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1. 发明授权

US07638509B2 Diene compounds and formulations 失效
标题翻译：二烯化合物和配方
公开(公告)号：US07638509B2
公开(公告)日：2009-12-29
申请号：US12405970
申请日：2009-03-17
申请人： Henry A. Lardy , Padma Marwah , Ashok Marwah
发明人： Henry A. Lardy , Padma Marwah , Ashok Marwah
IPC分类号： A61K31/58 , A61K31/567 , C07J1/00
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

2. 发明申请

US20080021006A1 Pharmaceutical Compositions 有权
标题翻译：药物组合物
公开(公告)号：US20080021006A1
公开(公告)日：2008-01-24
申请号：US11835334
申请日：2007-08-07
申请人： Henry Lardy , Padma Marwah , James Frincke
发明人： Henry Lardy , Padma Marwah , James Frincke
IPC分类号： A61K31/56
CPC分类号： A61K31/568 , A61K31/565 , A61K31/567 , A61K31/5685 , A61K45/06 , C07J1/00 , C07J1/0011 , C07J1/0022 , C07J1/0025 , C07J1/0048 , C07J31/00 , C07J41/00
摘要： The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for agents that modulate the biological activity of the androgen receptor. The invention also provides methods and compositions suitable for therapeutic applications.
摘要翻译：本发明提供了治疗诸如前列腺癌或改善与前列腺癌相关的一种或多种症状的病症或调节雄激素受体生物学活性的药物的方法。本发明还提供适用于治疗应用的方法和组合物。

3. 发明申请

US20080004250A1 Compounds and Formulations 失效
标题翻译：化合物和配方
公开(公告)号：US20080004250A1
公开(公告)日：2008-01-03
申请号：US11838154
申请日：2007-08-13
申请人： Henry Lardy , Ashok Marwah , Padma Marwah
发明人： Henry Lardy , Ashok Marwah , Padma Marwah
IPC分类号： A61K31/58 , A61P5/28 , C07J21/00
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

4. 发明申请

US20090181936A1 Diene and Triene Compounds and Formulations 失效
标题翻译：二烯和三烯化合物和配方
公开(公告)号：US20090181936A1
公开(公告)日：2009-07-16
申请号：US12406033
申请日：2009-03-17
申请人： Henry A. Lardy , Ashok Marwah , Padma Marwah
发明人： Henry A. Lardy , Ashok Marwah , Padma Marwah
IPC分类号： A61K31/58 , C07J21/00 , A61K31/56
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

5. 发明授权

US07550450B2 Prostate cancer treatment 失效
标题翻译：前列腺癌治疗
公开(公告)号：US07550450B2
公开(公告)日：2009-06-23
申请号：US11862153
申请日：2007-09-26
申请人： Henry A. Lardy , Ashok Marwah , Padma Marwah
发明人： Henry A. Lardy , Ashok Marwah , Padma Marwah
IPC分类号： A61K31/58
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

6. 发明授权

US07462610B2 Prostate cancer treatment 失效
标题翻译：前列腺癌治疗
公开(公告)号：US07462610B2
公开(公告)日：2008-12-09
申请号：US11837508
申请日：2007-08-11
申请人： Henry A. Lardy , Padma Marwah , Ashok Marwah
发明人： Henry A. Lardy , Padma Marwah , Ashok Marwah
IPC分类号： A61K31/58
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

7. 发明申请

US20060079492A1 Compositions and treatment methods 审中-公开
标题翻译：组合和治疗方法
公开(公告)号：US20060079492A1
公开(公告)日：2006-04-13
申请号：US11234675
申请日：2005-09-23
申请人： Clarence Ahlem , Christopher Reading , James Frincke , Dwight Stickney , Henry Lardy , Padma Marwah , Ashok Marwah , Patrick Prendergast
发明人： Clarence Ahlem , Christopher Reading , James Frincke , Dwight Stickney , Henry Lardy , Padma Marwah , Ashok Marwah , Patrick Prendergast
IPC分类号： A61K31/57
CPC分类号： A61K31/57 , A61K9/0019 , A61K31/343 , A61K47/34 , A61K47/44
摘要： The invention relates to the use of compounds to treat a number of conditions, such as thrombocytopenia, neutropenia or the delayed effects of radiation therapy. Compounds that can be used in the invention include methyl-2,3,4-trihydroxy-1-O-(7,17-dioxoandrost-5-ene-3β-yl)-β-D-glucopyranosiduronate, 16α,3α-dihydroxy-5α-androstan-17-one or 3,7,16,17-tetrahydroxyandrost-5-ene, 3,7,16,17-tetrahydroxyandrost-4-ene, 3,7,16,17-tetrahydroxyandrost-1-ene or 3,7,16,17-tetrahydroxyandrostane that can be used in the treatment method.
摘要翻译：本发明涉及化合物用于治疗诸如血小板减少症，中性粒细胞减少症或辐射治疗的延迟作用的许多病症的用途。可用于本发明的化合物包括甲基-2,3,4-三羟基-1-O-（7,17-二氧雄甾-5-烯-3β-基）-β-D-吡喃葡萄糖醛酸呃酯，16α，3α-二羟基 -5α-雄甾烷-17-酮或3,7,16,17-四羟基雄甾-5-烯，3,7,16,17-四羟基雄甾-4-烯，3,7,16,17-四羟基雄甾-1-烯或可用于治疗方法的3,7,16,17-四羟基雄甾烷。

8. 发明授权

US06686486B1 Process for effecting allylic oxidation 失效
标题翻译：进行烯丙基氧化的方法
公开(公告)号：US06686486B1
公开(公告)日：2004-02-03
申请号：US09639027
申请日：2000-08-14
申请人： Padma Marwah , Henry A. Lardy
发明人： Padma Marwah , Henry A. Lardy
IPC分类号： C07J100
CPC分类号： C07C49/675 , C07C45/30 , C07C49/627 , C07C49/786
摘要： A procedure for oxidizing organic compounds having allylic hydrogen atom(s) involving the steps of reactively contacting the organic compound with a combination of a periodic acid or metal periodate and an alkyl hydroperoxide under conditions of normal as well as elevated pressure of a suitable gas like air. The reaction can conveniently be conducted at temperatures between about 0-65° C. in a cosolvent system of water and organic solvent(s).
摘要翻译：用于氧化具有烯丙基氢原子的有机化合物的方法涉及以下步骤：在合适的气体如正常和高压的条件下，将有机化合物与高碘酸或高碘酸钾和烷基氢过氧化物的组合反应接触，空气。反应可以方便地在约0-65℃的温度下在共溶剂体系的水和有机溶剂中进行。

9. 发明授权

US06170438B2 Multipurpose bathrobe for pets 失效
标题翻译：多用途的浴衣为宠物
公开(公告)号：US06170438B2
公开(公告)日：2001-01-09
申请号：US09262521
申请日：1999-03-04
申请人： Padma Marwah , Ashok Kumar Marwah
发明人： Padma Marwah , Ashok Kumar Marwah
IPC分类号： A01K1300
CPC分类号： A01K13/006
摘要： A pet bathrobe for completely enclosing animal and made of one or more layers of water absorbent material. The bathrobe comprises a rectangular bag having four sides with small openings at both lower corners and an opening extending across entire longitudinal length of the upper side with one end extending into a cap like hood and other end having a small opening. The top opening can be closed with the help of a closure mechanism. The bathrobe may be covered with an optional detachable outer layer made of water impervious material and has a mechanism to hold bathrobe around animal's neck.
摘要翻译：宠物浴袍，用于完全封闭动物，并由一层或多层吸水材料制成。浴袍包括一个四边形的矩形袋，在两个下角处具有小的开口，并且在上侧的整个纵向长度上延伸出一个开口，一端延伸到帽状罩和另一端具有小开口。借助闭合机构，可以关闭顶部开口。浴袍可以用可防水材料制成的可选择的可拆卸外层覆盖，并且具有在动物颈部保持浴衣的机构。

10. 发明授权

US5869709A Process for effecting allylic oxidation 失效
标题翻译：进行烯丙基氧化的方法
公开(公告)号：US5869709A
公开(公告)日：1999-02-09
申请号：US851939
申请日：1997-05-07
申请人： Padma Marwah , Henry A. Lardy
发明人： Padma Marwah , Henry A. Lardy
IPC分类号： C07C45/30 , C07C49/675 , C07J1/00 , C07C45/00 , C07J9/00 , C07J21/00
CPC分类号： C07C49/675 , C07C45/30
摘要： A procedure for oxidizing organic compounds having allylic hydrogen atom(s) involving the steps of reactively contacting the organic compound with a combination of an alkali metal periodate and an alkyl hydroperoxide. The reaction can conveniently be conducted under ambient temperature and pressure conditions, and is conveniently conducted in a cosolvent system of water and organic solvent(s).
摘要翻译：用于氧化具有烯丙基氢原子的有机化合物的方法包括使有机化合物与碱金属高碘酸盐和烷基氢过氧化物的组合反应接触的步骤。该反应可以方便地在环境温度和压力条件下进行，并且方便地在水和有机溶剂的助溶剂体系中进行。

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