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1. 发明申请

US20080009472A1 Prostate Cancer Treatment 失效
公开(公告)号：US20080009472A1
公开(公告)日：2008-01-10
申请号：US11837508
申请日：2007-08-11
申请人： Henry Lardy , Ashok Marwah , Padma Marwah
发明人： Henry Lardy , Ashok Marwah , Padma Marwah
IPC分类号： A61K31/58 , A61P35/00
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.

2. 发明申请

US20080004250A1 Compounds and Formulations 失效
标题翻译：化合物和配方
公开(公告)号：US20080004250A1
公开(公告)日：2008-01-03
申请号：US11838154
申请日：2007-08-13
申请人： Henry Lardy , Ashok Marwah , Padma Marwah
发明人： Henry Lardy , Ashok Marwah , Padma Marwah
IPC分类号： A61K31/58 , A61P5/28 , C07J21/00
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

3. 发明申请

US20060079492A1 Compositions and treatment methods 审中-公开
标题翻译：组合和治疗方法
公开(公告)号：US20060079492A1
公开(公告)日：2006-04-13
申请号：US11234675
申请日：2005-09-23
申请人： Clarence Ahlem , Christopher Reading , James Frincke , Dwight Stickney , Henry Lardy , Padma Marwah , Ashok Marwah , Patrick Prendergast
发明人： Clarence Ahlem , Christopher Reading , James Frincke , Dwight Stickney , Henry Lardy , Padma Marwah , Ashok Marwah , Patrick Prendergast
IPC分类号： A61K31/57
CPC分类号： A61K31/57 , A61K9/0019 , A61K31/343 , A61K47/34 , A61K47/44
摘要： The invention relates to the use of compounds to treat a number of conditions, such as thrombocytopenia, neutropenia or the delayed effects of radiation therapy. Compounds that can be used in the invention include methyl-2,3,4-trihydroxy-1-O-(7,17-dioxoandrost-5-ene-3β-yl)-β-D-glucopyranosiduronate, 16α,3α-dihydroxy-5α-androstan-17-one or 3,7,16,17-tetrahydroxyandrost-5-ene, 3,7,16,17-tetrahydroxyandrost-4-ene, 3,7,16,17-tetrahydroxyandrost-1-ene or 3,7,16,17-tetrahydroxyandrostane that can be used in the treatment method.
摘要翻译：本发明涉及化合物用于治疗诸如血小板减少症，中性粒细胞减少症或辐射治疗的延迟作用的许多病症的用途。可用于本发明的化合物包括甲基-2,3,4-三羟基-1-O-（7,17-二氧雄甾-5-烯-3β-基）-β-D-吡喃葡萄糖醛酸呃酯，16α，3α-二羟基 -5α-雄甾烷-17-酮或3,7,16,17-四羟基雄甾-5-烯，3,7,16,17-四羟基雄甾-4-烯，3,7,16,17-四羟基雄甾-1-烯或可用于治疗方法的3,7,16,17-四羟基雄甾烷。

4. 发明申请

US20080070881A1 Prostate Cancer Treatment 失效
标题翻译：前列腺癌治疗
公开(公告)号：US20080070881A1
公开(公告)日：2008-03-20
申请号：US11862153
申请日：2007-09-26
申请人： Henry Lardy , Ashok Marwah , Padma Marwah
发明人： Henry Lardy , Ashok Marwah , Padma Marwah
IPC分类号： A61K31/58 , A61P35/00
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

5. 发明授权

US07638509B2 Diene compounds and formulations 失效
标题翻译：二烯化合物和配方
公开(公告)号：US07638509B2
公开(公告)日：2009-12-29
申请号：US12405970
申请日：2009-03-17
申请人： Henry A. Lardy , Padma Marwah , Ashok Marwah
发明人： Henry A. Lardy , Padma Marwah , Ashok Marwah
IPC分类号： A61K31/58 , A61K31/567 , C07J1/00
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

6. 发明授权

US07514420B2 Steroids having 1,8-unsaturation and formulations comprising same 失效
标题翻译：具有1,8-不饱和度的类固醇和包含其的制剂
公开(公告)号：US07514420B2
公开(公告)日：2009-04-07
申请号：US11838154
申请日：2007-08-13
申请人： Henry A. Lardy , Padma Marwah , Ashok Marwah
发明人： Henry A. Lardy , Padma Marwah , Ashok Marwah
IPC分类号： A61K31/56 , A61K31/58 , C07J5/00 , C07J7/00 , C07J21/00 , C07J71/00
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

7. 发明授权

US07842680B2 Diene and triene compounds and formulations 失效
标题翻译：二烯和三烯化合物和配方
公开(公告)号：US07842680B2
公开(公告)日：2010-11-30
申请号：US12406033
申请日：2009-03-17
申请人： Henry A. Lardy , Padma Marwah , Ashok Marwah
发明人： Henry A. Lardy , Padma Marwah , Ashok Marwah
IPC分类号： A61K31/56 , A61K31/58 , C07J5/00 , C07J7/00 , C07J21/00
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3'-乙酰氧基雄甾-1,5-二烯-17-亚乙基缩酮和3'-羟基雄-1,5-二烯-17-亚乙基缩酮，以及它们用于预防的方法和治疗由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

8. 发明申请

US20090181936A1 Diene and Triene Compounds and Formulations 失效
标题翻译：二烯和三烯化合物和配方
公开(公告)号：US20090181936A1
公开(公告)日：2009-07-16
申请号：US12406033
申请日：2009-03-17
申请人： Henry A. Lardy , Ashok Marwah , Padma Marwah
发明人： Henry A. Lardy , Ashok Marwah , Padma Marwah
IPC分类号： A61K31/58 , C07J21/00 , A61K31/56
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

9. 发明授权

US07550450B2 Prostate cancer treatment 失效
标题翻译：前列腺癌治疗
公开(公告)号：US07550450B2
公开(公告)日：2009-06-23
申请号：US11862153
申请日：2007-09-26
申请人： Henry A. Lardy , Ashok Marwah , Padma Marwah
发明人： Henry A. Lardy , Ashok Marwah , Padma Marwah
IPC分类号： A61K31/58
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

10. 发明授权

US07462610B2 Prostate cancer treatment 失效
标题翻译：前列腺癌治疗
公开(公告)号：US07462610B2
公开(公告)日：2008-12-09
申请号：US11837508
申请日：2007-08-11
申请人： Henry A. Lardy , Padma Marwah , Ashok Marwah
发明人： Henry A. Lardy , Padma Marwah , Ashok Marwah
IPC分类号： A61K31/58
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

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