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1. 发明申请

US20050069925A1 Microprocessors, devices, and methods for use in monitoring of physiological analytes 审中-公开
标题翻译：用于监测生理分析物的微处理器，装置和方法
公开(公告)号：US20050069925A1
公开(公告)日：2005-03-31
申请号：US10903672
申请日：2004-07-30
申请人： Russell Ford , Matthew Lesho , Janet Tamada , Michael Tierney
发明人： Russell Ford , Matthew Lesho , Janet Tamada , Michael Tierney
IPC分类号： A61B5/00 , G06F19/00 , C12Q1/68 , G01N33/48 , G01N33/50
CPC分类号： A61B5/4283 , A61B5/14532 , A61B5/4266 , A61B5/4881 , A61B5/7267 , A61B2560/0252 , G16H40/63
摘要： Described herein are microprocessors, devices, and methods useful for sweat and/or temperature detection that correlate more closely with changes in amperometric or charge signals related to analyte amount or concentration. The present invention provides methods for the establishment of more accurate sweat and/or temperature thresholds and new methods of compensation, such as correcting for the effects of sweat and rapidly changing temperature on measured analyte values. The present invention reduces the number of skipped or unuseable readings provided by analyte monitoring devices during periods of sweating or changing temperatures. Further, the present invention provides methods for improving the accuracy of reported readings of analyte amount or concentration. In one aspect, the present invention provides passive collection reservoir/sensing devices used in combination with active collection reservoir/sensing devices for detection of sweat and/or temperature related parameters.
摘要翻译：本文描述的是用于汗液和/或温度检测的微处理器，装置和方法，其更接近于与分析物量或浓度相关的电流或电荷信号的变化。本发明提供了用于建立更准确的汗液和/或温度阈值和新的补偿方法的方法，例如校正汗液和快速变化的温度对测量的分析物值的影响。本发明在出汗或变化的温度期间减少由分析物监测装置提供的跳过或不可用读数。此外，本发明提供了提高分析物量或浓度的报告读数精度的方法。在一个方面，本发明提供与用于检测汗和/或温度相关参数的主动收集储存器/感测装置组合使用的被动收集储存器/感测装置。

2. 发明申请

US20060127964A1 Microprocessors, devices, and methods for use in monitoring of physiological analytes 审中-公开
标题翻译：用于监测生理分析物的微处理器，装置和方法
公开(公告)号：US20060127964A1
公开(公告)日：2006-06-15
申请号：US11350193
申请日：2006-02-08
申请人： Russell Ford , Matthew Lesho , Janet Tamada , Michael Tierney
发明人： Russell Ford , Matthew Lesho , Janet Tamada , Michael Tierney
IPC分类号： C12Q1/54 , G06F19/00
CPC分类号： A61B5/14532 , A61B5/4266 , A61B5/4283 , A61B5/4881 , A61B5/7267 , G16H40/63
摘要： Described herein are microprocessors, devices, and methods useful for sweat and/or temperature detection that correlate more closely with changes in amperometric or charge signals related to analyte amount or concentration. The present invention provides methods for the establishment of more accurate sweat and/or temperature thresholds and new methods of compensation, such as correcting for the effects of sweat and rapidly changing temperature on measured analyte values. The present invention reduces the number of skipped or unuseable readings provided by analyte monitoring devices during periods of sweating or changing temperatures. Further, the present invention provides methods for improving the accuracy of reported readings of analyte amount or concentration. In one aspect, the present invention provides passive collection reservoir/sensing devices used in combination with active collection reservoir/sensing devices for detection of sweat and/or temperature related parameters.
摘要翻译：本文描述的是用于汗液和/或温度检测的微处理器，装置和方法，其更接近于与分析物量或浓度相关的电流或电荷信号的变化。本发明提供了用于建立更准确的汗液和/或温度阈值和新的补偿方法的方法，例如校正汗液和快速变化的温度对测量的分析物值的影响。本发明在出汗或变化的温度期间减少由分析物监测装置提供的跳过或不可用读数。此外，本发明提供了提高分析物量或浓度的报告读数精度的方法。在一个方面，本发明提供与用于检测汗和/或温度相关参数的主动收集储存器/感测装置组合使用的被动收集储存器/感测装置。

3. 发明申请

US20070038053A1 Signal processing for measurement of physiological analytes 审中-公开
标题翻译：用于测量生理分析物的信号处理
公开(公告)号：US20070038053A1
公开(公告)日：2007-02-15
申请号：US11583407
申请日：2006-10-19
申请人： Bret Berner , Timothy Dunn , Kathleen Farinas , Michael Garrison , Ronald Kurnik , Matthew Lesho , Russell Potts , Janet Tamada , Michael Tierney
发明人： Bret Berner , Timothy Dunn , Kathleen Farinas , Michael Garrison , Ronald Kurnik , Matthew Lesho , Russell Potts , Janet Tamada , Michael Tierney
IPC分类号： A61B5/05
CPC分类号： A61B5/1477 , A61B5/14532 , A61B5/14542 , A61B5/1486
摘要： A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentration of the target chemical analyte in the biological system. One important application of the invention involves a method for signal processing in a system for monitoring blood glucose values.
摘要翻译：提供了用于连续或连续地测量存在于生物系统中的目标化学分析物的浓度的方法，并且处理分析物特异性信号以获得与生物系统中的目标化学分析物的浓度密切相关的测量值。本发明的一个重要应用涉及用于监测血糖值的系统中的信号处理方法。

4. 发明申请

US20060074564A1 Micropressors, devices and methods for use in analyte monitoring systems 有权
标题翻译：用于分析物监测系统的微压机，装置和方法
公开(公告)号：US20060074564A1
公开(公告)日：2006-04-06
申请号：US11270856
申请日：2005-11-09
申请人： Miroslaw Bartkowiak , Wesley Harper , Eray Kulcu , Matthew Lesho , Janet Tamada
发明人： Miroslaw Bartkowiak , Wesley Harper , Eray Kulcu , Matthew Lesho , Janet Tamada
IPC分类号： G06F19/00
CPC分类号： A61B5/681 , A61B5/0531 , A61B5/14532 , A61B5/7242 , G01N27/3271 , Y10T436/144444
摘要： The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors. Further, the present invention relates to algorithms for improved optimization of parameters for use in prediction models that require optimization of adjustable parameters.
摘要翻译：本发明包括一个或多个微处理器，其被编程为执行用于改进分析物监测装置的性能的方法，包括通过利用预测的较慢时间常数（1 / k 2）来预测受试者中的葡萄糖水平，。在本发明的另一方面，可以使用前指数项（1 / c2）来提供信号衰减的校正（例如，增益因子）。在其他方面，本发明涉及一种或多种微处理器，其包括编程以控制（i）用于条件筛选数据点以减少跳过的测量的方法的执行，（ii）用于限定插值/外推分析物测量值的方法，（iii）获得分析物相关信号的最大积分的各种集成方法，以及包括这种微处理器的分析物监测装置。此外，本发明涉及用于改进需要优化可调参数的预测模型中使用的参数优化的算法。

5. 发明申请

US20050049473A1 Methods for estimating analyte-related signals, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods 有权
标题翻译：用于估计分析物相关信号的方法，包括用于控制方法性能的编程的微处理器以及采用该方法的分析物监测装置
公开(公告)号：US20050049473A1
公开(公告)日：2005-03-03
申请号：US10963853
申请日：2004-10-13
申请人： Shashi Desai , Timothy Dunn , Matthew Lesho , Russell Potts , Janet Tamada , Charles Wei
发明人： Shashi Desai , Timothy Dunn , Matthew Lesho , Russell Potts , Janet Tamada , Charles Wei
IPC分类号： A61B5/00 , A61N1/30 , A61B5/05
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/1477 , A61N1/30
摘要： The present invention relates to methods to increase the number of analyte-related signals used to provide analyte measurement values, e.g., when two or more analyte-related signals are used to obtain a single analyte measurement value a “rolling” value based on the two or more signals can be employed. In another aspect, interpolation and/or extrapolation methods are used to estimate unusable, missing or error-associated analyte-related signals. Further, interpolation and extrapolation of values are employed in another aspect of the invention that reduces the incident of failed calibrations. Further, the invention relates to methods, which employ gradients and/or predictive algorithms, to provide an alert related to analyte values exceeding predetermined thresholds. The invention includes the above-described methods, one or more microprocessors programmed to execute the methods, one or more microprocessors programmed to execute the methods and control at least one sensing and/or sampling device, and monitoring systems employing the methods described herein.
摘要翻译：本发明涉及增加用于提供分析物测量值的分析物相关信号的数量的方法，例如当使用两个或更多个与分析物相关的信号来获得单个分析物测量值时，基于两个分析物相关信号的“滚动”值或更多的信号。在另一方面，内插和/或外插方法用于估计不可用，缺失或与误差相关的分析物相关信号。此外，在本发明的另一方面，采用了内插和外推值来减少校准失败的事件。此外，本发明涉及采用梯度和/或预测算法来提供与超过预定阈值的分析物值相关的警报的方法。本发明包括上述方法，被编程为执行方法的一个或多个微处理器，被编程为执行方法和控制至少一个感测和/或采样装置的一个或多个微处理器，以及采用本文描述的方法的监视系统。

6. 发明申请

US20060085137A1 Micropressors, devices and methods for use in analyte monitoring systems 有权
公开(公告)号：US20060085137A1
公开(公告)日：2006-04-20
申请号：US11270857
申请日：2005-11-09
申请人： Miroslaw Bartkowiak , Wesley Harper , Eray Kulcu , Matthew Lesho , Janet Tamada
发明人： Miroslaw Bartkowiak , Wesley Harper , Eray Kulcu , Matthew Lesho , Janet Tamada
IPC分类号： G06F19/00
CPC分类号： A61B5/681 , A61B5/0531 , A61B5/14532 , A61B5/7242 , G01N27/3271 , Y10T436/144444
摘要： The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors. Further, the present invention relates to algorithms for improved optimization of parameters for use in prediction models that require optimization of adjustable parameters.

7. 发明申请

US20060063218A1 Micropressors, devices and methods for use in analyte monitoring systems 有权
公开(公告)号：US20060063218A1
公开(公告)日：2006-03-23
申请号：US11270063
申请日：2005-11-09
申请人： Miroslaw Bartkowiak , Wesley Harper , Eray Kulcu , Matthew Lesho , Janet Tamada
发明人： Miroslaw Bartkowiak , Wesley Harper , Eray Kulcu , Matthew Lesho , Janet Tamada
IPC分类号： G06F19/00 , C12Q1/54
CPC分类号： A61B5/681 , A61B5/0531 , A61B5/14532 , A61B5/7242 , G01N27/3271 , Y10T436/144444
摘要： The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors. Further, the present invention relates to algorithms for improved optimization of parameters for use in prediction models that require optimization of adjustable parameters.

8. 发明授权

US06529755B2 Chemical signal-impermeable mask 有权
公开(公告)号：US06529755B2
公开(公告)日：2003-03-04
申请号：US10006769
申请日：2001-12-06
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
IPC分类号： A61B500
CPC分类号： A61B5/1486 , A61N1/30 , C12Q1/001 , C12Q1/002 , C12Q1/006
摘要： A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g., concentration) of chemical signal that is transported from a given area of source material.

9. 发明申请

US20070142721A1 Monitoring of physiological analytes 有权
标题翻译：生理分析物的监测
公开(公告)号：US20070142721A1
公开(公告)日：2007-06-21
申请号：US11699850
申请日：2007-01-30
申请人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
发明人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
IPC分类号： A61B5/05
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/150022 , A61B5/150091 , A61B5/157 , A61N1/30 , C12Q1/006
摘要： Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.
摘要翻译：提供了用于测量生物系统中存在的目标化学分析物浓度的方法和装置。采用器件配置和/或测量技术来降低干扰物质对传感器灵敏度的影响。本发明的一个重要应用涉及用于监测血糖值的方法和装置。

10. 发明申请

US20050027179A1 Biosensor and methods of use thereof 有权
标题翻译：生物传感器及其使用方法
公开(公告)号：US20050027179A1
公开(公告)日：2005-02-03
申请号：US10936095
申请日：2004-09-08
申请人： Bret Berner , Lynn Kim , Norman Parris , Russell Potts , Janet Tamada , Michael Tierney
发明人： Bret Berner , Lynn Kim , Norman Parris , Russell Potts , Janet Tamada , Michael Tierney
IPC分类号： A61B5/00 , A61B5/0408 , A61B5/145 , A61B5/1477 , A61N1/30 , G01N27/28 , G01N27/30 , G01N27/416 , G01N33/487 , G01N33/66 , A61B5/05
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/1486 , A61B5/1495 , A61N1/30
摘要： An automated system for continual transdermal extraction of analytes present in a biological system is provided. The system can be used for detecting and/or measuring the concentration of the analyte using an electrochemical biosensor detection means. The system optionally uses reverse iontophoresis to carry out the continual transdermal extraction of the analytes.
摘要翻译：提供了一种用于连续透皮提取生物系统中存在的分析物的自动化系统。该系统可用于使用电化学生物传感器检测装置来检测和/或测量分析物的浓度。该系统可选择使用反向离子电渗法进行分析物的连续经皮提取。

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