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1. 发明授权

US07751192B2 Heatsink method and apparatus 失效
标题翻译：散热方法和装置
公开(公告)号：US07751192B2
公开(公告)日：2010-07-06
申请号：US11836755
申请日：2007-08-09
申请人： Roxanne E. Abul-Haj , N. Alan Abul-Haj , Timothy W. Stippick , Kevin H. Hazen
发明人： Roxanne E. Abul-Haj , N. Alan Abul-Haj , Timothy W. Stippick , Kevin H. Hazen
IPC分类号： H05K7/20
CPC分类号： H01L23/467 , F28F3/02 , F28F13/08 , H01L23/3737 , H01L2924/0002 , H01L2924/00
摘要： A heatsink having tapered geometry that improves passive cooling efficiency is discussed. A tapered geometry between heatsink heat dissipation elements, as a function of distance along a z-axis opposing gravity, decreases resistance to rarification of passively flowing cooling gas upon heating. Thus, the tapered heatsink elements result in higher velocity of gas flow and increased cooling efficiency of the heatsink. Optionally, the heatsink is made from a thermally conductive polymer allowing the heatsink to be created in complex shapes using injection molding.
摘要翻译：讨论了具有提高被动冷却效率的锥形几何形状的散热器。散热器散热元件之间的锥形几何形状作为与z轴相对重力的距离的函数，降低了被加热时对被动流动的冷却气体进行扩展的阻力。因此，锥形散热元件导致较高的气流速度和散热器的冷却效率。任选地，散热器由导热聚合物制成，允许使用注塑成型形成复杂形状的散热器。

2. 发明授权

US07593230B2 Apparatus for absorbing and dissipating excess heat generated by a system 失效
标题翻译：用于吸收和散发由系统产生的多余热量的装置
公开(公告)号：US07593230B2
公开(公告)日：2009-09-22
申请号：US11182309
申请日：2005-07-14
申请人： Roxanne E. Abul-Haj , N. Alan Abul-Haj , Timothy W. Stippick , Kevin H. Hazen
发明人： Roxanne E. Abul-Haj , N. Alan Abul-Haj , Timothy W. Stippick , Kevin H. Hazen
IPC分类号： H05K7/20
CPC分类号： H01L23/467 , F28F3/02 , F28F13/08 , H01L23/3737 , H01L2924/0002 , H01L2924/00
摘要： The invention relates to a heatsink. More particularly, the invention relates to a heatsink having tapered geometry that improves passive cooling efficiency. A tapered geometry between heatsink heat dissipation elements, as a function of distance along a z-axis opposing gravity, decreases resistance to rarification of passively flowing cooling gas upon heating. Thus, the tapered heatsink elements result in higher velocity of gas flow and increased cooling efficiency of the heatsink. Optionally, the heatsink is made from a thermally conductive polymer allowing the heatsink to be created in complex shapes using injection molding.
摘要翻译：本发明涉及一种散热器。更具体地说，本发明涉及具有提高被动冷却效率的锥形几何形状的散热器。散热器散热元件之间的锥形几何形状作为与z轴相对重力的距离的函数，降低了被加热时对被动流动的冷却气体进行扩展的阻力。因此，锥形散热元件导致较高的气流速度和散热器的冷却效率。任选地，散热器由导热聚合物制成，允许使用注塑成型形成复杂形状的散热器。

3. 发明授权

US06534012B1 Apparatus and method for reproducibly modifying localized absorption and scattering coefficients at a tissue measurement site during optical sampling 失效
标题翻译：在光学采样期间在组织测量部位可重复地修改局部吸收和散射系数的装置和方法
公开(公告)号：US06534012B1
公开(公告)日：2003-03-18
申请号：US09631440
申请日：2000-08-02
申请人： Kevin H. Hazen , George Acosta , N. Alan Abul-Haj , Roxanne E. Abul-Haj
发明人： Kevin H. Hazen , George Acosta , N. Alan Abul-Haj , Roxanne E. Abul-Haj
IPC分类号： G01N2147
CPC分类号： A61B5/0059 , A61B5/14552 , A61B5/6824 , A61B5/6843
摘要： An apparatus for varying localized absorption and scattering coefficients at a tissue measurement site in a controlled and reproducible manner during optical sampling of a tissue volume by controlling the pressure applied to a tissue measurement site by a spectroscopic analyzer allows applied pressure to be maintained at a constant level, or the applied pressure may be varied in a controlled, reproducible manner as a function of time. A rest for receiving a body part holds the body part in a fixed position and at a fixed elevation. A mechanical system advances a fiber optic probe until it makes contact with the body part with a constant amount of pressure. The applied force is supplied by a counterweight on a single arm balance. A temperature control allows the temperature of the fiber optic probe to be equilibrated with the temperature in the immediate vicinity of the tissue measurement site. Alternate embodiments allow the fiber optic probe to be brought into direct contact with the tissue measurement site, and displaced a known distance into the tissue. The invention is also embodied as a method in which the absorption and scattering coefficients for successive spectral measurements are calculated to determine optimum depth of penetration for detection of a target analyte.
摘要翻译：一种用于通过控制通过光谱分析仪施加到组织测量部位的压力而在组织体积的光学取样期间以受控和可再现的方式在组织测量部位处改变局部吸收和散射系数的装置，使施加的压力保持恒定水平或施加的压力可以以受控的，可再生的方式随时间变化。用于接收身体部分的休息部将身体部分保持在固定位置并且固定高度。机械系统推进光纤探针，直到其与身体部分以恒定的压力接触。施加的力由一个平衡臂上的配重提供。温度控制允许光纤探针的温度与组织测量位置附近的温度平衡。替代实施例允许光纤探针与组织测量部位直接接触，并将已知距离移位到组织中。本发明还被体现为其中计算连续光谱测量的吸收和散射系数以确定用于检测目标分析物的最佳穿透深度的方法。

4. 发明授权

US07606608B2 Optical sampling interface system for in-vivo measurement of tissue 有权
标题翻译：用于体内测量组织的光学取样界面系统
公开(公告)号：US07606608B2
公开(公告)日：2009-10-20
申请号：US11008001
申请日：2004-12-08
申请人： Thomas B. Blank , George Acosta , Mutua Mattu , Marcy Makarewicz , Stephen L. Monfre , Alexander D. Lorenz , Timothy L. Ruchti , Kevin H. Hazen , Donovan D. Berry , Roxanne E. Abul-Haj
发明人： Thomas B. Blank , George Acosta , Mutua Mattu , Marcy Makarewicz , Stephen L. Monfre , Alexander D. Lorenz , Timothy L. Ruchti , Kevin H. Hazen , Donovan D. Berry , Roxanne E. Abul-Haj
IPC分类号： A61B5/1455
CPC分类号： G01N21/359 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/6833
摘要： An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.
摘要翻译：公开了一种光学采样接口系统，其最小化并补偿由采样变化和测量位置状态波动引起的误差。本发明的实施例使用至少一个引导组织弯液面的形成的引导件，使由于表面不规则性引起的干扰最小化，控制组织体积的变化，使用两部分引导系统，使用指导控制样品探针的旋转并允许探针的z轴移动，使用独立的基本模块和样品模块与导轨结合使用，并使用控制旋转的指南。可选组件包括闭塞元件和耦合流体。

5. 发明授权

US07133710B2 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 有权
标题翻译：用于通过近红外光谱法无损测量葡萄糖的紧凑装置
公开(公告)号：US07133710B2
公开(公告)日：2006-11-07
申请号：US10472856
申请日：2003-03-07
申请人： George M. Acosta , James R. Henderson , N. Alan Abul Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
发明人： George M. Acosta , James R. Henderson , N. Alan Abul Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B5/1495 , A61B5/6833 , A61B5/7203 , A61B5/7225 , A61B5/726 , A61B2560/0223 , A61B2560/0233 , A61B2560/0252 , A61B2560/0412 , A61B2560/0443 , A61B2560/0456 , A61B2562/0242 , A61B2562/146 , A61B2562/227 , A61B2562/228 , G01N21/359 , G01N21/49
摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyze is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
摘要翻译：本发明涉及通过紧凑型分析仪监测生物参数。优选的装置是基于光谱仪的系统，其连续地或半连续地连接到人类受试者并收集用于确定采样组织中的生物学参数的光谱测量。优选的目标分析是葡萄糖。优选的分析仪是用于测定体内葡萄糖浓度的基于近红外的葡萄糖分析仪。

6. 发明授权

US06956649B2 Spectroscopic system and method using a ceramic optical reference 有权
标题翻译：光谱系统和方法使用陶瓷光学参考
公开(公告)号：US06956649B2
公开(公告)日：2005-10-18
申请号：US10723353
申请日：2003-11-25
申请人： George M. Acosta , Kevin H. Hazen , N. Alan Abul-Haj , Stephen L. Monfre , Thomas B. Blank
发明人： George M. Acosta , Kevin H. Hazen , N. Alan Abul-Haj , Stephen L. Monfre , Thomas B. Blank
IPC分类号： G01N21/27 , G01N21/47 , G01N21/49 , G01J3/28
CPC分类号： G01N21/278 , G01N21/4738 , G01N21/4785 , G01N21/49 , G01N2021/4735
摘要： A ceramic reference in conjunction with a spectrometer, a metallized ceramic material, and a method of utilizing a ceramic material as a reference in the ultraviolet, visible, near-infrared, or infrared spectral regions are presented. The preferred embodiments utilize a ceramic reference material to diffusely reflect incident source light toward a detector element for quantification in a reproducible fashion. Alternative embodiments metallize either the incident surface or back surface of to form a surface diffuse reflectance standard. Optional wavelength reference layers or protective layers may be added to the ceramic or to the metallized layer. The reference ceramic is used to provide a measure of optical signal of an analyzer as a function of the analyzers spatial, temporal, and environmental state.
摘要翻译：介绍了陶瓷参考文献，结合光谱仪，金属化陶瓷材料以及在紫外线，可见光，近红外或红外光谱区域中利用陶瓷材料作为参考的方法。优选实施例利用陶瓷参考材料将入射光源漫反射到检测器元件，以便以可再现的方式进行定量。替代实施例将入射表面或后表面金属化以形成表面漫反射标准。可选的波长参考层或保护层可以添加到陶瓷或金属化层。参考陶瓷用于根据分析仪的空间，时间和环境状态提供分析仪的光信号测量。

7. 发明授权

US07787924B2 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 有权
标题翻译：用于通过近红外光谱法无损测量葡萄糖的紧凑装置
公开(公告)号：US07787924B2
公开(公告)日：2010-08-31
申请号：US11324876
申请日：2006-01-03
申请人： George M. Acosta , James R. Henderson , N. Alan Abul Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
发明人： George M. Acosta , James R. Henderson , N. Alan Abul Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B5/1495 , A61B5/6833 , A61B5/7203 , A61B5/7225 , A61B5/726 , A61B2560/0223 , A61B2560/0233 , A61B2560/0252 , A61B2560/0412 , A61B2560/0443 , A61B2560/0456 , A61B2562/0242 , A61B2562/146 , A61B2562/227 , A61B2562/228 , G01N21/359 , G01N21/49
摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
摘要翻译：本发明涉及通过紧凑型分析仪监测生物参数。优选的装置是基于光谱仪的系统，其连续地或半连续地连接到人类受试者并收集用于确定采样组织中的生物学参数的光谱测量。优选的目标分析物是葡萄糖。优选的分析仪是用于测定体内葡萄糖浓度的基于近红外的葡萄糖分析仪。

8. 发明授权

US07299080B2 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 有权
标题翻译：用于通过近红外光谱法无损测量葡萄糖的紧凑装置
公开(公告)号：US07299080B2
公开(公告)日：2007-11-20
申请号：US10820322
申请日：2004-04-07
申请人： George Acosta , James R. Henderson , N. Alan Abul-Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
发明人： George Acosta , James R. Henderson , N. Alan Abul-Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/1075 , A61B5/14532 , A61B5/1495 , A61B5/441 , A61B5/4869 , A61B5/4872 , A61B5/6824 , A61B5/7203 , A61B5/726 , A61B2560/0233 , A61B2562/0233 , A61B2562/0242 , G01N21/359 , G01N21/474 , G01N21/49
摘要： A near IR spectrometer-based analyzer attaches continuously or semi-continuously to a human subject and collects spectral measurements for determining a biological parameter in the sampled tissue, such as glucose concentration. The analyzer includes an optical system optimized to target the cutaneous layer of the sampled tissue so that interference from the adipose layer is minimized. The optical system includes at least one optical probe. Spacing between optical paths and detection fibers of each probe and between probes is optimized to minimize sampling of the adipose subcutaneous layer and to maximize collection of light backscattered from the cutaneous layer. Penetration depth is optimized by limiting range of distances between paths and detection fibers. Minimizing sampling of the adipose layer greatly reduces interference contributed by the fat band in the sample spectrum, increasing signal-to-noise ratio. Providing multiple probes also minimizes interference in the sample spectrum due to placement errors.
摘要翻译：基于近红外光谱仪的分析仪连续或半连续地连接到人类受试者并且收集用于确定采样组织中的生物学参数（诸如葡萄糖浓度）的光谱测量。该分析仪包括优化的靶向采样组织的皮肤层的光学系统，使得来自脂肪层的干扰最小化。光学系统包括至少一个光学探针。针对每个探针和探针之间的光路和检测纤维之间的间距进行优化，以最小化脂肪皮下层的取样，并最大限度地收集从皮肤层反射的光。穿透深度通过限制路径和检测光纤之间的距离范围进行优化。最小化脂肪层的取样大大减少了样品谱中脂肪带所造成的干扰，提高了信噪比。提供多个探针也可以最小化由于放置误差而导致的样品光谱干扰。

9. 发明申请

US20220127122A1 BEVERAGE PRODUCT AMENDMENT APPARATUS AND METHOD OF USE THEREOF 有权
公开(公告)号：US20220127122A1
公开(公告)日：2022-04-28
申请号：US17120135
申请日：2020-12-12
申请人： Gavin Hazen , Kevin H. Hazen , Alton J. Reich , Michael Roth
发明人： Gavin Hazen , Kevin H. Hazen , Alton J. Reich , Michael Roth
IPC分类号： B67C3/02 , A23L33/105 , A23L2/52 , A23D7/005 , A23D7/04 , B67C7/00
摘要： The invention comprises a method and apparatus for amending a food product, comprising the steps of: (1) receiving into a second geographic zone the food product from a first geographic zone, where packaging greater than five milligrams per serving of tetrahydrocannabinol (THC) in the food product is illegal in the first geographic zone and legal in the second geographic zone; (2) forming a composition of the tetrahydrocannabinol comprising a viscosity of less than 2,000 mPa sec; and (3) injecting the food product with the composition of the tetrahydrocannabinol to form an amended food product, where the composition preferably comprises an emulsion of tetrahydrocannabinol, an emulsifier, and water with a mean particle size of less than 1000 nm and a viscosity of less than 100 mPa sec.

10. 发明申请

US20150041656A1 MULTIPLEXED NONINVASIVE ANALYZER APPARATUS AND METHOD OF USE THEREOF 审中-公开
标题翻译：多重非易失性分析仪装置及其使用方法
公开(公告)号：US20150041656A1
公开(公告)日：2015-02-12
申请号：US13963933
申请日：2013-08-09
申请人： Vlad Novotny , Sandeep Gulati , Thomas George , Timothy Ruchti , Alan Abul-Haj , Kevin H. Hazen
发明人： Vlad Novotny , Sandeep Gulati , Thomas George , Timothy Ruchti , Alan Abul-Haj , Kevin H. Hazen
IPC分类号： G01J3/42 , A61B5/145 , A61B5/1455
CPC分类号： G01J3/42 , A61B5/0022 , A61B5/1079 , A61B5/14532 , A61B5/1455 , A61B5/14552 , A61B5/6801 , G01N21/474 , G01N2021/4742 , G01N2021/4747 , G01N2201/0826
摘要： A noninvasive analyzer apparatus and method of use thereof is described using a plurality of time resolved sample illumination zones coupled to at least one two-dimensional detector array monitoring a plurality of detection zones. Control of illumination times and/or patterns along with selected detection zones yields pathlength resolved groups of spectra. Sectioned pixels and/or zones of the detector are optionally filtered for different light throughput as a function of wavelength. The pathlength resolved groups of spectra are subsequently analyzed to determine an analyte property. Optionally, in the mapping and/or collection phase, incident light is controllably varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, intensity, and/or detection angle. Optionally, one or more physiological property and/or model property related to a physiological property is used in the analyte property determination.
摘要翻译：使用耦合到监视多个检测区域的至少一个二维检测器阵列的多个时分解样本照明区域来描述非侵入性分析仪装置及其使用方法。照射时间和/或图案与所选检测区域的控制产生光程长度解析组。选择性地检测检测器的截面像素和/或区域作为波长的函数的不同光通量。随后分析路径长度解析的光谱组以确定分析物质。可选地，在映射和/或收集阶段，入射光可以根据以下任何方式在时间上可控地变化：样本探针位置，入射光立体角，入射光角，焦深，能量，强度和/或检测角。任选地，在分析物质性测定中使用与生理特性相关的一种或多种生理特性和/或模型性质。

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