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1. 发明申请

US20120045478A1 METHOD AND COMPOSITIONS 审中-公开
标题翻译：方法和组成
公开(公告)号：US20120045478A1
公开(公告)日：2012-02-23
申请号：US13146997
申请日：2010-01-29
申请人： Mark Stephen Baird , Juma'a Raheem Najeem Al Dulayymi , Johan Adriaan Marc Grooten , Seppe Vander Beken , Maximilliano Maza-Inglesias
发明人： Mark Stephen Baird , Juma'a Raheem Najeem Al Dulayymi , Johan Adriaan Marc Grooten , Seppe Vander Beken , Maximilliano Maza-Inglesias
IPC分类号： A61K31/7024 , C07H1/00 , A61P37/00 , A61P17/00 , A61P17/02 , A61P17/06 , C07H13/06 , G01N33/569
CPC分类号： C07H13/04 , A61K31/7024 , A61K39/04 , C07H23/00 , G01N33/5695
摘要： A method of preparing a compound of formula (III): wherein x is from 1 to 6, y is from 1 to 12, z is from 0 to 10, each M and each M′ is independently a mycolic acid residue including a β-hydroxy acid moiety and each S is a monosaccharide unit; the method comprising reacting one or more mycolic acids with one or more saccharide units wherein the hydroxyl group of each β-hydroxy acid moiety is protected prior to reaction with the one or more saccharide units.
摘要翻译：制备式（III）化合物的方法：其中x为1至6，y为1至12，z为0至10，每个M和每个M'独立地为包含“bgr”的霉菌酸残基; - 羟基酸部分，每个S是单糖单元; 所述方法包括使一种或多种霉菌酸与一种或多种糖单元反应，其中在与一个或多个糖单元反应之前，保护每个＆bgr-羟酸部分的羟基。

2. 发明授权

US08889894B2 Compounds for use in therapy 有权
标题翻译：用于治疗的化合物
公开(公告)号：US08889894B2
公开(公告)日：2014-11-18
申请号：US12988235
申请日：2009-04-22
申请人： Mark Stephen Baird , Juma′ a Raheem Najeem Al-Dulayy-mi , Cornelias Theunissen , Gani Koza , Seppe Vander-Beken , Johan Adriaan Marc Grooten
发明人： Mark Stephen Baird , Juma′ a Raheem Najeem Al-Dulayy-mi , Cornelias Theunissen , Gani Koza , Seppe Vander-Beken , Johan Adriaan Marc Grooten
IPC分类号： C07C59/185 , C07C61/04 , A61K9/127 , A61K31/00 , A61K9/00 , C07C59/11 , C07C59/13 , C07C59/215
CPC分类号： A61K31/00 , A61K9/0073 , A61K9/127 , C07B2200/07 , C07C59/11 , C07C59/13 , C07C59/185 , C07C59/215 , C07C2601/02
摘要： A compound of formula (I) for use in the treatment of a disease of the immune system; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R2, R3 and R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkenylene, arylene, alkylarylene, cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester and thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C—OR5; wherein R5 is alkyl or haloalkyl, and A is O, S or NR6, wherein R6 may be H or 20 alkyl.
摘要翻译：用于治疗免疫系统疾病的式（I）化合物; 其中R是具有1至50个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R1是具有1至40个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R 2，R 3和R 4各自独立地选自具有1至40个碳原子的任选取代的亚烷基，亚烯基，亚炔基，亚芳基，芳基亚烷基或烷基亚芳基; X，Y和Z各自独立地选自任选取代的亚烷基，亚烯基，亚烯基，亚芳基，亚烷基亚芳基，亚环烷基，酮，酯，酰胺，酰亚胺，亚胺，硫醚，醚，硫酯和硫酮; 并且P选自氢，烷基，糖残基或金属，鏻或铵物质; 其中X，Y和Z中的至少一个包括选自环丙基，C = A，C-AH和C-OR 5的部分; 其中R 5是烷基或卤代烷基，A是O，S或NR 6，其中R 6可以是H或20烷基。

3. 发明授权

US08728515B2 Adjuvants for use in vaccination 有权
标题翻译：用于疫苗接种的佐剂
公开(公告)号：US08728515B2
公开(公告)日：2014-05-20
申请号：US12988587
申请日：2009-04-22
申请人： Mark Stephen Baird , Juma' a Raheem Najeem Al-Dulayymi , Cornelia Theunissen , Gani Koza , Seppe Vander Beken , Johan Adriaan Marc Grooten
发明人： Mark Stephen Baird , Juma' a Raheem Najeem Al-Dulayymi , Cornelia Theunissen , Gani Koza , Seppe Vander Beken , Johan Adriaan Marc Grooten
IPC分类号： A61K9/127 , A61K39/00 , C07C61/00 , C07D303/12
CPC分类号： A61K39/39 , A61K2039/55555
摘要： A compound of formula (I) for use as an adjuvant in vaccination; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R2, R3 and R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene or cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester, thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C—OR5; wherein R5 is alkyl or haloalkyl, and A is S, O or NR6, wherein R6 maybe H or 20 alkyl.
摘要翻译：用作疫苗接种佐剂的式（I）化合物; 其中R是具有1至50个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R1是具有1至40个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R 2，R 3和R 4各自独立地选自具有1至40个碳原子的任选取代的亚烷基，亚烯基，亚炔基，亚芳基，芳基亚烷基或烷基亚芳基; X，Y和Z各自独立地选自任选取代的亚烷基，亚烯基，亚炔基，亚芳基，亚烷基亚芳基或亚环烷基，酮，酯，酰胺，酰亚胺，亚胺，硫醚，醚，硫酯，硫酮; 并且P选自氢，烷基，糖残基或金属，鏻或铵物质; 其中X，Y和Z中的至少一个包括选自环丙基，C = A，C-AH和C-OR 5的部分; 其中R 5是烷基或卤代烷基，A是S，O或NR 6，其中R 6可以是H或20烷基。

4. 发明授权

US06344192B1 Use of interleukin-15 有权
标题翻译：使用白细胞介素-15
公开(公告)号：US06344192B1
公开(公告)日：2002-02-05
申请号：US09380049
申请日：1999-08-23
申请人： Johan Adriaan Marc Grooten , Hans Peter Raf Dooms , Walter Charles Fiers
发明人： Johan Adriaan Marc Grooten , Hans Peter Raf Dooms , Walter Charles Fiers
IPC分类号： A61K4500
CPC分类号： A61K38/2086 , A61K38/1793 , Y10S930/14 , Y10S930/141
摘要： The invention relates to the use of IL-15 or active variants thereof and/or IL-15 activity enhancing compounds for the manufacture of a pharmaceutical composition for manipulating memory cells of the immune system, such as manipulating viability ad/or responsiveness of said memory cells. The IL-15 activity enhancing compound is for example lipopolysaccharidc (LPS). The invention further relates to the use of IL-15 inhibiting or eliminating compounds for the manufacture of a pharmaceutical composition for manipulating memory cells of the immune system. Such inhibiting or eliminating compounds are for example anti-IL-15 antibodies, anti-IL-15R&agr; antibodies, fragments of these antibodies, e.g. the Fab or F(ab′)2 fragment, soluble IL-15R&agr;, fusion proteins consisting of soluble IL-15R&agr;, and Fc fragment, compounds, e.g. peptides, binding and/or inhibiting functional IL-15 receptor, IL-15 antisense oligonucleotides.
摘要翻译：本发明涉及IL-15或其活性变体和/或IL-15活性增强化合物在制备用于操纵免疫系统的记忆细胞的药物组合物中的用途，例如操纵所述存储器的存活力或反应性细胞。 IL-15活性增强化合物是例如脂多糖（LPS）。本发明还涉及IL-15抑制或消除化合物用于制造用于操纵免疫系统的记忆细胞的药物组合物的用途。这样的抑制或消除化合物是例如抗IL-15抗体，抗IL-15Rα抗体，这些抗体的片段，例如， Fab或F（ab'）2片段，可溶性IL-15Rα，由可溶性IL-15Rα和Fc片段组成的融合蛋白，例如化合物。肽，结合和/或抑制功能性IL-15受体，IL-15反义寡核苷酸。

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