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    • 1. 发明申请
    • INFUSION STATUS INDICATOR
    • 输注状态指示器
    • US20080262441A1
    • 2008-10-23
    • US11738296
    • 2007-04-20
    • JONATHAN WALBORNROGER GREENWALDRENA BRADHAM
    • JONATHAN WALBORNROGER GREENWALDRENA BRADHAM
    • A61M5/168
    • A61M5/16804A61M5/1428A61M5/16877A61M2005/1405A61M2205/583
    • An infusion status indicator disposed in the medical infusion line includes a housing with an opening through which the status of the infusion may be determined. A flexible membrane is located at the opening to indicate the status of fluid in the cavity. A recessed flexible membrane indicates insufficient flow of medical fluid into the cavity from the fluid supply, a level flexible membrane indicates correct flow of fluid through the indicator, and a concave flexible membrane indicates an insufficient flow of medical fluid out of the cavity, possibly indicating an occlusion of the fluid line downstream of the indicator. Check valves may be included upstream and downstream of the cavity so that a bolus of fluid may be forced out of the cavity to the patient by pressing the flexible membrane into the cavity.
    • 布置在医用输液管线中的输液状态指示器包括具有开口的壳体,通过该开口可以确定输液的状态。 柔性膜位于开口处,以指示腔体中的流体状态。 凹陷的柔性膜表示医疗流体从流体供应流入空腔不足,水平柔性膜表示流体通过指示器的正确流动,并且凹形柔性膜表示医疗流体流出空腔的不充分的流动,可能指示 流体管线在指示器下游的闭塞。 止回阀可以包括在空腔的上游和下游,使得可以通过将柔性膜压入空腔而将大量液体推出腔体到达患者体内。
    • 2. 发明申请
    • Imaging of surgical biopsies
    • US20070195308A1
    • 2007-08-23
    • US11788920
    • 2007-04-23
    • James ZavislanRoger Greenwald
    • James ZavislanRoger Greenwald
    • G01N1/00G01J1/42
    • G02B21/0024A61B10/0096G01N1/36G02B21/34
    • In order to determine, rapidly and without the delay required by conventional tissue preparation techniques for pathological examination (freezing, sectioning, staining, etc.), whether, an excision, which may be a biopsy sample, is representative of the morphology of interest of whether an excisional biopsy in which the tissue taken completely removes the abnormality is, in either case, the tissue which is desired to be excisioned, the tissue specimen (18) in encapsulated, preferably as part of the biopsy procedure. The encapsulated tissue is contained in an optically transparent cassette (34). The cassette (34) or an endcap (38) enclosing the cassette is marked with a fiducial (40) indicating and corresponding to the location of the excision on the patient's body. An image, which is preferably a representation of a surface of the tissue specimen and the vertical section(s) area of the tissue internal of the specimen and adjacent to a surface thereof, is obtained by means of an electro-optical imaging system (10), preferably a confocal laser scanning microscope. The cassette is moved, preferably in a stage (22) which rotates the cassette while translating it, so that the head (12) of the confocal microscope (its objective lens) provides a linear scan in a direction perpendicular to the wall of the cassette (also perpendicular to the surface of the tissue encapsulated in the cassette). The display (28) from the microscope indicates the morphology at and in proximity to the surface of the specimen as well as the location thereof. The pathologist and the surgeon is thereby provided with information concerning the specimen and whether the entire abnormality desired to be removed has indeed been removed and/or whether the biopsy is representative of the body region of interest in the case of a biopsy sample.
    • 3. 发明申请
    • Orbital implant coating having bulbously raised suture zone
    • 轨道植入物涂层具有球状隆起的缝合带
    • US20070191942A1
    • 2007-08-16
    • US11726052
    • 2007-03-21
    • Arthur PerryRoger Greenwald
    • Arthur PerryRoger Greenwald
    • A61F2/14
    • A61F2/141A61F2/0077A61F2250/003A61F2250/0067A61F2250/0097
    • A coating for an orbital implant where the coating has an anterior portion having a different, longer term bioabsorbability than a posterior portion. This allows the implant to have a smooth surface for insertion and to provide reduced irritation to neighboring tissues, to help prevent exposure of the porous core of the implant, and to provide a stable anchorment for extraocular muscles, but which also encourages rapid fibrovascular ingrowth. The coating is marked with a visual indicator to facilitate proper orientation. Shell materials are further selected to allow for sterile packaging, the securing of therapeutic agents thereon, and to provide adequately strong securing of the coating to the core. Apertures are formed through the coating to enhance fluid flow to and from the core, and to provide exposure of the surface of the core to extraocular muscles, and for sutures. The apertures are sized and shaped to reduce irritating surface contact with orbital tissues. In an alternate embodiment, one of the coating portions has a bulbous raised zone encompassing suture holes. The gap created between the undersurface of the raised zone and the core facilitates threading of the sutures.
    • 用于轨道植入物的涂层,其中涂层具有与后部不同的长期生物吸收性的前部。 这允许植入物具有用于插入的光滑表面并且对邻近组织提供减少的刺激,以帮助防止植入物的多孔芯的暴露,并且为眼外肌提供稳定的锚定,但是也可以促进快速的纤维血管内生长。 涂层用可视指示标记,以方便正确的取向。 进一步选择壳材料以允许无菌包装,其上的治疗剂的固定,并提供涂层至芯的足够牢固的固定。 通过涂层形成孔径以增强流入和离心的流体流动,并提供芯的表面暴露于眼外肌和缝线。 孔的尺寸和形状可以减少与眼眶组织的刺激性表面接触。 在替代实施例中,一个涂覆部分具有包围缝合孔的球状隆起区域。 在凸起的区域的下表面和芯之间产生的间隙有利于缝线的穿线。
    • 5. 发明授权
    • Infusion status indicator
    • 输液状态指示
    • US08016790B2
    • 2011-09-13
    • US11738296
    • 2007-04-20
    • Jonathan WalbornRoger GreenwaldRena Bradham
    • Jonathan WalbornRoger GreenwaldRena Bradham
    • A61M1/00
    • A61M5/16804A61M5/1428A61M5/16877A61M2005/1405A61M2205/583
    • An infusion status indicator disposed in the medical infusion line includes a housing with an opening through which the status of the infusion may be determined. A flexible membrane is located at the opening to indicate the status of fluid in the cavity. A recessed flexible membrane indicates insufficient flow of medical fluid into the cavity from the fluid supply, a level flexible membrane indicates correct flow of fluid through the indicator, and a concave flexible membrane indicates an insufficient flow of medical fluid out of the cavity, possibly indicating an occlusion of the fluid line downstream of the indicator. Check valves may be included upstream and downstream of the cavity so that a bolus of fluid may be forced out of the cavity to the patient by pressing the flexible membrane into the cavity.
    • 布置在医用输液管线中的输液状态指示器包括具有开口的壳体,通过该开口可以确定输液的状态。 柔性膜位于开口处,以指示腔体中的流体状态。 凹陷的柔性膜表示医疗流体从流体供应流入空腔不足,水平柔性膜表示流体通过指示器的正确流动,并且凹形柔性膜表示医疗流体流出空腔的不充分的流动,可能指示 流体管线在指示器下游的闭塞。 止回阀可以包括在空腔的上游和下游,使得可以通过将柔性膜压入空腔而将大量液体推出腔体到达患者体内。
    • 7. 发明申请
    • Tissue specimen holder
    • US20050157386A1
    • 2005-07-21
    • US11020387
    • 2004-12-22
    • Roger GreenwaldJames Zavislan
    • Roger GreenwaldJames Zavislan
    • B01L3/00G01N1/36G01N21/03G02B21/00G02B21/34A61D1/02A61B17/22
    • G01N21/0303B01L3/508B01L2300/043B01L2300/0609B01L2300/0654B01L2300/0672B01L2300/0822B01L2400/0683G01N1/36G01N2021/0339G01N2021/0342G01N2021/0364G02B21/0028G02B21/34
    • A tray or holder for tissue specimens, especially of excised tissue, such as biopsied specimens, is used with a confocal imaging system, especially a laser scanning confocal microscope system. The tray may be disposable after imaging of the specimen carried therein or may archive the specimen. A window supports the specimen. Clamps mounted inside the tray restrain the tissue. A compliant bag is mounted outside the tray on one side of a window of the tray on which the specimen is disposed. During imaging the specimen is immersed in a liquid contained in the tray having an index of refraction which closely matches the index of refraction of the tissue. The bag also contains an index matching liquid preferably having the same index as the liquid in the tray. A stabilizing plate is attached to a surface of the bag which faces the window. An objective lens of the confocal imaging system receives and supports the plate, preferably by a magnetic coupling ring around the plate which is magnetically attached to the barrel of the objective lens. The lens may be fixed and a mechanism for positioning the tray with respect to the lens in a direction along the optical axis of the lens and in orthogonal directions perpendicular to that axis shares a common support with the lens. Wavefront distortion which may result from an effectively corrugated surface of the specimen is minimized by selecting an immersion liquid which equals the refractive index of the near surface tissues. The tissue determines the index of the immersion fluid. The thicknesses and refractive indices of the window and plate are then determined to correct the residual aberration of the optical system. Different trays having different window and plate thicknesses and indices may be provided for different specimen species such as kidney, liver, cervix, et cetera. Thus, a generic confocal imaging system with a generic objective lens is corrected for image aberration and wavefront distortion due to the surface corrugations of the tissue. The correction is simplified since the bag is compliant and compresses so that the optical thickness along the axis between the objective lens and the focal plane in or at the specimen is substantially invariant whether the beam is focused at the interface between the specimen and the window or within the specimen over a focusing range which can extend over several millimeters.