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1. 发明授权

US09096508B2 Method for producing carotenoid composition 有权
标题翻译：生产类胡萝卜素组合物的方法
公开(公告)号：US09096508B2
公开(公告)日：2015-08-04
申请号：US14130132
申请日：2012-06-29
申请人： Kento Kanaya , Koichi Kinoshita , Masaru Hirano
发明人： Kento Kanaya , Koichi Kinoshita , Masaru Hirano
IPC分类号： C12R1/645 , C12P23/00 , C07C45/78 , C07C403/24 , A61K31/122 , A61K31/575 , A61K36/07
CPC分类号： C07C45/78 , A61K31/122 , A61K31/575 , A61K36/07 , C07C403/24 , C07C2601/14 , C12P23/00
摘要： The present invention provides an efficient method for industrially producing a naturally-derived carotenoid composition with a large amount of a carotenoid such as astaxanthin from a culture of a yeast of the genus Xanthophyllomyces without requiring any special extraction equipment and any complicated refinement process and without any need for organic solvents harmful to humans. Provided is a method for producing a carotenoid composition, including the steps of washing a carotenoid-containing yeast of the genus Xanthophyllomyces with an organic solvent (A) at 30° C. or lower, and extracting a carotenoid from the washed yeast with an organic solvent (B) at 10° C. to 70° C.
摘要翻译：本发明提供一种有效的方法，用于工业生产具有大量类胡萝卜素的类胡萝卜素组合物，所述类胡萝卜素组合物具有大量的类胡萝卜素，如来自叶黄素属酵母的培养物中的虾青素，而不需要任何特殊的提取设备和任何复杂的精制过程，需要对人体有害的有机溶剂。本发明提供一种制备类胡萝卜素组合物的方法，包括以下步骤：用有机溶剂（A）在30℃或更低温度下清洗含有类胡萝卜素的酵母属的Xanthophyllomyces酵母，并用有机溶剂从洗涤的酵母中提取类胡萝卜素溶剂（B）在10℃至70℃

2. 发明申请

US20110091553A1 METHOD FOR PRODUCING MICROCAPSULES USING SOLID FAT 审中-公开
标题翻译：使用固体脂肪生产微球的方法
公开(公告)号：US20110091553A1
公开(公告)日：2011-04-21
申请号：US12995819
申请日：2009-06-02
申请人： Kento Kanaya , Masao Sato
发明人： Kento Kanaya , Masao Sato
IPC分类号： A61K9/00 , A61K38/40 , A61P31/04 , A23D9/00 , A23D9/05
CPC分类号： A61K35/20 , A23L33/19 , A23P10/35 , A61K9/1617 , A61K9/1694 , A61K38/00 , A61K47/14 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/44
摘要： An object of the present invention is to provide a method for production of fine microcapsules which encapsulate a hydrophilic bioactive substance at a high content and can be used in wide range of applications such as foods and medical drugs, which method enabling efficient industrial production. The present invention is directed to a method for production of S/O type microcapsules in which a hydrophilic bioactive substance is polydispersed in a solid fat matrix, including steps of: dispersing a complex of the hydrophilic bioactive substance with a surfactant (A) in a solid fat at a temperature not lower than the melting point of the solid fat to obtain an S/O suspension, followed by permitting liquid droplet dispersion of the S/O suspension, and hardening the solid fat by cooling the S/O suspension liquid droplets to lower than the melting point of the solid fat to obtain solid particles; and an S/O type microcapsule wherein a milk protein-derived ingredient such as lactoferrin is polydispersed in a solid fat matrix.
摘要翻译：本发明的目的在于提供一种以高含量包封亲水性生物活性物质的精细微胶囊的制造方法，能够广泛应用于食品，医药等领域，能够实现高效的工业化生产。本发明涉及一种生产S / O型微胶囊的方法，其中亲水性生物活性物质多分散在固体脂肪基质中，包括以下步骤：将亲水性生物活性物质与表面活性剂（A）的配合物分散在固体脂肪在固体脂肪的熔点以上的温度下得到S / O悬浮液，然后允许S / O悬浮液的液滴分散，并通过冷却S / O悬浮液液滴硬化固体脂肪低于固体脂肪的熔点，得到固体颗粒; 和S / O型微胶囊，其中乳蛋白衍生成分如乳铁蛋白多分散在固体脂肪基质中。

3. 发明授权

US09006493B2 Method for manufacturing a fat-soluble bioactive substance 有权
标题翻译：脂溶性生物活性物质的制造方法
公开(公告)号：US09006493B2
公开(公告)日：2015-04-14
申请号：US13811049
申请日：2011-07-22
申请人： Kento Kanaya , Yasuyuki Suzuki , Akihisa Kanda , Kazuya Yokoe
发明人： Kento Kanaya , Yasuyuki Suzuki , Akihisa Kanda , Kazuya Yokoe
IPC分类号： C07C45/00 , C07C45/80 , C12P7/66 , B01D11/02
CPC分类号： C07C45/80 , A23L29/10 , A23L33/105 , B01D11/0288 , C09B61/00 , C12P7/66
摘要： Provided is a production method of a lipophilic bioactive substance, which includes mixing an aqueous suspension of a microbial cell containing the lipophilic bioactive substance or a microbial cell homogenate thereof and an organic solvent in the presence of a particular surfactant, and extracting the lipophilic bioactive substance into the organic solvent phase.This production method enables extraction without using special dehydrating, drying facility, and without causing a decrease in the yield due to degraded separability between solvent and fungus body component, as well as efficient industrial production.
摘要翻译：本发明提供一种亲脂性生物活性物质的制造方法，其特征在于，在特定的表面活性剂的存在下，将含有所述亲油性生物活性物质的微生物细胞的水性悬浮液或其微生物细胞匀浆与有机溶剂混合，并且提取所述亲脂性生物活性物质进入有机溶剂相。该制造方法能够在不使用特殊的脱水干燥装置的情况下进行提取，并且不会由于溶剂和真菌体成分之间的分离性降低而导致产率降低，以及高效的工业生产。

4. 发明申请

US20130225868A1 METHOD FOR MANUFACTURING A FAT-SOLUBLE BIOACTIVE SUBSTANCE 有权
标题翻译：制造脂溶性生物活性物质的方法
公开(公告)号：US20130225868A1
公开(公告)日：2013-08-29
申请号：US13811049
申请日：2011-07-22
申请人： Kento Kanaya , Yasuyuki Suzuki , Akihisa Kanda , Kazuya Yokoe
发明人： Kento Kanaya , Yasuyuki Suzuki , Akihisa Kanda , Kazuya Yokoe
IPC分类号： C07C45/80
CPC分类号： C07C45/80 , A23L29/10 , A23L33/105 , B01D11/0288 , C09B61/00 , C12P7/66
摘要： Provided is a production method of a lipophilic bioactive substance, which includes mixing an aqueous suspension of a microbial cell containing the lipophilic bioactive substance or a microbial cell homogenate thereof and an organic solvent in the presence of a particular surfactant, and extracting the lipophilic bioactive substance into the organic solvent phase.This production method enables extraction without using special dehydrating, drying facility, and without causing a decrease in the yield due to degraded separability between solvent and fungus body component, as well as efficient industrial production.
摘要翻译：本发明提供一种亲脂性生物活性物质的制造方法，其特征在于，在特定的表面活性剂的存在下，将含有所述亲油性生物活性物质的微生物细胞的水性悬浮液或其微生物细胞匀浆与有机溶剂混合，并且提取所述亲脂性生物活性物质进入有机溶剂相。该制造方法能够在不使用特殊的脱水干燥装置的情况下进行提取，并且不会由于溶剂和真菌体成分之间的分离性降低而导致产率降低，以及高效的工业生产。

5. 发明申请

US20100004473A1 METHOD FOR PRODUCING COENZYME Q10 PARTICLE 有权
标题翻译：生产聚苯乙烯Q10颗粒的方法
公开(公告)号：US20100004473A1
公开(公告)日：2010-01-07
申请号：US12522792
申请日：2008-01-10
申请人： Kento Kanaya , Shiro Kitamura , Takahiro Ueda
发明人： Kento Kanaya , Shiro Kitamura , Takahiro Ueda
IPC分类号： C07C50/28
CPC分类号： A61K31/122 , A23V2250/314 , A61K9/1075 , A61K9/141 , A61K9/16 , A61K9/1617 , A61K9/1652 , A61K9/1688 , C07C46/10 , C07C50/28 , C09K15/08
摘要： The present invention aims to provide a production method capable of industrially and producing coenzyme Q10 particles having a high content and superior powder flowability characteristics by simple facility and convenient operations. The present invention provides a method of producing coenzyme Q10 particles, including mixing coenzyme Q10 and a poor solvent by stirring at a temperature not less than the melting point of coenzyme Q10, dispersing coenzyme Q10 into the form of oil droplets, and cooling them to a solidification temperature of coenzyme Q10 or below while stirring the dispersion to give solid particles, wherein the poor solvent is an aqueous solution comprising an organic solvent and/or a surfactant having an HLB of 6 or above. According to the production method of the present invention, coenzyme Q10 particles markedly superior in powder characteristics, and having, for example, a powder flowability index of not less than 80 can be obtained.
摘要翻译：本发明的目的是提供一种能够通过简单的设备和方便的操作在工业上生产具有高含量和优异的粉末流动性特性的辅酶Q10颗粒的生产方法。本发明提供一种生产辅酶Q10颗粒的方法，包括在不少于辅酶Q10的熔点的温度下搅拌辅助辅酶Q10和不良溶剂，将辅酶Q10分散成油滴形式，并将其冷却至在搅拌分散体以得到固体颗粒的同时，辅酶Q10或更低的固化温度，其中不良溶剂是包含HLB为6或更高的有机溶剂和/或表面活性剂的水溶液。根据本发明的制造方法，可以得到粉末特性显着优异的，具有例如不小于80的粉末流动指数的辅酶Q10颗粒。

6. 发明申请

US20130172538A1 METHOD FOR PRODUCING POROUS PARTICLES, POROUS PARTICLES, ADSORBENT BODY, AND METHOD FOR PURIFYING PROTEIN 审中-公开
标题翻译：生产多孔颗粒的方法，多孔颗粒，吸附体以及净化蛋白质的方法
公开(公告)号：US20130172538A1
公开(公告)日：2013-07-04
申请号：US13821836
申请日：2011-09-12
申请人： Masaru Hirano , Yasuyuki Suzuki , Kento Kanaya , Akihisa Kanda , Takuma Suzuki , Yoshikazu Kawai , Ken-Ichiro Morio
发明人： Masaru Hirano , Yasuyuki Suzuki , Kento Kanaya , Akihisa Kanda , Takuma Suzuki , Yoshikazu Kawai , Ken-Ichiro Morio
IPC分类号： C08B1/00 , B01J20/285 , C07K1/22
CPC分类号： C08B1/003 , B01D15/3809 , B01J20/262 , B01J20/267 , B01J20/28004 , B01J20/285 , B01J20/3212 , B01J20/3274 , C07K1/22 , C08J3/16 , C08J9/28 , C08J2201/0482 , C08J2207/12 , C08J2301/02 , Y10T428/2982
摘要： The objective of the present invention is to provide a method for easily producing a porous cellulose particle which can be used as an adsorbent for various substances in a safe manner without using a highly toxic solvent such as a calcium thiocyanate solution. In addition, the objective of the present invention is to provide a porous particle produced by the production method, an adsorbent which contains the porous particle and by which a highly pure protein can be efficiently purified in a safe manner, and a method for purifying a protein by using the adsorbent. The method for producing a porous particle according to the present invention is characterized in comprising the steps of preparing a solution containing cellulose and an ionic liquid; preparing a dispersion by dispersing the obtained cellulose solution into a liquid, wherein the liquid is not compatible with the ionic liquid; and coagulating the dispersion by bringing into contact with an alcohol or an alcohol aqueous solution in order in order to obtain the porous particle.
摘要翻译：本发明的目的是提供一种容易地制造多孔纤维素颗粒的方法，该方法可以在不使用高毒性溶剂如硫氰酸钙溶液的情况下以安全的方式用作各种物质的吸附剂。此外，本发明的目的是提供一种通过该制造方法制造的多孔质粒子，含有多孔质粒子的吸附剂，能够高效纯化高纯度蛋白质的方法，蛋白质。本发明的多孔质粒的制造方法的特征在于，包括以下步骤：制备含有纤维素和离子液体的溶液; 通过将获得的纤维素溶液分散到液体中制备分散体，其中液体与离子液体不相容; 并通过与醇或醇水溶液接触来依次凝固分散体，以获得多孔颗粒。

7. 发明申请

US20100297222A1 METHOD FOR PRODUCTION OF MICROCAPSULES USING SOLID FAT 失效
标题翻译：使用固体脂肪生产微胶囊的方法
公开(公告)号：US20100297222A1
公开(公告)日：2010-11-25
申请号：US12741565
申请日：2008-11-06
申请人： Kento Kanaya , Masao ` Sato , Akihisa Kanda
发明人： Kento Kanaya , Masao ` Sato , Akihisa Kanda
IPC分类号： A61K9/50 , A61K38/06 , A61K38/05 , A61P29/00 , A61P39/06 , A61P1/16
CPC分类号： B01J13/04 , A23L33/10 , A23L33/175 , A23P10/35 , A61K9/5015 , A61K38/05 , A61K38/063
摘要： A method for production of fine microcapsules which encapsulate a hydrophilic bioactive substance at a high content and can be used in wide range of applications such as foods and medical drugs, which method enabling efficient industrial production, is provided. A method for production of S/O type microcapsules including the steps of: (1) emulsifying and dispersing a mixture of a solid fat and an aqueous solution containing a hydrophilic bioactive substance at a temperature of at least the melting point of the solid fat to obtain a W/O emulsion; (2) removing moisture in the W/O emulsion at a temperature of at least the melting point and lower than the boiling point of the solid fat to obtain an S/O suspension; (3) adding the S/O suspension into an aqueous phase containing at least one selected from a surfactant (B), a thickening agent and a hydrophilic organic solvent, and permitting liquid droplet dispersion at a temperature of at least the melting point and lower than the boiling point of the solid fat to obtain an S/O/W emulsion; and (4) cooling the S/O/W emulsion to lower than the melting point of the solid fat to harden the solid fat, and further removing the moisture at a temperature lower than the melting point of the solid fat.
摘要翻译：提供了以高含量包封亲水性生物活性物质的精细微胶囊的制造方法，可以广泛应用于食品，医药等领域，能够实现高效的工业化生产。一种生产S / O型微胶囊的方法，包括以下步骤：（1）将固体脂肪和含有亲水性生物活性物质的水溶液的混合物在至少固体脂肪熔点的温度下乳化和分散至获得W / O乳液; （2）在至少熔点低于固体脂肪沸点的温度下除去W / O乳液中的水分，得到S / O悬浮液; （3）将S / O悬浮液加入到含有选自表面活性剂（B），增稠剂和亲水性有机溶剂中的至少一种的水相中，并允许液滴在至少熔点和更低的温度下分散比固体脂肪的沸点得到S / O / W乳液; 和（4）将S / O / W乳液冷却至低于固体脂肪的熔点，使固体脂肪硬化，并在低于固体脂肪熔点的温度下进一步除去水分。

8. 发明申请

US20140179657A1 METHOD FOR PRODUCING CAROTENOID COMPOSITION 有权
标题翻译：生产牙釉质组合物的方法
公开(公告)号：US20140179657A1
公开(公告)日：2014-06-26
申请号：US14130132
申请日：2012-06-29
申请人： Kento Kanaya , Koichi Kinoshita , Masaru Hirano
发明人： Kento Kanaya , Koichi Kinoshita , Masaru Hirano
IPC分类号： C07C45/78 , A61K31/575 , A61K36/07 , A61K31/122
CPC分类号： C07C45/78 , A61K31/122 , A61K31/575 , A61K36/07 , C07C403/24 , C07C2601/14 , C12P23/00
摘要： The present invention provides an efficient method for industrially producing a naturally-derived carotenoid composition with a large amount of a carotenoid such as astaxanthin from a culture of a yeast of the genus Xanthophyllomyces without requiring any special extraction equipment and any complicated refinement process and without any need for organic solvents harmful to humans. Provided is a method for producing a carotenoid composition, including the steps of washing a carotenoid-containing yeast of the genus Xanthophyllomyces with an organic solvent (A) at 30° C. or lower, and extracting a carotenoid from the washed yeast with an organic solvent (B) at 10° C. to 70° C.
摘要翻译：本发明提供一种有效的方法，用于工业生产具有大量类胡萝卜素的类胡萝卜素组合物，所述类胡萝卜素组合物具有大量的类胡萝卜素，如来自叶黄素属酵母的培养物中的虾青素，而不需要任何特殊的提取设备和任何复杂的精制过程，需要对人体有害的有机溶剂。本发明提供一种制备类胡萝卜素组合物的方法，包括以下步骤：用有机溶剂（A）在30℃或更低温度下清洗含有类胡萝卜素的酵母属的Xanthophyllomyces酵母，并用有机溶剂从洗涤的酵母中提取类胡萝卜素溶剂（B）在10℃至70℃

9. 发明授权

US08568779B2 Method for producing coenzyme Q10 particle 有权
标题翻译：辅酶Q10颗粒的生产方法
公开(公告)号：US08568779B2
公开(公告)日：2013-10-29
申请号：US12522792
申请日：2008-01-10
申请人： Kento Kanaya , Shiro Kitamura , Takahiro Ueda
发明人： Kento Kanaya , Shiro Kitamura , Takahiro Ueda
IPC分类号： A61K9/16 , A61K31/122 , C07C46/10 , A61K9/107 , C07C50/28 , C09K15/08
CPC分类号： A61K31/122 , A23V2250/314 , A61K9/1075 , A61K9/141 , A61K9/16 , A61K9/1617 , A61K9/1652 , A61K9/1688 , C07C46/10 , C07C50/28 , C09K15/08
摘要： The present invention aims to provide a production method capable of industrially and producing coenzyme Q10 particles having a high content and superior powder flowability characteristics by simple facility and convenient operations. The present invention provides a method of producing coenzyme Q10 particles, including mixing coenzyme Q10 and a poor solvent by stirring at a temperature not less than the melting point of coenzyme Q10, dispersing coenzyme Q10 into the form of oil droplets, and cooling them to a solidification temperature of coenzyme Q10 or below while stirring the dispersion to give solid particles, wherein the poor solvent is an aqueous solution comprising an organic solvent and/or a surfactant having an HLB of 6 or above. According to the production method of the present invention, coenzyme Q10 particles markedly superior in powder characteristics, and having, for example, a powder flowability index of not less than 80 can be obtained.
摘要翻译：本发明的目的是提供一种能够通过简单的设备和方便的操作在工业上生产具有高含量和优异的粉末流动性特性的辅酶Q10颗粒的生产方法。本发明提供一种生产辅酶Q10颗粒的方法，包括在不少于辅酶Q10的熔点的温度下搅拌辅助辅酶Q10和不良溶剂，将辅酶Q10分散成油滴形式，并将其冷却至在搅拌分散体以得到固体颗粒的同时，辅酶Q10或更低的固化温度，其中不良溶剂是包含HLB为6或更高的有机溶剂和/或表面活性剂的水溶液。根据本发明的制造方法，可以得到粉末特性显着优异的，具有例如不小于80的粉末流动指数的辅酶Q10颗粒。

10. 发明授权

US08496968B2 Method for production of microcapsules using solid fat 失效
标题翻译：使用固体脂肪生产微胶囊的方法
公开(公告)号：US08496968B2
公开(公告)日：2013-07-30
申请号：US12741565
申请日：2008-11-06
申请人： Kento Kanaya , Masao Sato , Akihisa Kanda
发明人： Kento Kanaya , Masao Sato , Akihisa Kanda
IPC分类号： A61K9/14 , A61K9/16
CPC分类号： B01J13/04 , A23L33/10 , A23L33/175 , A23P10/35 , A61K9/5015 , A61K38/05 , A61K38/063
摘要： A method for production of fine microcapsules which encapsulate a hydrophilic bioactive substance at a high content and can be used in wide range of applications such as foods and medical drugs, which method enabling efficient industrial production, is provided. A method for production of S/O type microcapsules including the steps of: (1) emulsifying and dispersing a mixture of a solid fat and an aqueous solution containing a hydrophilic bioactive substance at a temperature of at least the melting point of the solid fat to obtain a W/O emulsion; (2) removing moisture in the W/O emulsion at a temperature of at least the melting point and lower than the boiling point of the solid fat to obtain an S/O suspension; (3) adding the S/O suspension into an aqueous phase containing at least one selected from a surfactant (B), a thickening agent and a hydrophilic organic solvent, and permitting liquid droplet dispersion at a temperature of at least the melting point and lower than the boiling point of the solid fat to obtain an S/O/W emulsion; and (4) cooling the S/O/W emulsion to lower than the melting point of the solid fat to harden the solid fat, and further removing the moisture at a temperature lower than the melting point of the solid fat.
摘要翻译：提供了以高含量包封亲水性生物活性物质的精细微胶囊的制造方法，可以广泛应用于食品，医药等领域，能够实现高效的工业化生产。一种生产S / O型微胶囊的方法，包括以下步骤：（1）将固体脂肪和含有亲水性生物活性物质的水溶液的混合物在至少固体脂肪熔点的温度下乳化和分散至获得W / O乳液; （2）在至少熔点低于固体脂肪沸点的温度下除去W / O乳液中的水分，得到S / O悬浮液; （3）将S / O悬浮液加入到含有选自表面活性剂（B），增稠剂和亲水性有机溶剂中的至少一种的水相中，并允许液滴在至少熔点和更低的温度下分散比固体脂肪的沸点得到S / O / W乳液; 和（4）将S / O / W乳液冷却至低于固体脂肪的熔点，使固体脂肪硬化，并在低于固体脂肪熔点的温度下进一步除去水分。

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