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1. 发明申请

US20100172801A1 METHOD FOR UNIFORM APPLICATION OF FLUID INTO A REACTIVE REAGENT AREA 审中-公开
标题翻译：将流体均匀地应用于反应性试剂区域的方法
公开(公告)号：US20100172801A1
公开(公告)日：2010-07-08
申请号：US12688346
申请日：2010-01-15
申请人： Michael J. Pugia , James A. Profitt , Hai-Hang Kuo , Gert Blankenstein , Ralf-Peter Peters , Lloyd S. Schulman
发明人： Michael J. Pugia , James A. Profitt , Hai-Hang Kuo , Gert Blankenstein , Ralf-Peter Peters , Lloyd S. Schulman
IPC分类号： G01N30/00 , G01N33/487
CPC分类号： B01L3/502746 , B01L3/502723 , B01L2200/0684 , B01L2200/16 , B01L2300/0816 , B01L2400/0406 , B01L2400/0409 , B01L2400/0418 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , Y10T436/2575
摘要： Analytical results obtained with microfluidic devices are improved by providing structural features in areas containing dry supported reagents, the structural features directing the flow of a sample over the area in a predetermined uniform manner and facilitating the purging of air.
摘要翻译：通过在含有干支持试剂的区域中提供结构特征来改进用微流体装置获得的分析结果，其结构特征以预定均匀的方式引导样品流过该区域并促进空气吹扫。

2. 发明申请

US20130004988A1 DISPENSING OF A DIAGNOSTIC LIQUID ONTO A DIAGNOSTIC REAGENT 有权
标题翻译：将诊断液体分配到诊断试剂上
公开(公告)号：US20130004988A1
公开(公告)日：2013-01-03
申请号：US13608081
申请日：2012-09-10
申请人： Michael J. Pugia , James A. Profitt , Lloyd S. Schulman , Chris T. Zimmerle , Hai-Hang Kuo
发明人： Michael J. Pugia , James A. Profitt , Lloyd S. Schulman , Chris T. Zimmerle , Hai-Hang Kuo
IPC分类号： G01N1/38 , G01N21/25
CPC分类号： B01L3/0268 , B01J2219/0036 , B01J2219/00378 , B01J2219/00385 , B01J2219/00527 , B01J2219/00545 , B01J2219/00641 , B01J2219/00725 , B01J2219/0074 , B01L2400/0487 , G01N33/52 , G01N35/1016 , G01N2035/00158 , Y10T436/144444 , Y10T436/2575
摘要： Biological fluid samples are deposited by methods that produce a uniform layer of the sample over a reagent-containing surface. In one embodiment, a nozzle having multiple openings is used to deposit a sample over the reagent-containing surface simultaneously. In an alternative embodiment, single droplets of the sample are deposited in a pattern on the surface, preferably in a sequence of parallel lines. The reaction between the biological sample and the reagents is read from a spectrographic image of the reagent-containing surface obtained by optical methods.
摘要翻译：通过在含试剂的表面上产生均匀的样品层的方法沉积生物流体样品。在一个实施例中，使用具有多个开口的喷嘴同时将试样沉积在含有试剂的表面上。在替代实施例中，样品的单个液滴以图案沉积在表面上，优选地以一系列平行线沉积。从通过光学方法获得的含有试剂的表面的光谱图像中读取生物样品和试剂之间的反应。

3. 发明授权

US08486715B2 Dispensing of a diagnostic liquid onto a diagnostic reagent 有权
标题翻译：将诊断液体分配到诊断试剂上
公开(公告)号：US08486715B2
公开(公告)日：2013-07-16
申请号：US13608081
申请日：2012-09-10
申请人： Michael J. Pugia , James A. Profitt , Lloyd S. Schulman , Chris T. Zimmerle , Hai-Hang Kuo
发明人： Michael J. Pugia , James A. Profitt , Lloyd S. Schulman , Chris T. Zimmerle , Hai-Hang Kuo
IPC分类号： G01N1/10
CPC分类号： B01L3/0268 , B01J2219/0036 , B01J2219/00378 , B01J2219/00385 , B01J2219/00527 , B01J2219/00545 , B01J2219/00641 , B01J2219/00725 , B01J2219/0074 , B01L2400/0487 , G01N33/52 , G01N35/1016 , G01N2035/00158 , Y10T436/144444 , Y10T436/2575
摘要： Biological fluid samples are deposited by methods that produce a uniform layer of the sample over a reagent-containing surface. In one embodiment, a nozzle having multiple openings is used to deposit a sample over the reagent-containing surface simultaneously. In an alternative embodiment, single droplets of the sample are deposited in a pattern on the surface, preferably in a sequence of parallel lines. The reaction between the biological sample and the reagents is read from a spectrographic image of the reagent-containing surface obtained by optical methods.
摘要翻译：通过在含试剂的表面上产生均匀的样品层的方法沉积生物流体样品。在一个实施例中，使用具有多个开口的喷嘴同时将试样沉积在含有试剂的表面上。在替代实施例中，样品的单个液滴以图案沉积在表面上，优选地以一系列平行线沉积。从通过光学方法获得的含有试剂的表面的光谱图像中读取生物样品和试剂之间的反应。

4. 发明授权

US08263414B2 Dispensing of a diagnostic liquid onto a diagnostic reagent 有权
标题翻译：将诊断液体分配到诊断试剂上
公开(公告)号：US08263414B2
公开(公告)日：2012-09-11
申请号：US11135928
申请日：2005-05-23
申请人： Michael J. Pugia , James A. Profitt , Lloyd S. Schulman , Chris T. Zimmerle , Hai-Hang Kuo
发明人： Michael J. Pugia , James A. Profitt , Lloyd S. Schulman , Chris T. Zimmerle , Hai-Hang Kuo
IPC分类号： G01N1/10
CPC分类号： B01L3/0268 , B01J2219/0036 , B01J2219/00378 , B01J2219/00385 , B01J2219/00527 , B01J2219/00545 , B01J2219/00641 , B01J2219/00725 , B01J2219/0074 , B01L2400/0487 , G01N33/52 , G01N35/1016 , G01N2035/00158 , Y10T436/144444 , Y10T436/2575
摘要： Biological fluid samples are deposited by methods that produce a uniform layer of the sample over a reagent-containing surface. In one embodiment, a nozzle having multiple openings is used to deposit a sample over the reagent-containing surface simultaneously. In an alternative embodiment, single droplets of the sample are deposited in a pattern on the surface, preferably in a sequence of parallel lines. The reaction between the biological sample and the reagents is read from a spectrographic image of the reagent-containing surface obtained by optical methods.
摘要翻译：通过在含试剂的表面上产生均匀的样品层的方法沉积生物流体样品。在一个实施例中，使用具有多个开口的喷嘴同时将试样沉积在含有试剂的表面上。在替代实施例中，样品的单个液滴以图案沉积在表面上，优选地以一系列平行线沉积。从通过光学方法获得的含有试剂的表面的光谱图像中读取生物样品和试剂之间的反应。

5. 发明授权

US06183972B2 Method for the determination of analyte concentration in a lateral flow sandwich immunoassay exhibiting high-dose hook effect 失效
标题翻译：用于测定显示高剂量钩效应的侧流夹心免疫测定中的分析物浓度的方法
公开(公告)号：US06183972B2
公开(公告)日：2001-02-06
申请号：US09122736
申请日：1998-07-27
申请人： Hai-Hang Kuo , Lisa A. Meritt
发明人： Hai-Hang Kuo , Lisa A. Meritt
IPC分类号： G01N33544
CPC分类号： G01N33/54306 , G01N33/558 , Y10S435/805 , Y10S435/81 , Y10S435/96 , Y10S435/961 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/81
摘要： Disclosed is a method for determining the concentration of an analyte in a fluid test medium by use of an immunochromatographic test strip through which the test fluid can flow by capillarity. The test strip has at least two capture bands and optionally one or more collection bands which capture labeled anti-analyte antibody to provide a detectable signal. The signals from the label is quantitatively detected in each of the bands to provide a pattern of signals which is unique to the concentration of analyte in the test fluid. The pattern of signals are mathematically combined to create a monotonous dose-response curve to thereby factor out the high analyte hook effect which can be present in this type of assay.
摘要翻译：公开了一种通过使用免疫色谱测试条来测定流体测试介质中分析物的浓度的方法，通过该免检色谱测试条，测试流体可以通过毛细管作用流动。测试条具有至少两个捕获带和任选的一个或多个收集带，其捕获标记的抗分析物抗体以提供可检测信号。在每个频带中定量检测来自标签的信号，以提供对测试流体中分析物浓度唯一的信号模式。信号的模式在数学上被组合以产生单调的剂量 - 反应曲线，从而消除了可能存在于这种类型的测定中的高分析物钩效应。

6. 发明申请

US20060263902A1 Dispensing of a diagnostic liquid onto a diagnostic reagent 有权
公开(公告)号：US20060263902A1
公开(公告)日：2006-11-23
申请号：US11135928
申请日：2005-05-23
申请人： Michael Pugia , James Profitt , Lloyd Schulman , Chris Zimmerle , Hai-Hang Kuo
发明人： Michael Pugia , James Profitt , Lloyd Schulman , Chris Zimmerle , Hai-Hang Kuo
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01J2219/0036 , B01J2219/00378 , B01J2219/00385 , B01J2219/00527 , B01J2219/00545 , B01J2219/00641 , B01J2219/00725 , B01J2219/0074 , B01L2400/0487 , G01N33/52 , G01N35/1016 , G01N2035/00158 , Y10T436/144444 , Y10T436/2575
摘要： Biological fluid samples are deposited by methods that produce a uniform layer of the sample over a reagent-containing surface. In one embodiment, a nozzle having multiple openings is used to deposit a sample over the reagent-containing surface simultaneously. In an alternative embodiment, single droplets of the sample are deposited in a pattern on the surface, preferably in a sequence of parallel lines. The reaction between the biological sample and the reagents is read from a spectrographic image of the reagent-containing surface obtained by optical methods.

7. 发明授权

US06335204B1 Fixed volume liquid transfer device and method for transferring liquids 有权
标题翻译：固定体积液体输送装置和液体转移方法
公开(公告)号：US06335204B1
公开(公告)日：2002-01-01
申请号：US09408201
申请日：1999-09-29
申请人： Hai-Hang Kuo
发明人： Hai-Hang Kuo
IPC分类号： G01N100
CPC分类号： G01N35/1097 , B01L3/021 , Y10T436/2575
摘要： A fixed volume liquid transfer device defined by a small bore tube having an open end for collection of liquids and a plunger in the tube is disclosed. A piston is mounted around the open end and an air plug is mounted in the piston adjacent the open end. Liquid in a test tube is transferred to a testing site by inserting the transfer device into the test tube. As the piston contacts the liquid, the liquid is pumped into the tube. As the transfer device is inserted further, the air plug is actuated to balance air pressure across the piston. The device may then be withdrawn from the test tube and transported to a test site. At the test site, the plunger is depressed to expel the liquid into a testing device.
摘要翻译：公开了一种由具有用于收集液体的开口端的小孔管和管中的柱塞限定的固定体积的液体输送装置。活塞围绕开口端安装，气塞安装在靠近开口端的活塞中。试管中的液体通过将转移装置插入试管而被转移到试验部位。当活塞接触液体时，液体被泵入管中。当传送装置进一步插入时，空气塞被致动以平衡穿过活塞的气压。然后可以将该装置从试管中取出并运送到试验部位。在试验部位，柱塞被压下以将液体排出到测试装置中。

8. 发明授权

US5876944A Method for amplification of the response signal in a sandwich immunoassay 失效
标题翻译：用于在夹心免疫测定中扩增反应信号的方法
公开(公告)号：US5876944A
公开(公告)日：1999-03-02
申请号：US660923
申请日：1996-06-10
申请人： Hai-Hang Kuo
发明人： Hai-Hang Kuo
IPC分类号： G01N33/543 , G01N33/53
CPC分类号： G01N33/54306 , Y10S436/814
摘要： Disclosed is an improvement to a sandwich type immunoassay in which there is immobilized to a solid support an antibody which is specific to an epitope of the analyte whose presence or concentration is being sought and a first labeled antibody which is specific to another epitope of the analyte. The improvement involves providing a second labeled antibody which is specific to the first labeled antibody to thereby form a chain of two or more labeled antibodies which results in amplification of the signal generated upon formation of the sandwich.
摘要翻译：披露了对夹心型免疫测定法的改进，其中固定化成固体支持物，该抗体对其存在或浓度正在寻求的分析物的表位具有特异性，并且对分析物的另一表位是特异性的第一标记抗体。该改进涉及提供对第一标记抗体特异性的第二标记抗体，从而形成两个或多个标记抗体的链，其导致在形成夹心物时产生的信号的扩增。

9. 发明授权

US06436721B1 Device and method for obtaining clinically significant analyte ratios 失效
标题翻译：用于获得临床显着分析物比例的装置和方法
公开(公告)号：US06436721B1
公开(公告)日：2002-08-20
申请号：US08900586
申请日：1997-07-25
申请人： Hai-Hang Kuo , Carol A. Miller , Dayaweera Wijesuriya , Meitak Teresa Yip , Chris T. Zimmerle
发明人： Hai-Hang Kuo , Carol A. Miller , Dayaweera Wijesuriya , Meitak Teresa Yip , Chris T. Zimmerle
IPC分类号： G01N33558
CPC分类号： G01N33/558 , Y10S435/973 , Y10S436/909 , Y10T436/147777
摘要： Disclosed is a method for determining the concentration of an analyte in a sample of body fluid. The method involves contacting the body fluid sample with a test strip containing mobile, labeled specific binding partner for the analyte, through which strip the test fluid, analyte and any complex formed by interaction of the analyte and labeled specific binding partner therefore can flow by capillarity. The strip contains at least one zone for capture of the labeled specific binding partner and at least one separate zone for retention of the analyte/labeled specific binding partner complex. By determining the magnitude of the signal from the detectable label in the capture zone(s) and retention zone(s) and determining a final response signal by correlating signals using an algorithm and number of zones chosen in a manner that provides a final response signal best suited for the particular assay, the concentration of the analyte can be determined with greater precision.
摘要翻译：公开了一种用于测定体液样品中分析物浓度的方法。该方法包括使体液样品与包含用于分析物的可移动的，标记的特异性结合配偶体的测试条接触，通过该测试条，测试流体，分析物和通过分析物和标记的特异性结合配偶体的相互作用形成的任何复合物因此可以通过毛细管流动。条带含有至少一个用于捕获标记的特异性结合配偶体的区域和用于保留分析物/标记的特异性结合配偶体复合物的至少一个分离的区域。通过确定来自捕获区域和保留区域中的可检测标签的信号的幅度，并且通过使用算法和使用提供最终响应信号的方式选择的区域数量来相关信号来确定最终响应信号最适合于特定测定，可以更精确地测定分析物的浓度。

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