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1. 发明授权

US06830763B2 Continuous acidification demineralization process for producing osteoinductive bone; and osteoinductive bone produced thereby 有权
标题翻译：用于生产骨诱导骨的连续酸化脱矿质过程; 和由此产生的骨诱导性骨
公开(公告)号：US06830763B2
公开(公告)日：2004-12-14
申请号：US10180989
申请日：2002-06-26
申请人： Robert K. O'Leary , Jan Zajdowicz , Lloyd Wolfinbarger, Jr.
发明人： Robert K. O'Leary , Jan Zajdowicz , Lloyd Wolfinbarger, Jr.
IPC分类号： A61K3532
CPC分类号： A61K35/32
摘要： The invention is directed to a process for producing demineralized osteoinductive bone, and demineralized osteoinductive bone produced thereby. The process achieves demineralization of bone by subjecting bone, including for example ground bone, bone cubes, chips, strips, or essentially intact bone, to a rapid continuous acid demineralization process. The process includes subjecting bone to a continuous exchange of demineralizing acid solution where the demineralizing acid solution is recirculated from the substantially closed container through an ion exchange media to remove calcium and phosphate thereby producing a regenerated acid, and returning the regenerated acid to the substantially closed container to produce osteoinductive demineralized bone. The process allows bone to be rapidly demineralized to a precise and specific desired residual calcium level, without sacrificing osteoinductivity.
摘要翻译：本发明涉及一种用于生产软化的骨诱导骨的方法和由此产生的软化的骨诱导骨。该方法通过使骨骼（包括例如研磨骨，骨块，切片，条或基本上完整的骨）经历快速连续的酸脱矿质过程来实现骨的脱矿质。该方法包括使骨骼连续交换软化酸溶液，其中软化酸溶液通过离子交换介质从基本上密封的容器再循环以除去钙和磷酸盐，从而产生再生酸，并将再生酸返回到基本上封闭的容器生产骨诱导的软骨。该过程允许骨快速脱矿质至精确和特定的所需残留钙水平，而不牺牲骨诱导能力。

2. 发明授权

US06293970B1 Plasticized bone and soft tissue grafts and methods of making and using same 失效
标题翻译：增塑骨和软组织移植物及其制造和使用方法
公开(公告)号：US06293970B1
公开(公告)日：2001-09-25
申请号：US09107459
申请日：1998-06-30
申请人： Lloyd Wolfinbarger, Jr. , Robert K. O'Leary , Billy G. Anderson
发明人： Lloyd Wolfinbarger, Jr. , Robert K. O'Leary , Billy G. Anderson
IPC分类号： A61F228
CPC分类号： A61L27/362 , A61F2/02 , A61F2/4644 , A61F2002/2825 , A61F2002/2835 , A61F2002/2839 , A61F2002/30535 , A61F2002/4646 , A61F2002/4649 , A61F2250/0058 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/502 , A61L2430/02
摘要： The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.
摘要翻译：本发明提供一种不需要特殊储存条件（例如冷冻或冷冻）的塑化脱水或冷冻干燥的骨和/或软组织产品，其表现出近似于在正常水合组织中存在的性质的材料性质不脆，在临床植入之前不需要补液，并不是疾病传播的潜在来源。本发明用一种或多种允许组织脱水的增塑剂代替骨或软组织基质的分子结构中的水，但不会导致增塑产品的脆性增加，并且导致压缩和/或拉伸性能类似与正常水合骨的那些。不需要在植入之前用水替代化学增塑剂，因此，脱水的骨或软组织增塑产品可以直接放置在植入部位，而无需在手术室中大量准备。

3. 发明授权

US5484601A Flowable demineralized bone powder composition and its use in bone repair 失效
标题翻译：可流动的软骨骨粉组合物及其在骨修复中的应用
公开(公告)号：US5484601A
公开(公告)日：1996-01-16
申请号：US779401
申请日：1991-10-18
申请人： Robert K. O'Leary , Patrick A. McBrayer
发明人： Robert K. O'Leary , Patrick A. McBrayer
IPC分类号： A61K35/32 , A61L24/00 , A61L27/22 , A61L27/36
CPC分类号： A61L27/3608 , A61K35/32 , A61L24/0005 , A61L27/227 , A61L27/365 , A61F2002/2835 , A61L2400/06 , A61L2430/02 , Y10S514/801 , Y10S514/802
摘要： A flowable demineralized bone powder composition is provided for use in surgical bone repair.
摘要翻译：提供可用于外科手术骨修复的可流动的软化骨粉组合物。

4. 发明授权

US5118512A Process for cryopreserving biological materials and materials prepared thereby 失效
标题翻译：制备生物材料和材料的方法
公开(公告)号：US5118512A
公开(公告)日：1992-06-02
申请号：US468709
申请日：1990-01-23
申请人： Robert K. O'Leary , Ann Prewett
发明人： Robert K. O'Leary , Ann Prewett
IPC分类号： A01N1/02
CPC分类号： A01N1/0221 , A01N1/02
摘要： A process for cryopreserving a biological material which comprises contacting the biological material with both an effective amount at least one cryopreservation agent, and an agent to increase diffusion of the cryopreservation agent into the biological material, such as a surfactant or a permeation enhancer.
摘要翻译：一种用于冷冻保存生物材料的方法，其包括使生物材料与有效量的至少一种冷冻保存剂和增加冷冻保存剂扩散到生物材料例如表面活性剂或渗透增强剂中的试剂接触。

5. 发明授权

US06544289B2 Plasticized bone grafts, and methods of making and using same 有权
标题翻译：增塑骨移植物及其制造和使用方法
公开(公告)号：US06544289B2
公开(公告)日：2003-04-08
申请号：US09887418
申请日：2001-06-22
申请人： Lloyd Wolfinbarger, Jr. , Robert K. O'Leary , Billy G. Anderson
发明人： Lloyd Wolfinbarger, Jr. , Robert K. O'Leary , Billy G. Anderson
IPC分类号： A61F228
CPC分类号： A61L27/362 , A61F2/02 , A61F2/4644 , A61F2002/2825 , A61F2002/2835 , A61F2002/2839 , A61F2002/30535 , A61F2002/4646 , A61F2002/4649 , A61F2250/0058 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/502 , A61L2430/02
摘要： The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.
摘要翻译：本发明提供一种不需要特殊储存条件（例如冷冻或冷冻）的塑化脱水或冷冻干燥的骨和/或软组织产品，其表现出近似于在正常水合组织中存在的性质的材料性质不脆，在临床植入之前不需要补液，并不是疾病传播的潜在来源。本发明用一种或多种允许组织脱水的增塑剂代替骨或软组织基质的分子结构中的水，但不会导致增塑产品的脆性增加，并且导致压缩和/或拉伸性能类似与正常水合骨的那些。不需要在植入之前用水替代化学增塑剂，因此，脱水的骨或软组织增塑产品可以直接放置在植入部位，而无需在手术室中大量准备。

6. 发明授权

US5667985A Tissue biopsy cell suspender for cell analysis 失效
标题翻译：组织活检细胞悬液用于细胞分析
公开(公告)号：US5667985A
公开(公告)日：1997-09-16
申请号：US718850
申请日：1996-09-24
申请人： Robert K. O'Leary , Timothy Stevens , Richard L. Griffith
发明人： Robert K. O'Leary , Timothy Stevens , Richard L. Griffith
IPC分类号： B01L3/00 , B01L3/14 , C12M1/24 , C12M3/08 , C12Q1/02 , C12M3/00
CPC分类号： B01L3/502 , B01L3/50825 , C12M45/09 , Y10S435/81
摘要： A tissue biopsy cell suspender device includes a receptacle having a sealable opening. The receptacle contains a sufficient quantity of an aqueous medium to support an enzymatic dissociation of cells from a tissue biopsy sample. The device has a removable closure with a first sealing position and a second sealing position for sealing the opening in the receptacle. The device further includes a frangible container having a sufficient quantity of an enzyme therein to dissociate cells from the tissue biopsy sample. The frangible container is covered with a membrane that is permeable to water and to the enzyme. The frangible container is disposed within the receptacle so that the container is intact when the closure is in the first sealing position and the container is breached when the closure is in the second sealing position. When the frangible container is breached, the enzyme is released to permeate into the medium and for dissociation of the cells from the tissue sample.
摘要翻译：组织活检细胞悬挂装置包括具有可密封开口的容器。容器含有足够量的水性介质以支持来自组织活检样品的细胞的酶解离。该装置具有可拆卸的封闭件，其具有第一密封位置和用于密封容器中的开口的第二密封位置。该装置还包括具有足够量酶的易碎容器以从组织活检样品中分离细胞。易碎的容器被可渗透水和酶的膜覆盖。易碎容器设置在容器内，使得当封闭件处于第一密封位置时容器是完整的，并且当封闭件处于第二密封位置时容器被破坏。当易碎容器被破坏时，酶被释放以渗透到培养基中并使细胞与组织样品分离。

7. 发明授权

US5607476A Processing of fibrous connective tissue 失效
标题翻译：纤维结缔组织加工
公开(公告)号：US5607476A
公开(公告)日：1997-03-04
申请号：US598962
申请日：1996-02-09
申请人： Annamarie B. Prewett , Robert K. O'Leary
发明人： Annamarie B. Prewett , Robert K. O'Leary
IPC分类号： A61F2/00 , A61F2/08 , A61K35/32 , A61L27/36 , A61F2/64 , A61K35/22
CPC分类号： A61L27/3687 , A61K35/32 , A61L27/3604 , A61L27/3691 , A61F2/08 , A61F2250/0067
摘要： Fibrous connective tissue for surgical implantation is made substantially antigen-free by contact with one or more extraction agents. Solutions or mixtures of molecules having bipolar regions act as antigen removing permeation enhancers. Cationic, anionic, non-ionic or amphoteric surfactants are suitable bipolar permeation enhancers. One or more extraction agents can be combined to form extraction mixtures.
摘要翻译：用于手术植入的纤维结缔组织通过与一种或多种提取剂接触而基本上是无抗原的。具有双极区域的分子的溶液或混合物用作抗原去除渗透促进剂。阳离子，阴离子，非离子或两性表面活性剂是合适的双极渗透增强剂。一种或多种提取剂可以组合以形成提取混合物。

8. 发明授权

US5236456A Osteogenic composition and implant containing same 失效
标题翻译：成骨组合物和含有其的植入物
公开(公告)号：US5236456A
公开(公告)日：1993-08-17
申请号：US642633
申请日：1991-01-17
申请人： Robert K. O'Leary , Annamarie B. Prewett
发明人： Robert K. O'Leary , Annamarie B. Prewett
IPC分类号： A61L27/00 , A61K6/00 , A61K35/32 , A61L24/00 , A61L27/36 , A61L27/54
CPC分类号： A61L27/3608 , A61F2/30767 , A61K35/32 , A61L24/0005 , A61L24/0015 , A61L27/365 , A61L27/3683 , A61L27/54 , A61F2/32 , A61F2/4644 , A61F2002/2835 , A61F2002/30059 , A61F2310/00958 , A61L2300/414 , A61L2430/02 , A61L2430/40 , Y10S128/08
摘要： An osteogenic composition is obtained from demineralized bone tissue.
摘要翻译：从软化骨组织获得成骨组合物。

9. 发明授权

US06569200B2 Plasticized soft tissue grafts, and methods of making and using same 有权
公开(公告)号：US06569200B2
公开(公告)日：2003-05-27
申请号：US09874862
申请日：2001-06-05
申请人： Lloyd Wolfinbarger, Jr. , Robert K. O'Leary , Billy G. Anderson
发明人： Lloyd Wolfinbarger, Jr. , Robert K. O'Leary , Billy G. Anderson
IPC分类号： A61F208
CPC分类号： A61L27/362 , A61F2/02 , A61F2/4644 , A61F2002/2825 , A61F2002/2835 , A61F2002/2839 , A61F2002/30535 , A61F2002/4646 , A61F2002/4649 , A61F2250/0058 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/502 , A61L2430/02
摘要： The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.

10. 发明授权

US5439684A Shaped, swollen demineralized bone and its use in bone repair 失效
标题翻译：形状，肿胀的软化骨及其在骨修复中的用途
公开(公告)号：US5439684A
公开(公告)日：1995-08-08
申请号：US184306
申请日：1994-01-21
申请人： Annamarie B. Prewett , Roger C. Stikeleather , Simon Bogdansky , Robert K. O'Leary
发明人： Annamarie B. Prewett , Roger C. Stikeleather , Simon Bogdansky , Robert K. O'Leary
IPC分类号： A61K35/32 , A61L24/00 , A61L27/00 , A61L27/22 , A61L27/36 , A61B17/56
CPC分类号： A61L27/3608 , A61B17/686 , A61B17/82 , A61F2/2803 , A61F2/2846 , A61F2/4644 , A61K35/32 , A61L24/0005 , A61L27/227 , A61L27/365 , A61L27/3683 , A61F2/4455 , A61F2002/2817 , A61F2002/2835 , A61F2002/30075 , A61F2002/302 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2210/0061 , A61F2230/0065 , A61F2230/0069 , A61F2230/0082 , A61L2400/06 , A61L2430/02 , Y10S514/801 , Y10S514/802 , Y10S514/953
摘要： A shaped piece of swollen demineralized bone which can also be plasticized is provided for use in surgical bone repair.
摘要翻译：提供也可以塑化的成形的肿胀的软化骨，用于外科手术骨修复。

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