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1. 发明授权

US09012406B2 Light activated composite tissue adhesives 有权
标题翻译：光活化复合组织粘合剂
公开(公告)号：US09012406B2
公开(公告)日：2015-04-21
申请号：US12943771
申请日：2010-11-10
申请人： Barbara A. Soltz , Robert Soltz
发明人： Barbara A. Soltz , Robert Soltz
IPC分类号： A61K38/39 , A61K41/00 , A61K47/42 , A61L24/00 , A61L29/04 , A61L24/10
CPC分类号： A61L24/001 , A61L24/102 , A61L29/043 , Y10S514/801 , C08L89/06
摘要： Disclosed herein are compositions comprising gelatin, collagen, and a chromophore that produces a reactive oxygen species upon exposure to electromagnetic radiation. These compositions have also been found to be strong tissue adhesives that crosslinks the composition and tissue and are effective in closing and sealing wounds, fixation of grafts/implants and anastomoses.
摘要翻译：本文公开了包含明胶，胶原和在暴露于电磁辐射时产生活性氧物质的发色团的组合物。这些组合物也被发现是强的组织粘合剂，其使组合物和组织交联并且有效地封闭和密封伤口，固定移植物/植入物和吻合。

2. 发明授权

US08524226B2 Methods of prolonging patency of hemodialysis access 有权
标题翻译：延长血液透析通畅的方法
公开(公告)号：US08524226B2
公开(公告)日：2013-09-03
申请号：US13022070
申请日：2011-02-07
申请人： F. Nicholas Franano
发明人： F. Nicholas Franano
IPC分类号： C12N9/66 , A61K38/43 , A61K38/48 , C12Q1/25 , A61M25/00
CPC分类号： A61K38/4886 , A61K38/48 , A61K38/486 , Y10S514/801 , Y10S514/824 , Y10S514/929
摘要： The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation. The invention further includes methods for prolonging patency of hemodialysis access.
摘要翻译：本发明提供了治疗阻塞的生物导管的方法，其包括向导管施用可以降解阻塞组织的细胞外基质的试剂。具体的方法包括将酶或多种酶的混合物递送到阻塞区域或区域，其中酶具有降解阻塞物内的细胞外基质成分的能力，从而恢复被输送流体通过导管的正常流动。本发明还包括预防性扩张导管的一部分以最小化阻塞形成的风险。本发明还包括延长血液透析通路通畅的方法。

3. 发明授权

US08470354B2 Osteogenic implants with combined implant materials and methods for same 有权
标题翻译：具有组合种植体材料的成骨植入物及其相同的方法
公开(公告)号：US08470354B2
公开(公告)日：2013-06-25
申请号：US12684480
申请日：2010-01-08
申请人： William F. McKay , Scott D. Boden , Neil B. Beals
发明人： William F. McKay , Scott D. Boden , Neil B. Beals
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/18 , C07K14/78 , C07K14/51
CPC分类号： A61B17/707 , A61B17/8085 , A61B2017/00004 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/02 , C07K14/51 , C07K14/78 , Y10S514/801
摘要： Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
摘要翻译：描述的是成骨植入物，其包括至少部分地由承载成骨蛋白质例如骨形态发生蛋白质的第二种植体材料覆盖的第一种植体材料。第一植入材料可以包括矿物并且提供用于支撑骨向内生长的内部支架部分，并且第二植入材料可以包括覆盖第一植入材料并且具有吸入其中的液体成骨蛋白质制剂的胶原蛋白或其它海绵载体。相关植入材料及其制备和使用方法构成本发明的另外方面。

4. 发明授权

US08168599B2 Composition and method for healing tissues 有权
标题翻译：组织和组织愈合方法
公开(公告)号：US08168599B2
公开(公告)日：2012-05-01
申请号：US12659656
申请日：2010-03-16
申请人： George D. Petito , Anita M. Petito
发明人： George D. Petito , Anita M. Petito
IPC分类号： A61K31/70 , A61K31/715 , A61K31/727 , A61K47/00
CPC分类号： A61K38/39 , A61L15/225 , A61L26/0052 , A61L2430/16 , Y10S514/801 , A61K2300/00 , C08L5/08 , C08L89/06
摘要： The composition and method for healing tissues is a medicinal composition for facilitating the growth, protection and healing of tissues and cells in animals and humans. The composition is formulated as a either a powder, gel, paste, film, fluid injectable, rehydratable freeze-dried paste or sponge, sprayable solution, topically applied patch with adhesive and reservoir system, an intermediate for coatables such as films and bandages, a matrix for membranes, or as a matrix of flexible polymer(s), or delivered as either an orally ingestible liquid, tablet or capsule. The main ingredient of the formulated compositions is hydrolyzed collagen, which can be combined with polysulfated glycosaminoglycans, hyaluronic acid or salts thereof, or a glucosamine salt, and mixtures thereof. The composition may be formulated as an aqueous eye drop solution.
摘要翻译：用于愈合组织的组合物和方法是用于促进动物和人类中组织和细胞的生长，保护和愈合的药物组合物。该组合物配制成粉末，凝胶，糊剂，薄膜，可注射流体，可再水化的冷冻干燥的糊状物或海绵，可喷雾溶液，具有粘合剂和储存系统的局部施用的贴剂，用于诸如膜和绷带的涂层的中间体用于膜的基质，或作为柔性聚合物的基质，或作为口服摄入的液体，片剂或胶囊递送。配制的组合物的主要成分是水解胶原蛋白，其可与多硫酸化糖胺聚糖，透明质酸或其盐，或葡糖胺盐及其混合物组合。组合物可以配制成水性滴眼液。

5. 发明申请

US20110182876A1 Methods of Treatment with Elastase 有权
标题翻译：弹性蛋白酶治疗方法
公开(公告)号：US20110182876A1
公开(公告)日：2011-07-28
申请号：US13022070
申请日：2011-02-07
申请人： F. Nicholas Franano
发明人： F. Nicholas Franano
IPC分类号： A61K38/48 , A61P9/00 , A61P7/00
CPC分类号： A61K38/4886 , A61K38/48 , A61K38/486 , Y10S514/801 , Y10S514/824 , Y10S514/929
摘要： The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation.
摘要翻译：本发明提供了治疗阻塞的生物导管的方法，其包括向导管施用可以降解阻塞组织的细胞外基质的试剂。具体的方法包括将酶或多种酶的混合物递送到阻塞区域或区域，其中酶具有降解阻塞物内的细胞外基质成分的能力，从而恢复被输送流体通过导管的正常流动。本发明还包括预防性扩张导管的一部分以最小化阻塞形成的风险。

6. 发明授权

US07638495B2 Peptides as solubilizing excipients for transforming growth factor β proteins 失效
标题翻译：肽作为增溶赋形剂用于转化生长因子β蛋白
公开(公告)号：US07638495B2
公开(公告)日：2009-12-29
申请号：US11757807
申请日：2007-06-04
申请人： Pilarin Elizabeth Louise Nichols , Bernardo Perez-Ramirez
发明人： Pilarin Elizabeth Louise Nichols , Bernardo Perez-Ramirez
IPC分类号： A61K38/07 , A61K38/08 , A61K38/10 , A61K38/18 , C07K5/00 , C07K9/00 , C07K14/51
CPC分类号： C07K7/08 , A61K38/1875 , C07K14/51 , Y10S514/801
摘要： The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery that a peptide derived from the N-terminus extension of the T266 isoform of rhBMP-2 has properties that enhance the solubility of proteins. The invention also relates to methods of resolubilizing a protein that has precipitated, by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2. The invention also relates to methods of increasing the solubility of a protein by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2.
摘要翻译：本发明涉及包含赋形剂或蛋白质增溶剂的组合物。本发明涉及以下发现：衍生自rhBMP-2的T266同种型的N末端延伸的肽具有增强蛋白质溶解性的性质。本发明还涉及通过使蛋白质与由rhBMP-2的T266同种型的17个氨基酸延伸部分构成的肽接触而使已沉淀的蛋白质再溶解的方法。本发明还涉及通过使蛋白质与由rhBMP-2的T266同种型的17个氨基酸延伸部分构成的肽接触来增加蛋白质的溶解度的方法。

7. 发明申请

US20090060893A1 Methods for enlarging the diameter of a biological conduit in a human subject 有权
标题翻译：扩大人体内生物导管直径的方法
公开(公告)号：US20090060893A1
公开(公告)日：2009-03-05
申请号：US12229372
申请日：2008-08-22
申请人： F. Nicholas Franano
发明人： F. Nicholas Franano
IPC分类号： A61K38/43 , A61K38/48 , A61P9/00
CPC分类号： A61K38/4886 , A61K38/48 , A61K38/486 , Y10S514/801 , Y10S514/824 , Y10S514/929
摘要： The invention provides methods for treating a an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation.
摘要翻译：本发明提供了治疗阻塞的生物导管的方法，其包括向该导管施用可降解阻塞组织的细胞外基质的试剂。具体的方法包括将酶或多种酶的混合物递送到阻塞区域或区域，其中酶具有降解阻塞物内的细胞外基质成分的能力，从而恢复被输送流体通过导管的正常流动。本发明还包括预防性扩张导管的一部分以最小化阻塞形成的风险。

8. 发明申请

US20080317736A1 Methods for enlarging the diameter of a biological conduit in a human subject 有权
标题翻译：扩大人体内生物导管直径的方法
公开(公告)号：US20080317736A1
公开(公告)日：2008-12-25
申请号：US12082517
申请日：2008-04-10
申请人： F. Nicholas Franano
发明人： F. Nicholas Franano
IPC分类号： A61K38/48
CPC分类号： A61K38/4886 , A61K38/48 , A61K38/486 , Y10S514/801 , Y10S514/824 , Y10S514/929
摘要： The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation.
摘要翻译：本发明提供了治疗阻塞的生物导管的方法，其包括向导管施用可以降解阻塞组织的细胞外基质的试剂。具体的方法包括将酶或多种酶的混合物递送到阻塞区域或区域，其中酶具有降解阻塞物内的细胞外基质成分的能力，从而恢复被输送流体通过导管的正常流动。本发明还包括预防性地扩张导管的一部分以最小化阻塞形成的风险。

9. 发明授权

US07410947B2 Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects 失效
标题翻译：成骨装置及其用于修复软骨内骨和软骨缺损的方法
公开(公告)号：US07410947B2
公开(公告)日：2008-08-12
申请号：US11347699
申请日：2006-02-03
申请人： David C. Rueger , Marjorie M. Tucker
发明人： David C. Rueger , Marjorie M. Tucker
IPC分类号： A61K38/18 , A61K38/39 , A61K47/02 , A61K47/38 , C07K14/51
CPC分类号： A61L31/047 , A61F2002/2817 , A61L27/227 , Y10S514/801 , Y10S514/944
摘要： Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to: critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and defects resulting from degenerative diseases such as osteochondritis dessicans.
摘要翻译：本文公开了改进的成骨装置及其用于修复骨和软骨缺陷的方法。与本领域中的装置相比，装置和方法促进了使用较少成骨蛋白的增强的稳定性的修复组织的形成。本发明易于修复的缺陷包括但不限于：临界尺寸缺陷，非临界尺寸缺陷，非联合骨折，骨折，骨软骨缺损，软骨下缺陷以及由退行性疾病如骨软骨炎引起的缺陷。

10. 发明授权

US07189263B2 Biocompatible bone graft material 有权
标题翻译：生物相容性骨移植材料
公开(公告)号：US07189263B2
公开(公告)日：2007-03-13
申请号：US10771077
申请日：2004-02-03
申请人： Erik M. Erbe , Theodore D. Clineff , Charanpreet S. Bagga , Gina M. Nagvajara , Antony Koblish
发明人： Erik M. Erbe , Theodore D. Clineff , Charanpreet S. Bagga , Gina M. Nagvajara , Antony Koblish
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61B17/80 , A61B17/8095 , A61B17/86 , A61B2017/00004 , A61F2/2803 , A61F2/2875 , A61F2/30767 , A61F2/3094 , A61F2/30965 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/389 , A61F2/4241 , A61F2/4644 , A61F2002/2817 , A61F2002/2825 , A61F2002/2835 , A61F2002/2882 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30062 , A61F2002/3008 , A61F2002/30092 , A61F2002/30118 , A61F2002/30153 , A61F2002/30224 , A61F2002/30225 , A61F2002/30235 , A61F2002/30237 , A61F2002/30238 , A61F2002/30247 , A61F2002/30265 , A61F2002/30281 , A61F2002/30291 , A61F2002/30324 , A61F2002/30622 , A61F2002/30677 , A61F2002/30678 , A61F2002/30736 , A61F2002/30785 , A61F2002/30828 , A61F2002/30838 , A61F2002/30909 , A61F2002/30925 , A61F2002/4631 , A61F2210/0004 , A61F2210/0014 , A61F2230/0006 , A61F2230/0019 , A61F2230/0069 , A61F2230/0071 , A61F2230/0082 , A61F2230/0086 , A61F2230/0091 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0036 , A61F2250/0098 , A61F2310/00017 , A61F2310/00023 , A61F2310/00293 , A61F2310/00365 , A61F2310/00383 , A61F2310/00407 , A61L27/46 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/412 , A61L2300/64 , A61L2430/02 , Y10S514/801
摘要： Biocompatible bone graft material having a biocompatible, resorbable polymer and a biocompatible, resorbable inorganic material exhibiting macro, meso, and microporosities.
摘要翻译：生物相容性骨移植物材料具有生物相容性，可再吸收的聚合物和表现出宏观，中观和微孔的生物相容性，可再吸收的无机材料。

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