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1. 发明申请

US20130004988A1 DISPENSING OF A DIAGNOSTIC LIQUID ONTO A DIAGNOSTIC REAGENT 有权
标题翻译：将诊断液体分配到诊断试剂上
公开(公告)号：US20130004988A1
公开(公告)日：2013-01-03
申请号：US13608081
申请日：2012-09-10
申请人： Michael J. Pugia , James A. Profitt , Lloyd S. Schulman , Chris T. Zimmerle , Hai-Hang Kuo
发明人： Michael J. Pugia , James A. Profitt , Lloyd S. Schulman , Chris T. Zimmerle , Hai-Hang Kuo
IPC分类号： G01N1/38 , G01N21/25
CPC分类号： B01L3/0268 , B01J2219/0036 , B01J2219/00378 , B01J2219/00385 , B01J2219/00527 , B01J2219/00545 , B01J2219/00641 , B01J2219/00725 , B01J2219/0074 , B01L2400/0487 , G01N33/52 , G01N35/1016 , G01N2035/00158 , Y10T436/144444 , Y10T436/2575
摘要： Biological fluid samples are deposited by methods that produce a uniform layer of the sample over a reagent-containing surface. In one embodiment, a nozzle having multiple openings is used to deposit a sample over the reagent-containing surface simultaneously. In an alternative embodiment, single droplets of the sample are deposited in a pattern on the surface, preferably in a sequence of parallel lines. The reaction between the biological sample and the reagents is read from a spectrographic image of the reagent-containing surface obtained by optical methods.
摘要翻译：通过在含试剂的表面上产生均匀的样品层的方法沉积生物流体样品。在一个实施例中，使用具有多个开口的喷嘴同时将试样沉积在含有试剂的表面上。在替代实施例中，样品的单个液滴以图案沉积在表面上，优选地以一系列平行线沉积。从通过光学方法获得的含有试剂的表面的光谱图像中读取生物样品和试剂之间的反应。

2. 发明授权

US07125711B2 Method and apparatus for splitting of specimens into multiple channels of a microfluidic device 有权
标题翻译：将样品分离成微流体装置的多个通道的方法和装置
公开(公告)号：US07125711B2
公开(公告)日：2006-10-24
申请号：US10326157
申请日：2002-12-19
申请人： Michael J. Pugia , James A. Profitt , Gert Blankenstein , Ralf-Peter Peters
发明人： Michael J. Pugia , James A. Profitt , Gert Blankenstein , Ralf-Peter Peters
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L3/5027 , B01L3/5025 , B01L3/50273 , B01L2200/0605 , B01L2200/0684 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , G01N35/00069 , G01N2035/00158 , G01N2035/00237 , G01N2035/1034
摘要： A microliter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved by capillary forces into one or more metering wells which define the amount of the sample to be analyzed in subsequent steps. The defined amount of the sample is transferred from the metering wells to one or more conditioning and reagent wells for measuring the amount of an analyte contained in each metered amount of the sample.
摘要翻译：在使用离心和毛细管力的装置中分析微升液体样品，特别是生物样品。样品通过毛细管力移动到一个或多个计量孔中，其限定在后续步骤中要分析的样品的量。将定义的样品量从计量孔转移到一个或多个调理和试剂孔，以测量每个计量量的样品中所含的分析物的量。

3. 发明授权

US08304254B2 Piezo dispensing of a diagnostic liquid onto a reagent surface 失效
标题翻译：诊断液体在试剂表面上的压电分配
公开(公告)号：US08304254B2
公开(公告)日：2012-11-06
申请号：US12598150
申请日：2008-03-14
申请人： Michael J. Pugia , James A. Profitt
发明人： Michael J. Pugia , James A. Profitt
IPC分类号： G01N1/38
CPC分类号： G01N35/1016 , G01N2035/1034 , Y10T436/144444 , Y10T436/25 , Y10T436/2575
摘要： Assays in which samples of biological fluids are dispensed onto reagent-containing porous substrates are improved in the accuracy and repeatability by dispensing the biological fluids in two or more fractions thereof, separated by intervals in which the biological fluid is not dispensed. Reagents and other fluids may be dispensed during the intervals when the biological fluid is not dispensed. Alternatively, reagents and other fluids may be dispensed in a similar manner onto substrates already containing biological fluids.
摘要翻译：生物流体样品分配到含有试剂的多孔基材上的测定通过将生物流体分配在两个或更多个部分中，通过分配生物流体不分配的间隔而提高了精度和重复性。在不分配生物流体的间隔期间，可以分配试剂和其它流体。或者，可以以类似的方式将试剂和其它流体分配到已经含有生物流体的基底上。

4. 发明申请

US20100255592A1 PIEZO DISPENSING OF A DIAGNOSTIC LIQUID ONTO A REAGENT SURFACE 失效
标题翻译：将诊断液体的PIEZO分配到试剂表面
公开(公告)号：US20100255592A1
公开(公告)日：2010-10-07
申请号：US12598150
申请日：2008-03-14
申请人： Michael J. Pugia , James A. Profitt
发明人： Michael J. Pugia , James A. Profitt
IPC分类号： G01N33/72 , G01N33/68 , G01N33/66
CPC分类号： G01N35/1016 , G01N2035/1034 , Y10T436/144444 , Y10T436/25 , Y10T436/2575
摘要： Assays in which samples of biological fluids are dispensed onto reagent-containing porous substrates are improved in the accuracy and repeatability by dispensing the biological fluids in two or more fractions thereof, separated by intervals in which the biological fluid is not dispensed. Reagents and other fluids may be dispensed during the intervals when the biological fluid is not dispensed. Alternatively, reagents and other fluids may be dispensed in a similar manner onto substrates already containing biological fluids.
摘要翻译：生物流体样品分配到含有试剂的多孔基材上的测定通过将生物流体分配在两个或更多个部分中，通过分配生物流体不分配的间隔而提高了精度和重复性。在不分配生物流体的间隔期间，可以分配试剂和其它流体。或者，可以以类似的方式将试剂和其它流体分配到已经含有生物流体的基底上。

5. 发明申请

US20100172801A1 METHOD FOR UNIFORM APPLICATION OF FLUID INTO A REACTIVE REAGENT AREA 审中-公开
标题翻译：将流体均匀地应用于反应性试剂区域的方法
公开(公告)号：US20100172801A1
公开(公告)日：2010-07-08
申请号：US12688346
申请日：2010-01-15
申请人： Michael J. Pugia , James A. Profitt , Hai-Hang Kuo , Gert Blankenstein , Ralf-Peter Peters , Lloyd S. Schulman
发明人： Michael J. Pugia , James A. Profitt , Hai-Hang Kuo , Gert Blankenstein , Ralf-Peter Peters , Lloyd S. Schulman
IPC分类号： G01N30/00 , G01N33/487
CPC分类号： B01L3/502746 , B01L3/502723 , B01L2200/0684 , B01L2200/16 , B01L2300/0816 , B01L2400/0406 , B01L2400/0409 , B01L2400/0418 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , Y10T436/2575
摘要： Analytical results obtained with microfluidic devices are improved by providing structural features in areas containing dry supported reagents, the structural features directing the flow of a sample over the area in a predetermined uniform manner and facilitating the purging of air.
摘要翻译：通过在含有干支持试剂的区域中提供结构特征来改进用微流体装置获得的分析结果，其结构特征以预定均匀的方式引导样品流过该区域并促进空气吹扫。

6. 发明授权

US09439630B2 Non-visible detectable marking for medical diagnostics 有权
标题翻译：用于医疗诊断的不可见的可检测标记
公开(公告)号：US09439630B2
公开(公告)日：2016-09-13
申请号：US12674944
申请日：2008-08-27
申请人： Chris T. Zimmerle , Michael J. Pugia , James A. Profitt
发明人： Chris T. Zimmerle , Michael J. Pugia , James A. Profitt
IPC分类号： G01N33/543 , A61B10/00 , G01N33/558 , G01N35/00
CPC分类号： A61B10/007 , A61B90/90 , A61B90/96 , G01N33/558 , G01N35/00732 , G01N2035/00752 , G01N2035/00772
摘要： Sample media for the analysis of analytes in a fluid test sample includes a carrier, at least one test field on the surface of the carrier including at least one reagent reactive with the analytes and capable of providing a detectable response. A non-visible bar code formed by at least two distinct non-visible marker fields is located on the carrier. The marker fields are configured to reflect electro-magnetic (EM) radiation within one or more ranges of non-visible wavelengths to form a coded sequence of reflectances correlated to identification of the sample media.
摘要翻译：用于分析流体测试样品中的分析物的样品介质包括载体，载体表面上的至少一个测试场包括至少一种与分析物反应的试剂并且能够提供可检测的反应。由至少两个不同的不可见标记字段形成的不可视条形码位于载体上。标记场被配置为在不可见波长的一个或多个范围内反映电磁（EM）辐射，以形成与样本介质的识别相关的反射的编码序列。

7. 发明授权

US08361782B2 Piezo dispensing of a diagnostic liquid into microfluidic devices 有权
标题翻译：将诊断液体压电分配到微流体装置中
公开(公告)号：US08361782B2
公开(公告)日：2013-01-29
申请号：US12598141
申请日：2008-03-14
申请人： Michael J. Pugia , James A. Profitt
发明人： Michael J. Pugia , James A. Profitt
IPC分类号： C12M1/36
CPC分类号： B01L3/502738 , B01L3/0268 , B01L3/50273 , B01L2200/0621 , B01L2300/0636 , B01L2300/0825 , B01L2400/0406 , B01L2400/0688 , B01L2400/086 , Y10T436/118339
摘要： Assays in which samples of biological fluids are dispensed into the inlet port of a microfluidic device are improved in the accuracy and repeatability by dispensing the biological sample and/or associated liquids in small droplets and at timed intervals to control the operation of the microfluidic device.
摘要翻译：通过以小液滴和定时的间隔分配生物样品和/或相关液体来控制微流体装置的操作，通过将生物流体的样品分配到微流体装置的入口端口的分析物的精度和重复性得到改善。

8. 发明申请

US20110111522A1 NON-VISIBLE DETECTABLE MARKING FOR MEDICAL DIAGNOSTICS 有权
标题翻译：用于医学诊断的不可见检测标记
公开(公告)号：US20110111522A1
公开(公告)日：2011-05-12
申请号：US12674944
申请日：2008-08-27
申请人： Chris T. Zimmerie , Michael J. Pugia , James A. Profitt
发明人： Chris T. Zimmerie , Michael J. Pugia , James A. Profitt
IPC分类号： G01N33/53 , G01N21/75 , G06K7/10
CPC分类号： A61B10/007 , A61B90/90 , A61B90/96 , G01N33/558 , G01N35/00732 , G01N2035/00752 , G01N2035/00772
摘要： Sample media for the analysis of analytes in a fluid test sample includes a carrier, at least one test field on the surface of the carrier including at least one reagent reactive with the analytes and capable of providing a detectable response. A non-visible bar code formed by at least two distinct non-visible marker fields is located on the carrier. The marker fields are configured to reflect electro-magnetic (EM) radiation within one or more ranges of non-visible wavelengths to form a coded sequence of reflectances correlated to identification of the sample media.
摘要翻译：用于分析流体测试样品中的分析物的样品介质包括载体，载体表面上的至少一个测试场包括至少一种与分析物反应的试剂并且能够提供可检测的反应。由至少两个不同的不可见标记字段形成的不可视条形码位于载体上。标记场被配置为在不可见波长的一个或多个范围内反映电磁（EM）辐射，以形成与样本介质的识别相关的反射的编码序列。

9. 发明申请

US20100239137A1 Two Dimensional Imaging of Reacted Areas On a Reagent 审中-公开
标题翻译：反应区域的二维成像在试剂上
公开(公告)号：US20100239137A1
公开(公告)日：2010-09-23
申请号：US12681180
申请日：2008-10-06
申请人： Michael J. Pugia , James A. Profitt , Chris T. Zimmerle
发明人： Michael J. Pugia , James A. Profitt , Chris T. Zimmerle
IPC分类号： G06K9/00 , H04N7/18
CPC分类号： G01N33/54366 , G01N21/274 , G01N21/8483 , G01N2201/062
摘要： A system for reading an assay includes a camera and a processor. The assay is used as a test for the presence or absence of a reaction between a sample and a reagent. The assay is defined by a test area and a background area. The test area is, preferably, substantially circular with a diameter between about 0.1 mm and about 5 mm. The camera simultaneously captures a two-dimensional image of the test area and the background area. The processor determines a first color response from the background area and a second color response from the test area. The processor then calibrates the second color response according to the first color response and generates a result of the test according to the second color response. The system may also include a uniform field illuminator that provides a substantially uniform level of illumination across the assay.
摘要翻译：用于读取测定的系统包括照相机和处理器。该测定用作样品和试剂之间存在或不存在反应的测试。测定由测试区域和背景区域定义。测试区域优选为直径在约0.1mm至约5mm之间的大致圆形。相机同时捕获测试区域和背景区域的二维图像。处理器确定来自背景区域的第一颜色响应和来自测试区域的第二颜色响应。然后处理器根据第一颜色响应校准第二颜色响应，并根据第二颜色响应生成测试结果。该系统还可以包括统一的场照明器，其在整个测定中提供基本均匀的照明水平。

10. 发明申请

US20090041627A1 PACKAGING OF MICROFLUIDIC DEVICES 审中-公开
标题翻译：微流体装置的包装
公开(公告)号：US20090041627A1
公开(公告)日：2009-02-12
申请号：US12205949
申请日：2008-09-08
申请人： Michael J. Pugia , James A. Profitt , Ronald G. Sommer , Sung-Kwon Jung
发明人： Michael J. Pugia , James A. Profitt , Ronald G. Sommer , Sung-Kwon Jung
IPC分类号： B01J19/00 , B32B37/12 , B01L3/00
CPC分类号： B01L3/502707 , B01L2200/142 , B01L2200/16 , B01L2300/0672 , B01L2400/0406 , B01L2400/0677 , B01L2400/0683 , B29K2509/08
摘要： A microfluidic device containing liquid reagents having an extended shelf life contains the liquid reagents in micro-reservoirs that limit the escape of moisture to less than 10% over the shelf life of the device. The micro-reservoir preferably is made of polypropylene and covered with a metallized plastic film.
摘要翻译：包含具有延长的保存期限的液体试剂的微流体装置包含微储存器中的液体试剂，其在装置的保存期限内将水分逸出限制在小于10％。微型储存器优选由聚丙烯制成并用金属化塑料膜覆盖。

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