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1. 发明授权

US09458103B2 Compositions and methods for inhibition of cathepsins 有权
标题翻译：用于抑制组织蛋白酶的组合物和方法
公开(公告)号：US09458103B2
公开(公告)日：2016-10-04
申请号：US14505165
申请日：2014-10-02
申请人： OXiGENE, Inc. , Baylor University
发明人： David J. Chaplin , Kishore Kumar Gaddale Devanna , Erica Parker , Kevin G. Pinney , Jiangli Song , Mary L. Trawick
IPC分类号： C07C337/08 , C07C49/786
CPC分类号： C07C337/08 , C07C49/786
摘要： This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.

2. 发明申请

US20140303374A1 METHOD FOR PRODUCING COMPOUND WITH CARBONYL GROUP BY USING RUTHENIUM CARBONYL COMPLEX HAVING TRIDENTATE LIGAND AS DEHYDROGENATION OXIDATION CATALYST 有权
标题翻译：通过使用具有三氯甲烷配位体的碳酸氢钠复合物作为脱氢氧化催化剂生产碳化合物的方法
公开(公告)号：US20140303374A1
公开(公告)日：2014-10-09
申请号：US14113326
申请日：2012-04-18
申请人： Taichiro Touge , Kunimori Aoki , Hideki Nara , Wataru Kuriyama
发明人： Taichiro Touge , Kunimori Aoki , Hideki Nara , Wataru Kuriyama
IPC分类号： C07D453/02 , B01J31/22 , C07C51/265 , C07C51/29 , C07C51/235 , C07C51/255
CPC分类号： B01J31/2295 , B01J31/189 , B01J31/20 , B01J2231/763 , B01J2531/0238 , B01J2531/821 , C07B33/00 , C07C45/29 , C07C51/235 , C07C51/255 , C07C51/265 , C07C51/29 , C07C67/40 , C07D453/02 , C07F15/0046 , C07F17/02 , C07C69/24 , C07C69/78 , C07C47/02 , C07C47/228 , C07C47/238 , C07C47/54 , C07C49/403 , C07C49/413 , C07C49/603 , C07C49/78 , C07C49/786
摘要： Provided by the present invention is a method for efficient oxidation of alcohols by using, as a catalyst for dehydrogenation oxidation, a ruthenium complex which can be easily produced and easily handled and is obtainable at a relatively low cost. The invention relates to a method of producing a compound having a carbonyl group by dehydrogenation oxidation of alcohols by using as a catalyst the ruthenium carbonyl complex represented by the following general formula (1) RuXY(CO)(L) (1) (in the general formula (1), X and Y may be the same or different from each other and represent an anionic ligand, and L represents a tridentate aminodiphosphine ligand).
摘要翻译：通过本发明提供的是通过使用可以容易地制备和容易处理的钌络合物作为脱氢氧化催化剂来有效地氧化醇的方法，并且可以以相对低的成本获得。本发明涉及通过使用由以下通式（1）RuXY（CO）（L）（1）表示的钌羰基络合物作为催化剂，通过醇的脱氢氧化制备具有羰基的化合物的方法（在通式（1）中，X和Y可以相同或不同，表示阴离子配体，L表示三齿氨基二膦配体）。

3. 发明申请

US20110112282A1 IDO INHIBITORS AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译： IDO抑制剂及其治疗用途
公开(公告)号：US20110112282A1
公开(公告)日：2011-05-12
申请号：US12736526
申请日：2009-04-15
申请人： Ute Roehrig , Loay Awad , Olivier Michelin , Benoit Van Den Eynde , Luc Pilotte , Vincent Stroobant , Pierre Larrieu
发明人： Ute Roehrig , Loay Awad , Olivier Michelin , Benoit Van Den Eynde , Luc Pilotte , Vincent Stroobant , Pierre Larrieu
IPC分类号： C07H7/04 , C07D209/48 , C07C211/58 , C07C211/63 , C07D215/38 , C07C237/20 , C07D207/16
CPC分类号： A61K31/136 , A61K31/05 , A61K31/085 , A61K31/12 , A61K31/167 , A61K31/4045 , A61K31/4192 , A61K31/428 , A61K31/4439 , A61K31/47 , C07C35/36 , C07C35/38 , C07C39/367 , C07C43/23 , C07C49/786 , C07C49/83 , C07C215/86 , C07C217/90 , C07C237/04 , C07C251/22 , C07C2602/10 , C07C2603/18 , C07D207/16 , C07D209/14 , C07D209/48 , C07D209/88 , C07D215/26 , C07D215/38 , C07D215/40 , C07D249/06 , C07D277/36 , C07D277/40 , C07D277/72 , C07D277/74 , C07D401/04
摘要： Compounds of formula (I), and pharmaceutically acceptable salts thereof, in which each compound is adapted to occupy the binding site of human IDO, which comprises a large hydrophobic pocket A and a second, proximal hydrophobic pocket B, the compound comprising at least one of the following elements: (i) a large hydrophobic fragment to substantially fill pocket A in the binding site of human IDO; (ii) an atom that can coordinate to the heme iron of human IDO, (iii) a positively charged group that can form a salt-bridge with the heme 7-propionate of the human IDO; (iv) a negatively charged group that can form a salt-bridge with Arg231 of the human IDO; (v) a hydrophobic group that can form van der Waals interactions with pocket B; and (vi) one or more substituents that can hydrogen bond to Ser167 and to Gly262, and as IDO inhibitors and their therapeutic use, eg in the treatment of cancer.
摘要翻译：其中每种化合物适于占据人IDO的结合位点的式（I）化合物及其药学上可接受的盐，其包含大的疏水性口袋A和第二近端疏水口袋B，所述化合物包含至少一种的以下元素：（i）大的疏水性片段，以基本上填充人IDO的结合位点中的口袋A; （ii）可以配合人类IDO的血红素铁的原子，（iii）可以与人类IDO的7-丙酸血红素形成盐桥的带正电荷的基团; （iv）可以与人类IDO的Arg231形成盐桥的带负电荷的基团; （v）可与袋B形成范德华相互作用的疏水基团; 和（vi）可以与Ser167和Gly262氢键合的一个或多个取代基，以及作为IDO抑制剂及其治疗用途，例如用于治疗癌症。

4. 发明授权

US07166753B2 Process for production of hydrogen and carbonyl compounds by reacting sub- or super-critical water with alcohols 失效
标题翻译：通过使亚临界或超临界水与醇反应来生产氢和羰基化合物的方法
公开(公告)号：US07166753B2
公开(公告)日：2007-01-23
申请号：US10510972
申请日：2003-04-09
申请人： Koichi Nakahara , Kenzo Nagami , Okitsugu Kajimoto , Kazuya Kobiro
发明人： Koichi Nakahara , Kenzo Nagami , Okitsugu Kajimoto , Kazuya Kobiro
IPC分类号： C07C45/29
CPC分类号： B01J3/006 , B01J3/008 , C01B3/32 , C01B2203/0216 , C01B2203/0805 , C01B2203/1217 , C01B2203/1229 , C07C45/002 , Y02P20/544 , C07C49/786 , C07C49/403 , C07C49/08 , C07C47/06
摘要： A process for producing a carbonyl compound involves allowing water to undergo phase transition to a supercritical or subcritical state in the presence of an alcohol compound so as to produce/generate water-derived hydrogen and at the same time convert the alcohol compound into a corresponding carbonyl compound. Specifically, the process is carried out by introducing the alcohol in a reaction tube along with water and heating and/or pressurizing the mixture of the alcohol and the water to bring the water into a subcritical or supercritical state. In this manner, water-derived hydrogen is produced and the alcohol is converted to a corresponding carbonyl compound. The process is preferably carried out in an oxygen-free environment.
摘要翻译：制备羰基化合物的方法包括使水在醇化合物的存在下进行相转变为超临界或亚临界状态，以产生/产生水源氢，同时将醇化合物转化为相应的羰基复合。具体地，该方法通过将醇与水一起引入反应管中并加热和/或加压醇和水的混合物以使水进入亚临界或超临界状态来进行。以这种方式，产生水衍生的氢，并将醇转化为相应的羰基化合物。该方法优选在无氧环境中进行。

5. 发明申请

US20050154237A1 Process for production of hydrogen and carbonyl compounds by reacting sub-or super-critical water with alcohols 失效
标题翻译：通过使亚临界或超临界水与醇反应来生产氢和羰基化合物的方法
公开(公告)号：US20050154237A1
公开(公告)日：2005-07-14
申请号：US10510972
申请日：2003-04-09
申请人： Koichi Nakahara , Kenzo Nagami , Okitsugu Kajimoto , Kazuya Kobiro
发明人： Koichi Nakahara , Kenzo Nagami , Okitsugu Kajimoto , Kazuya Kobiro
IPC分类号： B01J3/00 , C01B3/32 , C07C45/00 , C07C45/29
CPC分类号： B01J3/006 , B01J3/008 , C01B3/32 , C01B2203/0216 , C01B2203/0805 , C01B2203/1217 , C01B2203/1229 , C07C45/002 , Y02P20/544 , C07C49/786 , C07C49/403 , C07C49/08 , C07C47/06
摘要： A process for producing a carbonyl compound involves allowing water to undergo phase transition to a supercritical or subcritical state in the presence of an alcohol compound so as to produce/generate water-derived hydrogen and at the same time convert the alcohol compound into a corresponding carbonyl compound. Specifically, the process is carried out by introducing the alcohol in a reaction tube along with water and heating and/or pressurizing the mixture of the alcohol and the water to bring the water into a subcritical or supercritical state. In this manner, water-derived hydrogen is produced and the alcohol is converted to a corresponding carbonyl compound. The process is preferably carried out in an oxygen-free environment.
摘要翻译：制备羰基化合物的方法包括使水在醇化合物的存在下进行相转变为超临界或亚临界状态，以产生/产生水源氢，同时将醇化合物转化为相应的羰基复合。具体地，该方法通过将醇与水一起引入反应管中并加热和/或加压醇和水的混合物以使水进入亚临界或超临界状态来进行。以这种方式，产生水衍生的氢，并将醇转化为相应的羰基化合物。该方法优选在无氧环境中进行。

6. 发明授权

US06548722B1 Process for the preparation of substituted aromatic compound employing friedel-crafts reaction using a reusable basic anionic clay catalyst 失效
标题翻译：使用可重复使用的碱性阴离子粘土催化剂使用Friedel-Crafts反应制备取代的芳族化合物的方法
公开(公告)号：US06548722B1
公开(公告)日：2003-04-15
申请号：US09685682
申请日：2000-10-10
申请人： Vasant Ramchandra Choudhary , Suman Kumar Jana
发明人： Vasant Ramchandra Choudhary , Suman Kumar Jana
IPC分类号： C07C30900
CPC分类号： C07C41/30 , C07C2/861 , C07C2/864 , C07C45/46 , C07C201/12 , C07C2521/10 , C07C2523/08 , C07C2527/236 , C07C2603/24 , C07C15/16 , C07C49/784 , C07C49/83 , C07C49/84 , C07C49/786 , C07C205/06 , C07C15/12 , C07C15/28 , C07C43/205
摘要： A process for Friedel-Crafts type liquid-phase alkylation or acylation of an aromatic compound using a hydrotalcite-type basic anionic clay catalyst represented by a formula: [(M2−)1−x(M3+)x(OH)2]x+[Ay−]x/yqH2O where M2+ is a divalent cation selected from Mg2+, Zn2+, Ni2+, Co2+, Mn2+, Cu2+ or a mixture thereof; M3+ is a trivalent cation selected from Ga3+, In3+ Al3+, Fe3+ Cr3+ or a mixture thereof; x is a mole fraction of trivalent cations in the range of about 0.05 to about 0.5; 0 is oxygen; H is hydrogen; Ay− is an anion; y minus is an anionic negative charge having a value of 1 minus or 2 minus; and q is a number of water molecules, as the water of hydration; and involving following steps: i. pretreating said catalyst by contacting it with a halogen containing compound in the presence or absence of a non-aqueous solvent and optionally washing the pretreated catalyst with non-aqueous solvent or liquid aromatic compound to be alkylated or acylated; and then ii. contacting a liquid reaction mixture comprising said aromatic compound and said alkylating or acylating agent in the presence or absence of a non-aqueous solvent with the catalyst obtained from step (i) in a stirred batch reactor fitted with a reflux condenser under vigorous stirring, in the presence or absence of an inert gas bubbling through the reaction mixture, at effective reaction conditions; iii. cooling the reaction mixture to a temperature about 30° C., removing said catalyst from the reaction mixture by filtration and then separating the reaction products from the reaction mixture, and optionally washing the used catalyst by non-aqueous solvent, and if desired, iv. reusing the used catalyst directly with or without drying for the subsequent reaction batch avoiding step (i), is disclosed.
摘要翻译：使用由下式表示的水滑石型碱性阴离子粘土催化剂，使用Friedel-Crafts型液相烷基化或芳族化合物酰化的方法：其中M2 +是选自Mg2 +，Zn2 +，Ni2 +，Co2 +，Mn2 +，Cu2 +或其混合物; M3 +是选自Ga3 +，In3 + Al3 +，Fe3 + Cr3 +或其混合物的三价阳离子; x是三价阳离子在约0.05至约0.5范围内的摩尔分数; 0是氧; H是氢; Ay-是阴离子; y minus是具有值1或2减去的阴离子负电荷; 和q是水分子的数量，作为水合水; 并涉及以下步骤：i。在存在或不存在非水溶剂的情况下，通过使其与含卤素的化合物接触来预处理所述催化剂，并任选地用待进行烷基化或酰化的非水溶剂或液体芳族化合物洗涤预处理的催化剂; 然后。在非水溶剂存在或不存在下，将含有所述芳族化合物和所述烷基化或酰化剂的液体反应混合物与步骤（i）获得的催化剂在剧烈搅拌下在装有回流冷凝器的搅拌间歇式反应器中接触，在有效的反应条件下存在或不存在通过反应混合物鼓泡的惰性气体; iii。将反应混合物冷却至约30℃的温度，通过过滤从反应混合物中除去所述催化剂，然后将反应产物与反应混合物分离，并任选地通过非水溶剂洗涤所用催化剂，如果需要，将iv 。公开了直接使用或不用干燥后续反应批次的用过的催化剂，以避免步骤（i）。

7. 发明申请

US20020137974A1 Catalysis using phosphine oxide and sulfoxide compounds 有权
标题翻译：使用氧化膦和亚砜化合物进行催化
公开(公告)号：US20020137974A1
公开(公告)日：2002-09-26
申请号：US09900353
申请日：2001-07-06
发明人： George Y. Li
IPC分类号： C07C211/45 , C07C041/18 , C07C015/14
CPC分类号： C07F9/5325 , B01J31/1875 , B01J2231/4233 , B01J2531/80 , B01J2531/824 , B01J2531/847 , C07B37/04 , C07C1/321 , C07C1/326 , C07C41/30 , C07C45/68 , C07C67/343 , C07C209/10 , C07C319/14 , C07C319/20 , C07C2531/22 , C07D211/12 , C07D295/023 , C07D295/073 , C07D295/096 , C07F9/46 , C07F9/5077 , C07C15/00 , C07C49/786 , C07C69/618 , C07C69/738 , C07C211/55 , C07C321/28 , C07C43/205
摘要： Phosphine oxide and sulfoxide compounds were used with transition metals, preferably palladium and nickel, to produce biaryls, arylthiols, arylphosphine oxides and arylamines via cross-coupling reactions with aryl halides and arylboronic acids, aryl Grignard reagents, thiols, phosphine oxides or amines.
摘要翻译：氧化膦和亚砜化合物与过渡金属，优选钯和镍一起使用，通过与芳基卤化物和芳基硼酸，芳基格氏试剂，硫醇，氧化膦或胺的交叉偶联反应制备联芳基，芳基硫醇，芳基氧化膦和芳基胺。

9. 发明授权

US09624248B2 Ionic liquid compound 有权
公开(公告)号：US09624248B2
公开(公告)日：2017-04-18
申请号：US14784742
申请日：2014-04-21
申请人： RELIANCE INDUSTRIES LIMITED
发明人： Pavankumar Aduri , Parasu Veera Uppara , Viswanath Kotra , Mangesh Sakhalkar , Vibhuti Dukhande
IPC分类号： C07F5/06 , C07F9/90 , B01J37/04 , C07C37/16 , C07C2/26 , C07C45/45 , C01F7/00 , C07C2/66 , C07C2/86 , C07C67/293 , C07C211/63 , C07C45/46 , B01J31/02 , C07C2/68
CPC分类号： C07F5/069 , B01J31/0237 , B01J31/0287 , B01J31/0291 , B01J31/0298 , B01J37/04 , B01J2231/20 , B01J2231/326 , B01J2231/4205 , C01F7/00 , C07C2/26 , C07C2/66 , C07C2/68 , C07C2/861 , C07C37/16 , C07C45/45 , C07C45/46 , C07C67/293 , C07C211/63 , C07C2101/16 , C07C2527/125 , C07C2531/02 , C07C2601/16 , C07F9/90 , C07C15/107 , C07C15/16 , C07C39/06 , C07C69/145 , C07C49/78 , C07C49/786
摘要： The present disclosure provides an ionic liquid compound of Formula (I) and its application in reactions such as alkylation, arylation, acylation, diels alder and oligomerization, The present disclosure also provides a process for preparing the ionic liquid compound of Formula (I) which involves preparing an ionic salt complex represented by Formula [(NR1R2R3)iM1]n+[Xj]n− by mixing an amine represented by Formula NR1R2R3 and a metal salt represented by formula M1Xj; and mixing the ionic salt complex and a metal salt represented by formula M2Yk to obtain the ionic liquid compound.

10. 发明申请

US20160102038A1 PREPARATION METHOD OF CARBOXYLIC ACIDS OR KETONES USING OZONE, SINGLET STATE-OXYGEN ATOM OR HYDROXYL FREE RADICAL 有权
标题翻译：使用臭氧，单体状态氧原子或羟基自由基的羧酸或者酮的制备方法
公开(公告)号：US20160102038A1
公开(公告)日：2016-04-14
申请号：US14818139
申请日：2015-08-04
申请人： NATIONAL TSING HUA UNIVERSITY
发明人： Kuo-Chu HWANG
IPC分类号： C07C51/34 , B01J19/12 , C07C45/40
CPC分类号： C07C51/34 , B01J19/123 , C07C45/40 , C07C49/385 , C07C49/395 , C07C49/403 , C07C49/413 , C07C49/78 , C07C49/786 , C07C55/02 , C07C55/12 , C07C55/14 , C07C55/16 , C07C63/06 , C07C63/16 , C07C63/24 , C07C63/26
摘要： A preparation method of carboxylic acids or ketones using ozone, singlet state oxygen atom O(1D) or hydroxyl free radical is provided. The method includes: filling ozone, singlet state oxygen atom O(1D) and/or hydroxyl free radical to cycloalkanes or benzenes at a pre-determined temperature and a pre-determined pressure in the presence or absence of light irradiation to produce carboxylic acids or ketones. The reaction occurs at room temperature and atmospheric pressure without producing harmful side products. The preparation method is a simple, low energy consuming, and eco-friendly method.
摘要翻译：提供了使用臭氧，单态氧原子O（1D）或羟基自由基的羧酸或酮的制备方法。该方法包括：在存在或不存在光照射的情况下，以预定温度和预定压力将臭氧，单态氧原子O（1D）和/或羟基自由基填充到环烷烃或苯以产生羧酸或酮类反应发生在室温和大气压下，不会产生有害副产物。制备方法简单，耗能低，环保。

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