件的末端置于支撑元件上，使得末端相对于光耦合装置可再现地定位和支撑。支架具有很小的接触面积，使测量点与皮肤接触最小化。接口模块是可调整的，适合任何物体。通过使用最小的接触支持可重复地定位和支撑身体附件，由于与接口模块接触的位置变化，施加的压力和温度瞬变引起的频谱干扰大大降低。

7. 发明授权

US06788965B2 Intelligent system for detecting errors and determining failure modes in noninvasive measurement of blood and tissue analytes 有权
标题翻译：用于检测血液和组织分析物的非侵入性测量中的错误和确定失败模式的智能系统
公开(公告)号：US06788965B2
公开(公告)日：2004-09-07
申请号：US10211478
申请日：2002-08-01
申请人： Timothy L. Ruchti , Christopher C. Briggs , Thomas B. Blank , Alexander D. Lorenz , Mutua Mattu , Marcy Makarewicz
发明人： Timothy L. Ruchti , Christopher C. Briggs , Thomas B. Blank , Alexander D. Lorenz , Mutua Mattu , Marcy Makarewicz
IPC分类号： A61B500
CPC分类号： A61B5/1459 , A61B5/0064 , A61B5/0075 , A61B5/01 , A61B5/14532 , A61B5/14546 , A61B5/1495 , A61B5/441 , A61B5/7264 , G01N21/274 , G01N21/359 , G06N3/004
摘要： An intelligent system for detecting errors and determining failure modes operates on an absorbance spectrum of in vivo skin tissue. Application of the system results in improved prediction accuracy through rejection of invalid and poor samples. System components include a noninvasive blood glucose meter, such as a near IR spectrometer, an error detection system (EDS); a system for diagnosing and mitigating errors; and a reporting method. In the EDS, a pattern classification engine and hierarchy of levels analyzes, detects and diagnoses instrument, interface and sample errors manifested in the spectrum to determine suitability of an absorbance spectrum for blood glucose measurement. The final component of the system evaluates the error condition, diagnoses the specific mode of failure (if necessary) and reports actions to be taken. Sub-components and levels of the EDS can operate independently of the other system elements to the benefit of a noninvasive glucose measurement system.
摘要翻译：用于检测错误并确定故障模式的智能系统对体内皮肤组织的吸收光谱进行操作。该系统的应用通过排除无效和差的样本提高了预测精度。系统组件包括无创血糖仪，例如近红外光谱仪，误差检测系统（EDS）; 用于诊断和减轻错误的系统; 和报告方法。在EDS中，模式分类引擎和级别层次分析，检测和诊断谱图中出现的仪器，界面和样本误差，以确定血糖测量的吸收光谱的适用性。系统的最终组件评估错误状况，诊断具体的失败模式（如有必要）并报告要采取的操作。 EDS的子组件和级别可以独立于其他系统元件运行，以有益于非侵入性葡萄糖测量系统。

8. 再颁专利

USRE41333E1 Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction 失效
标题翻译：开发用于非侵入性血液分析物预测的局部校准模型的多层方法
公开(公告)号：USRE41333E1
公开(公告)日：2010-05-11
申请号：US11046673
申请日：2005-01-27
申请人： Thomas B. Blank , Stephen L. Monfre , Timothy L. Ruchti , Suresh N. Thennadill
发明人： Thomas B. Blank , Stephen L. Monfre , Timothy L. Ruchti , Suresh N. Thennadill
IPC分类号： A61B5/1455
CPC分类号： G01N21/274 , A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/7264 , A61B2560/0223 , A61B2560/0233 , G01N21/359 , G01N21/4785 , G01N21/49
摘要： A method of multi-tier classification and calibration in noninvasive blood analyte prediction minimizes prediction error by limiting co-varying spectral interferents. Tissue samples are categorized based on subject demographic and instrumental skin measurements, including in vivo near-IR spectral measurements. A multi-tier intelligent pattern classification sequence organizes spectral data into clusters having a high degree of internal consistency in tissue properties. In each tier, categories are successively refined using subject demographics, spectral measurement information and other device measurements suitable for developing tissue classifications.The multi-tier classification approach to calibration utilizes multivariate statistical arguments and multi-tiered classification using spectral features. Variables used in the multi-tiered classification can be skin surface hydration, skin surface temperature, tissue volume hydration, and an assessment of relative optical thickness of the dermis by the near-IR fat band. All tissue parameters are evaluated using the NIR spectrum signal along key wavelength segments.
摘要翻译：非侵入性血液分析物预测中的多层分类和校准方法通过限制共同变化的光谱干扰来最小化预测误差。组织样品根据受试者的人口统计学和仪器皮肤测量进行分类，包括体内近红外光谱测量。多层智能图案分类序列将光谱数据组织成具有组织性质内部高度一致性的簇。在每个层次中，使用主题人口统计学，光谱测量信息和适合于开发组织分类的其它装置测量法来连续地改进类别。校准的多层分类方法利用多变量统计学参数和使用光谱特征的多层次分类。用于多层次分类的变量可以是皮肤表面水合，皮肤表面温度，组织体积水合，以及近红外脂肪带对真皮的相对光学厚度的评估。使用沿关键波长段的NIR光谱信号评估所有组织参数。

9. 发明授权

US07697966B2 Noninvasive targeting system method and apparatus 有权
标题翻译：无创瞄准系统的方法和装置
公开(公告)号：US07697966B2
公开(公告)日：2010-04-13
申请号：US11361143
申请日：2006-02-23
申请人： Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen , Alan Abul-Haj , Tim Ruchti , James Ryan Henderson , Tim Stippick , Roxanne Abul-Haj
发明人： Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen , Alan Abul-Haj , Tim Ruchti , James Ryan Henderson , Tim Stippick , Roxanne Abul-Haj
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/061 , A61B5/1455 , A61B5/1495 , A61B5/489 , A61B5/7264 , A61B2562/0242 , A61B2562/146
摘要： The invention provides a targeting system used to direct a measuring system to a targeted sample site or volume. The targeting system increases analyte estimation performance by increasing precision and accuracy of sampling and/or by targeting an analyte rich tissue volume.
摘要翻译：本发明提供了一种用于将测量系统引导到目标样品位点或体积的靶向系统。靶向系统通过提高采样的精度和准确度和/或通过靶向富含分析物的组织体积来增加分析物估计性能。

10. 发明申请

US20080146899A1 METHOD OF SAMPLE CONTROL AND CALIBRATION ADJUSTMENT FOR USE WITH A NONINVASIVE ANALYZER 审中-公开
标题翻译：使用无损分析仪的样品控制和校准调整方法
公开(公告)号：US20080146899A1
公开(公告)日：2008-06-19
申请号：US12027934
申请日：2008-02-07
申请人： Timothy L. RUCHTI , Kevin H. Hazen , Thomas B. Blank
发明人： Timothy L. RUCHTI , Kevin H. Hazen , Thomas B. Blank
IPC分类号： A61B5/1455
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/1455 , A61B5/1495 , G01N21/359
摘要： A method and apparatus for easing the use of an optically based noninvasive analyzer is presented. More particularly, a simplified algorithm is used that removes the daily requirement of collecting and using a noninvasive spectrum to update a calibration model. In another embodiment, a guide is used to substantially reduce variation in sample probe placement in relation to a skin tissue sampling site, resulting in the ability to maintain calibration performance with the use of a reference analyte concentration, with or without the use of a reference spectrum collected nearby in time.
摘要翻译：提出了一种用于缓解光学非侵入式分析仪的使用的方法和装置。更具体地，使用简化的算法，其消除收集和使用非侵入光谱以更新校准模型的每日需求。在另一个实施例中，引导件用于相对于皮肤组织取样部位显着减少样本探针放置的变化，从而产生使用参考分析物浓度来维持校准性能的能力，有或没有使用参考频谱在时间附近收集。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式