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1. 发明授权

US5439684A Shaped, swollen demineralized bone and its use in bone repair 失效
标题翻译：形状，肿胀的软化骨及其在骨修复中的用途
公开(公告)号：US5439684A
公开(公告)日：1995-08-08
申请号：US184306
申请日：1994-01-21
申请人： Annamarie B. Prewett , Roger C. Stikeleather , Simon Bogdansky , Robert K. O'Leary
发明人： Annamarie B. Prewett , Roger C. Stikeleather , Simon Bogdansky , Robert K. O'Leary
IPC分类号： A61K35/32 , A61L24/00 , A61L27/00 , A61L27/22 , A61L27/36 , A61B17/56
CPC分类号： A61L27/3608 , A61B17/686 , A61B17/82 , A61F2/2803 , A61F2/2846 , A61F2/4644 , A61K35/32 , A61L24/0005 , A61L27/227 , A61L27/365 , A61L27/3683 , A61F2/4455 , A61F2002/2817 , A61F2002/2835 , A61F2002/30075 , A61F2002/302 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2210/0061 , A61F2230/0065 , A61F2230/0069 , A61F2230/0082 , A61L2400/06 , A61L2430/02 , Y10S514/801 , Y10S514/802 , Y10S514/953
摘要： A shaped piece of swollen demineralized bone which can also be plasticized is provided for use in surgical bone repair.
摘要翻译：提供也可以塑化的成形的肿胀的软化骨，用于外科手术骨修复。

2. 发明授权

US5298254A Shaped, swollen demineralized bone and its use in bone repair 失效
标题翻译：形状，肿胀的软化骨及其在骨修复中的用途
公开(公告)号：US5298254A
公开(公告)日：1994-03-29
申请号：US809580
申请日：1991-12-17
申请人： Annamarie B. Prewett , Roger C. Stikeleather , Simon Bogdansky , Robert K. O'Leary
发明人： Annamarie B. Prewett , Roger C. Stikeleather , Simon Bogdansky , Robert K. O'Leary
IPC分类号： A61K35/32 , A61L24/00 , A61L27/00 , A61L27/22 , A61L27/36
CPC分类号： A61L27/3608 , A61B17/686 , A61B17/82 , A61F2/2803 , A61F2/2846 , A61F2/4644 , A61K35/32 , A61L24/0005 , A61L27/227 , A61L27/365 , A61L27/3683 , A61F2/4455 , A61F2002/2817 , A61F2002/2835 , A61F2002/30075 , A61F2002/302 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2210/0061 , A61F2230/0065 , A61F2230/0069 , A61F2230/0082 , A61L2400/06 , A61L2430/02 , Y10S514/801 , Y10S514/802 , Y10S514/953
摘要： A shaped piece of swollen demineralized bone which can also be plasticized is provided for use in surgical bone repair.
摘要翻译：提供也可以塑化的成形的肿胀的软化骨，用于外科手术骨修复。

3. 发明授权

US5405390A Osteogenic composition and implant containing same 失效
标题翻译：成骨组合物和含有其的植入物
公开(公告)号：US5405390A
公开(公告)日：1995-04-11
申请号：US71449
申请日：1993-06-02
申请人： Robert K. O'Leary , Annamarie B. Prewett
发明人： Robert K. O'Leary , Annamarie B. Prewett
IPC分类号： A61L27/00 , A61K6/00 , A61K35/32 , A61L24/00 , A61L27/36 , A61L27/54 , A61F2/28
CPC分类号： A61L27/3608 , A61F2/30767 , A61K35/32 , A61L24/0005 , A61L24/0015 , A61L27/365 , A61L27/3683 , A61L27/54 , A61F2/32 , A61F2/4644 , A61F2002/2835 , A61F2002/30059 , A61F2310/00958 , A61L2300/414 , A61L2430/02 , A61L2430/40 , Y10S128/08
摘要： An osteogenic composition is obtained from demineralized bone tissue.
摘要翻译：从软化骨组织获得成骨组合物。

4. 发明授权

US5607476A Processing of fibrous connective tissue 失效
标题翻译：纤维结缔组织加工
公开(公告)号：US5607476A
公开(公告)日：1997-03-04
申请号：US598962
申请日：1996-02-09
申请人： Annamarie B. Prewett , Robert K. O'Leary
发明人： Annamarie B. Prewett , Robert K. O'Leary
IPC分类号： A61F2/00 , A61F2/08 , A61K35/32 , A61L27/36 , A61F2/64 , A61K35/22
CPC分类号： A61L27/3687 , A61K35/32 , A61L27/3604 , A61L27/3691 , A61F2/08 , A61F2250/0067
摘要： Fibrous connective tissue for surgical implantation is made substantially antigen-free by contact with one or more extraction agents. Solutions or mixtures of molecules having bipolar regions act as antigen removing permeation enhancers. Cationic, anionic, non-ionic or amphoteric surfactants are suitable bipolar permeation enhancers. One or more extraction agents can be combined to form extraction mixtures.
摘要翻译：用于手术植入的纤维结缔组织通过与一种或多种提取剂接触而基本上是无抗原的。具有双极区域的分子的溶液或混合物用作抗原去除渗透促进剂。阳离子，阴离子，非离子或两性表面活性剂是合适的双极渗透增强剂。一种或多种提取剂可以组合以形成提取混合物。

5. 发明授权

US5236456A Osteogenic composition and implant containing same 失效
标题翻译：成骨组合物和含有其的植入物
公开(公告)号：US5236456A
公开(公告)日：1993-08-17
申请号：US642633
申请日：1991-01-17
申请人： Robert K. O'Leary , Annamarie B. Prewett
发明人： Robert K. O'Leary , Annamarie B. Prewett
IPC分类号： A61L27/00 , A61K6/00 , A61K35/32 , A61L24/00 , A61L27/36 , A61L27/54
CPC分类号： A61L27/3608 , A61F2/30767 , A61K35/32 , A61L24/0005 , A61L24/0015 , A61L27/365 , A61L27/3683 , A61L27/54 , A61F2/32 , A61F2/4644 , A61F2002/2835 , A61F2002/30059 , A61F2310/00958 , A61L2300/414 , A61L2430/02 , A61L2430/40 , Y10S128/08
摘要： An osteogenic composition is obtained from demineralized bone tissue.
摘要翻译：从软化骨组织获得成骨组合物。

6. 发明授权

US5507810A Processing of fibrous connective tissue 失效
标题翻译：纤维结缔组织加工
公开(公告)号：US5507810A
公开(公告)日：1996-04-16
申请号：US995940
申请日：1992-12-21
申请人： Annamarie B. Prewett , Robert K. O'Leary
发明人： Annamarie B. Prewett , Robert K. O'Leary
IPC分类号： A61F2/00 , A61F2/08 , A61K35/32 , A61L27/36 , A61F2/64 , A61K35/22
CPC分类号： A61L27/3687 , A61K35/32 , A61L27/3604 , A61L27/3691 , A61F2/08 , A61F2250/0067
摘要： Fibrous connective tissue for surgical implantation is made substantially antigen-free by contact with one or more extraction agents. Solutions or mixtures of molecules having bipolar regions act as antigen removing permeation enhancers. Cationic, anionic, non-ionic or amphoteric surfactants are suitable bipolar permeation enhancers. One or more extraction agents can be combined to form extraction mixtures.
摘要翻译：用于手术植入的纤维结缔组织通过与一种或多种提取剂接触而基本上是无抗原的。具有双极区域的分子的溶液或混合物用作抗原去除渗透促进剂。阳离子，阴离子，非离子或两性表面活性剂是合适的双极渗透增强剂。一种或多种提取剂可以组合以形成提取混合物。

7. 发明授权

US5120656A Process for debriding bone 失效
标题翻译：骨髓切除手术
公开(公告)号：US5120656A
公开(公告)日：1992-06-09
申请号：US560661
申请日：1990-08-03
申请人： Robert K. O'Leary , Annamarie B. Prewett
发明人： Robert K. O'Leary , Annamarie B. Prewett
IPC分类号： C12N9/48 , A61B17/56 , A61F2/28 , A61L27/00 , A61L27/36 , A61L31/00 , C12N9/66 , C12N9/76
CPC分类号： A61L27/3608 , A61F2/28 , A61L27/3683 , A61L31/005
摘要： Bone is enzymatically debrided prior to undergoing further processing which renders the bone suitable for osteoprosthetic use.

8. 发明授权

US5284655A Swollen demineralized bone particles, flowable osteogenic composition containing same and use of the composition in the repair of osseous defects 失效
标题翻译：肿胀的软化骨质颗粒，包含其的可流动的成骨组合物和组合物用于修复骨缺损
公开(公告)号：US5284655A
公开(公告)日：1994-02-08
申请号：US830942
申请日：1992-02-04
申请人： Simon Bogdansky , Robert K. O'Leary
发明人： Simon Bogdansky , Robert K. O'Leary
IPC分类号： A61K35/32 , A61L24/00 , A61L27/00 , A61L27/22 , A61L27/36 , A61K47/26 , A61K47/36
CPC分类号： A61L27/3608 , A61B17/686 , A61B17/82 , A61F2/2803 , A61F2/2846 , A61F2/4644 , A61K35/32 , A61L24/0005 , A61L27/227 , A61L27/365 , A61L27/3683 , A61F2/4455 , A61F2002/2817 , A61F2002/2835 , A61F2002/30075 , A61F2002/302 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2210/0061 , A61F2230/0065 , A61F2230/0069 , A61F2230/0082 , A61L2400/06 , A61L2430/02 , Y10S514/801 , Y10S514/802 , Y10S514/953
摘要： Swollen demineralized bone particles are formulated into a flowable osteogenic composition which is useful in the repair of osseous defects.
摘要翻译：溶胀的软化骨颗粒被配制成可用于修复骨缺损的可流动的成骨组合物。

9. 发明授权

US06544289B2 Plasticized bone grafts, and methods of making and using same 有权
标题翻译：增塑骨移植物及其制造和使用方法
公开(公告)号：US06544289B2
公开(公告)日：2003-04-08
申请号：US09887418
申请日：2001-06-22
申请人： Lloyd Wolfinbarger, Jr. , Robert K. O'Leary , Billy G. Anderson
发明人： Lloyd Wolfinbarger, Jr. , Robert K. O'Leary , Billy G. Anderson
IPC分类号： A61F228
CPC分类号： A61L27/362 , A61F2/02 , A61F2/4644 , A61F2002/2825 , A61F2002/2835 , A61F2002/2839 , A61F2002/30535 , A61F2002/4646 , A61F2002/4649 , A61F2250/0058 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/502 , A61L2430/02
摘要： The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.
摘要翻译：本发明提供一种不需要特殊储存条件（例如冷冻或冷冻）的塑化脱水或冷冻干燥的骨和/或软组织产品，其表现出近似于在正常水合组织中存在的性质的材料性质不脆，在临床植入之前不需要补液，并不是疾病传播的潜在来源。本发明用一种或多种允许组织脱水的增塑剂代替骨或软组织基质的分子结构中的水，但不会导致增塑产品的脆性增加，并且导致压缩和/或拉伸性能类似与正常水合骨的那些。不需要在植入之前用水替代化学增塑剂，因此，脱水的骨或软组织增塑产品可以直接放置在植入部位，而无需在手术室中大量准备。

10. 发明授权

US5667985A Tissue biopsy cell suspender for cell analysis 失效
标题翻译：组织活检细胞悬液用于细胞分析
公开(公告)号：US5667985A
公开(公告)日：1997-09-16
申请号：US718850
申请日：1996-09-24
申请人： Robert K. O'Leary , Timothy Stevens , Richard L. Griffith
发明人： Robert K. O'Leary , Timothy Stevens , Richard L. Griffith
IPC分类号： B01L3/00 , B01L3/14 , C12M1/24 , C12M3/08 , C12Q1/02 , C12M3/00
CPC分类号： B01L3/502 , B01L3/50825 , C12M45/09 , Y10S435/81
摘要： A tissue biopsy cell suspender device includes a receptacle having a sealable opening. The receptacle contains a sufficient quantity of an aqueous medium to support an enzymatic dissociation of cells from a tissue biopsy sample. The device has a removable closure with a first sealing position and a second sealing position for sealing the opening in the receptacle. The device further includes a frangible container having a sufficient quantity of an enzyme therein to dissociate cells from the tissue biopsy sample. The frangible container is covered with a membrane that is permeable to water and to the enzyme. The frangible container is disposed within the receptacle so that the container is intact when the closure is in the first sealing position and the container is breached when the closure is in the second sealing position. When the frangible container is breached, the enzyme is released to permeate into the medium and for dissociation of the cells from the tissue sample.
摘要翻译：组织活检细胞悬挂装置包括具有可密封开口的容器。容器含有足够量的水性介质以支持来自组织活检样品的细胞的酶解离。该装置具有可拆卸的封闭件，其具有第一密封位置和用于密封容器中的开口的第二密封位置。该装置还包括具有足够量酶的易碎容器以从组织活检样品中分离细胞。易碎的容器被可渗透水和酶的膜覆盖。易碎容器设置在容器内，使得当封闭件处于第一密封位置时容器是完整的，并且当封闭件处于第二密封位置时容器被破坏。当易碎容器被破坏时，酶被释放以渗透到培养基中并使细胞与组织样品分离。

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