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1. 发明申请

US20180305513A1 POLYMER AEROGEL WITH IMPROVED MECHANICAL AND THERMAL PROPERTIES 审中-公开
公开(公告)号：US20180305513A1
公开(公告)日：2018-10-25
申请号：US15963839
申请日：2018-04-26
申请人： BLUESHIFT MATERIALS, INC.
发明人： Alan D. SAKAGUCHI , Garrett D. Poe , David J. Irvin , Alysa M. Joaquin , Janae D. Manning
IPC分类号： C08J9/28 , B01J13/00 , C08G73/10
CPC分类号： C08J9/28 , B01J13/0091 , C08G73/10 , C08G73/1071 , C08J2201/0482 , C08J2201/0502 , C08J2205/024 , C08J2205/026 , C08J2205/028 , C08J2205/042 , C08J2205/044 , C08J2205/05 , C08J2207/00 , C08J2207/10 , C08J2300/202 , C08J2379/08
摘要： An aerogel comprising an open-cell structured polymer matrix that includes a polyamic amide polymer is described.

2. 发明授权

US10079378B2 Polyolefin microporous membrane and production method thereof 有权
公开(公告)号：US10079378B2
公开(公告)日：2018-09-18
申请号：US15312558
申请日：2015-05-28
申请人： TORAY INDUSTRIES, INC.
发明人： Tomiko Matsumoto , Masami Sugata , Koichi Kono
IPC分类号： H01M2/16 , H01M2/14 , B01D67/00 , B01D69/02 , B01D71/26 , B29C47/00 , B29C47/16 , B29C47/60 , B29C47/88 , B29C55/00 , B29C55/14 , C08J5/18 , C08J9/28 , C08L23/06 , B29C47/40 , B29L31/34 , B29K23/00 , B29K105/04
CPC分类号： H01M2/1653 , B01D67/002 , B01D67/0027 , B01D69/02 , B01D71/26 , B01D2325/20 , B01D2325/22 , B01D2325/24 , B01D2325/34 , B29C48/0018 , B29C48/08 , B29C48/30 , B29C48/31 , B29C48/40 , B29C48/625 , B29C48/914 , B29C55/005 , B29C55/143 , B29K2023/0683 , B29K2105/041 , B29K2995/0065 , B29L2031/3468 , C08J5/18 , C08J9/28 , C08J2201/0482 , C08J2205/044 , C08J2323/06 , C08J2423/06 , C08L23/06 , C08L2207/068 , H01M2/145
摘要： A polyolefin microporous membrane is disclosed. The membrane includes at least one microporous membrane layer, where the microporous membrane layer has an air permeability between about 100 sec/100 cc and about 220 sec/100 cc, a pin puncture strength of at least 550 gf, and a crystallization half time t1/2 of from 10 to 35 minutes when subjected to isothermal crystallization at 117° C. The air permeability and the pin puncture strength are normalized to a thickness of 16 μm.

3. 发明申请

US20180127560A1 Lyophilized Foams of End Block-Containing Absorbable Polymers 审中-公开
公开(公告)号：US20180127560A1
公开(公告)日：2018-05-10
申请号：US15864207
申请日：2018-01-08
申请人： Ethicon, Inc.
发明人： Jackie Donners , Marc Wisnudel , Mark Timmer
IPC分类号： C08J9/26 , A61L31/14 , C08G63/08 , A61L31/06 , A61L27/58 , A61L27/56 , A61L27/18 , C08J9/36 , C08L67/04
CPC分类号： C08J9/26 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/06 , A61L31/146 , A61L31/148 , C08G63/08 , C08J9/36 , C08J2201/0482 , C08J2205/02 , C08J2205/05 , C08J2207/10 , C08J2300/16 , C08J2367/04 , C08L67/04
摘要： Novel absorbable foams, lyophilizing solutions, and lyophilizing and annealing processes are disclosed. The foams are made from copolymers of glycolide and epsilon-caprolactone. The foams are useful in or as implantable medical devices.

4. 发明授权

US09556325B2 NFC stabilized foam 有权
标题翻译： NFC稳定泡沫
公开(公告)号：US09556325B2
公开(公告)日：2017-01-31
申请号：US14413579
申请日：2013-07-10
申请人： Cellutech AB
发明人： Nicholas Tchang Cervin , Lennart Bergström , Lars-Erik Wågberg
IPC分类号： C08K5/19 , C08B15/06 , C08J9/28 , D21H11/18 , D21H11/20 , D21H27/10 , D21H21/56 , C08B11/12 , C08B11/20 , C08L1/28 , C08J9/00 , C08K5/17 , B82Y30/00
CPC分类号： C08K5/19 , B82Y30/00 , C08B11/12 , C08B11/20 , C08B15/06 , C08J9/0028 , C08J9/28 , C08J2201/0482 , C08J2301/00 , C08K5/17 , C08L1/286 , C08L1/288 , C08L2205/16 , D21H11/18 , D21H11/20 , D21H21/56 , D21H27/10
摘要： A hydrophobized nanofibrillated cellulose foam comprising a charged hydrophobic amine, a method for providing such foam and its use.
摘要翻译：包含带电疏水性胺的疏水化纳米纤维素纤维素泡沫，提供这种泡沫的方法及其用途。

5. 发明申请

US20160354510A1 Absorbable Medical Devices Based on Novel Films and Foams Made From Semi-Crystalline, Segmented Copolymers of Lactide and Epsilon-Caprolactone Exhibiting Long Term Absorption Characteristics 审中-公开
标题翻译：基于新型薄膜和由半乳状态和ε-己内酯的分段共聚物制成的泡沫的可吸收医疗器械展示长期吸收特性
公开(公告)号：US20160354510A1
公开(公告)日：2016-12-08
申请号：US14728177
申请日：2015-06-02
申请人： Ethicon, Inc.
发明人： Sasa Andjelic , Dennis D. Jamiolkowski , Jackie Donners , Mark Timmer
IPC分类号： A61L24/04 , C08J5/18 , C08L67/04 , A61L24/00 , C08G63/08
CPC分类号： A61L24/046 , A61L24/001 , A61L24/0036 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/06 , A61L31/146 , A61L31/148 , C08G63/08 , C08G2101/00 , C08J5/18 , C08J9/04 , C08J9/26 , C08J2201/03 , C08J2201/0482 , C08J2205/02 , C08J2300/16 , C08J2367/04 , C08L67/04
摘要： Absorbable medical devices based on novel foams and films made from semi-crystalline, segmented copolymers of lactide and epsilon-caprolactone exhibiting long term absorption characteristics are disclosed. Also disclosed are methods of producing said foams and films, and useful polymer solutions.
摘要翻译：公开了基于由具有长期吸收特性的丙交酯和ε-己内酯的半结晶分段共聚物制成的新型泡沫和薄膜的可吸收医疗器械。还公开了制备所述泡沫和膜以及有用的聚合物溶液的方法。

6. 发明授权

US09133295B2 Preparation of phenol-formaldehyde resin beads using suspension or emulsion polymerization 有权
标题翻译：使用悬浮液或乳液聚合制备酚醛树脂珠
公开(公告)号：US09133295B2
公开(公告)日：2015-09-15
申请号：US14092267
申请日：2013-11-27
申请人： Georgia-Pacific Chemicals LLC
发明人： Shahid P. Qureshi , Xing Dong , Charles C. Chan , Joseph Frank Ludvik
IPC分类号： C08G8/10 , C08G8/32 , C08G8/22 , C08G85/00
CPC分类号： C08G8/32 , C08G8/10 , C08G8/22 , C08G85/004 , C08J9/16 , C08J9/28 , C08J2201/026 , C08J2201/0482 , C08J2201/0502 , C08J2205/02 , C08J2361/06
摘要： Methods for making polymer particles in gel form via an emulsion and/or suspension polymerization are provided. In at least one specific embodiment, the method can include reacting a first reaction mixture comprising a phenolic monomer, an aldehyde monomer, and a first catalyst to produce a prepolymer. The method can also include combining the prepolymer with a carrier fluid and a second catalyst to produce a second reaction mixture. The second catalyst can include a dicarboxylic acid, an anhydride, a dihydroxybenzene, or any mixture thereof. The method can also include polymerizing the prepolymer to form polymer particles in gel form.
摘要翻译：提供了通过乳液和/或悬浮聚合制备凝胶形式的聚合物颗粒的方法。在至少一个具体实施方案中，该方法可以包括使包含酚单体，醛单体和第一催化剂的第一反应混合物反应以产生预聚物。该方法还可以包括将预聚物与载体流体和第二催化剂组合以产生第二反应混合物。第二催化剂可以包括二羧酸，酸酐，二羟基苯或其任何混合物。该方法还可包括聚合预聚物以形成凝胶形式的聚合物颗粒。

7. 发明申请

US20150247016A1 Polyethylene Aerogel and Method of Production 审中-公开
标题翻译：聚乙烯气凝胶及其生产方法
公开(公告)号：US20150247016A1
公开(公告)日：2015-09-03
申请号：US14700387
申请日：2015-04-30
申请人： Yosry A. Attia
发明人： Yosry A. Attia
IPC分类号： C08J9/00
CPC分类号： C08J9/00 , C08J9/28 , C08J9/33 , C08J2201/0482 , C08J2201/0524 , C08J2205/026 , C08J2323/04 , C08J2323/06 , C08J2323/08
摘要： A method for making polyethylene aerogels, including high molecular weight aerogels, commences by in a hydrocarbon solvent (e.g., toluene or benzene) in which polyethylene is insoluble at room temperature, adding polyethylene to the solvent heated to a temperature at which said polyethylene is soluble to form a reaction mixture. A free-radical catalyst is added to the reaction mixture and the reaction mixture is held until the desired gelation of the polyethylene has been achieved. The reaction mixture is cooled to about room temperature; and the hydrocarbon solvent is replaced with a gas (e.g., CO2 or air) to form the polyethylene aerogel. Optionally, the cooled reaction mixture can be contacted with an anti-solvent for polyethylene to replace the hydrocarbon solvent with the anti-solvent. Silica aerogel particles can be encapsulated in polyethylene aerogel by adding the particles to the polyethylene gelation reaction mixture.
摘要翻译：制造聚乙烯气凝胶的方法，包括高分子量气凝胶，在烃溶剂（如甲苯或苯）中开始，其中聚乙烯在室温下不溶解，加入聚乙烯加热到所述聚乙烯可溶的温度以形成反应混合物。向反应混合物中加入自由基催化剂，并保持反应混合物，直至达到所需的聚乙烯凝胶化。将反应混合物冷却至约室温; 并且用气体（例如CO 2或空气）代替烃溶剂以形成聚乙烯气凝胶。任选地，冷却的反应混合物可与用于聚乙烯的反溶剂接触以用抗溶剂代替烃溶剂。通过将颗粒加入到聚乙烯凝胶化反应混合物中，可以将二氧化硅气凝胶颗粒包封在聚乙烯气凝胶中。

8. 发明申请

US20150158995A1 NFC STABILIZED FOAM 有权
标题翻译： NFC稳定泡沫
公开(公告)号：US20150158995A1
公开(公告)日：2015-06-11
申请号：US14413579
申请日：2013-07-10
申请人： Cellutech AB , Cellutech AB
发明人： Nicholas Tchang Cervin , Lennart Bergström , Lars-Erik Wågberg
IPC分类号： C08K5/19 , C08K5/17 , C08J9/00
CPC分类号： C08K5/19 , B82Y30/00 , C08B11/12 , C08B11/20 , C08B15/06 , C08J9/0028 , C08J9/28 , C08J2201/0482 , C08J2301/00 , C08K5/17 , C08L1/286 , C08L1/288 , C08L2205/16 , D21H11/18 , D21H11/20 , D21H21/56 , D21H27/10
摘要： A hydrophobized nanofibrillated cellulose foam comprising a charged hydrophobic amine, a method for providing such foam and its use.
摘要翻译：包含带电疏水性胺的疏水化纳米纤维素纤维素泡沫，提供这种泡沫的方法及其用途。

9. 发明授权

US06838493B2 Medical devices and applications of polyhydroxyalkanoate polymers 有权
标题翻译：聚羟基链烷酸酯聚合物的医疗装置和应用
公开(公告)号：US06838493B2
公开(公告)日：2005-01-04
申请号：US10082954
申请日：2002-02-26
申请人： Simon F. Williams , David P. Martin , Frank A. Skraly
发明人： Simon F. Williams , David P. Martin , Frank A. Skraly
IPC分类号： A61B17/58 , A61F2/84 , A61K45/00 , A61L15/64 , A61L17/00 , A61L17/12 , A61L27/00 , A61L27/18 , A61L27/58 , A61L31/06 , A61L31/14 , C08G63/06 , C08K5/00 , C12P7/62 , C08L67/04 , A61F13/00
CPC分类号： A61L27/58 , A61F2/07 , A61F2210/0004 , A61K31/715 , A61L17/12 , A61L27/18 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/00 , C08G63/06 , C08J9/26 , C08J2201/0444 , C08J2201/0482 , C08J2367/04 , C08K5/0033 , C08L67/04 , C12P7/625 , Y10S606/911
摘要： Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.
摘要翻译：由生物相容性聚羟基链烷酸酯形成或包括生物相容性聚羟基链烷酸酯的设备具有受控的降解速率，优选在生理条件下小于一年。优选的装置包括缝线，缝线紧固件，弯液面修复装置，铆钉，钉，钉，螺钉（包括干涉螺钉），骨板和骨电镀系统，外科手术网，修复贴片，吊索，心血管贴片，矫形针材料），粘附屏障，支架，引导组织修复/再生装置，关节软骨修复装置，神经导管，肌腱修复装置，房间隔缺损修复装置，心包块，填充剂和填充剂，静脉瓣，骨髓支架，半月板再生装置，韧带和腱移植物，眼细胞植入物，脊髓融合笼，皮肤替代物，硬脑膜替代物，骨移植物替代物，骨榫，伤口敷料和止血剂。聚羟基链烷酸酯可以含有由单体的混合物形成的添加剂，或者在其主链中包括侧基或修饰，或者可以化学改性，以改变降解速率。聚羟基链烷酸酯组合物还在生理条件下的期望时间范围内提供有利的机械性能，生物相容性和降解时间。

10. 发明申请

US20030236320A1 Polyhydroxyalkanoate compositions having controlled degradation rates 有权
标题翻译：具有受控降解速率的聚羟基链烷酸酯组合物
公开(公告)号：US20030236320A1
公开(公告)日：2003-12-25
申请号：US10403942
申请日：2003-03-28
申请人： Metabolix, Inc.
发明人： David P. Martin , Frank Skraly , Simon F. Williams
IPC分类号： C08K003/00
CPC分类号： C08G63/912 , A61K9/1647 , A61K47/593 , A61K47/6957 , A61L15/26 , A61L17/10 , A61L17/12 , A61L24/0042 , A61L26/0019 , A61L26/009 , A61L27/18 , A61L27/34 , A61L27/58 , A61L29/06 , A61L31/06 , A61L31/148 , C08G63/06 , C08G63/64 , C08G63/6852 , C08G63/6882 , C08J9/26 , C08J2201/0444 , C08J2201/0482 , C08J2367/04 , C08K5/0033 , C12N5/0068 , C12N2533/30 , C12P7/625 , C08L67/04
摘要： Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant groups or modifications in their backbones to alter their degradation rates. In still another embodiment, the polyhydroxyalkanoates are chemically modified. Methods for manufacturing the devices which increase porosity or exposed surface area can be used to alter degradability. For example, as demonstrated by the examples, porous polyhydroxyalkanoates can be made using methods that creates pores, voids, or interstitial spacing, such as an emulsion or spray drying technique, or which incorporate leachable or lyophilizable particles within the polymer. Examples describe poly(4HB) compositions including foams, coatings, meshes, and microparticles. As demonstrated by the examples, these polyhydroxyalkanoate compositions have extremely favorable mechanical properties, as well as are biocompatible and degrade within desirable time frames under physioogical conditions. These polyhydroxyalkanoate materials provide a wider range of polyhydroxyalkanoate degradation rates than are currently available. Methods for processing these materials, particularly for therapeutic, prophylactic or diagnostic applications, or into devices which can be implanted or injected, are also described.
摘要翻译：已经开发了具有受控降解速率的生物相容性聚羟基链烷酸酯组合物。在一个实施方案中，聚羟基链烷酸酯含有改变降解速率的添加剂。在另一个实施方案中，聚羟基链烷酸酯由单体的混合物形成或包括侧链基团或其主链中的修饰以改变其降解速率。在另一个实施方案中，聚羟基链烷酸酯被化学改性。用于制造增加孔隙率或暴露表面积的装置的方法可用于改变降解性。例如，如通过实施例所证明的，多孔聚羟基链烷酸酯可以使用产生孔，空隙或间隙的方法，例如乳液或喷雾干燥技术，或者在聚合物内含有可浸出或可冷冻干燥的颗粒。实例描述了包括泡沫，涂层，网格和微粒的聚（4HB）组合物。如实施例所示，这些聚羟基链烷酸酯组合物具有非常有利的机械性能，并且在生理条件下在期望的时间范围内是生物相容的和降解的。这些聚羟基链烷酸酯材料提供比目前可获得的更广泛的聚羟基链烷酸酯降解速率。还描述了用于处理这些材料的方法，特别是用于治疗，预防或诊断应用，或可植入或注射的装置。

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