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    • 2. 发明申请
    • METHOD OF REMOVING RESIDUAL ETHYLENE OXIDE MONOMER IN POLYETHYLENE OXIDE
    • 在聚氧乙烯中除去残留的乙烯氧化物单体的方法
    • US20090036644A1
    • 2009-02-05
    • US11912020
    • 2006-04-12
    • Shinji KobayashiMasaki TeramotoMakoto KatouTohru Ido
    • Shinji KobayashiMasaki TeramotoMakoto KatouTohru Ido
    • C08G65/04
    • C08G65/30
    • The present invention relates to a method of removing a residual ethylene oxide monomer in polyethylene oxide used as a raw material for pharmaceutical preparations. More particularly, the method of the present invention comprises retaining high-molecular weight polyethylene oxide particles at a temperature not higher than a crystal melting point of the polyethylene oxide in the absence of an aggregation inhibitor under an atmospheric pressure in the standing state and, then, cooling the particles to 40° C. or lower under an atmospheric pressure and in the standing state, thereby, reducing a residual ethylene oxide monomer concentration to 1 ppm or lower without influencing on physical properties such as a specific surface area of the high-molecular weight polyethylene oxide particles.
    • 本发明涉及一种去除用作药物制剂原料的聚环氧乙烷中残留的环氧乙烷单体的方法。 更具体地说,本发明的方法包括在常压下在不存在聚集抑制剂的情况下,在不高于聚环氧乙烷的结晶熔点的温度下保持高分子量聚环氧乙烷粒子,然后, 在大气压下,在常压状态下将颗粒冷却至40℃以下,从而将残留的环氧乙烷单体浓度降低至1ppm以下,而不影响高分子化合物的比表面积等物理性质, 分子量聚环氧乙烷颗粒。