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1. 发明申请

US20130041236A1 SAMPLE ANALYSIS SYSTEM AND METHOD OF USE 审中-公开
标题翻译：样本分析系统及其使用方法
公开(公告)号：US20130041236A1
公开(公告)日：2013-02-14
申请号：US13643633
申请日：2011-04-22
申请人： Michael J. Pugia , Gregory Paul Panebianco , Henry Lu
发明人： Michael J. Pugia , Gregory Paul Panebianco , Henry Lu
IPC分类号： A61B5/20 , G01N33/53 , G01N33/48 , B23P17/04
CPC分类号： A61B10/007 , A61B10/0045 , B01L3/5027 , B01L3/502707 , B01L3/508 , B01L2200/025 , B01L2200/027 , B01L2200/0621 , B01L2300/0654 , B01L2300/0816 , B01L2300/0832 , B01L2300/0851 , B01L2400/0406 , B01L2400/0457 , Y10T29/49826
摘要： A sample collection device having a sample container and microfluidic device having one or more microfluidic circuits, the system for analyzing biological samples. The microfluidic device has a sample inlet port, a microconduit in communication with the inlet port and with reaction chamber. The reaction chamber is connected to an air vent via another microconduit. Air may be vented from the microfluidic circuit via the air vent of the microfluidic circuit via an air vent in the sample container.
摘要翻译：具有样品容器和具有一个或多个微流体电路的微流体装置的样品收集装置，用于分析生物样品的系统。微流体装置具有样品入口，与入口连通的微型管道和反应室。反应室通过另一个微型管道连接到通风口。空气可以经由微流体回路的通气孔从微流体回路经由样品容器中的排气口排出。

2. 发明授权

US08304254B2 Piezo dispensing of a diagnostic liquid onto a reagent surface 失效
标题翻译：诊断液体在试剂表面上的压电分配
公开(公告)号：US08304254B2
公开(公告)日：2012-11-06
申请号：US12598150
申请日：2008-03-14
申请人： Michael J. Pugia , James A. Profitt
发明人： Michael J. Pugia , James A. Profitt
IPC分类号： G01N1/38
CPC分类号： G01N35/1016 , G01N2035/1034 , Y10T436/144444 , Y10T436/25 , Y10T436/2575
摘要： Assays in which samples of biological fluids are dispensed onto reagent-containing porous substrates are improved in the accuracy and repeatability by dispensing the biological fluids in two or more fractions thereof, separated by intervals in which the biological fluid is not dispensed. Reagents and other fluids may be dispensed during the intervals when the biological fluid is not dispensed. Alternatively, reagents and other fluids may be dispensed in a similar manner onto substrates already containing biological fluids.
摘要翻译：生物流体样品分配到含有试剂的多孔基材上的测定通过将生物流体分配在两个或更多个部分中，通过分配生物流体不分配的间隔而提高了精度和重复性。在不分配生物流体的间隔期间，可以分配试剂和其它流体。或者，可以以类似的方式将试剂和其它流体分配到已经含有生物流体的基底上。

3. 发明授权

US07858758B2 Monoclonal antibodies for detection of urinary trypsin inhibitors 有权
标题翻译：用于检测尿胰蛋白酶抑制剂的单克隆抗体
公开(公告)号：US07858758B2
公开(公告)日：2010-12-28
申请号：US12144909
申请日：2008-06-24
申请人： Michael J. Pugia , Linda Anderson-Mauser , Solomon H. Murphy , Ronald G. Sommer , Shannon Gleason
发明人： Michael J. Pugia , Linda Anderson-Mauser , Solomon H. Murphy , Ronald G. Sommer , Shannon Gleason
IPC分类号： C07K16/00
CPC分类号： G01N33/573 , C07K16/18 , G01N2333/8107 , G01N2333/811 , G01N2333/976
摘要： Certain monoclonal antibodies are able to detect urinary trypsin inhibitors (UTIs) that are characteristic of disease in humans. In particular, the UTIs include AMBK, Bikunin, Uristatin, Uristatin-1, Uristatin-2, as defined herein, also including the fragments and aggregates thereof.
摘要翻译：某些单克隆抗体能检测出在人类中具有疾病特征的尿胰蛋白酶抑制剂（UTIs）。特别地，UTI包括本文定义的AMBK，Bikunin，Uristatin，Uristatin-1，Uristatin-2，还包括其片段和聚集体。

4. 发明申请

US20100255592A1 PIEZO DISPENSING OF A DIAGNOSTIC LIQUID ONTO A REAGENT SURFACE 失效
标题翻译：将诊断液体的PIEZO分配到试剂表面
公开(公告)号：US20100255592A1
公开(公告)日：2010-10-07
申请号：US12598150
申请日：2008-03-14
申请人： Michael J. Pugia , James A. Profitt
发明人： Michael J. Pugia , James A. Profitt
IPC分类号： G01N33/72 , G01N33/68 , G01N33/66
CPC分类号： G01N35/1016 , G01N2035/1034 , Y10T436/144444 , Y10T436/25 , Y10T436/2575
摘要： Assays in which samples of biological fluids are dispensed onto reagent-containing porous substrates are improved in the accuracy and repeatability by dispensing the biological fluids in two or more fractions thereof, separated by intervals in which the biological fluid is not dispensed. Reagents and other fluids may be dispensed during the intervals when the biological fluid is not dispensed. Alternatively, reagents and other fluids may be dispensed in a similar manner onto substrates already containing biological fluids.
摘要翻译：生物流体样品分配到含有试剂的多孔基材上的测定通过将生物流体分配在两个或更多个部分中，通过分配生物流体不分配的间隔而提高了精度和重复性。在不分配生物流体的间隔期间，可以分配试剂和其它流体。或者，可以以类似的方式将试剂和其它流体分配到已经含有生物流体的基底上。

5. 发明申请

US20100172801A1 METHOD FOR UNIFORM APPLICATION OF FLUID INTO A REACTIVE REAGENT AREA 审中-公开
标题翻译：将流体均匀地应用于反应性试剂区域的方法
公开(公告)号：US20100172801A1
公开(公告)日：2010-07-08
申请号：US12688346
申请日：2010-01-15
申请人： Michael J. Pugia , James A. Profitt , Hai-Hang Kuo , Gert Blankenstein , Ralf-Peter Peters , Lloyd S. Schulman
发明人： Michael J. Pugia , James A. Profitt , Hai-Hang Kuo , Gert Blankenstein , Ralf-Peter Peters , Lloyd S. Schulman
IPC分类号： G01N30/00 , G01N33/487
CPC分类号： B01L3/502746 , B01L3/502723 , B01L2200/0684 , B01L2200/16 , B01L2300/0816 , B01L2400/0406 , B01L2400/0409 , B01L2400/0418 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , Y10T436/2575
摘要： Analytical results obtained with microfluidic devices are improved by providing structural features in areas containing dry supported reagents, the structural features directing the flow of a sample over the area in a predetermined uniform manner and facilitating the purging of air.
摘要翻译：通过在含有干支持试剂的区域中提供结构特征来改进用微流体装置获得的分析结果，其结构特征以预定均匀的方式引导样品流过该区域并促进空气吹扫。

6. 发明申请

US20090143275A1 ADIPONECTIN RECEPTOR FRAGMENTS AND METHODS OF USE 有权
标题翻译： ADIPONECTIN受体片段和使用方法
公开(公告)号：US20090143275A1
公开(公告)日：2009-06-04
申请号：US12169983
申请日：2008-07-09
申请人： Michael J. Pugia , Rui Ma
发明人： Michael J. Pugia , Rui Ma
IPC分类号： A61K38/02 , A61P3/10 , A61P35/00
CPC分类号： C07K14/72 , A61K38/00
摘要： Methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using C-terminal fragments of adiponectin receptor R1. Methods of causing the secretion of insulin in healthy and diabetic patients using C-terminal fragments of adiponectin receptor R1 are also disclosed. In addition, methods are disclosed of increasing the insulin levels in healthy patients using C-terminal fragments of adiponectin receptor R1. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed.
摘要翻译：公开了使用脂联素受体R1的C末端片段治疗糖尿病，异常脂肪细胞活性和胰岛素抵抗的方法。还公开了使用脂联素受体R1的C末端片段在健康和糖尿病患者中分泌胰岛素的方法。此外，公开了使用脂联素受体R1的C末端片段增加健康患者的胰岛素水平的方法。另外，处理异常脂肪细胞活性，治疗代谢综合征，引起胰岛素分泌，增加胰岛素水平，抑制胰岛素降解酶，治疗阿尔茨海默氏病，治疗与脂联素水平相关的心血管疾病，抑制ADAM-17酶，治疗与公开了TNF-α和治疗与HER2-neu相关的病症。还公开了组合物，剂型和试剂盒。

7. 发明授权

US6074881A Method for the prevention of hemoglobin interference in reagent systems for measuring peroxidase activity 失效
标题翻译：用于预防用于测定过氧化物酶活性的试剂体系血红蛋白干扰的方法
公开(公告)号：US6074881A
公开(公告)日：2000-06-13
申请号：US128009
申请日：1998-08-03
申请人： Todd K. Cast , Michael J. Pugia
发明人： Todd K. Cast , Michael J. Pugia
IPC分类号： C12Q1/28 , G01N33/70 , G01N33/72 , G01N33/48 , G01N33/493
CPC分类号： C12Q1/28 , G01N33/70 , G01N33/72 , Y10T436/14 , Y10T436/147777 , Y10T436/206664 , Y10T436/25125
摘要： The present invention involves an improvement to an assay for the activity of a metal chelate, such as copper II/creatinine, which activity is related to the concentration of the analyte in a fluid test sample. In carrying out the assay, there is combined the fluid test sample, the metal chelate or precursors thereof, a hydroperoxide, an oxidizable indicator and a pyrazole derivative which inhibits the ability of hemoglobin to oxidize the oxidizable dye.
摘要翻译：本发明涉及对金属螯合物如铜II /肌酸酐的活性的测定的改进，该活性与流体测试样品中分析物的浓度有关。在进行测定时，将流体测试样品，金属螯合物或其前体，氢过氧化物，可氧化指示剂和吡唑衍生物组合，其抑制血红蛋白氧化可氧化染料的能力。

8. 发明授权

US5362633A Method of assaying for peroxidatively active substances 失效
标题翻译：测定过氧化物质活性物质的方法
公开(公告)号：US5362633A
公开(公告)日：1994-11-08
申请号：US187384
申请日：1994-01-27
申请人： Michael J. Pugia
发明人： Michael J. Pugia
IPC分类号： G01N31/00 , C12Q1/28 , G01N31/22 , G01N33/50 , G01N33/52 , G01N33/72 , C12Q1/26 , C12Q1/56
CPC分类号： G01N33/521 , C12Q1/28 , G01N33/725 , C12Q2326/12 , Y10S436/904
摘要： A method of determining the presence or concentration of a peroxidatively active substance, such as hemoglobin, in a test sample is disclosed. The method comprises contacting the test sample with an indicator reagent composition which interacts with the peroxidatively active substance to produce a measurable or detecable color change. The indicator reagent composition comprises a redox indicator dye, a hydroperoxide, a ferric ion and a phosphorous compound having the formula ##STR1## wherein R.sub.1 or R.sub.2 are certain substituted or an unsubstituted aromatic moieties or certain polyhydric compounds, and wherein X is O, S or NH. The assay can be performed in wet phase or the composition can be incorporated into a carrier matrix. The method provides a more accurate and trustworthy assay of a test sample for a peroxidatively active substance and is especially useful in the assay of urine for occult blood.
摘要翻译：公开了一种测定样品中过氧化物质活性物质如血红蛋白的存在或浓度的方法。该方法包括使测试样品与指示剂组合物接触，所述指示剂组合物与过氧化物质活性物质相互作用以产生可测量或可检测的颜色变化。指示剂组合物包含氧化还原指示剂染料，氢过氧化物，三价铁离子和具有式“IMAGE”的磷化合物，其中R1或R2是某些取代的或未被取代的芳族部分或某些多羟基化合物，并且其中X是O，S 或NH。该测定可以在湿相中进行，或者该组合物可以并入载体基质中。该方法提供了对于过氧化活性物质的测试样品的更准确和可靠的测定，并且在用于潜血的尿液测定中特别有用。

9. 发明授权

US08865648B2 Monomeric and dimeric forms of adiponectin receptor fragments and methods of use 有权
标题翻译：脂联素受体片段的单体和二聚体形式和使用方法
公开(公告)号：US08865648B2
公开(公告)日：2014-10-21
申请号：US13265968
申请日：2010-04-13
申请人： Michael J. Pugia , Rui Ma
发明人： Michael J. Pugia , Rui Ma
IPC分类号： A61K38/00 , A61K38/26 , A61K38/22 , C07K14/605 , A61K38/28 , C07K14/575 , C07K7/06 , C07K7/02 , C07K7/64 , C07K11/00 , C07K14/47 , C07K14/785 , A61K39/00 , C07K14/005 , G01N33/574
CPC分类号： C07K14/705 , G01N33/574 , G01N33/57415 , G01N33/6872 , G01N2333/575 , G01N2800/2821 , G01N2800/52 , G01N2800/56
摘要： Methods are disclosed for determining progression of a condition, onset of a condition, or efficacy of treatment of a condition characterized by an adipocyte imbalance in a patient. In addition, methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using monomeric, homodimeric, and heterodimeric forms of certain C-terminal fragments of adiponectin receptor. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, inhibiting a protease, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed.
摘要翻译：公开了用于确定条件进展，条件开始或治疗以患者脂肪细胞不平衡为特征的病症的功效的方法。此外，公开了使用脂联素受体的某些C末端片段的单体，同二聚体和异二聚体形式治疗糖尿病，异常脂肪细胞活性和胰岛素抵抗的方法。此外，治疗异常脂肪细胞活性，治疗代谢综合征，引起胰岛素分泌，增加胰岛素水平，抑制胰岛素降解酶，治疗阿尔茨海默病，治疗与脂联素水平相关的心血管疾病，抑制ADAM-17酶，抑制蛋白酶，治疗公开了与TNF-α相关的病症和治疗与HER2-neu相关的病症。还公开了组合物，剂型和试剂盒。

10. 发明申请

US20130004988A1 DISPENSING OF A DIAGNOSTIC LIQUID ONTO A DIAGNOSTIC REAGENT 有权
标题翻译：将诊断液体分配到诊断试剂上
公开(公告)号：US20130004988A1
公开(公告)日：2013-01-03
申请号：US13608081
申请日：2012-09-10
申请人： Michael J. Pugia , James A. Profitt , Lloyd S. Schulman , Chris T. Zimmerle , Hai-Hang Kuo
发明人： Michael J. Pugia , James A. Profitt , Lloyd S. Schulman , Chris T. Zimmerle , Hai-Hang Kuo
IPC分类号： G01N1/38 , G01N21/25
CPC分类号： B01L3/0268 , B01J2219/0036 , B01J2219/00378 , B01J2219/00385 , B01J2219/00527 , B01J2219/00545 , B01J2219/00641 , B01J2219/00725 , B01J2219/0074 , B01L2400/0487 , G01N33/52 , G01N35/1016 , G01N2035/00158 , Y10T436/144444 , Y10T436/2575
摘要： Biological fluid samples are deposited by methods that produce a uniform layer of the sample over a reagent-containing surface. In one embodiment, a nozzle having multiple openings is used to deposit a sample over the reagent-containing surface simultaneously. In an alternative embodiment, single droplets of the sample are deposited in a pattern on the surface, preferably in a sequence of parallel lines. The reaction between the biological sample and the reagents is read from a spectrographic image of the reagent-containing surface obtained by optical methods.
摘要翻译：通过在含试剂的表面上产生均匀的样品层的方法沉积生物流体样品。在一个实施例中，使用具有多个开口的喷嘴同时将试样沉积在含有试剂的表面上。在替代实施例中，样品的单个液滴以图案沉积在表面上，优选地以一系列平行线沉积。从通过光学方法获得的含有试剂的表面的光谱图像中读取生物样品和试剂之间的反应。

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