专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5821388A Process for preparing .alpha.-haloacetophenone derivative 失效
标题翻译： α-卤代乙酰苯衍生物的制备方法
公开(公告)号：US5821388A
公开(公告)日：1998-10-13
申请号：US834544
申请日：1997-03-27
申请人： Junichi Sakamoto , Hideaki Nishiguchi , Hiroshi Goda
发明人： Junichi Sakamoto , Hideaki Nishiguchi , Hiroshi Goda
IPC分类号： B01J23/30 , C07B61/00 , C07C315/02 , C07C317/24 , C07C319/20 , C07C323/22
CPC分类号： C07C319/20 , C07C315/02
摘要： The present invention provides processes for preparing .alpha.-halo(methylthio)acetophenone and .alpha.-halo (methylsulfonyl)acetophenone in an industrially simple and economically advantageous manner. In the invention, methylthioacetophenone is halogenated with a halogenating agent in the presence of an alcohol, giving .alpha.-halo(methylthio) acetophenone. Then the compound is oxidized with an oxidizing agent, giving .alpha.-halo(methylsulfonyl)acetophenone.
摘要翻译：本发明提供了工业上简单且经济有利的方法制备α-卤代（甲硫基）苯乙酮和α-卤代（甲基磺酰基）苯乙酮的方法。在本发明中，甲基硫代苯乙酮用卤化剂在醇的存在下卤化，得到α-卤代（甲硫基）苯乙酮。然后用氧化剂氧化化合物，得到α-卤代（甲基磺酰基）苯乙酮。

2. 发明授权

US5210287A 2,5-dichlorophenylthioglycolic acid derivative and method for its production 失效
标题翻译： 2,5-二氯乙酰胆酸衍生物及其生产方法
公开(公告)号：US5210287A
公开(公告)日：1993-05-11
申请号：US824313
申请日：1992-01-23
申请人： Hiroshi Goda , Nario Kimura , Naohiro Yoshikawa , Katsuhiko Yoshida
发明人： Hiroshi Goda , Nario Kimura , Naohiro Yoshikawa , Katsuhiko Yoshida
IPC分类号： C07C323/66
CPC分类号： C07C323/66
摘要： The present invention is directed to novel 2,5-dichlorophenylthioglycolic acid derivative, a process for their production and a process for producing the desired product 2,5-dichlorophenylthioglycolic acid derived from said novel compounds. 2,5-dichlorophenylthioglycolic acid derivative of the present invention can be obtained by reacting 2,4,5-trichlorobenzensulfonates and thioglycolic acid in the presence of base, and said desired product can be obtained by desulfonating said compound in an aqueous solution of mineral acid. Novel 4-carboxymethylthio-2,5-dichlorobenzenesulfonates of the present invention can be used advantageously as an intermediate for the production of 2,5-dichlorophenylthioglycolic acid. The use of said intermediate makes it possible to obtain the desired product in a decreased process steps with high yield. In addition, it poses no problem of environmental pollution as pointed out with conventional methods because it uses no heavy metals.

3. 发明授权

US4853158A Process for preparing N,N-dialkylaniline salt of 5-acetyl-2-alkylbenzene sulfonic acid 失效
标题翻译：制备5-乙酰基-2-烷基苯磺酸的N，N-二烷基苯胺盐的方法
公开(公告)号：US4853158A
公开(公告)日：1989-08-01
申请号：US178833
申请日：1988-03-25
申请人： Kunioki Kato , Masao Kawamura , Hiroshi Goda , Kiyoshi Sawada , Kazuhiro Hamatani
发明人： Kunioki Kato , Masao Kawamura , Hiroshi Goda , Kiyoshi Sawada , Kazuhiro Hamatani
IPC分类号： C07C20060101 , C07C309/30 , C07C311/15
CPC分类号： C07C309/00
摘要： Process for preparing 2-alkyl-5-haloacetylbenzenesulfonamide represented by the general formula (1), ##STR1## (wherein R.sup.1 is an alkyl group having 1 to 5 carbon atoms; and X is a chlorine atom, bromine atom or iodine atom), characterized by halogenating a 5-acetyl-2-alkylbenzenesulfonamide represented by the general formula (2), ##STR2## (wherein R.sup.1 is the same as defined above) in a lower alcohol represented by the general formula (3),R.sup.4 --OH(wherein R.sup.4 is an alkyl group having 1 to 5 carbon atoms).
摘要翻译：用于制备由通式（1）表示的2-烷基-5-卤代乙酰基苯磺酰胺的方法，其中R1是具有1-5个碳原子的烷基; X是氯原子，溴原子或碘原子），其特征在于在通式（3）表示的低级醇中卤化由通式（2）表示的5-乙酰基-2-烷基苯磺酰胺，（IMAG）（2）（其中R 1与上述相同）），R4-OH（其中R4是具有1至5个碳原子的烷基）。

4. 发明申请

US20120051485A1 CORIUM COOLING PROMOTING APPARATUS AND CONTAINMENT 审中-公开
标题翻译： CORIUM冷却促进装置和容纳
公开(公告)号：US20120051485A1
公开(公告)日：2012-03-01
申请号：US13318588
申请日：2009-07-24
申请人： Hiroshi Goda , Makoto Yamagishi , Tadahiko Suzuta , Yoshiyuki Kondo
发明人： Hiroshi Goda , Makoto Yamagishi , Tadahiko Suzuta , Yoshiyuki Kondo
IPC分类号： G21C9/016 , G21C15/02
CPC分类号： G21C9/016 , G21C15/12 , G21C15/18 , Y02E30/32
摘要： In a corium cooling promoting apparatus and a containment, a pressurized water reactor (12) is contained inside the containment (11), and a cavity (56) to which cooling water can be supplied in an emergency is provided below the pressurized water reactor (12). The cooling promoting apparatus (61) is disposed in the cavity (56), and an inclined plate (62) for spreading a corium (debris) from the pressurized water reactor (12) is provided, as the cooling promoting apparatus (61), at a position below the pressurized water reactor (12) in the cavity (56). The cooling of the corium falling from the nuclear reactor is thereby facilitated, and the corium is cooled at an early stage to improve safety.
摘要翻译：在ium冷却促进装置和容器中，压缩水反应器（12）容纳在容纳物（11）的内部，并且在压力水反应器的下方设置有能够在紧急情况下供应冷却水的空腔（56） 12）。冷却促进装置（61）设置在空腔（56）中，并且设置有用于从加压水反应器（12）扩散腐蚀物（碎屑）的倾斜板（62）作为冷却促进装置（61）在空腔（56）中的加压水反应器（12）下方的位置处。因此，从核反应堆落下的金属的冷却变得容易，并且早期阶段冷却，以提高安全性。

5. 发明申请

US20080152067A1 Granulation accelerating device and nuclear reactor housing 审中-公开
标题翻译：造粒加速装置和核反应堆壳
公开(公告)号：US20080152067A1
公开(公告)日：2008-06-26
申请号：US11806321
申请日：2007-05-31
申请人： Hiroshi Goda , Yoshinori Yamakoshi , Makoto Yamagishi , Koichi Tanimoto
发明人： Hiroshi Goda , Yoshinori Yamakoshi , Makoto Yamagishi , Koichi Tanimoto
IPC分类号： G21C9/016
CPC分类号： G21C9/016 , Y02E30/32
摘要： A nuclear reactor housing includes a vertically held pressurized water reactor and a cavity formed below the pressurized water reactor. A granulating member is positioned between the pressurized water reactor and the cavity and that accelerates granulation of debris falling from the pressurized water reactor into the cavity.
摘要翻译：核反应堆壳体包括垂直保持的加压水反应器和形成在加压水反应器下方的空腔。造粒构件位于加压水反应器和空腔之间，并且加速从压水反应堆落入空腔中的碎屑的造粒。

6. 发明授权

US5939548A Process for preparation of 3-piperazinylbenzisothiazoles 有权
标题翻译： 3-哌嗪基苯并异噻唑的制备方法
公开(公告)号：US5939548A
公开(公告)日：1999-08-17
申请号：US128540
申请日：1998-08-04
申请人： Hiroshi Goda , Junichi Sakamoto , Shigeki Sakaue , Sakae Kajihara , Miki Todo
发明人： Hiroshi Goda , Junichi Sakamoto , Shigeki Sakaue , Sakae Kajihara , Miki Todo
IPC分类号： C07D275/04 , C07D275/06 , C07D417/04
CPC分类号： C07D275/06
摘要： There is disclosed a process for preparing 3-piperazinylbenzisothiazoles comprising reacting the specified 3-halo-1,2-benzisothiazole or 2-cyanobenzenesulfenyl halide in the presence of an alkylene glycol derivative. The process is industrially effective, easy and economical and can provide useful intermediates for production of pharmaceutical preparations.
摘要翻译：公开了一种制备3-哌嗪基苯并异噻唑的方法，包括在亚烷基二醇衍生物存在下使指定的3-卤代-1,2-苯并异噻唑或2-氰基苯硫基卤化物反应。该方法在工业上有效，容易和经济，并且可以提供制备药物制剂的有用中间体。

7. 发明授权

US5861511A Process for preparation of 3 piperazinylbenzisothiazoles 失效
标题翻译：制备3哌嗪基苯并异噻唑的方法
公开(公告)号：US5861511A
公开(公告)日：1999-01-19
申请号：US938845
申请日：1997-09-26
申请人： Hiroshi Goda , Junichi Sakamoto , Shigeki Sakaue , Sakae Kajihara , Miki Todo
发明人： Hiroshi Goda , Junichi Sakamoto , Shigeki Sakaue , Sakae Kajihara , Miki Todo
IPC分类号： C07D275/04 , C07D275/06 , C07D417/04
CPC分类号： C07D275/06
摘要： There is disclosed a process for preparing 3-piperazinylbenzisothiazoles comprising reacting the specified 3-halo-1,2-benzisothiazole or 2-cyanobenzenesulfenyl halide in the presence of an alkylene glycol derivative. The process is industrially effective, easy and economical and can provide useful intermediates for production of pharmaceutical preparations.
摘要翻译：公开了一种制备3-哌嗪基苯并异噻唑的方法，包括在亚烷基二醇衍生物存在下使指定的3-卤代-1,2-苯并异噻唑或2-氰基苯硫基卤化物反应。该方法在工业上有效，容易和经济，并且可以提供制备药物制剂的有用中间体。

8. 发明授权

US5310940A Production of thiophene-2,5-dicarboxylic acid diesters, tetrahydrothiophene-2,5-dicarboxylic acid diesters and dibenzoxazolylthiophenes 失效
标题翻译：噻吩-2,5-二羧酸二酯，四氢噻吩-2,5-二羧酸二酯和二苯并恶唑基噻吩的制备
公开(公告)号：US5310940A
公开(公告)日：1994-05-10
申请号：US5463
申请日：1993-01-19
申请人： Hiroshi Goda , Nario Kimura , Satoshi Kimura , Naohiro Yoshikawa , Masaki Teramoto , Yoshihide Masuda , Yuuji Matuzaki
发明人： Hiroshi Goda , Nario Kimura , Satoshi Kimura , Naohiro Yoshikawa , Masaki Teramoto , Yoshihide Masuda , Yuuji Matuzaki
IPC分类号： C07D333/28 , C07D333/38 , C07D413/14
CPC分类号： C07D413/14 , C07D333/28 , C07D333/38
摘要： A method of producing a dibenzoxazolyl thiophene represented by the formula ##STR1## wherein R"' represents a hydrogen, an alkyl of 1-8 carbons, a cycloalkyl, a phenyl, a substituted phenyl or a benzyl, which includes: reacting a thiophene-2,5-dicarboxylic acid diester represented by the formula ##STR2## wherein R' represents a branched alkyl of 3-5 carbons, phenyl, or tolyl, with an aminophenol represented by the formula ##STR3## wherein R"' is the same as before, in the presence of an acid catalyst, wherein the acid catalyst is boric acid, phosphoric acid, polyphosphoric acid, zinc chloride, ferric chloride, or sulfuric acid.
摘要翻译：由式（V）表示的二苯并恶唑基噻吩的制备方法，其中R“表示氢，1-8个碳的烷基，环烷基，苯基，取代的苯基或苄基，其包括：使由式（I'）表示的噻吩-2,5-二羧酸二酯与其中R'表示3-5个碳的支链烷基，苯基或甲苯基与由式“IMAGE”表示的氨基苯酚反应，（VI）其中R“'与之前相同，在酸催化剂存在下，其中酸催化剂是硼酸，磷酸，多磷酸，氯化锌，氯化铁或硫酸。

9. 发明授权

US5093504A Production of thiophene-2,5-dicarboxylic acid diesters, tetrahydrothiophene-2,5-dicarboxylic acid diesters and dibenzoxazolylthiophenes 失效
标题翻译：二硫代-2,5-二羧酸二异氰酸酯的制备，四氢二羟基-2,5-二羧酸二异氰酸酯和二苯并咪唑啉酮
公开(公告)号：US5093504A
公开(公告)日：1992-03-03
申请号：US492072
申请日：1990-03-12
申请人： Hiroshi Goda , Nario Kimura , Satoshi Kimura , Naohiro Yoshikawa , Masaki Teramoto , Yoshihide Masuda , Yuuji Matuzaki
发明人： Hiroshi Goda , Nario Kimura , Satoshi Kimura , Naohiro Yoshikawa , Masaki Teramoto , Yoshihide Masuda , Yuuji Matuzaki
IPC分类号： C07D333/28 , C07D333/38 , C07D413/14
CPC分类号： C07D413/14 , C07D333/28 , C07D333/38
摘要： There is disclosed a method of producing a thiophene-2,5-dicarboxylic acid diester represented by the formula ##STR1## wherein R' represents an alkyl of 1-8 carbons, a phenyl, a substituted phenyl or benzyl, which comprises:halogenating a tetrahydrothiophene-2,5-dicarboxylic acid diester represented by the formula ##STR2## wherein R' is the same as before, with a halogenating agent selected from the group consisting of halogens and sulfuryl halides in an amount of 2-4 moles per mole of the tetrahydrothiophene-2,5-dicarboxylic acid diester; and thendehydrohalogenating the resultant halogenated tetrahydrothiphpene-2,5-dicarboxylic acid diester in the presence of an alcohol, a base, a metal or a metal ion.There is also disclosed a method of producing tetrahydrothiophene-2,5-dicarboxylic acid diester and dibenzoxazolyl thiophenes. Some of the thiophene-2,5-dicarboxylic acid diesters and tetrahydrothiophene-2,5-dicarboxylic acid diesters are novel.

10. 发明授权

US4792612A Thiophene derivatives and methods for producing the same 失效
标题翻译：噻吩衍生物及其制备方法
公开(公告)号：US4792612A
公开(公告)日：1988-12-20
申请号：US171388
申请日：1988-03-21
申请人： Hiroshi Goda , Masao Kawamura , Kunioki Kato , Makoto Sato
发明人： Hiroshi Goda , Masao Kawamura , Kunioki Kato , Makoto Sato
IPC分类号： C07D333/22 , C07D333/28 , C07D333/34 , C07D333/38 , C07D333/44
CPC分类号： C07D333/44 , C07D333/22 , C07D333/28 , C07D333/34 , C07D333/38
摘要： Novel compounds, 2-(.alpha.-alkoxyimino)ethylthiophenes are susceptible to electrophilic substitution reactions, and the acetylation, nitration, sulfonation and halogenation of the compounds provide 5-acetyl-2-(.alpha.-alkoxyimino)ethylthiophenes, 5-nitro-2-(.alpha.-alkoxyimino)ethylthiophenes, 5-(.alpha.-alkoxyimino)ethyl-2-thiophenesulfonic acid and 5-halo-2-(.alpha.-alkoxyimino)ethylthiophenes, respectively.The hydrolysis of 5-acetyl-2-(.alpha.-alkoxyimino)ethylthiophenes readily provides a known compound, 2,5-diacetylthiophene which is an important intermediate for the production of medicines, whereas the haloform reaction provides novel compounds, 5-(.alpha.-alkoxyimino)ethyl-2-thiophenecarboxylic acids, the hydrolysis of which compounds readily provides a known compound, 5-acetyl-2-thiophenecarboxylic acids, an important intermediate for the production of medicines.The hydrolysis of 5-(.alpha.-alkoxyimino)ethyl-2-thiophenesulfonic acids and their salts provide novel 5-acetyl-2-thiophenesulfonic acid and its salts, respectively.Novel compounds, 2-(.alpha.-alkoxyimino)ethylthiophenes are obtained either by 0-alkylation of 2-acetylthiophene oxime or by directly reacting 2-acetylthiophene with an 0-alkylhydroxylamine.
摘要翻译：新化合物2-（α-烷氧基亚氨基）乙基噻吩对亲电取代反应敏感，化合物的乙酰化，硝化，磺化和卤化提供5-乙酰基-2-（α-烷氧基亚氨基）乙基噻吩，5-硝基-2- （α-烷氧基亚氨基）乙基噻吩，5-（α-烷氧基亚氨基）乙基-2-噻吩磺酸和5-卤代-2-（α-烷氧基亚氨基）乙基噻吩。 5-乙酰基-2-（α-烷氧基亚氨基）乙基噻吩的水解容易提供已知的化合物，2,5-二乙酰基噻吩，其是制备药物的重要中间体，而卤代反应提供新化合物5-（α- 烷氧基亚氨基）乙基-2-噻吩羧酸，其中哪些化合物的水解容易提供已知化合物5-乙酰基-2-噻吩羧酸，这是生产药物的重要中间体。 5-（α-烷氧基亚氨基）乙基-2-噻吩磺酸及其盐的水解分别提供新的5-乙酰基-2-噻吩磺酸及其盐。通过2-乙酰基噻吩肟的O-烷基化或通过使2-乙酰基噻吩与O-烷基羟胺直接反应得到2-（α-烷氧基亚氨基）乙基噻吩的新型化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式