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1. 发明授权

US09506921B2 Method for determining exposure to mycobacteria 有权
标题翻译：确定分枝杆菌暴露的方法
公开(公告)号：US09506921B2
公开(公告)日：2016-11-29
申请号：US14008127
申请日：2012-03-30
申请人： Christopher David Gwenin , Mark Stephen Baird
发明人： Christopher David Gwenin , Mark Stephen Baird
IPC分类号： G01N33/53 , A61K39/04 , A61K39/02 , G01N33/569 , G01N33/58
CPC分类号： G01N33/5695 , G01N33/582 , G01N2469/20
摘要： A method of determining the presence or absence in a sample of a biomarker indicative of exposure to mycobacteria, the method comprising: (a) providing a substrate carrying a mycolic acid derived antigen; (b) contacting the substrate with the sample; (c) contacting the substrate with a fluorophore species; (d) creating an evanescent wave at the boundary of the substrate and the sample; (e) detecting the presence or absence of fluorescence.
摘要翻译：一种确定样品中存在或不存在指示暴露于分枝杆菌的生物标志物的方法，所述方法包括：（a）提供携带霉菌酸衍生抗原的底物; （b）使基材与样品接触; （c）使基底与荧光团物质接触; （d）在衬底和样品的边界处产生ev逝波; （e）检测是否存在荧光。

2. 发明授权

US08889894B2 Compounds for use in therapy 有权
标题翻译：用于治疗的化合物
公开(公告)号：US08889894B2
公开(公告)日：2014-11-18
申请号：US12988235
申请日：2009-04-22
申请人： Mark Stephen Baird , Juma′ a Raheem Najeem Al-Dulayy-mi , Cornelias Theunissen , Gani Koza , Seppe Vander-Beken , Johan Adriaan Marc Grooten
发明人： Mark Stephen Baird , Juma′ a Raheem Najeem Al-Dulayy-mi , Cornelias Theunissen , Gani Koza , Seppe Vander-Beken , Johan Adriaan Marc Grooten
IPC分类号： C07C59/185 , C07C61/04 , A61K9/127 , A61K31/00 , A61K9/00 , C07C59/11 , C07C59/13 , C07C59/215
CPC分类号： A61K31/00 , A61K9/0073 , A61K9/127 , C07B2200/07 , C07C59/11 , C07C59/13 , C07C59/185 , C07C59/215 , C07C2601/02
摘要： A compound of formula (I) for use in the treatment of a disease of the immune system; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R2, R3 and R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkenylene, arylene, alkylarylene, cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester and thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C—OR5; wherein R5 is alkyl or haloalkyl, and A is O, S or NR6, wherein R6 may be H or 20 alkyl.
摘要翻译：用于治疗免疫系统疾病的式（I）化合物; 其中R是具有1至50个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R1是具有1至40个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R 2，R 3和R 4各自独立地选自具有1至40个碳原子的任选取代的亚烷基，亚烯基，亚炔基，亚芳基，芳基亚烷基或烷基亚芳基; X，Y和Z各自独立地选自任选取代的亚烷基，亚烯基，亚烯基，亚芳基，亚烷基亚芳基，亚环烷基，酮，酯，酰胺，酰亚胺，亚胺，硫醚，醚，硫酯和硫酮; 并且P选自氢，烷基，糖残基或金属，鏻或铵物质; 其中X，Y和Z中的至少一个包括选自环丙基，C = A，C-AH和C-OR 5的部分; 其中R 5是烷基或卤代烷基，A是O，S或NR 6，其中R 6可以是H或20烷基。

3. 发明授权

US08728515B2 Adjuvants for use in vaccination 有权
标题翻译：用于疫苗接种的佐剂
公开(公告)号：US08728515B2
公开(公告)日：2014-05-20
申请号：US12988587
申请日：2009-04-22
申请人： Mark Stephen Baird , Juma' a Raheem Najeem Al-Dulayymi , Cornelia Theunissen , Gani Koza , Seppe Vander Beken , Johan Adriaan Marc Grooten
发明人： Mark Stephen Baird , Juma' a Raheem Najeem Al-Dulayymi , Cornelia Theunissen , Gani Koza , Seppe Vander Beken , Johan Adriaan Marc Grooten
IPC分类号： A61K9/127 , A61K39/00 , C07C61/00 , C07D303/12
CPC分类号： A61K39/39 , A61K2039/55555
摘要： A compound of formula (I) for use as an adjuvant in vaccination; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R2, R3 and R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene or cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester, thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C—OR5; wherein R5 is alkyl or haloalkyl, and A is S, O or NR6, wherein R6 maybe H or 20 alkyl.
摘要翻译：用作疫苗接种佐剂的式（I）化合物; 其中R是具有1至50个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R1是具有1至40个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R 2，R 3和R 4各自独立地选自具有1至40个碳原子的任选取代的亚烷基，亚烯基，亚炔基，亚芳基，芳基亚烷基或烷基亚芳基; X，Y和Z各自独立地选自任选取代的亚烷基，亚烯基，亚炔基，亚芳基，亚烷基亚芳基或亚环烷基，酮，酯，酰胺，酰亚胺，亚胺，硫醚，醚，硫酯，硫酮; 并且P选自氢，烷基，糖残基或金属，鏻或铵物质; 其中X，Y和Z中的至少一个包括选自环丙基，C = A，C-AH和C-OR 5的部分; 其中R 5是烷基或卤代烷基，A是S，O或NR 6，其中R 6可以是H或20烷基。

4. 发明申请

US20110009487A1 METHOD OF OBTAINING A SOLID COMPONENT RICH IN A PETROSELINIC COMPOUND 有权
标题翻译：获得在石油化合物中的固体组分的方法
公开(公告)号：US20110009487A1
公开(公告)日：2011-01-13
申请号：US12810001
申请日：2008-12-22
申请人： Mark Stephen Baird , David Preskett
发明人： Mark Stephen Baird , David Preskett
IPC分类号： A61K8/97 , C11B1/10 , C11B15/00 , A61Q19/00 , C10L5/00
CPC分类号： C11B1/10 , C11B7/0016 , C11B7/0025
摘要： A method of obtaining a solid component rich in a petroselinic compound from the seed of a plant of the Apiaceae or Araliaceae families, the method comprising: (a) treating a portion of the seed of the plant with an extraction solvent; and (b) inducing formation of the solid component.
摘要翻译：一种从伞形科或亚利奈科植物的种子获得富含岩石素化合物的固体成分的方法，所述方法包括：（a）用提取溶剂处理植物的一部分种子; 和（b）诱导固体成分的形成。

5. 发明申请

US20120296073A1 Composition and Method 审中-公开
标题翻译：组成和方法
公开(公告)号：US20120296073A1
公开(公告)日：2012-11-22
申请号：US13469470
申请日：2012-05-11
申请人： Mark Stephen Baird , David Preskett
发明人： Mark Stephen Baird , David Preskett
IPC分类号： C07H1/06 , C07C67/00 , C07H1/00 , C11C1/04 , C11B1/00
CPC分类号： A61K36/25 , A01N37/36 , A01N43/16 , A01N65/08
摘要： A process of obtaining a saponin-rich component from a plant of the Araliaceae family, the process comprising the steps of: (a) treating a portion of the plant with an extraction solvent in which saponin-containing compounds are soluble; and (b) treating the portion of plant or the extract obtained therefrom to remove fatty acid residues from said portion of plant or extract thereof.
摘要翻译：一种从花椰菜科植物获得富含皂苷的组分的方法，该方法包括以下步骤：（a）用含有皂苷的化合物可溶的提取溶剂处理一部分植物; 和（b）处理植物的部分或由其获得的提取物以从植物的部分或其提取物中除去脂肪酸残基。

6. 发明申请

US20140127709A1 METHOD FOR DETERMINING THE PRESENCE OR ABSENCE OF A BIOMARKER 有权
标题翻译：确定生物标记物存在或不存在的方法
公开(公告)号：US20140127709A1
公开(公告)日：2014-05-08
申请号：US14115929
申请日：2012-05-04
申请人： Christopher David Gwenin , Mark Stephen Baird , Vanessa Valerie Gwenin , Mark Pitts
发明人： Christopher David Gwenin , Mark Stephen Baird , Vanessa Valerie Gwenin , Mark Pitts
IPC分类号： G01N33/569 , C07H13/04 , C07C321/06
CPC分类号： G01N33/5695 , C07C321/06 , C07H13/04 , G01N33/585
摘要： A method of determining the presence or absence in a sample of a biomarker, the method comprising: (a) linking an antigen to colloidal gold to provide a gold-antigen species; (b) contacting the gold-antigen species with the sample; (c) adding a diagnosis agent to the sample; and (d) observing the colour of the sample.
摘要翻译：一种确定生物标志物样品中存在或不存在的方法，所述方法包括：（a）将抗原与胶体金连接以提供金抗原物种; （b）将金抗原物质与样品接触; （c）向样品添加诊断试剂; 和（d）观察样品的颜色。

7. 发明申请

US20120045478A1 METHOD AND COMPOSITIONS 审中-公开
标题翻译：方法和组成
公开(公告)号：US20120045478A1
公开(公告)日：2012-02-23
申请号：US13146997
申请日：2010-01-29
申请人： Mark Stephen Baird , Juma'a Raheem Najeem Al Dulayymi , Johan Adriaan Marc Grooten , Seppe Vander Beken , Maximilliano Maza-Inglesias
发明人： Mark Stephen Baird , Juma'a Raheem Najeem Al Dulayymi , Johan Adriaan Marc Grooten , Seppe Vander Beken , Maximilliano Maza-Inglesias
IPC分类号： A61K31/7024 , C07H1/00 , A61P37/00 , A61P17/00 , A61P17/02 , A61P17/06 , C07H13/06 , G01N33/569
CPC分类号： C07H13/04 , A61K31/7024 , A61K39/04 , C07H23/00 , G01N33/5695
摘要： A method of preparing a compound of formula (III): wherein x is from 1 to 6, y is from 1 to 12, z is from 0 to 10, each M and each M′ is independently a mycolic acid residue including a β-hydroxy acid moiety and each S is a monosaccharide unit; the method comprising reacting one or more mycolic acids with one or more saccharide units wherein the hydroxyl group of each β-hydroxy acid moiety is protected prior to reaction with the one or more saccharide units.
摘要翻译：制备式（III）化合物的方法：其中x为1至6，y为1至12，z为0至10，每个M和每个M'独立地为包含“bgr”的霉菌酸残基; - 羟基酸部分，每个S是单糖单元; 所述方法包括使一种或多种霉菌酸与一种或多种糖单元反应，其中在与一个或多个糖单元反应之前，保护每个＆bgr-羟酸部分的羟基。

8. 发明申请

US20110150981A1 Compounds for Use in Therapy 有权
标题翻译：化合物用于治疗
公开(公告)号：US20110150981A1
公开(公告)日：2011-06-23
申请号：US12988235
申请日：2009-04-22
申请人： Mark Stephen Baird , Juma' a Raheem Najeem Al-Dulayymi , Cornelias Theunissen , Gani Koza , Seppe Vander Beken , Johan Adriann March Grooten
发明人： Mark Stephen Baird , Juma' a Raheem Najeem Al-Dulayymi , Cornelias Theunissen , Gani Koza , Seppe Vander Beken , Johan Adriann March Grooten
IPC分类号： A61K31/231 , C07C59/01 , C07C59/11 , C07C59/215 , C07C69/533 , C07D303/38 , A61K31/20 , A61K31/201 , A61K31/336 , A61K9/127 , A61P37/00 , A61P11/06 , A61P17/00 , A61P25/00 , A61P21/04 , A61P3/10
CPC分类号： A61K31/00 , A61K9/0073 , A61K9/127 , C07B2200/07 , C07C59/11 , C07C59/13 , C07C59/185 , C07C59/215 , C07C2601/02
摘要： A compound of formula (I) for use in the treatment of a disease of the immune system; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R2, Wand R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkenylene, arylene, alkylarylene, cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester and thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C-OR5; wherein R5 is alkyl or haloalkyl, and A is O, S or Me, wherein R6 may be H or 20 alkyl.
摘要翻译：用于治疗免疫系统疾病的式（I）化合物; 其中R是具有1至50个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R1是具有1至40个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R 2，R 4和R 4各自独立地选自具有1至40个碳原子的任选取代的亚烷基，亚烯基，亚炔基，亚芳基，芳基亚烷基或烷基亚芳基; X，Y和Z各自独立地选自任选取代的亚烷基，亚烯基，亚烯基，亚芳基，亚烷基亚芳基，亚环烷基，酮，酯，酰胺，酰亚胺，亚胺，硫醚，醚，硫酯和硫酮; 并且P选自氢，烷基，糖残基或金属，鏻或铵物质; 其中X，Y和Z中的至少一个包括选自环丙基，C = A，C-AH和C-OR 5的部分; 其中R 5是烷基或卤代烷基，A是O，S或Me，其中R 6可以是H或20烷基。

9. 发明授权

US09945852B2 Method for determining the presence or absence of a biomarker 有权
公开(公告)号：US09945852B2
公开(公告)日：2018-04-17
申请号：US14115929
申请日：2012-05-04
申请人： Christopher David Gwenin , Mark Stephen Baird , Vanessa Valerie Gwenin , Mark Pitts
发明人： Christopher David Gwenin , Mark Stephen Baird , Vanessa Valerie Gwenin , Mark Pitts
IPC分类号： G01N33/569 , C07H13/04 , C07C321/06 , G01N33/58
CPC分类号： G01N33/5695 , C07C321/06 , C07H13/04 , G01N33/585
摘要： A method of determining the presence or absence in a sample of a biomarker, the method comprising: (a) linking an antigen to colloidal gold to provide a gold-antigen species; (b) contacting the gold-antigen species with the sample; (c) adding a diagnosis agent to the sample; and (d) observing the color of the sample.

10. 发明申请

US20140051599A1 METHOD FOR DETERMINING EXPOSURE TO MYCOBACTERIA 有权
标题翻译：用于确定暴露于MYCOBACTERIA的方法
公开(公告)号：US20140051599A1
公开(公告)日：2014-02-20
申请号：US14008127
申请日：2012-03-30
申请人： Christopher David Gwenin , Mark Stephen Baird
发明人： Christopher David Gwenin , Mark Stephen Baird
IPC分类号： G01N33/569
CPC分类号： G01N33/5695 , G01N33/582 , G01N2469/20
摘要： A method of determining the presence or absence in a sample of a biomarker indicative of exposure to mycobacteria, the method comprising: (a) providing a substrate carrying a mycolic acid derived antigen; (b) contacting the substrate with the sample; (c) contacting the substrate with a fluorophore species; (d) creating an evanescent wave at the boundary of the substrate and the sample; (e) detecting the presence or absence of fluorescence.
摘要翻译：一种确定样品中存在或不存在指示暴露于分枝杆菌的生物标志物的方法，所述方法包括：（a）提供携带霉菌酸衍生抗原的底物; （b）使基材与样品接触; （c）使基底与荧光团物质接触; （d）在衬底和样品的边界处产生ev逝波; （e）检测是否存在荧光。

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