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1. 发明申请

US20100331987A1 RADIALLY COMPRESSED DEHYDRATED SPINAL NUCLEUS IMPLANTS 审中-公开
标题翻译：径向压缩脱水椎间盘植入物
公开(公告)号：US20100331987A1
公开(公告)日：2010-12-30
申请号：US12874322
申请日：2010-09-02
申请人： Gerald Gontarz , Ann Prewett
发明人： Gerald Gontarz , Ann Prewett
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61F2/30907 , A61F2/3094 , A61F2/30965 , A61F2/441 , A61F2002/30016 , A61F2002/30075 , A61F2002/3008 , A61F2002/30092 , A61F2002/30113 , A61F2002/30125 , A61F2002/30133 , A61F2002/30191 , A61F2002/30224 , A61F2002/30252 , A61F2002/30677 , A61F2002/30971 , A61F2002/444 , A61F2002/485 , A61F2002/487 , A61F2210/0014 , A61F2210/0061 , A61F2230/0004 , A61F2230/0006 , A61F2230/0008 , A61F2230/0015 , A61F2230/0069 , A61F2230/0073 , A61F2250/0019 , A61F2250/0098
摘要： A radially compressed xerogel spinal nucleus implant is manufactured and utilized for implantation into an intervertebral disc space. The implant has an optimized cross-sectional ellipsoid configuration which facilitates insertion of the implant through a minimal incision in the annulus. Radial compression is achieved by exerting substantially equilateral circumferential compression on an object contained within a radially collapsible member for exerting substantially equilateral circumferential compression on the object. Radial compression may also be achieved by exerting substantially equilateral circumferential compression force on a spinal nucleus implant via gas pressure in a sealed chamber.
摘要翻译：制造径向压缩的干凝胶脊髓植入物并用于植入椎间盘空间。植入物具有优化的横截面椭圆体构造，其有助于植入物通过环空中的最小切口插入。径向压缩是通过对包含在径向可折叠构件中的物体施加基本上等边的周向压缩来实现的，以在物体上施加基本上等边的周向压缩。径向压缩也可以通过在密封腔中经由气体压力在脊髓植入物上施加基本上等边的周向压缩力来实现。

2. 发明授权

US5118512A Process for cryopreserving biological materials and materials prepared thereby 失效
标题翻译：制备生物材料和材料的方法
公开(公告)号：US5118512A
公开(公告)日：1992-06-02
申请号：US468709
申请日：1990-01-23
申请人： Robert K. O'Leary , Ann Prewett
发明人： Robert K. O'Leary , Ann Prewett
IPC分类号： A01N1/02
CPC分类号： A01N1/0221 , A01N1/02
摘要： A process for cryopreserving a biological material which comprises contacting the biological material with both an effective amount at least one cryopreservation agent, and an agent to increase diffusion of the cryopreservation agent into the biological material, such as a surfactant or a permeation enhancer.
摘要翻译：一种用于冷冻保存生物材料的方法，其包括使生物材料与有效量的至少一种冷冻保存剂和增加冷冻保存剂扩散到生物材料例如表面活性剂或渗透增强剂中的试剂接触。

3. 发明申请

US20100222881A1 VESSEL PROTECTION DEVICE 审中-公开
标题翻译：船舶保护装置
公开(公告)号：US20100222881A1
公开(公告)日：2010-09-02
申请号：US12573670
申请日：2009-10-05
申请人： Ann Prewett , Mark Dingledine , Alan C. Chen
发明人： Ann Prewett , Mark Dingledine , Alan C. Chen
IPC分类号： A61F2/02
CPC分类号： A61L31/10
摘要： The present disclosure relates to a vessel/tissue protection device having a polymer coated reinforcing layer. The polymer can comprise a biocompatible polymer that will not promote tissue in-growth or attachment, such as segmented polyurethane, polycarbonate urethane, polyether urethane, polyacrylonitrile, etc. The reinforcing layer can comprise any suitable woven, non-woven, knitted, or braided reinforcing polymer, fabric, or foil that is biocompatible and capable of holding a suture, staple, or other attachment device.
摘要翻译：本公开涉及具有聚合物涂覆的增强层的血管/组织保护装置。聚合物可以包含不促进组织生长或附着的生物相容性聚合物，例如分段聚氨酯，聚碳酸酯聚氨酯，聚醚聚氨酯，聚丙烯腈等。增强层可以包括任何合适的织造，无纺布，针织或编织增强聚合物，织物或箔，其是生物相容的并且能够保持缝合线，钉或其它附接装置。

4. 发明申请

US20060136065A1 Radially compressed dehydrated spinal nucleus implants 有权
标题翻译：径向压缩脱水脊髓核植入物
公开(公告)号：US20060136065A1
公开(公告)日：2006-06-22
申请号：US11303767
申请日：2005-12-16
申请人： Gerald Gontarz , Ann Prewett
发明人： Gerald Gontarz , Ann Prewett
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61F2/30907 , A61F2/3094 , A61F2/30965 , A61F2/441 , A61F2002/30016 , A61F2002/30075 , A61F2002/3008 , A61F2002/30092 , A61F2002/30113 , A61F2002/30125 , A61F2002/30133 , A61F2002/30191 , A61F2002/30224 , A61F2002/30252 , A61F2002/30677 , A61F2002/30971 , A61F2002/444 , A61F2002/485 , A61F2002/487 , A61F2210/0014 , A61F2210/0061 , A61F2230/0004 , A61F2230/0006 , A61F2230/0008 , A61F2230/0015 , A61F2230/0069 , A61F2230/0073 , A61F2250/0019 , A61F2250/0098
摘要： A radially compressed xerogel spinal nucleus implant is manufactured and utilized for implantation into an intervertebral disc space. The implant has an optimized cross-sectional ellipsoid configuration which facilitates insertion of the implant through a minimal incision in the annulus. Radial compression is achieved by exerting substantially equilateral circumferential compression on an object contained within a radially collapsible member for exerting substantially equilateral circumferential compression on the object. Radial compression may also be achieved by exerting substantially equilateral circumferential compression force on a spinal nucleus implant via gas pressure in a sealed chamber.
摘要翻译：制造径向压缩的干凝胶脊髓植入物并用于植入椎间盘空间。植入物具有优化的横截面椭圆体构造，其有助于植入物通过环空中的最小切口插入。径向压缩是通过对包含在径向可折叠构件中的物体施加基本上等边的周向压缩来实现的，以在物体上施加基本上等边的周向压缩。径向压缩也可以通过在密封腔中经由气体压力在脊髓植入物上施加基本上等边的周向压缩力来实现。

5. 发明授权

US09131965B2 Swellable interspinous stabilization implant 有权
标题翻译：可膨胀的椎间稳定植入物
公开(公告)号：US09131965B2
公开(公告)日：2015-09-15
申请号：US12580101
申请日：2009-10-15
申请人： Ann Prewett , Alan Chen , Frederick H. Hardenbrook
发明人： Ann Prewett , Alan Chen , Frederick H. Hardenbrook
IPC分类号： A61B17/70 , A61F2/44 , A61B17/00
CPC分类号： A61B17/7065 , A61B17/7068 , A61B2017/00871 , A61B2017/00898 , A61F2/4405 , A61F2/441
摘要： A swellable, resilient interspinous implant is provided that includes a swellable polymeric medium, said polymeric medium being dispersed throughout the implant, the implant being dimensioned and configured to fit between two spinous processes of two adjacent vertebrae and buttress the space between the two adjacent vertebrae. In embodiments, the implant has a first configuration of reduced size such that it can be inserted into the patient in a minimally invasive manner. Once inserted to an application point within the patient, the implant expands in size to dynamically maintain the adjacent spinous processes in beneficial alignment. Also provided is a method of making a swellable, resilient interspinous implant as described herein. Also provided is a method of treating a degenerative condition of a spine which includes creating an incision and inserting, through the incision, between two spinous processes of two adjacent vertebrae, a swellable, resilient interspinous implant as described herein.
摘要翻译：提供了可膨胀的弹性棘突间植入物，其包括可溶胀的聚合物介质，所述聚合物介质分散在整个植入物中，所述植入物的尺寸和构造适于配合在两个相邻椎骨的两个棘突之间并且支撑两个相邻椎骨之间的空间。在实施例中，植入物具有减小尺寸的第一构造，使得其可以以微创方式插入患者体内。一旦插入到患者内的应用点，植入物的尺寸就会扩大，从而动态地保持邻近的棘突以有益的对准。还提供了如本文所述的制造可溶胀，弹性棘突间植入物的方法。还提供了一种治疗脊柱退行性病症的方法，其包括产生切口并通过切口插入两个相邻椎骨的两个棘突之间，如本文所述的可溶胀的弹性棘突间植入物。

6. 发明申请

US20130282121A1 SPINAL FACET AUGMENTATION IMPLANT AND METHOD 审中-公开
标题翻译：脊柱填充植入物和方法
公开(公告)号：US20130282121A1
公开(公告)日：2013-10-24
申请号：US13848873
申请日：2013-03-22
申请人： Ann Prewett
发明人： Ann Prewett
IPC分类号： A61F2/30
CPC分类号： A61F2/30756 , A61F2/30965 , A61F2/4405 , A61F2002/30075 , A61F2002/30224 , A61F2002/30225 , A61F2002/30677 , A61F2002/30754
摘要： A spinal facet joint implant suitable for minimally invasive implantation and capable of transitioning from a compact first configuration to an expanded second configuration is made of a swellable and compressible fluid absorbing polymer. The implant is dimensioned and configured, while in the first configuration, to fit within the lumen of a surgical needle. In the expanded, second configuration, the implant exerts pressure within the facet joint which helps keep the facet joint from collapsing and anchors the implant in place. A spinal facet joint implant herein may also be dimensioned and configured to occupy a portion of the capsule of a facet joint. A spinal facet joint implant for treating inflammation made from a fluid absorbing polymer absorbs and sequesters inflammatory agents as it absorbs synovial fluid in situ. Methods of making and implanting a spinal facet implant are provided.
摘要翻译：适合于微创植入并且能够从紧凑的第一构型转变为膨胀的第二构型的脊椎小关节植入物由可溶胀和可压缩的流体吸收聚合物制成。植入物的尺寸和构造，而在第一构型中，适合于外科用针的内腔。在扩展的第二构造中，植入物在小关节内施加压力，其有助于保持小面关节不塌陷并将植入物固定在适当位置。此处的脊柱小关节植入物也可以被设计成被构造成占据小面关节的胶囊的一部分。用于治疗由流体吸收聚合物制成的炎症的脊柱小关节植入物吸收并螯合炎症剂，因为它原位吸收滑液。提供了制造和植入脊髓小面植入物的方法。

7. 发明授权

US07806934B2 Radially compressed dehydrated spinal nucleus implants 有权
标题翻译：径向压缩脱水脊髓核植入物
公开(公告)号：US07806934B2
公开(公告)日：2010-10-05
申请号：US11303767
申请日：2005-12-16
申请人： Gerald Gontarz , Ann Prewett
发明人： Gerald Gontarz , Ann Prewett
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61F2/30907 , A61F2/3094 , A61F2/30965 , A61F2/441 , A61F2002/30016 , A61F2002/30075 , A61F2002/3008 , A61F2002/30092 , A61F2002/30113 , A61F2002/30125 , A61F2002/30133 , A61F2002/30191 , A61F2002/30224 , A61F2002/30252 , A61F2002/30677 , A61F2002/30971 , A61F2002/444 , A61F2002/485 , A61F2002/487 , A61F2210/0014 , A61F2210/0061 , A61F2230/0004 , A61F2230/0006 , A61F2230/0008 , A61F2230/0015 , A61F2230/0069 , A61F2230/0073 , A61F2250/0019 , A61F2250/0098
摘要： A radially compressed xerogel spinal nucleus implant is manufactured and utilized for implantation into an intervertebral disc space. The implant has an optimized cross-sectional ellipsoid configuration which facilitates insertion of the implant through a minimal incision in the annulus. Radial compression is achieved by exerting substantially equilateral circumferential compression on an object contained within a radially collapsible member for exerting substantially equilateral circumferential compression on the object. Radial compression may also be achieved by exerting substantially equilateral circumferential compression force on a spinal nucleus implant via gas pressure in a sealed chamber.
摘要翻译：制造径向压缩的干凝胶脊髓植入物并用于植入椎间盘空间。植入物具有优化的横截面椭圆体构造，其有助于植入物通过环空中的最小切口插入。径向压缩是通过对包含在径向可折叠构件中的物体施加基本上等边的周向压缩来实现的，以在物体上施加基本上等边的周向压缩。径向压缩也可以通过在密封腔中经由气体压力在脊髓植入物上施加基本上等边的周向压缩力来实现。

8. 发明申请

US20100100183A1 SWELLABLE INTERSPINOUS STABILIZATION IMPLANT 有权
标题翻译：可膨胀的互补稳定植入物
公开(公告)号：US20100100183A1
公开(公告)日：2010-04-22
申请号：US12580101
申请日：2009-10-15
申请人： Ann Prewett , Alan Chen , Frederick H. Hardenbrook
发明人： Ann Prewett , Alan Chen , Frederick H. Hardenbrook
IPC分类号： A61F2/44 , B29C39/24
CPC分类号： A61B17/7065 , A61B17/7068 , A61B2017/00871 , A61B2017/00898 , A61F2/4405 , A61F2/441
摘要： A swellable, resilient interspinous implant is provided that includes a swellable polymeric medium, said polymeric medium being dispersed throughout the implant, the implant being dimensioned and configured to fit between two spinous processes of two adjacent vertebrae and buttress the space between the two adjacent vertebrae. In embodiments, the implant has a first configuration of reduced size such that it can be inserted into the patient in a minimally invasive manner. Once inserted to an application point within the patient, the implant expands in size to dynamically maintain the adjacent spinous processes in beneficial alignment. Also provided is a method of making a swellable, resilient interspinous implant as described herein. Also provided is a method of treating a degenerative condition of a spine which includes creating an incision and inserting, through the incision, between two spinous processes of two adjacent vertebrae, a swellable, resilient interspinous implant as described herein.
摘要翻译：提供了可膨胀的弹性棘突间植入物，其包括可溶胀的聚合物介质，所述聚合物介质分散在整个植入物中，所述植入物的尺寸和构造适于配合在两个相邻椎骨的两个棘突之间并且支撑两个相邻椎骨之间的空间。在实施例中，植入物具有减小尺寸的第一构造，使得其可以以微创方式插入患者体内。一旦插入到患者内的应用点，植入物的尺寸就会扩大，从而动态地保持邻近的棘突以有益的对准。还提供了如本文所述的制造可溶胀，弹性棘突间植入物的方法。还提供了一种治疗脊柱退行性病症的方法，其包括产生切口并通过切口插入两个相邻椎骨的两个棘突之间，如本文所述的可溶胀的弹性棘突间植入物。

9. 发明申请

US20070191956A1 Radially extended support member for spinal nucleus implants and methods of use 审中-公开
标题翻译：用于脊髓细胞核植入物的径向延伸的支撑构件和使用方法
公开(公告)号：US20070191956A1
公开(公告)日：2007-08-16
申请号：US11657157
申请日：2007-01-24
申请人： Ann Prewett , Gerald Gontarz
发明人： Ann Prewett , Gerald Gontarz
IPC分类号： A61F2/44 , A61F2/46
CPC分类号： A61F2/442 , A61F2/441 , A61F2/4611 , A61F2002/30031 , A61F2002/30075 , A61F2002/3008 , A61F2002/30092 , A61F2002/30224 , A61F2002/30841 , A61F2002/444 , A61F2210/0014 , A61F2210/0061 , A61F2230/0069 , A61F2250/0056 , A61F2250/0098 , A61L27/52 , A61L2430/38
摘要： A spinal nucleus implant is provided which includes an implant body and an interiorly embedded support member which extends out from the implant body. In one embodiment, the support member is fabric selected from the group consisting of mesh, woven fabric and nonwoven fabric. In one embodiment, the support member includes at least one portion which is located outside of the body, said portion adapted to engage one or more guides for orienting the implant. In one embodiment, the implant is capable of expanding from a compact, substantially dehydrated configuration to an expanded hydrated configuration. A method of manufacturing a spinal nucleus implant is provided which includes coagulating a liquid polymer such that at least a portion of said support member extends beyond the perimeter of the polymer to form a spinal nucleus implant having an interiorly disposed support member which extends out of the polymer. A method of implanting such a spinal nucleus implant is provided.
摘要翻译：提供脊髓植入物，其包括植入体和从植入体延伸出的内部嵌入的支撑构件。在一个实施方案中，支撑构件是选自网，织物和非织造织物的织物。在一个实施例中，支撑构件包括位于主体外部的至少一个部分，所述部分适于接合用于定向植入物的一个或多个引导件。在一个实施例中，植入物能够从紧凑的，基本上脱水的构型扩展成膨胀的水合构型。提供了一种制造脊髓植入物的方法，其包括凝固液体聚合物，使得所述支撑构件的至少一部分延伸超出聚合物的周边，以形成具有内部设置的支撑构件的脊柱植入物，所述支撑构件延伸出聚合物。提供了一种植入这种脊髓植入物的方法。

10. 发明申请

US20090149958A1 STRUCTURALLY REINFORCED SPINAL NUCLEUS IMPLANTS 审中-公开
标题翻译：结构性增强脊髓NUCLEUS植入物
公开(公告)号：US20090149958A1
公开(公告)日：2009-06-11
申请号：US12263797
申请日：2008-11-03
申请人： Ann Prewett , Gerald Gontarz
发明人： Ann Prewett , Gerald Gontarz
IPC分类号： A61F2/44 , B32B38/08
CPC分类号： B29C70/24 , A61F2/30965 , A61F2/442 , A61F2002/2817 , A61F2002/30062 , A61F2002/30075 , A61F2002/30092 , A61F2002/30677 , A61F2002/444 , A61F2002/4495 , A61F2210/0004 , A61F2210/0014 , A61F2210/0061 , B29C70/46 , B29L2031/7532
摘要： A spinal nucleus implant is provided which includes a braided three-dimensional reinforcement member having a polymeric matrix imbued therein, the implant configured to have a shape consistent with a cavity within an intervertebral disc space. The polymeric matrix may be a fluid absorbing polymer, e.g., a hydrogel or a substantially non-fluid absorbing in-situ curable elastic polymer. A method of making a spinal nucleus implant is provided which includes providing a braided three-dimensional reinforcement member configured and dimensioned to have a shape consistent with a cavity in an intervertebral space and infusing the braided three-dimensional reinforcement member with a liquid polymer capable of forming a polymeric matrix. Also provided is a spinal nucleus implant including a three-dimensional reinforcement member adapted and configured to undergo anisotropic expansion, the implant configured to have a shape consistent with a cavity within an intervertebral disc space. A method of treating a degenerating intervertebral disc includes creating an incision in an annulus; removing at least a portion of a nucleus pulposus; and inserting, through the incision, a spinal nucleus implant according to the present disclosure.
摘要翻译：提供脊髓核植入物，其包括编织的三维加强构件，其具有嵌入其中的聚合物基质，所述植入物构造成具有与椎间盘空间内的空腔一致的形状。聚合物基质可以是流体吸收聚合物，例如水凝胶或基本上非流体吸收的原位固化弹性聚合物。提供了一种制造脊髓核植入物的方法，其包括提供编织的三维加强构件，其被构造和尺寸设计成具有与椎间空间中的空腔一致的形状，并且用编织的三维加强构件用能够形成聚合物基质。还提供了一种脊髓核植入体，其包括适于和构造成经历各向异性膨胀的三维加强构件，所述植入物构造成具有与椎间盘空间内的空腔一致的形状。一种治疗退行性椎间盘的方法，包括在环空中形成切口; 去除髓核的至少一部分; 以及通过所述切口插入根据本公开的脊髓植入物。

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