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1. 发明申请

US20190242911A1 MEASUREMENT METHOD FOR GLYCATED HEMOGLOBIN RATIO 审中-公开
公开(公告)号：US20190242911A1
公开(公告)日：2019-08-08
申请号：US16343941
申请日：2016-11-04
申请人： GREEN CROSS MEDICAL SCIENCE
发明人： Hyu Jeong KIM , Hyong Soo KIM , Dong Han KIM , Eun Myung SHIN , Jung Sub SHIN , Soon Min HONG , Su Hyun LEE , Dong Cheol CHOI
IPC分类号： G01N33/72
CPC分类号： G01N33/723 , G01N33/66 , G01N33/72 , G01N33/726 , G01N35/00
摘要： Disclosed is a measurement method for a glycated hemoglobin ratio. According to a measurement method for a glycated hemoglobin ratio of the present invention, reagents are easy and convenient to use because of their sequential leakage during the rotation of a cassette, are all discharged by the rotation with no remaining reagent, and are not mixed with each other. Therefore, measurement results are accurate, with fewer errors in the quantities of used reagents and sample blood.

2. 发明申请

US20180116515A1 A NON-INVASIVE BIO-FLUID DETECTOR AND PORTABLE SENSOR-TRANSMITTER-RECEIVER SYSTEM 审中-公开
公开(公告)号：US20180116515A1
公开(公告)日：2018-05-03
申请号：US15566754
申请日：2016-04-15
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： Soumyadipta Acharya , Ashley Polhemus , Kevin Colbert , Vaishakhi Mayya , Aaron Enten , Joshua Budman
IPC分类号： A61B5/00 , G01N33/49 , A61B5/1455
CPC分类号： A61B5/0022 , A61B5/14535 , A61B5/1455 , A61B5/6826 , A61B5/6838 , A61B5/7264 , A61B5/743 , A61B2560/0214 , G01N9/24 , G01N21/00 , G01N33/4925 , G01N33/72 , G01N2333/805 , G01S19/00 , G06F19/3418 , G16H40/63 , G16H50/30 , H04B10/50
摘要： The present invention is directed to a bio-fluid detector such as a hemoglobin detector having the capability of receiving, storing and transmitting health information utilizing a portable transmitter and receiver including electronic PDAs such as cell phones. Further, the present invention utilizes a non-invasive hemoglobin detector that is connected to a portable transmitter-receiver such as PDAs including, but not limited to, cell phones.

3. 发明申请

US20170246626A1 TEST DEVICE AND METHOD 审中-公开
公开(公告)号：US20170246626A1
公开(公告)日：2017-08-31
申请号：US15508314
申请日：2015-08-31
申请人： CLINICAL GENOMICS PTY LTD
发明人： Howard Milne CHANDLER
IPC分类号： B01L3/00 , G01N33/72 , A61B10/00 , G01N33/52
CPC分类号： B01L3/5023 , A61B10/0038 , B01L3/5027 , B01L2200/0605 , B01L2200/0668 , B01L2200/141 , B01L2300/043 , B01L2300/0681 , B01L2300/069 , B01L2300/161 , G01N1/12 , G01N33/52 , G01N33/72 , G01N33/725 , G01N33/726
摘要： Provided is a test device for testing an analyte in a collected sample comprising: an enclosure having at least one sample receiving port for receiving the sample; a test strip located within the enclosure, the test strip containing at least one reagent for detecting the analyte and for providing an indication showing a test result for the sample, the enclosure including a detection arrangement for allowing detection of the indication of the test strip; a sample receiving matrix positioned behind the at least one sample receiving port and having a defined saturation capacity, the sample receiving matrix being impregnated with reagents for pre-treatment of the sample and being in liquid conductive communication with the test strip. Also provided is a method for use of said test device comprising: delivering one or more samples to the at least one sample receiving port to saturate the sample receiving matrix such that a quantified amount of the sample is transferred to the test strip and an indication of the test result is effected.

4. 发明申请

US20170059589A1 IMMUNOCHROMATOGRAPHIC ANALYSIS KIT, IMMUNOCHROMATOGRAPHIC ANALYSIS DEVICE, AND IMMUNOCHROMATOGRAPHIC ANALYSIS METHOD 审中-公开
标题翻译：免疫印迹分析试剂盒，免疫荧光分析装置和免疫印迹分析方法
公开(公告)号：US20170059589A1
公开(公告)日：2017-03-02
申请号：US15308068
申请日：2015-04-28
申请人： TANAKA KIKINZOKU KOGYO K.K.
发明人： Koji Okamoto , Yuya Kato , Daisuke Ito , Ayi Miyata , Satoru Nakajima
IPC分类号： G01N33/72
CPC分类号： G01N33/723 , G01N33/48 , G01N33/53 , G01N33/543 , G01N33/558 , G01N33/72
摘要： An object is to provide an immunochromatographic analysis kit, with which detection with high sensitivity is realized even in the case of a blood analyte containing saliva collected from the inside of an oral cavity, and an immunochromatographic analysis can be performed without pain or stress. The above object was achieved by an immunochromatographic analysis kit wherein an alkyl glucoside and an anionic surfactant are included in at least one of an analyte dilution solution and a part upstream in the development direction of a detection part.
摘要翻译：目的是提供一种免疫色谱分析试剂盒，即使在含有从口腔内部收集的唾液的血液分析仪的情况下也可实现高灵敏度的检测，并且可以在没有疼痛或压力的情况下进行免疫色谱分析。上述目的是通过免疫色谱分析试剂盒实现的，其中烷基葡糖苷和阴离子表面活性剂包括在分析物稀释溶液和检测部分的显影方向上游的部分中的至少一种中。

5. 发明授权

US09442118B2 Human cellular models with biosensors 有权
标题翻译：具有生物传感器的人类细胞模型
公开(公告)号：US09442118B2
公开(公告)日：2016-09-13
申请号：US15055202
申请日：2016-02-26
申请人： Tempo Bioscience, Inc.
发明人： Angela Huang
IPC分类号： C07K14/435 , G01N33/58 , G01N33/50 , C07K14/00 , G01N33/72 , G01N33/53 , C12N9/16
CPC分类号： G01N33/582 , C07K14/00 , C07K2319/03 , C07K2319/04 , C07K2319/06 , C07K2319/09 , C07K2319/60 , C12N9/16 , G01N33/5091 , G01N33/5308 , G01N33/542 , G01N33/5735 , G01N33/72 , G01N33/721 , G01N2400/00 , G01N2500/04 , G01N2500/10
摘要： This invention provides biosensors, cell models, and methods of their use for monitoring heme, oxygen or ATP. Biosensors can include targeting domains, sensing domains and reporting domains. Biosensors can be introduced into cells reprogrammed to represent experimental or pathologic cells of interest. Model cells expressing the biosensors can be contacted with putative bioactive agents to determine possible activities.
摘要翻译：本发明提供生物传感器，细胞模型及其用于监测血红素，氧或ATP的方法。生物传感器可以包括定位域，感知域和报告域。可以将生物传感器引入重新编程以代表感兴趣的实验或病理细胞的细胞中。可以将表达生物传感器的模型细胞与推定的生物活性剂接触以确定可能的活性。

6. 发明授权

US09131903B2 Diabetes treatment support apparatus, diabetes treatment support method, diabetes treatment support program 有权
标题翻译：糖尿病治疗支持装置，糖尿病治疗支持方法，糖尿病治疗支持方案
公开(公告)号：US09131903B2
公开(公告)日：2015-09-15
申请号：US14377737
申请日：2012-11-12
申请人： OMRON HEALTHCARE CO., LTD.
发明人： Muneo Tokita , Satoshi Nakajima
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1473 , G01N27/416 , G01N33/66 , G01N33/72 , G06F19/00
CPC分类号： A61B5/7278 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/486 , A61B5/4866 , A61B5/7282 , A61B5/742 , G01N27/416 , G01N33/66 , G01N33/72 , G01N2800/042 , G06F19/00 , G16H40/63
摘要： A control unit obtains, from a memory unit, data of a plurality of pre-meal blood sugar levels that are blood sugar levels measured before meals and data of a plurality of post-meal blood sugar levels that are blood sugar levels measured after meals, calculates a pre-meal average value that is an average value of the plurality of pre-meal blood sugar levels, calculates a post-meal average value that is an average value of the plurality of post-meal blood sugar levels, calculates an average blood sugar level that is an average of the pre-meal average value and the post-meal average value, calculates an estimated HbA1c value using the average blood sugar level, and displays the calculated estimated HbA1c value in a display unit.
摘要翻译：控制单元从存储器单元获取餐前测量的血糖水平的多个餐前血糖水平的数据和饭后测量的血糖水平的多个膳食后血糖水平的数据，计算作为多个膳食前血糖水平的平均值的餐前平均值，计算作为多次餐后血糖水平的平均值的餐后平均值，计算平均血液作为餐前平均值和餐后平均值的平均值的糖水平，使用平均血糖水平计算估计的HbA1c值，并将计算出的估计HbA1c值显示在显示单元中。

7. 发明申请

US20150031013A1 DIAGNOSTIC AGENT FOR TUMOR 有权
标题翻译：肿瘤诊断剂
公开(公告)号：US20150031013A1
公开(公告)日：2015-01-29
申请号：US14374043
申请日：2013-01-15
申请人： SBI Pharmaceuticals Co., Ltd.
发明人： Tohru Tanaka , Kiwamu Takahashi , Motowo Nakajima , Fuminori Abe , Masahiro Ishizuka , Urara Ota
IPC分类号： G01N33/72 , G01N33/70
CPC分类号： G01N33/72 , A61K49/0036 , G01N33/574 , G01N33/70 , G01N2800/7028
摘要： It is to provide a tumor diagnostic agent and a tumor determination method enabling not only determination of the presence or absence of a tumor in a subject, but also determination of whether the tumor is a malignant tumor or a benign tumor, which can be used simply at low cost with reduced side effects and burden. 5-aminolevulinic acid (ALA) or its derivative, or a salt thereof is orally administered at a dose of 5 to 7 mg in terms of ALA per kg of body weight, and a urine sample 4 to 12 hours after the administration is collected. Porphyrins and creatinine in the urine sample are quantitated, and based on the value (nmol/gCre) obtained by dividing the amount of porphyrins by the amount of creatinine, a distinction among an individual without a tumor, an individual with a benign tumor, and an individual with a malignant tumor is determined. The presence or absence of a malignant tumor in a subject can be clearly determined by administering 1 to 3 mg of ALAs in terms of ALA per kg of body weight.
摘要翻译：本发明提供一种肿瘤诊断剂和肿瘤测定方法，其不仅可以确定受试者中肿瘤的存在或不存在，而且能够确定肿瘤是恶性肿瘤还是良性肿瘤，其可以简单地使用成本低，副作用和负担减轻。 5-氨基乙酰丙酸（ALA）或其衍生物或其盐以每kg体重ALA为5〜7mg的剂量口服，收集给药后4〜12小时的尿样。对尿样中的卟啉和肌酐进行定量，并根据通过将卟啉的量除以肌酸酐的量而得到的值（nmol / gCre），没有肿瘤的个体，具有良性肿瘤的个体和确定具有恶性肿瘤的个体。患者中恶性肿瘤的存在或不存在可以通过以每kg体重为基础的ALA计算1至3mg的ALA来清楚地确定。

8. 发明申请

US20130224761A1 NON COVALENT MOLECULAR STRUCTURE, COMPRISING A PORPHYRIN BASED GLYCOCONJUGATE, DEVICE COMPRISING THE SAME AND ITS USE FOR DETECTION OF LECTIN 审中-公开
标题翻译：包含基于吡啶基的甘油三酯的非共价分子结构，其包含其的装置及其用于检测LECTIN
公开(公告)号：US20130224761A1
公开(公告)日：2013-08-29
申请号：US13805099
申请日：2011-06-16
申请人： Anne Imberty , Sébastien Vidal , Alexander Star
发明人： Anne Imberty , Sébastien Vidal , Alexander Star
IPC分类号： G01N33/569
CPC分类号： G01N33/56911 , C01B32/174 , G01N33/5438 , G01N33/72 , G01N2333/4724
摘要： The present invention relates to a non covalent molecular structure comprising a carbon nanostructure and a porphyrin based glycoconjugate (I) which is linked to the said carbon nanostructure by a non covalent link, the said glycoconjugate (I) having the formula (I): wherein M is a metal selected in the group comprising Fe, Ni, Zn, Cu, Mn, Cr or Co, B is a group which is present on at least one of the four phenyl group (C6H5) represented in (I), n is an integer from 1 to 3, that is to say that one to three B group(s) may be present on each phenyl group, and B is represented by a -A-C group wherein A is selected in the group comprising an oxygen atom, a sulfur atom, a NH group or a (CH2)n1 group, n1 being an integer from 1 to 10, C is a group of formula (II). The present invention also relates to an electronic device comprising the said non covalent molecular structure, and to the use of this device for the detection of a lectin involved in bacterial or viral infections. Thus the invention also relates to a method for detecting the presence of a lectin in a sample to be analysed.
摘要翻译：本发明涉及包含碳纳米结构和通过非共价键与所述碳纳米结构连接的卟啉基糖缀合物（I）的非共价分子结构，所述糖缀合物（I）具有式（I）：其中 M是选自Fe，Ni，Zn，Cu，Mn，Cr或Co组成的金属，B是存在于（I）中所表示的四个苯基（C 6 H 5）中的至少一个上的基团，n是 1〜3的整数，也就是说，可以在每个苯基上存在一至三个B基团，B由-AC基团表示，其中A选自氧原子，硫原子，NH基或（CH 2）n1基，n1为1〜10的整数，C为式（II）的基团。本发明还涉及包含所述非共价分子结构的电子器件，以及该装置用于检测涉及细菌或病毒感染的凝集素的用途。因此，本发明还涉及用于检测待分析样品中凝集素的存在的方法。

9. 发明申请

US20120028294A1 HOME TEST KIT FOR DETECTING FECAL BLOOD 有权
标题翻译：用于检测正气血液的家用试剂盒
公开(公告)号：US20120028294A1
公开(公告)日：2012-02-02
申请号：US12900714
申请日：2010-10-08
申请人： G. Joseph Fitzgerald
发明人： G. Joseph Fitzgerald
IPC分类号： C12Q1/04 , C12M1/34
CPC分类号： G01N33/72
摘要： A home test kit for detecting fecal blood includes a scoop device for collecting a fecal sample, a luminescent for mixing with the sample, a hollow container for containing the sample, water and the luminescent, or luminol during use of the kit. A base may be provided for supporting the container during testing, and the container may include an integrally formed lid. Detection of the blood in the sample is possible because the luminescent undergoes a light-producing reaction that involves, as a reactant or catalyst, blood or blood components or products. The blood is thus visible, or glows in darkened surroundings. The kit is compact, easy to use, and formed from biodegradable material for easy disposal.
摘要翻译：用于检测粪便血液的家用测试试剂盒包括用于收集粪便样品的勺装置，用于与样品混合的发光装置，用于在试剂盒使用期间容纳样品，水和发光剂或鲁米诺的中空容器。可以提供用于在测试期间支撑容器的底座，并且容器可以包括一体形成的盖子。检测样品中的血液是可能的，因为发光体经历作为反应物或催化剂的血液或血液成分或产物的发光反应。因此血液是可见的，或者在黑暗环境中发光。该套件紧凑，易于使用，并由可生物降解材料形成，便于处理。

10. 发明授权

US08053203B2 Methods and device for the detection of occult blood 有权
标题翻译：潜血检测方法及装置
公开(公告)号：US08053203B2
公开(公告)日：2011-11-08
申请号：US11978820
申请日：2007-10-30
申请人： John Wan , Zhijing Wan
发明人： John Wan , Zhijing Wan
IPC分类号： G01N33/543 , G01N31/00 , A61K39/00
CPC分类号： G01N33/558 , G01N33/72
摘要： The present invention relates generally to detection of occult blood. In particular, the present invention provides a device and methods for the simultaneous detection of hemoglobin and transferrin in fecal samples, which permit a more sensitive diagnosis of occult blood in fecal sample and a differential diagnosis of bleeding of the upper GI tract versus the lower GI tract.
摘要翻译：本发明一般涉及潜血检测。特别地，本发明提供了一种用于同时检测粪便样品中的血红蛋白和转铁蛋白的装置和方法，其允许对粪便样品中的潜血进行更敏感的诊断，并且鉴定上GI肠道与下GI的出血的鉴别诊断道。

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