专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050148004A1 Chemical arrays and methods of using the same 失效
标题翻译：化学数组及其使用方法
公开(公告)号：US20050148004A1
公开(公告)日：2005-07-07
申请号：US11008603
申请日：2004-12-08
申请人： Paul Wolber , Robert Kincaid , Douglas Amorese , Diane Ilsley-Tyree , Andrew Atwell , Mel Kronick , Eric Leproust
发明人： Paul Wolber , Robert Kincaid , Douglas Amorese , Diane Ilsley-Tyree , Andrew Atwell , Mel Kronick , Eric Leproust
IPC分类号： B01J19/00 , C12Q1/68 , C40B40/06 , C40B70/00 , C12P19/34
CPC分类号： C12Q1/6883 , B01J2219/00497 , B01J2219/00572 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00617 , B01J2219/00626 , B01J2219/00659 , B01J2219/00675 , B01J2219/00722 , B82Y30/00 , C12Q1/6806 , C12Q1/6837 , C12Q1/6876 , C12Q2600/158 , C40B40/06 , C40B50/14 , C40B70/00 , C12Q2565/537 , C12Q2525/161 , C12Q2565/525 , C12Q2525/131 , C12Q2521/301
摘要： Methods and compositions for generating mixtures of product molecules from an initial chemical array are provided. In the subject methods, a chemical array of surface immobilized first moieties is subjected to cleavage conditions such that a composition of solution phase first moieties is produced. The resultant composition of solution phase first moieties is then contacted with one or more reactants to produce a mixture of product molecules that are different from the first moieties. Also provided are the arrays employed in the subject methods and kits for practicing the subject methods.
摘要翻译：提供了从初始化学阵列产生产物分子的混合物的方法和组合物。在本发明方法中，表面固定的第一部分的化学阵列经受切割条件，使得产生溶液相第一部分的组合物。然后将所得到的溶液相第一部分的组合物与一种或多种反应物接触以产生不同于第一部分的产物分子的混合物。还提供了用于实践本发明方法的主题方法和试剂盒中使用的阵列。

2. 发明申请

US20050244885A1 Array based methods for synthesizing nucleic acid mixtures 审中-公开
标题翻译：用于合成核酸混合物的基于阵列的方法
公开(公告)号：US20050244885A1
公开(公告)日：2005-11-03
申请号：US11174042
申请日：2005-07-01
申请人： Paul Wolber , Robert Kincaid , Douglas Amorese , Diane Ilsley , Andrew Atwell
发明人： Paul Wolber , Robert Kincaid , Douglas Amorese , Diane Ilsley , Andrew Atwell
IPC分类号： B01J19/00 , C12Q1/68 , C40B40/06 , C40B70/00 , C12P19/34
CPC分类号： C12Q1/6883 , B01J2219/00497 , B01J2219/00572 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00617 , B01J2219/00626 , B01J2219/00659 , B01J2219/00675 , B01J2219/00722 , B82Y30/00 , C12Q1/6806 , C12Q1/6837 , C12Q1/6876 , C12Q2600/158 , C40B40/06 , C40B50/14 , C40B70/00 , C12Q2565/537 , C12Q2525/161 , C12Q2565/525 , C12Q2525/131 , C12Q2521/301
摘要： Methods for generating mixtures of nucleic acids, e.g., oligonucleotide primers, are provided. In the subject methods, an array is employed as template to generate mixtures of nucleic acids via a template driven primer extension reaction. In preferred embodiments, each probe on the array employed in the subject methods comprises a constant domain and a variable domain, where the constant domain is further characterized by having at least a recognition domain. Also provided are the arrays employed in the subject methods and kits for practicing the subject methods. The subject methods find use in a variety of applications, including the generation of target nucleic acids from an mRNA sample for use in hybridization assays, e.g., differential gene expression analyses.
摘要翻译：提供了产生核酸混合物的方法，例如寡核苷酸引物。在主题方法中，使用阵列作为模板，以通过模板驱动的引物延伸反应产生核酸的混合物。在优选实施方案中，在本方法中使用的阵列上的每个探针包括恒定结构域和可变结构域，其中恒定结构域的进一步特征在于至少具有识别结构域。还提供了用于实践本发明方法的主题方法和试剂盒中使用的阵列。本发明方法可用于各种应用，包括从用于杂交测定的mRNA样品中产生靶核酸，例如差异基因表达分析。

3. 发明申请

US20050026306A1 Method and system for generating virtual-microarrays 审中-公开
标题翻译：用于生成虚拟微阵列的方法和系统
公开(公告)号：US20050026306A1
公开(公告)日：2005-02-03
申请号：US10633470
申请日：2003-07-31
申请人： Robert Kincaid , Paul Wolber
发明人： Robert Kincaid , Paul Wolber
IPC分类号： C12M1/34 , G01N33/543 , G06F19/00
CPC分类号： G16B25/00
摘要： A method and system for generating virtual-microarray feature data from a virtualizing catalog array comprising a catalog microarray associated with data that can be together processed to produce any of numerous sets of virtual-microarray feature data. The catalog array portion of the virtualizing microarray may include many thousands, tens of thousands, or hundreds of thousands of different features from which a very large number of feature subsets may be generated. The data associated with the virtualizing microarray allows for rapid and transparent partitioning of the catalog-microarray features. Logic included within a microarray scanner, a computer system used to process data scanned from microarrays, a microarray-data visualization system, or other microarray-related processing entities can be used to generate feature data for any number of user-specified virtual arrays based on partitioning of the features included in the catalog-microarray component of the virtualizing microarray.
摘要翻译：一种用于从虚拟化目录数组生成虚拟微阵列特征数据的方法和系统，其包括与数据相关联的目录微阵列，其可以被一起处理以产生多组虚拟微阵列特征数据中的任何一组。虚拟化微阵列的目录阵列部分可以包括可能产生非常大量特征子集的数千，数万或数十万个不同特征。与虚拟化微阵列相关联的数据允许对目录 - 微阵列特征进行快速和透明的分区。包括在微阵列扫描器内的逻辑，用于处理从微阵列扫描的数据的计算机系统，微阵列数据可视化系统或其他微阵列相关处理实体可用于基于基于以下的任何数量的用户指定的虚拟阵列生成特征数据：分割虚拟化微阵列的目录 - 微阵列组件中包含的功能。

4. 发明申请

US20050136427A1 Methods for controlling cross-hybridization in analysis of nucleic acid sequences 审中-公开
标题翻译：在核酸序列分析中控制交叉杂交的方法
公开(公告)号：US20050136427A1
公开(公告)日：2005-06-23
申请号：US10877159
申请日：2004-06-24
申请人： Paul Wolber , Robert Kincaid
发明人： Paul Wolber , Robert Kincaid
IPC分类号： C12Q1/68 , B05D3/00 , C12M1/34 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12Q1/6813
摘要： Methods, reagents and kits are disclosed for selecting target-specific oligonucleotide probes, which may be used in analyzing a target nucleic acid sequence. In one aspect the present invention is directed to selecting a set of target-specific oligonucleotide probes. A cross-hybridization oligonucleotide probe is identified based on a candidate target-specific oligonucleotide probe for the target nucleic acid sequence. The cross-hybridization oligonucleotide probe measures the extent of occurrence of a cross-hybridization event having a predetermined probability. Cross-hybridization results are determined employing the cross-hybridization oligonucleotide probe and the target-specific oligonucleotide probe. The target-specific oligonucleotide probe is selected or rejected for the set based on the cross-hybridization results.
摘要翻译：公开了用于选择可用于分析靶核酸序列的靶特异性寡核苷酸探针的方法，试剂和试剂盒。一方面，本发明涉及选择一组靶特异性寡核苷酸探针。基于目标核酸序列的候选靶特异性寡核苷酸探针鉴定交叉杂交寡核苷酸探针。交叉杂交寡核苷酸探针测量具有预定概率的交叉杂交事件的发生程度。使用交叉杂交寡核苷酸探针和靶特异性寡核苷酸探针测定交叉杂交结果。基于交叉杂交结果，针对该组选择或拒绝靶特异性寡核苷酸探针。

5. 发明申请

US20050027461A1 Methods for evaluating oligonucleotide probe sequences 审中-公开
标题翻译：评估寡核苷酸探针序列的方法
公开(公告)号：US20050027461A1
公开(公告)日：2005-02-03
申请号：US10877231
申请日：2004-06-24
申请人： Karen Shannon , Paul Wolber , Glenda Delenstarr , Peter Webb , Robert Kincaid
发明人： Karen Shannon , Paul Wolber , Glenda Delenstarr , Peter Webb , Robert Kincaid
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/20 , G06F19/24 , G06F19/00
CPC分类号： G16B25/00 , G16B40/00
摘要： Methods are disclosed for predicting the potential of an oligonucleotide to hybridize to a target nucleotide sequence. A predetermined number of unique oligonucleotides is identified. The unique oligonucleotides are chosen to sample the entire length of a nucleotide sequence that is hybridizable with the target nucleotide sequence. At least one parameter that is independently predictive of the ability of each of the oligonucleotides of the set to hybridize to the target nucleotide sequence is determined and evaluated for each of the above oligonucleotides. A subset of oligonucleotides within the predetermined number of unique oligonucleotides is identified based on the evaluation of the parameter. Oligonucleotides in the subset are identified that are clustered along a region of the nucleotide sequence that is hybridizable to the target nucleotide sequence. The method may be carried out with the aid of a computer.
摘要翻译：公开了用于预测寡核苷酸与靶核苷酸序列杂交的潜力的方法。鉴定出预定数量的唯一寡核苷酸。选择独特的寡核苷酸来对可与靶核苷酸序列杂交的核苷酸序列的整个长度进行采样。确定并评估每种上述寡核苷酸的至少一个独立地预测该组寡核苷酸与靶核苷酸序列杂交的能力的参数。基于参数的评估来鉴定预定数量的唯一寡核苷酸内的寡核苷酸的子集。鉴定了亚群中的寡核苷酸，其沿着与靶核苷酸序列可杂交的核苷酸序列的区域聚集。该方法可以借助于计算机进行。

6. 发明授权

US09898578B2 Visualizing expression data on chromosomal graphic schemes 有权
公开(公告)号：US09898578B2
公开(公告)日：2018-02-20
申请号：US10817244
申请日：2004-04-03
申请人： Zohar Yakhini , Robert Kincaid , Amir Ben-Dor , Leslie A. Leonard , Nicholas M. Sampas
发明人： Zohar Yakhini , Robert Kincaid , Amir Ben-Dor , Leslie A. Leonard , Nicholas M. Sampas
IPC分类号： G01N33/48 , G01N33/50 , G06F19/26 , G06F19/12 , G06F19/24 , G06F19/18 , G06F19/20
CPC分类号： G06F19/26 , G06F19/12 , G06F19/18 , G06F19/20 , G06F19/24
摘要： Systems and methods for displaying gene- and/or protein-related data with respect to chromosome maps at locations identifying relevant positioning of the genes with which the gene- and/or protein related data are associated. Multiple experiments may be plotted onto the display adjacent one or more chromosome maps. Automatic extraction of genomic location, based on accession numbers or other unique identifiers and cross connection with expression data is provided. Statistical assessments of correlations between expression and genome localization may be performed. Zooming capabilities, thumbnail/fullview toggling, browsability and linked data may be included as features of the visualization systems described.

7. 发明申请

US20060263789A1 Unique identifiers for indicating properties associated with entities to which they are attached, and methods for using 审中-公开
标题翻译：用于指示与其相关联的实体相关联的属性的唯一标识符，以及使用方法
公开(公告)号：US20060263789A1
公开(公告)日：2006-11-23
申请号：US11133120
申请日：2005-05-19
申请人： Robert Kincaid
发明人： Robert Kincaid
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G01N33/48721 , C12Q1/68 , C12Q2563/179
摘要： Methods, systems and computer readable media for sequencing a biopolymer specimen and tracking a source from which the specimen was derived. Methods, systems and computer readable media for multiplex sequencing biopolymer samples. Methods, systems and computer readable media for efficiently sequencing biopolymeric specimens through a high-throughput sequencer. Methods, systems and computer readable media for performing ratio-based analysis with a high throughput sequencer.
摘要翻译：方法，系统和计算机可读介质，用于对生物聚合物样品进行测序并跟踪来自样品的来源。用于多重测序生物聚合物样品的方法，系统和计算机可读介质。方法，系统和计算机可读介质，用于通过高通量测序仪有效地测序生物聚合物样品。用于使用高通量序列器执行基于比率的分析的方法，系统和计算机可读介质。

8. 发明申请

US20060084067A1 Method and system for analysis of array-based, comparative-hybridization data 审中-公开
标题翻译：基于阵列的比较杂交数据的分析方法和系统
公开(公告)号：US20060084067A1
公开(公告)日：2006-04-20
申请号：US10953958
申请日：2004-09-29
申请人： Zohar Yakhini , Amir Ben-Dor , Robert Kincaid
发明人： Zohar Yakhini , Amir Ben-Dor , Robert Kincaid
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G16B25/00 , C12Q1/6841
摘要： Embodiments of the present invention include methods and systems for analysis of comparative genomic hybridization (“CGH”) data, including CGH data obtained from microarray experiments. Various embodiments of the present invention include parametric and non-parametric normalization methods for CGH data, methods for identifying sets of one or more contiguous chromosomal DNA subsequences that are amplified or deleted in cells from particular tissue samples, and methods for determining amplifications and deletions common to a set of analyzed samples. When combined with well-designed microarray-based experimental systems, method embodiments of the present invention provide markedly increased quantitative precision in the identification of chromosomal abnormalities, including amplified and deleted DNA subsequences based on CGH data.
摘要翻译：本发明的实施方案包括用于分析比较基因组杂交（“CGH”）数据的方法和系统，包括从微阵列实验获得的CGH数据。本发明的各种实施方案包括用于CGH数据的参数和非参数归一化方法，用于鉴定在特定组织样品的细胞中扩增或缺失的一个或多个连续染色体DNA亚序列的集合的方法，以及用于确定扩增和缺失的方法到一组分析的样品。当与精心设计的基于微阵列的实验系统结合使用时，本发明的方法实施例提供了显着增加的染色体异常鉴定的定量精确度，包括基于CGH数据的扩增和缺失的DNA子序列。

9. 发明申请

US20050206644A1 Systems, tools and methods for focus and context viewving of large collections of graphs 有权
标题翻译：用于焦点和上下文查看大图集合的系统，工具和方法
公开(公告)号：US20050206644A1
公开(公告)日：2005-09-22
申请号：US11124500
申请日：2005-05-06
申请人： Robert Kincaid
发明人： Robert Kincaid
IPC分类号： G06F19/20 , G06F19/26 , G06T11/20
CPC分类号： G06F19/26 , G06F19/20 , G06T11/206
摘要： Systems, tools, methods and computer readable media for visualizing a collection of graphs to provide context and focus. A compressed visualization is formed by compressing all of the graphs in a direction along a compression axis of the visualization. At least one of the compressed graphs may be zoomed to make a visualization of the at least one graph having a greater scale along the second axis than a scale of the compressed graphs. The zoomed graph or graphs may be displayed along with the compressed graphs, wherein the zoomed graph or graphs are displayed in a same order relative to the compressed graphs and each other as occupied prior to the zooming. A user interface for use in visualizing a collection of graphs in an overall view while at the same time providing the ability to view detail with regard to at least one of the graphs includes a display configured to visualize the collection of graphs in compressed form, and a feature for selecting a graph from the visualization of the compressed collection, wherein upon selecting a graph, the interface zooms at least the selected graph to make a visualization of at least the selected graph having a greater scale along an axis of compression of the compressed visualization than a scale of the compressed graphs along the axis of compression. The selected graph and any other zoomed graphs may be displayed in the same order that they occupied in the compressed visualization, relative to the graphs remaining compressed and each other.
摘要翻译：系统，工具，方法和计算机可读介质，用于可视化图形集合以提供上下文和焦点。通过沿着可视化的压缩轴的方向压缩所有图形来形成压缩可视化。压缩图中的至少一个可以被缩放以使得沿着第二轴具有比压缩图的比例更大的尺度的至少一个图的可视化。可以与压缩图形一起显示缩放的图形或图形，其中缩放的图形或图形以相对于压缩图形的相同顺序显示，并且彼此在缩放之前被占用。用于在整体视图中可视化图形集合的用户界面，同时提供关于至少一个图形来查看细节的能力，包括被配置为可视化压缩形式的图形集合的显示器，以及用于从所述压缩集合的可视化中选择图形的特征，其中在选择图形时，所述界面至少缩放所选择的图形，以使至少所选择的图形的可视化沿压缩的压缩轴线具有更大的尺度可视化比沿着压缩轴的压缩图的尺度。所选图形和任何其他缩放图可以按照压缩可视化中占用的相同顺序显示，相对于剩余的压缩图和彼此。

10. 发明申请

US20050112689A1 Systems and methods for statistically analyzing apparent CGH data anomalies and plotting same 审中-公开
标题翻译：用于统计分析表观CGH数据异常和绘制图形的系统和方法
公开(公告)号：US20050112689A1
公开(公告)日：2005-05-26
申请号：US10964524
申请日：2004-10-12
申请人： Robert Kincaid
发明人： Robert Kincaid
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G01N33/53 , G06F19/20 , G06F19/24 , G06F19/00
CPC分类号： G16B40/00 , G16B25/00
摘要： Methods, systems and computer readable media for statistically analyzing apparent anomalies in CGH data, wherein the CGH data is ordered corresponding to locations of matter on chromosomes from which the CGH data was derived. A set of CGH ratio values is considered and Z-score values are computed for each CGH ratio value. The Z-score values are classified based upon a predetermined cutoff value. The number of Z-scores that are greater than the predetermined cutoff value are counted, the number of Z-scores that are less than a negative of the predetermined cutoff value are counted, and the total number of Z-scores are counted. A subset of the set of CGH ratios are considered, being defined by a window of predetermined size. A secondary Z-score is computed to measure the significance of at least one of overabundance and underabundance of at least one of significant positive deviations and significant negative deviations in the subset.
摘要翻译：用于统计分析CGH数据中的表观异常的方法，系统和计算机可读介质，其中CGH数据对应于衍生CGH数据的染色体上的物质的位置。考虑一组CGH比值，并计算每个CGH比值的Z分数值。 Z分数值根据预定的截止值进行分类。计数大于预定截止值的Z分数，计数小于预定截止值的负数的Z分数，并对Z分数的总数进行计数。考虑CGH比率集合的子集，由预定大小的窗口定义。计算次级Z得分以测量亚组中至少一个显着正偏差和显着负偏差中至少一个的过量和不足的显着性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式