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1. 发明授权

US07638509B2 Diene compounds and formulations 失效
标题翻译：二烯化合物和配方
公开(公告)号：US07638509B2
公开(公告)日：2009-12-29
申请号：US12405970
申请日：2009-03-17
申请人： Henry A. Lardy , Padma Marwah , Ashok Marwah
发明人： Henry A. Lardy , Padma Marwah , Ashok Marwah
IPC分类号： A61K31/58 , A61K31/567 , C07J1/00
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

2. 发明授权

US07514420B2 Steroids having 1,8-unsaturation and formulations comprising same 失效
标题翻译：具有1,8-不饱和度的类固醇和包含其的制剂
公开(公告)号：US07514420B2
公开(公告)日：2009-04-07
申请号：US11838154
申请日：2007-08-13
申请人： Henry A. Lardy , Padma Marwah , Ashok Marwah
发明人： Henry A. Lardy , Padma Marwah , Ashok Marwah
IPC分类号： A61K31/56 , A61K31/58 , C07J5/00 , C07J7/00 , C07J21/00 , C07J71/00
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

3. 发明授权

US07842680B2 Diene and triene compounds and formulations 失效
标题翻译：二烯和三烯化合物和配方
公开(公告)号：US07842680B2
公开(公告)日：2010-11-30
申请号：US12406033
申请日：2009-03-17
申请人： Henry A. Lardy , Padma Marwah , Ashok Marwah
发明人： Henry A. Lardy , Padma Marwah , Ashok Marwah
IPC分类号： A61K31/56 , A61K31/58 , C07J5/00 , C07J7/00 , C07J21/00
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3'-乙酰氧基雄甾-1,5-二烯-17-亚乙基缩酮和3'-羟基雄-1,5-二烯-17-亚乙基缩酮，以及它们用于预防的方法和治疗由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

4. 发明申请

US20090181936A1 Diene and Triene Compounds and Formulations 失效
标题翻译：二烯和三烯化合物和配方
公开(公告)号：US20090181936A1
公开(公告)日：2009-07-16
申请号：US12406033
申请日：2009-03-17
申请人： Henry A. Lardy , Ashok Marwah , Padma Marwah
发明人： Henry A. Lardy , Ashok Marwah , Padma Marwah
IPC分类号： A61K31/58 , C07J21/00 , A61K31/56
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

5. 发明授权

US07550450B2 Prostate cancer treatment 失效
标题翻译：前列腺癌治疗
公开(公告)号：US07550450B2
公开(公告)日：2009-06-23
申请号：US11862153
申请日：2007-09-26
申请人： Henry A. Lardy , Ashok Marwah , Padma Marwah
发明人： Henry A. Lardy , Ashok Marwah , Padma Marwah
IPC分类号： A61K31/58
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

6. 发明授权

US07462610B2 Prostate cancer treatment 失效
标题翻译：前列腺癌治疗
公开(公告)号：US07462610B2
公开(公告)日：2008-12-09
申请号：US11837508
申请日：2007-08-11
申请人： Henry A. Lardy , Padma Marwah , Ashok Marwah
发明人： Henry A. Lardy , Padma Marwah , Ashok Marwah
IPC分类号： A61K31/58
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

7. 发明申请

US20110028711A1 Unsaturated Steroid Compounds 审中-公开
标题翻译：不饱和类固醇化合物
公开(公告)号：US20110028711A1
公开(公告)日：2011-02-03
申请号：US12905778
申请日：2010-10-15
申请人： Henry A. Lardy , Ashok Marwah , Padma Marwah
发明人： Henry A. Lardy , Ashok Marwah , Padma Marwah
IPC分类号： C07J1/00 , C07J21/00
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3'-乙酰氧基雄甾-1,5-二烯-17-亚乙基缩酮和3'-羟基雄-1,5-二烯-17-亚乙基缩酮，以及它们用于预防的方法和治疗由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

8. 发明申请

US20090176752A1 Diene Compounds and Formulations 失效
标题翻译：二烯化合物和制剂
公开(公告)号：US20090176752A1
公开(公告)日：2009-07-09
申请号：US12405970
申请日：2009-03-17
申请人： Henry A. Lardy , Ashok Marwah , Padma Marwah
发明人： Henry A. Lardy , Ashok Marwah , Padma Marwah
IPC分类号： A61K31/58 , C07J21/00 , C07J1/00 , A61K31/566 , A61P35/00
CPC分类号： C07J1/00 , C07J1/0011 , C07J21/00 , C07J21/008
摘要： The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by androgen receptors. Thus, for example, compounds of the invention are useful in the prevention and treatment of prostrate cancer. Furthermore, it has been discovered that compounds of the invention are useful in the prevention and treatment of androgen-independent cancers such as androgen-independent prostrate cancer. Finally, inventive compounds may be used to treat antiandrogen induced withdrawal syndrome.
摘要翻译：本发明提供了有效的抗雄激素化合物，例如3β-乙酰氧基己二氢-1,5-二烯-17-亚乙基缩酮和3,3-羟基雄甾-1,5-二烯-17-亚乙基缩酮，以及用于预防和治疗的方法由雄激素受体介导的生物学条件。因此，例如，本发明的化合物可用于预防和治疗前列腺癌。此外，已经发现本发明的化合物可用于预防和治疗雄激素依赖性癌症如雄激素依赖性前列腺癌。最后，本发明化合物可用于治疗抗雄激素诱导的戒断综合征。

9. 发明申请

US20100240633A1 Cancer treatment methods 失效
标题翻译：癌症治疗方法
公开(公告)号：US20100240633A1
公开(公告)日：2010-09-23
申请号：US12792942
申请日：2010-06-03
申请人： Henry A. Lardy , Padma Marwah , James M. Frincke
发明人： Henry A. Lardy , Padma Marwah , James M. Frincke
IPC分类号： A61K31/57 , A61P35/00
CPC分类号： A61K31/568 , A61K31/565 , A61K31/567 , A61K31/5685 , A61K45/06 , C07J1/00 , C07J1/0011 , C07J1/0022 , C07J1/0025 , C07J1/0048 , C07J31/00 , C07J41/00
摘要： The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for agents that modulate the biological activity of the androgen receptor. The invention also provides methods and compositions suitable for therapeutic applications.
摘要翻译：本发明提供了治疗诸如前列腺癌或改善与前列腺癌相关的一种或多种症状的病症或调节雄激素受体生物学活性的药物的方法。本发明还提供适用于治疗应用的方法和组合物。

10. 发明申请

US20080176823A1 Breast and Prostate Cancer Treatment Method 失效
标题翻译：乳腺癌和前列腺癌治疗方法
公开(公告)号：US20080176823A1
公开(公告)日：2008-07-24
申请号：US11835397
申请日：2007-08-07
申请人： Henry A. Lardy , Padma Marwah , James M. Frincke
发明人： Henry A. Lardy , Padma Marwah , James M. Frincke
IPC分类号： A61K31/56
CPC分类号： A61K31/568 , A61K31/565 , A61K31/567 , A61K31/5685 , A61K45/06 , C07J1/00 , C07J1/0011 , C07J1/0022 , C07J1/0025 , C07J1/0048 , C07J31/00 , C07J41/00
摘要： The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for agents that modulate the biological activity of the androgen receptor. The invention also provides methods and compositions suitable for therapeutic applications.
摘要翻译：本发明提供了治疗诸如前列腺癌或改善与前列腺癌相关的一种或多种症状的病症或调节雄激素受体生物学活性的药物的方法。本发明还提供适用于治疗应用的方法和组合物。

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