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1. 发明授权

US08568779B2 Method for producing coenzyme Q10 particle 有权
标题翻译：辅酶Q10颗粒的生产方法
公开(公告)号：US08568779B2
公开(公告)日：2013-10-29
申请号：US12522792
申请日：2008-01-10
申请人： Kento Kanaya , Shiro Kitamura , Takahiro Ueda
发明人： Kento Kanaya , Shiro Kitamura , Takahiro Ueda
IPC分类号： A61K9/16 , A61K31/122 , C07C46/10 , A61K9/107 , C07C50/28 , C09K15/08
CPC分类号： A61K31/122 , A23V2250/314 , A61K9/1075 , A61K9/141 , A61K9/16 , A61K9/1617 , A61K9/1652 , A61K9/1688 , C07C46/10 , C07C50/28 , C09K15/08
摘要： The present invention aims to provide a production method capable of industrially and producing coenzyme Q10 particles having a high content and superior powder flowability characteristics by simple facility and convenient operations. The present invention provides a method of producing coenzyme Q10 particles, including mixing coenzyme Q10 and a poor solvent by stirring at a temperature not less than the melting point of coenzyme Q10, dispersing coenzyme Q10 into the form of oil droplets, and cooling them to a solidification temperature of coenzyme Q10 or below while stirring the dispersion to give solid particles, wherein the poor solvent is an aqueous solution comprising an organic solvent and/or a surfactant having an HLB of 6 or above. According to the production method of the present invention, coenzyme Q10 particles markedly superior in powder characteristics, and having, for example, a powder flowability index of not less than 80 can be obtained.
摘要翻译：本发明的目的是提供一种能够通过简单的设备和方便的操作在工业上生产具有高含量和优异的粉末流动性特性的辅酶Q10颗粒的生产方法。本发明提供一种生产辅酶Q10颗粒的方法，包括在不少于辅酶Q10的熔点的温度下搅拌辅助辅酶Q10和不良溶剂，将辅酶Q10分散成油滴形式，并将其冷却至在搅拌分散体以得到固体颗粒的同时，辅酶Q10或更低的固化温度，其中不良溶剂是包含HLB为6或更高的有机溶剂和/或表面活性剂的水溶液。根据本发明的制造方法，可以得到粉末特性显着优异的，具有例如不小于80的粉末流动指数的辅酶Q10颗粒。

2. 发明申请

US20100004473A1 METHOD FOR PRODUCING COENZYME Q10 PARTICLE 有权
标题翻译：生产聚苯乙烯Q10颗粒的方法
公开(公告)号：US20100004473A1
公开(公告)日：2010-01-07
申请号：US12522792
申请日：2008-01-10
申请人： Kento Kanaya , Shiro Kitamura , Takahiro Ueda
发明人： Kento Kanaya , Shiro Kitamura , Takahiro Ueda
IPC分类号： C07C50/28
CPC分类号： A61K31/122 , A23V2250/314 , A61K9/1075 , A61K9/141 , A61K9/16 , A61K9/1617 , A61K9/1652 , A61K9/1688 , C07C46/10 , C07C50/28 , C09K15/08
摘要： The present invention aims to provide a production method capable of industrially and producing coenzyme Q10 particles having a high content and superior powder flowability characteristics by simple facility and convenient operations. The present invention provides a method of producing coenzyme Q10 particles, including mixing coenzyme Q10 and a poor solvent by stirring at a temperature not less than the melting point of coenzyme Q10, dispersing coenzyme Q10 into the form of oil droplets, and cooling them to a solidification temperature of coenzyme Q10 or below while stirring the dispersion to give solid particles, wherein the poor solvent is an aqueous solution comprising an organic solvent and/or a surfactant having an HLB of 6 or above. According to the production method of the present invention, coenzyme Q10 particles markedly superior in powder characteristics, and having, for example, a powder flowability index of not less than 80 can be obtained.
摘要翻译：本发明的目的是提供一种能够通过简单的设备和方便的操作在工业上生产具有高含量和优异的粉末流动性特性的辅酶Q10颗粒的生产方法。本发明提供一种生产辅酶Q10颗粒的方法，包括在不少于辅酶Q10的熔点的温度下搅拌辅助辅酶Q10和不良溶剂，将辅酶Q10分散成油滴形式，并将其冷却至在搅拌分散体以得到固体颗粒的同时，辅酶Q10或更低的固化温度，其中不良溶剂是包含HLB为6或更高的有机溶剂和/或表面活性剂的水溶液。根据本发明的制造方法，可以得到粉末特性显着优异的，具有例如不小于80的粉末流动指数的辅酶Q10颗粒。

3. 发明授权

US08067217B2 Method for preserving reduced coenzyme Q10 有权
标题翻译：保留还原型辅酶Q10的方法
公开(公告)号：US08067217B2
公开(公告)日：2011-11-29
申请号：US11315161
申请日：2005-12-23
申请人： Takahiro Ueda , Tadao Ono , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takahiro Ueda , Tadao Ono , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C12N9/98
CPC分类号： A61K9/4816
摘要： The present invention has its object to provide a method for stably preserving a capsule containing reduced coenzyme Q10, which is useful as foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. The present invention relates to a method for preserving reduced coenzyme Q10 which comprises producing or obtaining a capsule containing reduced coenzyme Q10, and controlling environment surrounding the capsule to a relative humidity of not less than 0% but not more than 60%. According to this method, reduced coenzyme Q10 can be preserved stably, without requiring huge cost and labor, or special equipment.
摘要翻译：本发明的目的是提供一种用于稳定保存含有还原型辅酶Q10的胶囊的方法，所述还原型辅酶Q10可用作食品，功能营养食品，特定保健食品，营养补充剂，营养物质，动物药物，饮料，饲料，化妆品，药物，补救剂，预防药物等。本发明涉及一种保存还原型辅酶Q10的方法，其包括制备或获得含有还原型辅酶Q10的胶囊，并且将胶囊周围的环境控制在相对湿度不小于0％但不超过超过60％。根据该方法，可以稳定地保持还原型辅酶Q10，而不需要巨大的成本和劳动力，或特殊设备。

4. 发明申请

US20110263906A1 METHOD OF PRODUCING REDUCED COENZYME Q10 CRYSTALS WITH EXCELLENT HANDLING PROPERTIES 有权
标题翻译：生产具有优异处理性能的还原型COYZYME Q10水晶的方法
公开(公告)号：US20110263906A1
公开(公告)日：2011-10-27
申请号：US13176479
申请日：2011-07-05
申请人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C07C41/40
CPC分类号： C07C41/40 , C07C43/23
摘要： The present invention provides a method of producing reduced coenzyme Q10 crystals suitable for commercial scale production thereof.According to a method of the present invention of producing a reduced coenzyme Q10 crystal which comprises a crystallization of reduced coenzyme Q10 in a solution of alcohols and/or ketones, reduced coenzyme Q10 crystal excellent in slurry properties and crystalline properties maybe obtained. Moreover, an isolation process including a crystal separation or the whole process including the isolation process maybe minimized and simplified. Thus, highly pure reduced coenzyme Q10 may be obtained in a high yield.
摘要翻译：本发明提供了适合于商业规模生产的还原型辅酶Q10晶体的制造方法。根据本发明的制备还原型辅酶Q10晶体的方法，所述还原型辅酶Q10晶体包括在醇和/或酮溶液中结晶还原型辅酶Q10，可得到浆料性能和结晶性能优异的还原型辅酶Q10晶体。此外，包括晶体分离的分离过程或包括隔离过程的整个过程可以被最小化和简化。因此，可以高产率获得高纯度还原型辅酶Q10。

5. 发明申请

US20100234643A1 METHOD FOR PRODUCTION OF REDUCED COENZYME Q10 USING WATER-CONTAINING ORGANIC SOLVENT 有权
标题翻译：使用含水有机溶剂生产降低COENZYME Q10的方法
公开(公告)号：US20100234643A1
公开(公告)日：2010-09-16
申请号：US12740086
申请日：2008-10-29
申请人： Takahiro Ueda , Shiro Kitamura
发明人： Takahiro Ueda , Shiro Kitamura
IPC分类号： C07C45/41
CPC分类号： C07C41/26 , C07C41/40 , C07C43/23
摘要： The present invention aims to provide reduced coenzyme Q10, which is useful as food, food with nutrient function claims, food for specified health use, nutritional supplement, nutritional product, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, and a production method of reduced coenzyme Q10. The present invention provides a production method of reduced coenzyme Q10, which includes reducing oxidized coenzyme Q10 with ascorbic acid or its analogue(s) as a reducing agent in a water-containing organic solvent at not more than pH 5. Using the method, the reaction time can be drastically shortened even without adding a basic substance and the like, and unpreferable side reactions can be minimized. Therefore, reduced coenzyme Q10 with high quality can be produced.
摘要翻译：本发明旨在提供可用作食物，具有营养功能要求的食物，用于特定健康用途的食物，营养补充剂，营养产品，动物药物，饮料，饲料，化妆品，药物，治疗药物，预防性药物的还原型辅酶Q10 药物等，以及还原型辅酶Q10的制造方法。本发明提供还原型辅酶Q10的制造方法，该方法包括在不高于pH 5的含水有机溶剂中，用抗坏血酸或其类似物还原氧化型辅酶Q10作为还原剂。使用该方法，即使没有添加碱性物质等，反应时间也可以大大缩短，并且不利的副反应可以最小化。因此，可以生产具有高质量的还原型辅酶Q10。

6. 发明申请

US20080152636A1 Composition containing reduced coenzyme Q10 and lysolecithin 审中-公开
标题翻译：含有还原型辅酶Q10和溶血卵磷脂的组合物
公开(公告)号：US20080152636A1
公开(公告)日：2008-06-26
申请号：US11896976
申请日：2007-09-07
申请人： Takahiro Ueda , Shiro Kitamura , Yoshiyuki Shinagawa , Taizou Kawabe , Hideyuki Kishida , Kazunori Hosoe
发明人： Takahiro Ueda , Shiro Kitamura , Yoshiyuki Shinagawa , Taizou Kawabe , Hideyuki Kishida , Kazunori Hosoe
IPC分类号： A61K8/35
CPC分类号： A23K20/10 , A23K20/158 , A23L33/10 , A61K8/347 , A61K8/553 , A61K9/08 , A61K31/122 , A61Q19/00
摘要： The present invention provides a method of improving the absorbability of reduced coenzyme Q10, which includes affording a composition containing lysolecithin and reduced coenzyme Q10 in combination. The composition containing lysolecithin and reduced coenzyme Q10 of the present invention shows superior absorption of reduced coenzyme Q10 and can be utilized for food, food with nutrient function, food for specified health uses, nutritional supplement, nutritional product, animal drug, beverage, feed, pet food, cosmetics, pharmaceutical product, therapeutic drug, preventive drug and the like.
摘要翻译：本发明提供了提高还原型辅酶Q 10的吸收性的方法，其包括组合物提供含有溶血卵磷脂和还原型辅酶Q 10的组合物。含有本发明的溶血卵磷脂和还原型辅酶Q 10的组合物显示出优异的还原型辅酶Q 10的吸收，并且可以用于食品，具有营养功能的食物，具体的食品保健用品，营养补充剂，营养制品，动物药，饮料，饲料，宠物食品，化妆品，药品，治疗药物，预防药物等。

7. 发明申请

US20070161825A1 Method of producing reduced coenzyme Q10 as oily product 有权
公开(公告)号：US20070161825A1
公开(公告)日：2007-07-12
申请号：US11716828
申请日：2007-03-12
申请人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C07C43/20
CPC分类号： C07C41/26 , C07C41/34 , C07C43/23
摘要： The present invention provides a method for obtaining reduced coenzyme Q10 which is useful as an ingredient in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. suited for a commercial scale production in high quality and efficiently. The high-quality oily reduced coenzyme Q10 which has low viscosity and thereby easily handled may be produced by separating an aqueous phase from the reaction mixture obtainable by oily reacting oxidized coenzyme Q10 with a reducing agent in water, or by distilling off an coexisting organic solvent at or above the melting temperature of reduced coenzyme Q10 in concentrating the organic phase containing reduced coenzyme Q10. Moreover, a solution or slurry of reduced coenzyme Q10 may be obtained by adding a desired solvent to the obtained oily product, or a solid of reduced coenzyme Q10 may be produced by contacting the oily product with a seed crystal.

8. 发明授权

US08574568B2 Reduced coenzyme Q10-containing composition comprising a surfactant which is stable against oxidation and method for stabilization by mixing with surfactant(s) 有权
标题翻译：包含对氧化稳定的表面活性剂的还原型辅酶Q 10组合物和与表面活性剂混合的稳定化方法，
公开(公告)号：US08574568B2
公开(公告)日：2013-11-05
申请号：US12092925
申请日：2006-11-07
申请人： Takahiro Ueda , Shiro Kitamura
发明人： Takahiro Ueda , Shiro Kitamura
IPC分类号： A61K31/15 , A61K47/14
CPC分类号： A61K9/4858 , A61K9/4875 , A61K31/05
摘要： The present invention provides a method for stabilization of reduced coenzyme Q10 characterized by concurrently containing a propylene glycol fatty acid ester in a composition containing reduced coenzyme Q10, and a composition containing reduced coenzyme Q10 and a propylene glycol fatty acid ester as essential constituting ingredients. According to the present invention, reduced coenzyme Q10, which is useful as a food, food with nutrient function claims, food for specified health use, nutritional supplement, nutritional product, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like can be stabilized especially without being made into a complicated composition.
摘要翻译：本发明提供还原型辅酶Q10的稳定化方法，其特征在于含有还原型辅酶Q10的组合物中含有丙二醇脂肪酸酯，还含有还原型辅酶Q10和丙二醇脂肪酸酯作为必要构成成分的组合物。根据本发明，可用作食品的具有营养功能的食品的还原型辅酶Q10，用于特定健康用途的食物，营养补充剂，营养产品，动物药物，饮料，饲料，化妆品，药物产品，治疗药物，预防药物等可以稳定化，而不会形成复杂的组合物。

9. 发明授权

US08562975B2 Method for stabilizing reduced coenzyme Q10 and composition therefor 有权
标题翻译：稳定还原型辅酶Q10及其组成的方法
公开(公告)号：US08562975B2
公开(公告)日：2013-10-22
申请号：US10501698
申请日：2003-01-20
申请人： Yasuyoshi Ueda , Takahiro Ueda , Tadao Ono , Shiro Kitamura , Kenji Fujii , Kazunori Hosoe
发明人： Yasuyoshi Ueda , Takahiro Ueda , Tadao Ono , Shiro Kitamura , Kenji Fujii , Kazunori Hosoe
IPC分类号： A61K38/43
CPC分类号： A61K8/347 , A23D9/007 , A23K20/105 , A23L33/10 , A23V2002/00 , A61K8/345 , A61K8/355 , A61K8/375 , A61K8/39 , A61K8/92 , A61K8/922 , A61K8/925 , A61K31/122 , A61K47/10 , A61K47/14 , A61K2800/52 , A61Q19/00 , C07C41/46 , C07C43/23 , A23V2250/314 , A23V2250/1842 , A23V2250/18 , A23V2250/192 , A23V2250/1944
摘要： The present invention relates to a method for stabilizing reduced coenzyme Q10, which is useful as an ingredient in good foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc., and to a composition therefor. The composition comprises reduced coenzyme Q10, a fat and oil (excluding olive oil) and/or a polyol, and doesn't substantially inhibit the stabilization of reduced coenzyme Q10. Additionally, the composition is a reduced coenzyme Q10-containing composition which comprises reduced coenzyme Q10, a polyglycerol fatty acid ester, and a fat and oil and/or a polyol.
摘要翻译：本发明涉及一种用于稳定还原型辅酶Q10的方法，其可用作良好食品中的成分，功能营养食品，特定保健食品，营养补充剂，营养物质，动物药物，饮料，饲料，化妆品，药物，补救剂，预防剂药物等，以及其组合物。组合物包含还原型辅酶Q10，脂肪和油（不包括橄榄油）和/或多元醇，并且基本上不抑制还原型辅酶Q10的稳定化。此外，该组合物是还原型辅酶Q 10组合物，其包含还原型辅酶Q10，聚甘油脂肪酸酯和脂肪和油和/或多元醇。

10. 发明授权

US07829080B2 Stabilization method of reduced coenzyme Q10 有权
标题翻译：还原型辅酶Q10的稳定化方法
公开(公告)号：US07829080B2
公开(公告)日：2010-11-09
申请号：US11741290
申请日：2007-04-27
申请人： Takahiro Ueda , Shiro Kitamura , Hiroshi Kubo , Kazunori Hosoe
发明人： Takahiro Ueda , Shiro Kitamura , Hiroshi Kubo , Kazunori Hosoe
IPC分类号： A61K9/64 , A61K38/43 , A61K38/54
CPC分类号： A61K31/047 , A61K9/4858
摘要： The present invention provides a method for stabilizing reduced coenzyme Q10, which is useful as a food, nutritional product, nutritional supplement, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like. The present invention also provides a method of producing a reduced coenzyme Q10-containing composition which includes the co-presence of reduced coenzyme Q10 and reduced coenzyme Q9 and/or reduced coenzyme Q11.
摘要翻译：本发明提供一种用于稳定还原型辅酶Q10的方法，其可用作食品，营养产品，营养补充剂，动物药物，饮料，饲料，化妆品，药物，治疗药物，预防药物等。本发明还提供了还原型辅酶Q 10组合物的制造方法，该组合物包括还原型辅酶Q 10和还原型辅酶Q 9和/或还原型辅酶Q 11的共存。

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