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1. 发明申请

US20110136191A1 Processes for producing coenzyme Q10 有权
标题翻译：生产辅酶Q10的方法
公开(公告)号：US20110136191A1
公开(公告)日：2011-06-09
申请号：US13020500
申请日：2011-02-03
申请人： Kazuyoshi YAJIMA , Takahisa KATO , Akihisa KANDA , Shiro KITAMURA , Yasuyoshi UEDA
发明人： Kazuyoshi YAJIMA , Takahisa KATO , Akihisa KANDA , Shiro KITAMURA , Yasuyoshi UEDA
IPC分类号： C12P7/22
CPC分类号： C12P7/66 , C12P7/22
摘要： The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus produced reduced coenzyme Q10. The present invention also relates to a process for producing oxidized coenzyme Q10 which comprises either recovering oxidized coenzyme Q10 after oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Q10 from the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Q10 thereafter. According to the processes of the present invention, reduced coenzyme Q10 and oxidized coenzyme Q10 can be produced simply on the industrial scale.
摘要翻译：本发明涉及一种还原型辅酶Q10的制备方法，其包括在整个辅酶Q10中获得含有还原型辅酶Q10比例不小于70摩尔％的微生物细胞，任选地破坏细胞并回收所生成的还原型辅酶Q10。本发明还涉及氧化型辅酶Q10的制造方法，该方法包括在氧化上述微生物细胞或其破坏的产物后回收氧化型辅酶Q10，或将还原型辅酶Q10从上述微生物细胞或其破坏性产物回收至此后氧化由此得到的还原型辅酶Q10。根据本发明的方法，可以简单地在工业规模上制备还原型辅酶Q10和氧化型辅酶Q10。

2. 发明授权

US09315839B2 Processes for producing coenzyme Q10 有权
标题翻译：生产辅酶Q10的方法
公开(公告)号：US09315839B2
公开(公告)日：2016-04-19
申请号：US13020500
申请日：2011-02-03
申请人： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C12P7/66 , C12P7/22
CPC分类号： C12P7/66 , C12P7/22
摘要： The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus produced reduced coenzyme Q10. The present invention also relates to a process for producing oxidized coenzyme Q10 which comprises either recovering oxidized coenzyme Q10 after oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Q10 from the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Q10 thereafter. According to the processes of the present invention, reduced coenzyme Q10 and oxidized coenzyme Q10 can be produced simply on the industrial scale.
摘要翻译：本发明涉及一种还原型辅酶Q10的制备方法，其包括在整个辅酶Q10中获得含有还原型辅酶Q10比例不小于70摩尔％的微生物细胞，任选地破坏细胞并回收所生成的还原型辅酶Q10。本发明还涉及氧化型辅酶Q10的制造方法，该方法包括在氧化上述微生物细胞或其破坏的产物后回收氧化型辅酶Q10，或将还原型辅酶Q10从上述微生物细胞或其破坏性产物回收至此后氧化由此得到的还原型辅酶Q10。根据本发明的方法，可以简单地在工业规模上制备还原型辅酶Q10和氧化型辅酶Q10。

3. 发明授权

US08496968B2 Method for production of microcapsules using solid fat 失效
标题翻译：使用固体脂肪生产微胶囊的方法
公开(公告)号：US08496968B2
公开(公告)日：2013-07-30
申请号：US12741565
申请日：2008-11-06
申请人： Kento Kanaya , Masao Sato , Akihisa Kanda
发明人： Kento Kanaya , Masao Sato , Akihisa Kanda
IPC分类号： A61K9/14 , A61K9/16
CPC分类号： B01J13/04 , A23L33/10 , A23L33/175 , A23P10/35 , A61K9/5015 , A61K38/05 , A61K38/063
摘要： A method for production of fine microcapsules which encapsulate a hydrophilic bioactive substance at a high content and can be used in wide range of applications such as foods and medical drugs, which method enabling efficient industrial production, is provided. A method for production of S/O type microcapsules including the steps of: (1) emulsifying and dispersing a mixture of a solid fat and an aqueous solution containing a hydrophilic bioactive substance at a temperature of at least the melting point of the solid fat to obtain a W/O emulsion; (2) removing moisture in the W/O emulsion at a temperature of at least the melting point and lower than the boiling point of the solid fat to obtain an S/O suspension; (3) adding the S/O suspension into an aqueous phase containing at least one selected from a surfactant (B), a thickening agent and a hydrophilic organic solvent, and permitting liquid droplet dispersion at a temperature of at least the melting point and lower than the boiling point of the solid fat to obtain an S/O/W emulsion; and (4) cooling the S/O/W emulsion to lower than the melting point of the solid fat to harden the solid fat, and further removing the moisture at a temperature lower than the melting point of the solid fat.
摘要翻译：提供了以高含量包封亲水性生物活性物质的精细微胶囊的制造方法，可以广泛应用于食品，医药等领域，能够实现高效的工业化生产。一种生产S / O型微胶囊的方法，包括以下步骤：（1）将固体脂肪和含有亲水性生物活性物质的水溶液的混合物在至少固体脂肪熔点的温度下乳化和分散至获得W / O乳液; （2）在至少熔点低于固体脂肪沸点的温度下除去W / O乳液中的水分，得到S / O悬浮液; （3）将S / O悬浮液加入到含有选自表面活性剂（B），增稠剂和亲水性有机溶剂中的至少一种的水相中，并允许液滴在至少熔点和更低的温度下分散比固体脂肪的沸点得到S / O / W乳液; 和（4）将S / O / W乳液冷却至低于固体脂肪的熔点，使固体脂肪硬化，并在低于固体脂肪熔点的温度下进一步除去水分。

4. 发明授权

US09006493B2 Method for manufacturing a fat-soluble bioactive substance 有权
标题翻译：脂溶性生物活性物质的制造方法
公开(公告)号：US09006493B2
公开(公告)日：2015-04-14
申请号：US13811049
申请日：2011-07-22
申请人： Kento Kanaya , Yasuyuki Suzuki , Akihisa Kanda , Kazuya Yokoe
发明人： Kento Kanaya , Yasuyuki Suzuki , Akihisa Kanda , Kazuya Yokoe
IPC分类号： C07C45/00 , C07C45/80 , C12P7/66 , B01D11/02
CPC分类号： C07C45/80 , A23L29/10 , A23L33/105 , B01D11/0288 , C09B61/00 , C12P7/66
摘要： Provided is a production method of a lipophilic bioactive substance, which includes mixing an aqueous suspension of a microbial cell containing the lipophilic bioactive substance or a microbial cell homogenate thereof and an organic solvent in the presence of a particular surfactant, and extracting the lipophilic bioactive substance into the organic solvent phase.This production method enables extraction without using special dehydrating, drying facility, and without causing a decrease in the yield due to degraded separability between solvent and fungus body component, as well as efficient industrial production.
摘要翻译：本发明提供一种亲脂性生物活性物质的制造方法，其特征在于，在特定的表面活性剂的存在下，将含有所述亲油性生物活性物质的微生物细胞的水性悬浮液或其微生物细胞匀浆与有机溶剂混合，并且提取所述亲脂性生物活性物质进入有机溶剂相。该制造方法能够在不使用特殊的脱水干燥装置的情况下进行提取，并且不会由于溶剂和真菌体成分之间的分离性降低而导致产率降低，以及高效的工业生产。

5. 发明申请

US20130225868A1 METHOD FOR MANUFACTURING A FAT-SOLUBLE BIOACTIVE SUBSTANCE 有权
标题翻译：制造脂溶性生物活性物质的方法
公开(公告)号：US20130225868A1
公开(公告)日：2013-08-29
申请号：US13811049
申请日：2011-07-22
申请人： Kento Kanaya , Yasuyuki Suzuki , Akihisa Kanda , Kazuya Yokoe
发明人： Kento Kanaya , Yasuyuki Suzuki , Akihisa Kanda , Kazuya Yokoe
IPC分类号： C07C45/80
CPC分类号： C07C45/80 , A23L29/10 , A23L33/105 , B01D11/0288 , C09B61/00 , C12P7/66
摘要： Provided is a production method of a lipophilic bioactive substance, which includes mixing an aqueous suspension of a microbial cell containing the lipophilic bioactive substance or a microbial cell homogenate thereof and an organic solvent in the presence of a particular surfactant, and extracting the lipophilic bioactive substance into the organic solvent phase.This production method enables extraction without using special dehydrating, drying facility, and without causing a decrease in the yield due to degraded separability between solvent and fungus body component, as well as efficient industrial production.
摘要翻译：本发明提供一种亲脂性生物活性物质的制造方法，其特征在于，在特定的表面活性剂的存在下，将含有所述亲油性生物活性物质的微生物细胞的水性悬浮液或其微生物细胞匀浆与有机溶剂混合，并且提取所述亲脂性生物活性物质进入有机溶剂相。该制造方法能够在不使用特殊的脱水干燥装置的情况下进行提取，并且不会由于溶剂和真菌体成分之间的分离性降低而导致产率降低，以及高效的工业生产。

6. 发明申请

US20080171373A1 Processes for producing coenzyme Q10 有权
标题翻译：生产辅酶Q10的方法
公开(公告)号：US20080171373A1
公开(公告)日：2008-07-17
申请号：US11981181
申请日：2007-10-31
申请人： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C12N9/00
CPC分类号： C12P7/66 , C12P7/22
摘要： The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus-produced reduced coenzyme Q10. The present invention also relates to a process for producing oxidized coenzyme Q10 which comprises either recovering oxidized coenzyme Q10 after oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Q10 from the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Q10 thereafter. According to the processes of the present invention, reduced coenzyme Q10 and oxidized coenzyme Q10 can be produced simply on the industrial scale.
摘要翻译：本发明涉及一种还原型辅酶Q 10的制备方法，该方法包括：将全部还原型辅酶Q 10的比例不小于70摩尔％的还原型辅酶Q 10 辅酶Q 10，任选地破坏细胞并回收如此生产的还原型辅酶Q 10。本发明还涉及一种生产氧化型辅酶Q 10的方法，其包括在氧化上述微生物细胞或其破坏的产物之后回收氧化型辅酶Q 10，或从上述微生物细胞中回收还原型辅酶Q 10 N或其破坏产物，从而氧化由此得到的还原型辅酶Q 10。根据本发明的方法，可以简单地在工业规模上制备还原型辅酶Q 10和氧化型辅酶Q 10。

7. 发明申请

US20130172538A1 METHOD FOR PRODUCING POROUS PARTICLES, POROUS PARTICLES, ADSORBENT BODY, AND METHOD FOR PURIFYING PROTEIN 审中-公开
标题翻译：生产多孔颗粒的方法，多孔颗粒，吸附体以及净化蛋白质的方法
公开(公告)号：US20130172538A1
公开(公告)日：2013-07-04
申请号：US13821836
申请日：2011-09-12
申请人： Masaru Hirano , Yasuyuki Suzuki , Kento Kanaya , Akihisa Kanda , Takuma Suzuki , Yoshikazu Kawai , Ken-Ichiro Morio
发明人： Masaru Hirano , Yasuyuki Suzuki , Kento Kanaya , Akihisa Kanda , Takuma Suzuki , Yoshikazu Kawai , Ken-Ichiro Morio
IPC分类号： C08B1/00 , B01J20/285 , C07K1/22
CPC分类号： C08B1/003 , B01D15/3809 , B01J20/262 , B01J20/267 , B01J20/28004 , B01J20/285 , B01J20/3212 , B01J20/3274 , C07K1/22 , C08J3/16 , C08J9/28 , C08J2201/0482 , C08J2207/12 , C08J2301/02 , Y10T428/2982
摘要： The objective of the present invention is to provide a method for easily producing a porous cellulose particle which can be used as an adsorbent for various substances in a safe manner without using a highly toxic solvent such as a calcium thiocyanate solution. In addition, the objective of the present invention is to provide a porous particle produced by the production method, an adsorbent which contains the porous particle and by which a highly pure protein can be efficiently purified in a safe manner, and a method for purifying a protein by using the adsorbent. The method for producing a porous particle according to the present invention is characterized in comprising the steps of preparing a solution containing cellulose and an ionic liquid; preparing a dispersion by dispersing the obtained cellulose solution into a liquid, wherein the liquid is not compatible with the ionic liquid; and coagulating the dispersion by bringing into contact with an alcohol or an alcohol aqueous solution in order in order to obtain the porous particle.
摘要翻译：本发明的目的是提供一种容易地制造多孔纤维素颗粒的方法，该方法可以在不使用高毒性溶剂如硫氰酸钙溶液的情况下以安全的方式用作各种物质的吸附剂。此外，本发明的目的是提供一种通过该制造方法制造的多孔质粒子，含有多孔质粒子的吸附剂，能够高效纯化高纯度蛋白质的方法，蛋白质。本发明的多孔质粒的制造方法的特征在于，包括以下步骤：制备含有纤维素和离子液体的溶液; 通过将获得的纤维素溶液分散到液体中制备分散体，其中液体与离子液体不相容; 并通过与醇或醇水溶液接触来依次凝固分散体，以获得多孔颗粒。

8. 发明授权

US07910340B2 Processes for producing coenzyme Q10 有权
标题翻译：生产辅酶Q10的方法
公开(公告)号：US07910340B2
公开(公告)日：2011-03-22
申请号：US11981181
申请日：2007-10-31
申请人： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C12P1/00 , C12P7/66
CPC分类号： C12P7/66 , C12P7/22
摘要： The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus-produced reduced coenzyme Q10. The present invention also relates to a process for producing oxidized coenzyme Q10 which comprises either recovering oxidized coenzyme Q10 after oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Q10 from the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Q10 thereafter. According to the processes of the present invention, reduced coenzyme Q10 and oxidized coenzyme Q10 can be produced simply on the industrial scale.
摘要翻译：本发明涉及还原型辅酶Q10的制备方法，其包括在整个辅酶Q10中获得含有不少于70摩尔％的还原型辅酶Q10的微生物细胞，任选地破坏细胞并回收如此生产的还原型辅酶Q10。本发明还涉及氧化型辅酶Q10的制造方法，该方法包括在氧化上述微生物细胞或其破坏的产物后回收氧化型辅酶Q10，或将还原型辅酶Q10从上述微生物细胞或其破坏性产物回收至此后氧化由此得到的还原型辅酶Q10。根据本发明的方法，可以简单地在工业规模上制备还原型辅酶Q10和氧化型辅酶Q10。

9. 发明申请

US20100297222A1 METHOD FOR PRODUCTION OF MICROCAPSULES USING SOLID FAT 失效
标题翻译：使用固体脂肪生产微胶囊的方法
公开(公告)号：US20100297222A1
公开(公告)日：2010-11-25
申请号：US12741565
申请日：2008-11-06
申请人： Kento Kanaya , Masao ` Sato , Akihisa Kanda
发明人： Kento Kanaya , Masao ` Sato , Akihisa Kanda
IPC分类号： A61K9/50 , A61K38/06 , A61K38/05 , A61P29/00 , A61P39/06 , A61P1/16
CPC分类号： B01J13/04 , A23L33/10 , A23L33/175 , A23P10/35 , A61K9/5015 , A61K38/05 , A61K38/063
摘要： A method for production of fine microcapsules which encapsulate a hydrophilic bioactive substance at a high content and can be used in wide range of applications such as foods and medical drugs, which method enabling efficient industrial production, is provided. A method for production of S/O type microcapsules including the steps of: (1) emulsifying and dispersing a mixture of a solid fat and an aqueous solution containing a hydrophilic bioactive substance at a temperature of at least the melting point of the solid fat to obtain a W/O emulsion; (2) removing moisture in the W/O emulsion at a temperature of at least the melting point and lower than the boiling point of the solid fat to obtain an S/O suspension; (3) adding the S/O suspension into an aqueous phase containing at least one selected from a surfactant (B), a thickening agent and a hydrophilic organic solvent, and permitting liquid droplet dispersion at a temperature of at least the melting point and lower than the boiling point of the solid fat to obtain an S/O/W emulsion; and (4) cooling the S/O/W emulsion to lower than the melting point of the solid fat to harden the solid fat, and further removing the moisture at a temperature lower than the melting point of the solid fat.
摘要翻译：提供了以高含量包封亲水性生物活性物质的精细微胶囊的制造方法，可以广泛应用于食品，医药等领域，能够实现高效的工业化生产。一种生产S / O型微胶囊的方法，包括以下步骤：（1）将固体脂肪和含有亲水性生物活性物质的水溶液的混合物在至少固体脂肪熔点的温度下乳化和分散至获得W / O乳液; （2）在至少熔点低于固体脂肪沸点的温度下除去W / O乳液中的水分，得到S / O悬浮液; （3）将S / O悬浮液加入到含有选自表面活性剂（B），增稠剂和亲水性有机溶剂中的至少一种的水相中，并允许液滴在至少熔点和更低的温度下分散比固体脂肪的沸点得到S / O / W乳液; 和（4）将S / O / W乳液冷却至低于固体脂肪的熔点，使固体脂肪硬化，并在低于固体脂肪熔点的温度下进一步除去水分。

10. 发明申请

US20050069996A1 Processes for producing coenzyme q10 审中-公开
标题翻译：生产辅酶q10的方法
公开(公告)号：US20050069996A1
公开(公告)日：2005-03-31
申请号：US10500249
申请日：2002-12-27
申请人： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C12N1/14 , C12N1/20 , C12P7/22 , C12P7/66
CPC分类号： C12P7/66 , C12P7/22
摘要： The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus-produced reduced coenzyme Q10. The present invention also relates to a process for producing oxidized coenzyme Q10 which comprises either recovering oxidized coenzyme Q10 after oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Q10 from the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Q10 thereafter. According to the processes of the present invention, reduced coenzyme Q10 and oxidized coenzyme Q10 can be produced simply on the industrial scale.
摘要翻译：本发明涉及还原型辅酶Q10的制备方法，其包括在整个辅酶Q10中获得含有不少于70摩尔％的还原型辅酶Q10的微生物细胞，任选地破坏细胞并回收如此生产的还原型辅酶Q10。本发明还涉及氧化型辅酶Q10的制造方法，该方法包括在氧化上述微生物细胞或其破坏的产物后回收氧化型辅酶Q10，或将还原型辅酶Q10从上述微生物细胞或其破坏性产物回收至此后氧化由此得到的还原型辅酶Q10。根据本发明的方法，可以简单地在工业规模上制备还原型辅酶Q10和氧化型辅酶Q10。

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