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    • 4. 发明申请
    • Methods for controlling cross-hybridization in analysis of nucleic acid sequences
    • 在核酸序列分析中控制交叉杂交的方法
    • US20050136427A1
    • 2005-06-23
    • US10877159
    • 2004-06-24
    • Paul WolberRobert Kincaid
    • Paul WolberRobert Kincaid
    • C12Q1/68B05D3/00C12M1/34G01N33/48G01N33/50G06F19/00
    • C12Q1/6813
    • Methods, reagents and kits are disclosed for selecting target-specific oligonucleotide probes, which may be used in analyzing a target nucleic acid sequence. In one aspect the present invention is directed to selecting a set of target-specific oligonucleotide probes. A cross-hybridization oligonucleotide probe is identified based on a candidate target-specific oligonucleotide probe for the target nucleic acid sequence. The cross-hybridization oligonucleotide probe measures the extent of occurrence of a cross-hybridization event having a predetermined probability. Cross-hybridization results are determined employing the cross-hybridization oligonucleotide probe and the target-specific oligonucleotide probe. The target-specific oligonucleotide probe is selected or rejected for the set based on the cross-hybridization results.
    • 公开了用于选择可用于分析靶核酸序列的靶特异性寡核苷酸探针的方法,试剂和试剂盒。 一方面,本发明涉及选择一组靶特异性寡核苷酸探针。 基于目标核酸序列的候选靶特异性寡核苷酸探针鉴定交叉杂交寡核苷酸探针。 交叉杂交寡核苷酸探针测量具有预定概率的交叉杂交事件的发生程度。 使用交叉杂交寡核苷酸探针和靶特异性寡核苷酸探针测定交叉杂交结果。 基于交叉杂交结果,针对该组选择或拒绝靶特异性寡核苷酸探针。
    • 6. 发明申请
    • Multidentate arrays
    • 多数列
    • US20050095614A1
    • 2005-05-05
    • US10877342
    • 2004-06-24
    • Paul Wolber
    • Paul Wolber
    • A61L2/00C12M1/34C12Q1/68
    • C12Q1/6837C12Q2525/161C12Q2565/513C12Q2565/107
    • A method of evaluating for the presence of a target polynucleotide in a sample, using an addressable array of multiple polynucleotide probes linked to a substrate. The sample is exposed to the array and a set of polynucleotide target probes, such that target polynucleotide which may be present will bind to a predetermined feature of the array through multiple target probes of the set by forming at respective target regions on a target molecule, simultaneous hybrids with anti-target regions of the multiple target probes. A binding pattern on the array is observed and the presence of the target polynucleotide evaluated based on the observed binding pattern. Kits using such arrays, and methods for selecting target probes are further provided.
    • 使用连接到底物的多个多核苷酸探针的可寻址阵列来评估样品中靶多核苷酸的存在的方法。 将样品暴露于阵列和一组多核苷酸靶探针,使得可存在的靶多核苷酸通过在靶分子上的各个靶区域形成而通过该组的多个靶探针结合阵列的预定特征, 同时具有多个目标探针的抗靶区域的杂交体。 观察到阵列上的结合模式,并且基于观察到的结合模式评价靶多核苷酸的存在。 进一步提供使用这种阵列的套件以及用于选择目标探针的方法。