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1. 发明授权

US08889894B2 Compounds for use in therapy 有权
标题翻译：用于治疗的化合物
公开(公告)号：US08889894B2
公开(公告)日：2014-11-18
申请号：US12988235
申请日：2009-04-22
申请人： Mark Stephen Baird , Juma′ a Raheem Najeem Al-Dulayy-mi , Cornelias Theunissen , Gani Koza , Seppe Vander-Beken , Johan Adriaan Marc Grooten
发明人： Mark Stephen Baird , Juma′ a Raheem Najeem Al-Dulayy-mi , Cornelias Theunissen , Gani Koza , Seppe Vander-Beken , Johan Adriaan Marc Grooten
IPC分类号： C07C59/185 , C07C61/04 , A61K9/127 , A61K31/00 , A61K9/00 , C07C59/11 , C07C59/13 , C07C59/215
CPC分类号： A61K31/00 , A61K9/0073 , A61K9/127 , C07B2200/07 , C07C59/11 , C07C59/13 , C07C59/185 , C07C59/215 , C07C2601/02
摘要： A compound of formula (I) for use in the treatment of a disease of the immune system; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R2, R3 and R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkenylene, arylene, alkylarylene, cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester and thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C—OR5; wherein R5 is alkyl or haloalkyl, and A is O, S or NR6, wherein R6 may be H or 20 alkyl.
摘要翻译：用于治疗免疫系统疾病的式（I）化合物; 其中R是具有1至50个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R1是具有1至40个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R 2，R 3和R 4各自独立地选自具有1至40个碳原子的任选取代的亚烷基，亚烯基，亚炔基，亚芳基，芳基亚烷基或烷基亚芳基; X，Y和Z各自独立地选自任选取代的亚烷基，亚烯基，亚烯基，亚芳基，亚烷基亚芳基，亚环烷基，酮，酯，酰胺，酰亚胺，亚胺，硫醚，醚，硫酯和硫酮; 并且P选自氢，烷基，糖残基或金属，鏻或铵物质; 其中X，Y和Z中的至少一个包括选自环丙基，C = A，C-AH和C-OR 5的部分; 其中R 5是烷基或卤代烷基，A是O，S或NR 6，其中R 6可以是H或20烷基。

2. 发明授权

US08728515B2 Adjuvants for use in vaccination 有权
标题翻译：用于疫苗接种的佐剂
公开(公告)号：US08728515B2
公开(公告)日：2014-05-20
申请号：US12988587
申请日：2009-04-22
申请人： Mark Stephen Baird , Juma' a Raheem Najeem Al-Dulayymi , Cornelia Theunissen , Gani Koza , Seppe Vander Beken , Johan Adriaan Marc Grooten
发明人： Mark Stephen Baird , Juma' a Raheem Najeem Al-Dulayymi , Cornelia Theunissen , Gani Koza , Seppe Vander Beken , Johan Adriaan Marc Grooten
IPC分类号： A61K9/127 , A61K39/00 , C07C61/00 , C07D303/12
CPC分类号： A61K39/39 , A61K2039/55555
摘要： A compound of formula (I) for use as an adjuvant in vaccination; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R2, R3 and R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene or cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester, thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C—OR5; wherein R5 is alkyl or haloalkyl, and A is S, O or NR6, wherein R6 maybe H or 20 alkyl.
摘要翻译：用作疫苗接种佐剂的式（I）化合物; 其中R是具有1至50个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R1是具有1至40个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R 2，R 3和R 4各自独立地选自具有1至40个碳原子的任选取代的亚烷基，亚烯基，亚炔基，亚芳基，芳基亚烷基或烷基亚芳基; X，Y和Z各自独立地选自任选取代的亚烷基，亚烯基，亚炔基，亚芳基，亚烷基亚芳基或亚环烷基，酮，酯，酰胺，酰亚胺，亚胺，硫醚，醚，硫酯，硫酮; 并且P选自氢，烷基，糖残基或金属，鏻或铵物质; 其中X，Y和Z中的至少一个包括选自环丙基，C = A，C-AH和C-OR 5的部分; 其中R 5是烷基或卤代烷基，A是S，O或NR 6，其中R 6可以是H或20烷基。

3. 发明申请

US20110150981A1 Compounds for Use in Therapy 有权
标题翻译：化合物用于治疗
公开(公告)号：US20110150981A1
公开(公告)日：2011-06-23
申请号：US12988235
申请日：2009-04-22
申请人： Mark Stephen Baird , Juma' a Raheem Najeem Al-Dulayymi , Cornelias Theunissen , Gani Koza , Seppe Vander Beken , Johan Adriann March Grooten
发明人： Mark Stephen Baird , Juma' a Raheem Najeem Al-Dulayymi , Cornelias Theunissen , Gani Koza , Seppe Vander Beken , Johan Adriann March Grooten
IPC分类号： A61K31/231 , C07C59/01 , C07C59/11 , C07C59/215 , C07C69/533 , C07D303/38 , A61K31/20 , A61K31/201 , A61K31/336 , A61K9/127 , A61P37/00 , A61P11/06 , A61P17/00 , A61P25/00 , A61P21/04 , A61P3/10
CPC分类号： A61K31/00 , A61K9/0073 , A61K9/127 , C07B2200/07 , C07C59/11 , C07C59/13 , C07C59/185 , C07C59/215 , C07C2601/02
摘要： A compound of formula (I) for use in the treatment of a disease of the immune system; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R2, Wand R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkenylene, arylene, alkylarylene, cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester and thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C-OR5; wherein R5 is alkyl or haloalkyl, and A is O, S or Me, wherein R6 may be H or 20 alkyl.
摘要翻译：用于治疗免疫系统疾病的式（I）化合物; 其中R是具有1至50个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R1是具有1至40个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R 2，R 4和R 4各自独立地选自具有1至40个碳原子的任选取代的亚烷基，亚烯基，亚炔基，亚芳基，芳基亚烷基或烷基亚芳基; X，Y和Z各自独立地选自任选取代的亚烷基，亚烯基，亚烯基，亚芳基，亚烷基亚芳基，亚环烷基，酮，酯，酰胺，酰亚胺，亚胺，硫醚，醚，硫酯和硫酮; 并且P选自氢，烷基，糖残基或金属，鏻或铵物质; 其中X，Y和Z中的至少一个包括选自环丙基，C = A，C-AH和C-OR 5的部分; 其中R 5是烷基或卤代烷基，A是O，S或Me，其中R 6可以是H或20烷基。

4. 发明申请

US20110142916A1 Adjuvants for Use in Vaccination 有权
标题翻译：佐剂用于疫苗接种
公开(公告)号：US20110142916A1
公开(公告)日：2011-06-16
申请号：US12988587
申请日：2009-04-22
申请人： Mark Stephen Baird , Juma' a Raheem Najeem Al-Dulayymi , Cornelias Theunissen , Gani Koza , Seppe Vander Beken , Johan Adriann Marc Grooten
发明人： Mark Stephen Baird , Juma' a Raheem Najeem Al-Dulayymi , Cornelias Theunissen , Gani Koza , Seppe Vander Beken , Johan Adriann Marc Grooten
IPC分类号： A61K9/127 , A61K39/00 , C07C59/01 , C07C61/12 , C07C61/04 , C07C59/90 , C07D303/38 , A61P31/00
CPC分类号： A61K39/39 , A61K2039/55555
摘要： A compound of formula (I) for use as an adjuvant in vaccination; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R2, R3 and R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene or cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester, thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C—OR5; wherein R5 is alkyl or haloalkyl, and A is S, O or NR6, wherein R6 maybe H or 20 alkyl.
摘要翻译：用作疫苗接种佐剂的式（I）化合物; 其中R是具有1至50个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R1是具有1至40个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R 2，R 3和R 4各自独立地选自具有1至40个碳原子的任选取代的亚烷基，亚烯基，亚炔基，亚芳基，芳基亚烷基或烷基亚芳基; X，Y和Z各自独立地选自任选取代的亚烷基，亚烯基，亚炔基，亚芳基，亚烷基亚芳基或亚环烷基，酮，酯，酰胺，酰亚胺，亚胺，硫醚，醚，硫酯，硫酮; 并且P选自氢，烷基，糖残基或金属，鏻或铵物质; 其中X，Y和Z中的至少一个包括选自环丙基，C = A，C-AH和C-OR 5的部分; 其中R 5是烷基或卤代烷基，A是S，O或NR 6，其中R 6可以是H或20烷基。

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